| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L R Oliveira, A Ribeiro-Silv. Prognostic significance of immunohistochemical biomarkers in oral squamous cell carcinoma. International journal of oral and maxillofacial surgery. vol 40. issue 3. 2011-06-28. PMID:21269808. |
22 molecular biomarkers were identified and classified into five groups based on their biological functions: cell cycle acceleration and proliferation; tumour suppression and apoptosis; hypoxia; angiogenesis; and cell adhesion and matrix degradation. |
2011-06-28 |
2023-08-12 |
Not clear |
| C Urso, G Caim. [Oxidative stress and endothelial dysfunction]. Minerva medica. vol 102. issue 1. 2011-06-28. PMID:21317849. |
reactive oxygen species (ros) can modulate cellular function, receptor signals and immune responses in physiological conditions, but when present in excess, they mediate progressive endothelial damage through growth and migration of vascular smooth muscle and inflammatory cells, alteration of extracellular matrix, apoptosis of endothelial cells, activation of transcription factors (nfkb, ap-1), over-expression of inflammatory cytokines and adhesion molecules (icam-1, vcam-1 , e-selectin). |
2011-06-28 |
2023-08-12 |
Not clear |
| Cornelia Amalinei, Corina Cianga, Raluca Balan, Petru Cianga, Simona Giusca, Irina-Draga Carunt. Immunohistochemical analysis of steroid receptors, proliferation markers, apoptosis related molecules, and gelatinases in non-neoplastic and neoplastic endometrium. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. vol 193. issue 1. 2011-06-22. PMID:21145716. |
endometrioid endometrial carcinoma developed from endometrial hyperplasia is associated with anomalies of proliferation, apoptosis, and matrix metalloproteinase (mmp) expression. |
2011-06-22 |
2023-08-12 |
Not clear |
| Luan D Truong, Lillian Gaber, Garabed Eknoya. Obstructive uropathy. Contributions to nephrology. vol 169. 2011-06-17. PMID:21252529. |
this induces progressive tubular epithelial cell injury, including apoptosis, proliferation, loss of differentiation and atrophy; interstitial inflammatory cell infiltrates composed predominantly of macrophages and t cells; and interstitial fibrosis characterized by an increase and activation of interstitial fibroblasts, deposition of extracellular matrix proteins and loss of peritubular capillaries. |
2011-06-17 |
2023-08-12 |
mouse |
| Reza B Jalili, Alireza Moeen Rezakhanlou, Azadeh Hosseini-Tabatabaei, Ziliang Ao, Garth L Warnock, Aziz Ghahar. Fibroblast populated collagen matrix promotes islet survival and reduces the number of islets required for diabetes reversal. Journal of cellular physiology. vol 226. issue 7. 2011-06-17. PMID:21506112. |
islet-extracellular matrix disengagement, which occurs during islet isolation process, leads to subsequent islet cell apoptosis and is an important contributing factor to early islet loss. |
2011-06-17 |
2023-08-12 |
Not clear |
| Yasunori Saitoh, Vicente Javier Martínez Bruyn, Shin Uota, Atsuhiko Hasegawa, Naoki Yamamoto, Issei Imoto, Johji Inazawa, Shoji Yamaok. Overexpression of NF-κB inducing kinase underlies constitutive NF-κB activation in lung cancer cells. Lung cancer (Amsterdam, Netherlands). vol 70. issue 3. 2011-06-14. PMID:20338663. |
nik depletion induced apoptosis in a549 cells, reduced the matrix metalloproteinase 9 (mmp-9) and survivin mrna expression and affected efficiency of anchorage-independent h1299 cell growth, suggesting a role for nik in the manifestation of oncogenic phenotype. |
2011-06-14 |
2023-08-12 |
human |
| Pål Aukrust, Wiggo J Sandberg, Kari Otterdal, Leif E Vinge, Lars Gullestad, Arne Yndestad, Bente Halvorsen, Thor Uelan. Tumor necrosis factor superfamily molecules in acute coronary syndromes. Annals of medicine. vol 43. issue 2. 2011-06-10. PMID:21039303. |
these plaque destabilization pathways involve the bidirectional interaction between platelets and endothelial cells/monocytes, activation of vascular smooth muscle cells, and co-stimulatory effects on t cells, promoting inflammation, thrombus formation, matrix degradation, and apoptosis. |
2011-06-10 |
2023-08-12 |
Not clear |
| Mohita Shrivastava, S Vivekanandhan, Uttam Pati, Madhuri Behari, Taposh K Da. Mitochondrial perturbance and execution of apoptosis in platelet mitochondria of patients with amyotrophic lateral sclerosis. The International journal of neuroscience. vol 121. issue 3. 2011-06-07. PMID:21138397. |
greater exposure of phosphatidyl serine (ps) residue vindicated by annexin v binding and lesser accumulation of mitotracker red in mitochondrial matrix demonstrated initiation of apoptosis in als platelets. |
2011-06-07 |
2023-08-12 |
Not clear |
| Paula P Campos, Anilton C Vasconcelos, Mônica A N D Ferreira, Silvia P Andrad. Alterations in the dynamics of inflammation, proliferation and apoptosis in subcutaneous implants of lupus-prone mice. Histology and histopathology. vol 26. issue 4. 2011-06-07. PMID:21360436. |
wound repair is a complex process that involves inflammation, proliferation, extracellular matrix deposition/remodeling and apoptosis. |
2011-06-07 |
2023-08-12 |
mouse |
| Andrew J Fowell, Jane E Collins, Dale R Duncombe, Judith A Pickering, William M C Rosenberg, R Christopher Benyo. Silencing tissue inhibitors of metalloproteinases (TIMPs) with short interfering RNA reveals a role for TIMP-1 in hepatic stellate cell proliferation. Biochemical and biophysical research communications. vol 407. issue 2. 2011-06-03. PMID:21300026. |
timps are believed to promote hepatic fibrosis by inhibiting both matrix degradation and apoptosis of hsc. |
2011-06-03 |
2023-08-12 |
Not clear |
| Mahipal Singh, Cerrone R Foster, Suman Dalal, Krishna Sing. Role of osteopontin in heart failure associated with aging. Heart failure reviews. vol 15. issue 5. 2011-06-02. PMID:20127409. |
the post-mi infarct healing process involves temporarily overlapping phases that include the following--(1) inflammation with migration and adhesion of neutrophils and macrophages, phagocytosis and inflammatory gene expression; (2) tissue repair with fibroblast adhesion and proliferation, myofibroblast differentiation, extracellular matrix deposition and scar formation; and (3) structural and functional remodeling of infarcted and non-infarcted myocardium through cardiac myocyte apoptosis, hypertrophy and myocardial angiogenesis. |
2011-06-02 |
2023-08-12 |
mouse |
| Jianyin Long, Yin Wang, Wenjian Wang, Benny H J Chang, Farhad R Danes. MicroRNA-29c is a signature microRNA under high glucose conditions that targets Sprouty homolog 1, and its in vivo knockdown prevents progression of diabetic nephropathy. The Journal of biological chemistry. vol 286. issue 13. 2011-06-01. PMID:21310958. |
functionally, we found that mir-29c induces cell apoptosis and increases extracellular matrix protein accumulation. |
2011-06-01 |
2023-08-12 |
mouse |
| Ponnuraj Nagendraprabhu, Ganapasam Sudhandira. Astaxanthin inhibits tumor invasion by decreasing extracellular matrix production and induces apoptosis in experimental rat colon carcinogenesis by modulating the expressions of ERK-2, NFkB and COX-2. Investigational new drugs. vol 29. issue 2. 2011-05-27. PMID:19876598. |
astaxanthin inhibits tumor invasion by decreasing extracellular matrix production and induces apoptosis in experimental rat colon carcinogenesis by modulating the expressions of erk-2, nfkb and cox-2. |
2011-05-27 |
2023-08-12 |
rat |
| Jessica I Cohen, Laura E Nag. Pathogenesis of alcoholic liver disease: interactions between parenchymal and non-parenchymal cells. Journal of digestive diseases. vol 12. issue 1. 2011-05-24. PMID:21091930. |
this sensitization enhances the production of inflammatory mediators, such as tumor necrosis factor-α and reactive oxygen species that contribute to hepatocyte dysfunction, necrosis and apoptosis of hepatocytes and the generation of extracellular matrix proteins leading to fibrosis. |
2011-05-24 |
2023-08-12 |
Not clear |
| Hyoungshin Park, Benjamin L Larson, Maxime D Guillemette, Saloni R Jain, Casey Hua, George C Engelmayr, Lisa E Free. The significance of pore microarchitecture in a multi-layered elastomeric scaffold for contractile cardiac muscle constructs. Biomaterials. vol 32. issue 7. 2011-05-06. PMID:21144580. |
the 2l constructs exhibited reduced apoptosis, increased expression of connexin-43 (cx-43) and matrix metalloprotease-2 (mmp-2) genes, and increased cx-43 and cardiac troponin-i proteins when cultured with perfusion as compared to static controls. |
2011-05-06 |
2023-08-12 |
rat |
| Panagiotis Papageorgis, Kuanghung Cheng, Sait Ozturk, Yi Gong, Arthur W Lambert, Hamid M Abdolmaleky, Jin-Rong Zhou, Sam Thiagalinga. Smad4 inactivation promotes malignancy and drug resistance of colon cancer. Cancer research. vol 71. issue 3. 2011-05-02. PMID:21245094. |
overall, smad4 deficiency was responsible for the enhanced migration of colon cancer cells with a corresponding increase in matrix metalloprotease 9 enhanced hypoxia-induced glut1 expression, increased aerobic glycolysis, and resistance to 5'-fluoruracil-mediated apoptosis. |
2011-05-02 |
2023-08-12 |
Not clear |
| Anju Preet, Zahida Qamri, Mohd W Nasser, Anil Prasad, Konstantin Shilo, Xianghong Zou, Jerome E Groopman, Ramesh K Ganj. Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non-small cell lung cancer growth and metastasis. Cancer prevention research (Philadelphia, Pa.). vol 4. issue 1. 2011-04-28. PMID:21097714. |
upon further elucidation into the molecular mechanism, we observed that both cb1 and cb2 agonists inhibited phosphorylation of akt, a key signaling molecule controlling cell survival, migration, and apoptosis, and reduced matrix metalloproteinase 9 expression and activity. |
2011-04-28 |
2023-08-12 |
Not clear |
| Weifang Yu, Jian Liu, Michael A Shi, Jianan Wang, Meixiang Xiang, Shiro Kitamoto, Bing Wang, Galina K Sukhova, George F Murphy, Gabriela Orasanu, Anders Grubb, Guo-Ping Sh. Cystatin C deficiency promotes epidermal dysplasia in K14-HPV16 transgenic mice. PloS one. vol 5. issue 11. 2011-04-27. PMID:21085595. |
cysteine protease cathepsins are important in extracellular matrix protein degradation, cell apoptosis, and angiogenesis. |
2011-04-27 |
2023-08-12 |
mouse |
| Maria Martinou, Efstathia Giannopoulou, Georgia Malatara, Andreas A Argyriou, Haralabos P Kalofonos, Dimitrios Kardamaki. Ionizing radiation affects epidermal growth factor receptor signalling and metalloproteinase secretion in glioma cells. Cancer genomics & proteomics. vol 8. issue 1. 2011-04-27. PMID:21289335. |
the effect of different doses of x(-)rays on apoptosis, proliferation, epidermal growth factor receptor (egfr) and matrix metalloproteinase (mmp-2) expression was investigated in a human glioblastoma cell line. |
2011-04-27 |
2023-08-12 |
human |
| Y Zhao, J Xu, J Wei, J Li, J Cai, G Mia. Preservation of islet survival by upregulating α3 integrin signaling: the importance of 3-dimensional islet culture in basement membrane extract. Transplantation proceedings. vol 42. issue 10. 2011-04-25. PMID:21168751. |
the isolation process leads to the loss of the surrounding extracellular matrix, resulting in eventual islet disintegration and apoptosis. |
2011-04-25 |
2023-08-12 |
Not clear |