| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jennifer H Cox, Amanda E Starr, Reinhild Kappelhoff, Rendi Yan, Clive R Roberts, Christopher M Overal. Matrix metalloproteinase 8 deficiency in mice exacerbates inflammatory arthritis through delayed neutrophil apoptosis and reduced caspase 11 expression. Arthritis and rheumatism. vol 62. issue 12. 2011-03-09. PMID:21120997. |
matrix metalloproteinase 8 deficiency in mice exacerbates inflammatory arthritis through delayed neutrophil apoptosis and reduced caspase 11 expression. |
2011-03-09 |
2023-08-12 |
mouse |
| Yoram Yagil, Martin Hessner, Herbert Schulz, Claudia Gosele, Larissa Lebedev, Ronit Barkalifa, Marina Sapojnikov, Norbert Hubner, Chana Yagi. Geno-transcriptomic dissection of proteinuria in the uninephrectomized rat uncovers a molecular complexity with sexual dimorphism. Physiological genomics. vol 42A. issue 4. 2011-02-28. PMID:20876844. |
data mining revealed that these transcripts are involved in multiple molecular mechanisms, including immunity, inflammation, apoptosis, matrix deposition, and protease activity, with no single molecular pathway predominating in either sex. |
2011-02-28 |
2023-08-12 |
rat |
| Xinhua Liao, Xiangming Che, Wei Zhao, Danjie Zhang, Tieqiang Bi, Guanghui Wan. The β-adrenoceptor antagonist, propranolol, induces human gastric cancer cell apoptosis and cell cycle arrest via inhibiting nuclear factor κB signaling. Oncology reports. vol 24. issue 6. 2011-02-24. PMID:21042766. |
in this study, we evaluated whether β-adrenoceptors (β-ars), nuclear factor κb (nf-κb), vascular endothelial growth factor (vegf), cyclooxygenase-2 (cox-2), matrix metalloproteinase-2 (mmp-2) and matrix metalloproteinase-9 (mmp-9) were involved in modulating cell apoptosis and cell cycle arrest by propranolol in human gastric adenocarcinoma cell lines (sgc-7901 and bgc-823) in vitro. |
2011-02-24 |
2023-08-12 |
human |
| Zong-duo Guo, Xiao-chuan Sun, John H Zhan. Mechanisms of early brain injury after SAH: matrix metalloproteinase 9. Acta neurochirurgica. Supplement. vol 110. issue Pt 1. 2011-02-24. PMID:21116916. |
there have been reports that mmp-9 can mediate apoptosis, which called anoikis in cerebral ischemia models, through cleaving main components of the extracellular matrix (ecm), especially laminin. |
2011-02-24 |
2023-08-12 |
Not clear |
| Luke J Drury, Michael K Wendt, Michael B Dwinel. CXCL12 chemokine expression and secretion regulates colorectal carcinoma cell anoikis through Bim-mediated intrinsic apoptosis. PloS one. vol 5. issue 9. 2011-02-18. PMID:20877573. |
resistance to anoikis, apoptosis triggered by a loss of cellular adhesion to the underlying extracellular matrix, is a hallmark of metastatic cancer. |
2011-02-18 |
2023-08-12 |
Not clear |
| Odysseas Kargiotis, Aliki Geka, Jasti S Rao, Athanasios P Kyritsi. Effects of irradiation on tumor cell survival, invasion and angiogenesis. Journal of neuro-oncology. vol 100. issue 3. 2011-02-17. PMID:20449629. |
activation of cell surface receptors, such as the epidermal growth factor receptor, utilization of signaling pathways, and over-expression of cytokines, proteases and growth factors, for example the matrix metalloproteinases and vascular endothelial growth factor, protect tumor and non-tumor cells from apoptosis, increase their ability to invade to adjacent or distant areas, and trigger angiogenesis. |
2011-02-17 |
2023-08-12 |
Not clear |
| Chandramu Chetty, Sajani S Lakka, Praveen Bhoopathi, Christopher S Gondi, Krishna Kumar Veeravalli, Daniel Fassett, Jeffrey D Klopfenstein, Dzung H Dinh, Meena Gujrati, Jasti S Ra. Urokinase plasminogen activator receptor and/or matrix metalloproteinase-9 inhibition induces apoptosis signaling through lipid rafts in glioblastoma xenograft cells. Molecular cancer therapeutics. vol 9. issue 9. 2011-02-17. PMID:20716639. |
urokinase plasminogen activator receptor and/or matrix metalloproteinase-9 inhibition induces apoptosis signaling through lipid rafts in glioblastoma xenograft cells. |
2011-02-17 |
2023-08-12 |
human |
| Chandramu Chetty, Sajani S Lakka, Praveen Bhoopathi, Christopher S Gondi, Krishna Kumar Veeravalli, Daniel Fassett, Jeffrey D Klopfenstein, Dzung H Dinh, Meena Gujrati, Jasti S Ra. Urokinase plasminogen activator receptor and/or matrix metalloproteinase-9 inhibition induces apoptosis signaling through lipid rafts in glioblastoma xenograft cells. Molecular cancer therapeutics. vol 9. issue 9. 2011-02-17. PMID:20716639. |
small interfering rna (sirna)-mediated transcriptional knockdown of urokinase plasminogen activator receptor (upar) and matrix metalloproteinase-9 (mmp-9), alone or in combination, inhibits upar and/or mmp-9 expression and induces apoptosis in the human glioblastoma xenograft cell lines 4910 and 5310. sirna against upar (pu-si), mmp-9 (pm-si), or both (pum-si) induced apoptosis and was associated with the cleavage of caspase-8, caspase-3, and poly(adp-ribose) polymerase. |
2011-02-17 |
2023-08-12 |
human |
| Valerie Trapp, Basmina Parmakhtiar, Vartan Papazian, Lyndsay Willmott, John P Fruehau. Anti-angiogenic effects of resveratrol mediated by decreased VEGF and increased TSP1 expression in melanoma-endothelial cell co-culture. Angiogenesis. vol 13. issue 4. 2011-02-17. PMID:20927579. |
we hypothesized that the anti-angiogenic activity of resveratrol may be caused by modulation of tumor cell release of thrombospondin-1 (tsp1) and vascular endothelial growth factor (vegf) into the extracellular matrix, leading to vascular endothelial cell (vec) apoptosis. |
2011-02-17 |
2023-08-12 |
Not clear |
| Mercedes Zurita, Laura Otero, Concepción Aguayo, Celia Bonilla, Edgar Ferreira, Avelino Parajón, Jesús Vaquer. Cell therapy for spinal cord repair: optimization of biologic scaffolds for survival and neural differentiation of human bone marrow stromal cells. Cytotherapy. vol 12. issue 4. 2011-02-14. PMID:20465485. |
the suppression of cell apoptosis using a biodegradable scaffold to replace the missing or altered extracellular matrix (ecm) could increase the survival of transplanted cells and thus increase the effectiveness of cell therapy. |
2011-02-14 |
2023-08-12 |
human |
| Teresita Bellid. Antagonistic interplay between mechanical forces and glucocorticoids in bone: a tale of kinases. Journal of cellular biochemistry. vol 111. issue 1. 2011-02-14. PMID:20506204. |
recent evidence gained from studies on bone cell apoptosis has revealed that mechanical forces and gc exhibit converse effects on osteocyte and osteoblast survival resulting from divergent actions on the focal adhesion kinases fak and pyk2, molecules that regulate integrin-dependent interactions between bone cells and the extracellular matrix (ecm). |
2011-02-14 |
2023-08-12 |
Not clear |
| Michal Shachar, Orna Tsur-Gang, Tal Dvir, Jonathan Leor, Smadar Cohe. The effect of immobilized RGD peptide in alginate scaffolds on cardiac tissue engineering. Acta biomaterialia. vol 7. issue 1. 2011-02-14. PMID:20688198. |
the immobilized rgd peptide promoted cell adherence to the matrix, prevented cell apoptosis and accelerated cardiac tissue regeneration. |
2011-02-14 |
2023-08-12 |
rat |
| Jayesh Sagar, Kevin Sales, A Seifalian, M Winsle. Doxycycline in mitochondrial mediated pathway of apoptosis: a systematic review. Anti-cancer agents in medicinal chemistry. vol 10. issue 7. 2011-02-14. PMID:20879988. |
recently their role as matrix metalloproteinase inhibitor and in apoptosis has widely attracted attention in biological field. |
2011-02-14 |
2023-08-12 |
Not clear |
| Daryl M Okamura, Katie Pasichnyk, Jesus M Lopez-Guisa, Sarah Collins, Daniel K Hsu, Fu-Tong Liu, Allison A Edd. Galectin-3 preserves renal tubules and modulates extracellular matrix remodeling in progressive fibrosis. American journal of physiology. Renal physiology. vol 300. issue 1. 2011-02-09. PMID:20962111. |
taken together, these results suggested that gal-3 not only protects renal tubules from chronic injury by limiting apoptosis but that it may lead to enhanced matrix remodeling and fibrosis attenuation. |
2011-02-09 |
2023-08-12 |
mouse |
| Mona Hedayat, Mohammad Jafar Mahmoudi, Noel R Rose, Nima Rezae. Proinflammatory cytokines in heart failure: double-edged swords. Heart failure reviews. vol 15. issue 6. 2011-02-08. PMID:20405319. |
cardiac myocyte hypertrophy, contractile dysfunction, cardiac myocyte apoptosis, and extracellular matrix remodeling contribute enormously to the development and progression of chronic heart failure. |
2011-02-08 |
2023-08-12 |
Not clear |
| Jie Qiu, Rui Cheng, Xiao-yu Zhou, Jin-gai Zhu, Chun Zhu, Da-ni Qin, Chun-zhao Kou, Xi-rong Gu. Gene expression profiles of adipose tissue of high-fat diet-induced obese rats by cDNA microarrays. Molecular biology reports. vol 37. issue 8. 2011-02-07. PMID:20191385. |
different clusters of genes associated with lipid metabolism, extracellular matrix, signal transduction, cytoskeleton, cell apoptosis, etc., such as vlcs-h2, dgat, acadvl, phyh, scd, acaca, acs, mmp-2, mmp-15, cd38, camk2d, cacna1f, capza2, tmod3, arpc2, kns2, tpm1, mapk8, gadd45b, daxx, tok-1, prkaca, stat6, were concerned. |
2011-02-07 |
2023-08-12 |
rat |
| Youyou Zhao, Declan McLaughlin, Emma Robinson, Adam P Harvey, Michelle B Hookham, Ajay M Shah, Barbara J McDermott, David J Griev. Nox2 NADPH oxidase promotes pathologic cardiac remodeling associated with Doxorubicin chemotherapy. Cancer research. vol 70. issue 22. 2011-02-07. PMID:20884632. |
furthermore, in response to doxorubicin, nox2-/- mice exhibited less myocardial atrophy, cardiomyocyte apoptosis, and interstitial fibrosis, together with reduced increases in profibrotic gene expression (procollagen iiiαi, transforming growth factor-β3, and connective tissue growth factor) and matrix metalloproteinase-9 activity, versus wt controls. |
2011-02-07 |
2023-08-12 |
mouse |
| Joost P H Drenth, Melissa Chrispijn, Carsten Bergman. Congenital fibrocystic liver diseases. Best practice & research. Clinical gastroenterology. vol 24. issue 5. 2011-02-03. PMID:20955960. |
the fibrocystogenic process shares some common features including proliferation and dilatation of epithelial bile ducts with concomitant abnormal apoptosis, fluid secretion and extracellular matrix deposition. |
2011-02-03 |
2023-08-12 |
Not clear |
| MaLing Gou, Ke Men, Juan Zhang, YuHua Li, Jia Song, Shan Luo, HuaShan Shi, YanJun Wen, Gang Guo, MeiJuan Huang, Xia Zhao, ZhiYong Qian, YuQuan We. Efficient inhibition of C-26 colon carcinoma by VSVMP gene delivered by biodegradable cationic nanogel derived from polyethyleneimine. ACS nano. vol 4. issue 10. 2011-02-02. PMID:20839784. |
the plasmid expressing vesicular stomatitis virus matrix protein (pvsvmp) could be efficiently transfected into c-26 colon carcinoma cells by hpei nanogels in vitro, inhibiting the cell proliferation through apoptosis induction. |
2011-02-02 |
2023-08-12 |
mouse |
| Janne P Kallio, Sally Hopkins-Donaldson, Andrew H Baker, Veli-Matti Kähär. TIMP-3 promotes apoptosis in nonadherent small cell lung carcinoma cells lacking functional death receptor pathway. International journal of cancer. vol 128. issue 4. 2011-01-31. PMID:20473894. |
timp-3 inhibits adhesion of cells to extracellular matrix and promotes apoptosis through death receptor-activated, caspase-8-mediated pathway. |
2011-01-31 |
2023-08-12 |
Not clear |