| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Julie A W Stilley, Kathy L Sharpe-Timm. TIMP1 contributes to ovarian anomalies in both an MMP-dependent and -independent manner in a rat model. Biology of reproduction. vol 86. issue 2. 2012-07-09. PMID:22053095. |
we predict that mmp-dependent and mmp-independent events are involved in improper fortification of the follicular wall through multiple mechanisms, such as apoptosis inhibition, extracellular matrix components and angiogenesis. |
2012-07-09 |
2023-08-12 |
rat |
| Valentina Bizzarro, Antonello Petrella, Luca Parent. Annexin A1: novel roles in skeletal muscle biology. Journal of cellular physiology. vol 227. issue 8. 2012-07-03. PMID:22213240. |
anxa1 has been involved in a broad range of molecular and cellular processes, including anti-inflammatory signalling, kinase activities in signal transduction, maintenance of cytoskeleton and extracellular matrix integrity, tissue growth, apoptosis, and differentiation. |
2012-07-03 |
2023-08-12 |
Not clear |
| Hong Zhang, Xia Ran, Chang-Ling Hu, Lu-Ping Qin, Ying Lu, Cheng Pen. Therapeutic effects of liposome-enveloped Ligusticum chuanxiong essential oil on hypertrophic scars in the rabbit ear model. PloS one. vol 7. issue 2. 2012-06-29. PMID:22363569. |
on postoperative day 56, the scar tissue was excised for masson's trichrome staining, detection of fibroblast apoptosis, assays of the levels of collagens i and iii, and analysis of the mrna expression of matrix metalloproteinase-1 (mmp-1), caspase-3 and -9, and transforming growth factor beta 1 (tgf-β(1)). |
2012-06-29 |
2023-08-12 |
human |
| Vladislava Juric, Chih-Chiun Chen, Lester F La. TNFα-induced apoptosis enabled by CCN1/CYR61: pathways of reactive oxygen species generation and cytochrome c release. PloS one. vol 7. issue 2. 2012-06-29. PMID:22363611. |
however, several members of ccn (cyr61/ctgf/nov) family of extracellular matrix proteins enable tnfα-dependent apoptosis in vitro without inhibiting nfκb or de novo protein synthesis, and ccn1 (cyr61) is essential for optimal tnfα cytotoxicity in vivo. |
2012-06-29 |
2023-08-12 |
Not clear |
| Stav Simsa-Maziel, Efrat Monsonego-Orna. Interleukin-1β promotes proliferation and inhibits differentiation of chondrocytes through a mechanism involving down-regulation of FGFR-3 and p21. Endocrinology. vol 153. issue 5. 2012-06-29. PMID:22492305. |
here we show that il-1β affects bone growth by directly disturbing the normal sequence of events in the growth plate, resulting in increased proliferation and widening of the proliferative zone, whereas the hypertrophic zone becomes disorganized, with impaired matrix structure and increased apoptosis and osteoclast activity. |
2012-06-29 |
2023-08-12 |
Not clear |
| Yufeng Xie, Haitao Lv, Weihua Sheng, Jingcheng Miao, Jim Xiang, Jicheng Yan. Synergistic tumor suppression by adenovirus-mediated inhibitor of growth 4 and interleukin-24 gene cotransfer in hepatocarcinoma cells. Cancer biotherapy & radiopharmaceuticals. vol 26. issue 6. 2012-06-26. PMID:21988227. |
it was demonstrated that ad-ing4-il-24 induced synergistic growth inhibition, apoptosis, invasion suppression, as well as an enhanced effect on upregulation of p21, p27, fas, fasl, fadd, bad, bax, bak, cleaved bid, cleaved caspase-8, -9, and -3, and cleaved parp, downregulation of bcl-2, bcl-x(l), matrix metalloproteinase (mmp)-2, 9, vascular endothelial growth factor (vegf), il-8, cd34, and microvessel density, and cytochrome c release from mitochondria into cytosol in in vitro smmc-7721 and hepg2 hepatocarcinoma cells and/or in vivo smmc-7721 hepatocarcinoma subcutaneous xenografted tumors in athymic nude mice. |
2012-06-26 |
2023-08-12 |
mouse |
| Benjamin A Katchman, Kwasi Antwi, Galen Hostetter, Michael J Demeure, Aprill Watanabe, G Anton Decker, Laurence J Miller, Daniel D Von Hoff, Douglas F Lak. Quiescin sulfhydryl oxidase 1 promotes invasion of pancreatic tumor cells mediated by matrix metalloproteinases. Molecular cancer research : MCR. vol 9. issue 12. 2012-06-21. PMID:21989104. |
growth, cell cycle, apoptosis, invasion, and matrix metalloproteinase (mmp) activity were evaluated. |
2012-06-21 |
2023-08-12 |
Not clear |
| Gert-Jan Bakker, Volker Andresen, Robert M Hoffman, Peter Fried. Fluorescence lifetime microscopy of tumor cell invasion, drug delivery, and cytotoxicity. Methods in enzymology. vol 504. 2012-06-19. PMID:22264531. |
by correlating specific areas in the phasor plot to the actual image, we obtained direct insight into cancer-cell invasion into a 3d collagen matrix, the differential uptake of doxorubicin by cells, and the consequences on cell invasion and apoptosis induction. |
2012-06-19 |
2023-08-12 |
Not clear |
| Eduardo R Cobo, Sharon L Reed, Lynette B Corbei. Effect of vinyl sulfone inhibitors of cysteine proteinases on Tritrichomonas foetus infection. International journal of antimicrobial agents. vol 39. issue 3. 2012-06-15. PMID:22104282. |
cysteine proteinases (cps) released by t. foetus degrade immunoglobulin g (igg) antibodies, complement component 3 and matrix proteins as well as inducing apoptosis of bovine genital epithelial cells. |
2012-06-15 |
2023-08-12 |
human |
| Michelle L D'Antoni, Paul-André Risse, Pasquale Ferraro, James G Martin, Mara S Ludwi. Effects of decorin and biglycan on human airway smooth muscle cell adhesion. Matrix biology : journal of the International Society for Matrix Biology. vol 31. issue 2. 2012-06-14. PMID:22155154. |
growth on a decorin matrix results in decreased human airway smooth muscle cell (hasmc) number, by decreasing proliferation and increasing apoptosis. |
2012-06-14 |
2023-08-12 |
human |
| K Khoufache, N Michaud, N Harir, P Kibangou Bondza, A Akou. Anomalies in the inflammatory response in endometriosis and possible consequences: a review. Minerva endocrinologica. vol 37. issue 1. 2012-06-12. PMID:22382616. |
this review sheds light on cellular and immunological pro-inflammatory changes which were observed in patients with endometriosis, their impact on angiogenesis, apoptosis, extracellular matrix remodeling and hormonal production and consequences on fertility. |
2012-06-12 |
2023-08-12 |
Not clear |
| Jia-Ming Xu, Guo-Ping Sh. Emerging role of mast cells and macrophages in cardiovascular and metabolic diseases. Endocrine reviews. vol 33. issue 1. 2012-06-05. PMID:22240242. |
although more sophisticated mechanisms are still unknown, data from animal studies suggest that mast cells act similarly to macrophages and other inflammatory cells and contribute to human diseases through cell-cell interactions and the release of proinflammatory cytokines, chemokines, and proteases to induce inflammatory cell recruitment, cell apoptosis, angiogenesis, and matrix protein remodeling. |
2012-06-05 |
2023-08-12 |
human |
| Paola Ostano, Silvia Bione, Cristina Belgiovine, Ilaria Chiodi, Chiara Ghimenti, A Ivana Scovassi, Giovanna Chiorino, Chiara Mondell. Cross-analysis of gene and miRNA genome-wide expression profiles in human fibroblasts at different stages of transformation. Omics : a journal of integrative biology. vol 16. issue 1-2. 2012-06-05. PMID:22321013. |
these genes identified processes significantly deregulated in tumorigenic cells, such as cell differentiation, cell movement and extracellular matrix remodeling, cell cycle and apoptosis, together with upregulation of several cancer testis antigens. |
2012-06-05 |
2023-08-12 |
human |
| Saidan Ding, Bicheng Che. Pathogenesis of hepatic fibrosis analyzed at the proteome level. Saudi medical journal. vol 33. issue 2. 2012-06-05. PMID:22327750. |
here, we describe the mechanisms of action that are defined as being related to 1) oxidative stress and mitochondrial damage, 2) inflammatory response and immune injury, 3) abnormal cell proliferation and apoptosis, 4) abnormal metabolism, 5) abnormal cellular signal transduction, and 6) abnormal extracellular matrix metabolism. |
2012-06-05 |
2023-08-12 |
Not clear |
| Shiro Mizuno, Masanori Yasuo, Harm J Bogaard, Donatas Kraskauskas, Aysar Alhussaini, Jose Gomez-Arroyo, Daniela Farkas, Laszlo Farkas, Norbert F Voelke. Copper deficiency induced emphysema is associated with focal adhesion kinase inactivation. PloS one. vol 7. issue 1. 2012-06-04. PMID:22276220. |
cell detachment from the extracellular matrix can induce apoptosis (anoikis) via inactivation of focal adhesion kinase (fak). |
2012-06-04 |
2023-08-12 |
Not clear |
| Soodabeh Zandi, Sunil Kalia, Harvey Lu. UVA1 phototherapy: a concise and practical review. Skin therapy letter. vol 17. issue 1. 2012-06-04. PMID:22358227. |
uva1 radiation induces collagenase (matrix metalloproteinase-1) expression, t-cell apoptosis, and depletes langerhans and mast cells in the dermis. |
2012-06-04 |
2023-08-12 |
Not clear |
| Yi Zhang, Ren-Xiong Wei, Xiao-Bin Zhu, Lin Cai, Wei Jin, Hao H. Tanshinone IIA induces apoptosis and inhibits the proliferation, migration, and invasion of the osteosarcoma MG-63 cell line in vitro. Anti-cancer drugs. vol 23. issue 2. 2012-05-31. PMID:22126901. |
furthermore, we detected possible molecular mechanisms for tan iia activity by examining the levels of bcl-2, bax expression, and caspase-3, caspase-8, and caspase-9 activities that regulate apoptosis, matrix metalloproteinase (mmp)-2, and mmp-9 involved in regulating migration and invasion. |
2012-05-31 |
2023-08-12 |
human |
| Filippo Peder D'Andre. Intrinsic radiation resistance of mesenchymal cancer stem cells and implications for treatment response in a murine sarcoma model. Danish medical journal. vol 59. issue 2. 2012-05-25. PMID:22293058. |
several genes involved in matrix maintenance and apoptosis had altered levels of expression and this could be the driving force behind the cancer stem cells enhanced radiation resistance. |
2012-05-25 |
2023-08-12 |
human |
| Jin Suk Park, Wilson Lee, Christopher A McCulloc. Intercellular transfer of apoptotic signals via electrofusion. Experimental cell research. vol 318. issue 8. 2012-05-23. PMID:22426198. |
we determined whether cells that are induced to undergo anoikis by matrix detachment can initiate apoptosis in healthy cells following electroporation-induced fusion. |
2012-05-23 |
2023-08-12 |
Not clear |
| A P Bastos, L F Onuchi. Molecular and cellular pathogenesis of autosomal dominant polycystic kidney disease. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 44. issue 7. 2012-05-21. PMID:21625823. |
the cyst cell phenotype includes increased proliferation and apoptosis, dedifferentiation, defective planar polarity, and a secretory pattern associated with extracellular matrix remodeling. |
2012-05-21 |
2023-08-12 |
human |