| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ayman ElAli, Dirk M Herman. Liver X receptor activation enhances blood-brain barrier integrity in the ischemic brain and increases the abundance of ATP-binding cassette transporters ABCB1 and ABCC1 on brain capillary cells. Brain pathology (Zurich, Switzerland). vol 22. issue 2. 2012-11-06. PMID:21767321. |
moreover, lxr activation deactivates matrix metalloproteases-2/9 and inhibits microvascular apoptosis by deactivating jnk1/2 and caspase-3. |
2012-11-06 |
2023-08-12 |
mouse |
| L Yart, F Dessauge, L Finot, S Barbey, P G Marnet, V Lollivie. Ovariectomy improves lactation persistency in dairy cows. Journal of dairy science. vol 95. issue 7. 2012-11-05. PMID:22720935. |
the ovariectomy appears to have limited the decline in the milk yield after the peak of lactation by reducing mammary epithelial cell apoptosis [by reducing poly(adenosine diphosphate-ribose) polymerase expression] and mammary-tissue remodeling (by reducing matrix metalloproteinase activity). |
2012-11-05 |
2023-08-12 |
Not clear |
| Ming Ding, Yaojuan Lu, Sam Abbassi, Feifei Li, Xin Li, Yu Song, Valérie Geoffroy, Hee-Jeong Im, Qiping Zhen. Targeting Runx2 expression in hypertrophic chondrocytes impairs endochondral ossification during early skeletal development. Journal of cellular physiology. vol 227. issue 10. 2012-10-29. PMID:22223437. |
this will change the local matrix environment, delay chondrocyte maturation, reduce apoptosis and matrix mineralization, and eventually, lead to impaired endochondral ossification. |
2012-10-29 |
2023-08-12 |
mouse |
| Bin Hu, Mohan S Nandhu, Hosung Sim, Paula A Agudelo-Garcia, Joshua C Saldivar, Claire E Dolan, Maria E Mora, Gerard J Nuovo, Susan E Cole, Mariano S Viapian. Fibulin-3 promotes glioma growth and resistance through a novel paracrine regulation of Notch signaling. Cancer research. vol 72. issue 15. 2012-10-29. PMID:22665268. |
these findings underscore a major role for the tumor extracellular matrix in regulating glioma invasion and resistance to apoptosis via activation of the key notch pathway. |
2012-10-29 |
2023-08-12 |
Not clear |
| Chien-An Chen, Tsang-Shan Chen, Hung-Chun Che. Extracellular signal-regulated kinase plays a proapoptotic role in podocytes after reactive oxygen species treatment and inhibition of integrin-extracellular matrix interaction. Experimental biology and medicine (Maywood, N.J.). vol 237. issue 7. 2012-10-26. PMID:22829704. |
the effect of reactive oxygen species (ros) and blocking integrin-extracellular matrix (ecm) interaction on apoptosis in podocytes, and the related signal transduction pathways remain unclear. |
2012-10-26 |
2023-08-12 |
rat |
| Yuji Sakuma, Yukiko Yamazaki, Yoshiyasu Nakamura, Mitsuyo Yoshihara, Shoichi Matsukuma, Shiro Koizume, Yohei Miyag. NF-κB signaling is activated and confers resistance to apoptosis in three-dimensionally cultured EGFR-mutant lung adenocarcinoma cells. Biochemical and biophysical research communications. vol 423. issue 4. 2012-10-22. PMID:22695117. |
since the microenvironment of cells cultured in a monolayer are substantially different to that of cells existing in three-dimension (3d) in vivo, we assessed whether two egfr-mutant lung adenocarcinoma cell lines, hcc827 and h1975, were more resistant to egfr tki-induced apoptosis when cultured in a 3d extracellular matrix (ecm) as compared with in suspension. |
2012-10-22 |
2023-08-12 |
Not clear |
| A R Grassian, J L Coloff, J S Brugg. Extracellular matrix regulation of metabolism and implications for tumorigenesis. Cold Spring Harbor symposia on quantitative biology. vol 76. 2012-10-17. PMID:22105806. |
although apoptosis is the most rapid and effective mechanism that causes the death of matrix-detached cells, it has become apparent that detachment from matrix alters other aspects of cell physiology prior to commitment to cell death and that some of these alterations can lead to cell death under conditions where apoptosis is suppressed. |
2012-10-17 |
2023-08-12 |
Not clear |
| Yue Wang, Lingzhi Li, Xiaoqin Guo, Xin Jin, Weijia Sun, Xiaolei Zhang, Rui Cheng X. Interleukin-6 signaling regulates anchorage-independent growth, proliferation, adhesion and invasion in human ovarian cancer cells. Cytokine. vol 59. issue 2. 2012-10-16. PMID:22595649. |
further investigation indicates that il-6 promotes ovca cell proliferation by altering cell cycle distribution rather than inhibiting apoptosis and that il-6-enhanced ovca cell invasive may be associated with increased matrix metalloproteinase (mmp)-9 but not mmp-2 proteolytic activity. |
2012-10-16 |
2023-08-12 |
human |
| Guangcun Huang, David R Brigstoc. Regulation of hepatic stellate cells by connective tissue growth factor. Frontiers in bioscience (Landmark edition). vol 17. 2012-10-09. PMID:22652794. |
connective tissue growth factor (ctgf/ccn2) regulates cell proliferation, differentiation, adhesion, chemotaxis, migration, apoptosis and extracellular matrix production. |
2012-10-09 |
2023-08-12 |
Not clear |
| Yanling Zhang, Darren A Yuen, Andrew Advani, Kerri Thai, Suzanne L Advani, David Kepecs, M Golam Kabir, Kim A Connelly, Richard E Gilber. Early-outgrowth bone marrow cells attenuate renal injury and dysfunction via an antioxidant effect in a mouse model of type 2 diabetes. Diabetes. vol 61. issue 8. 2012-10-08. PMID:22596053. |
untreated db/db mice developed mesangial matrix expansion and tubular epithelial cell apoptosis in association with increased reactive oxygen species (ros) and overexpression of thioredoxin interacting protein (txnip). |
2012-10-08 |
2023-08-12 |
mouse |
| Yanling Zhang, Darren A Yuen, Andrew Advani, Kerri Thai, Suzanne L Advani, David Kepecs, M Golam Kabir, Kim A Connelly, Richard E Gilber. Early-outgrowth bone marrow cells attenuate renal injury and dysfunction via an antioxidant effect in a mouse model of type 2 diabetes. Diabetes. vol 61. issue 8. 2012-10-08. PMID:22596053. |
without affecting blood glucose or blood pressure, eocs not only attenuated mesangial and peritubular matrix expansion, as well as tubular apoptosis, but also diminished ros and txnip overexpression in the kidney of db/db mice. |
2012-10-08 |
2023-08-12 |
mouse |
| Alenka Lovy, Anthony J A Molina, Fernanda M Cerqueira, Kyle Trudeau, Orian S Shiriha. A faster, high resolution, mtPA-GFP-based mitochondrial fusion assay acquiring kinetic data of multiple cells in parallel using confocal microscopy. Journal of visualized experiments : JoVE. issue 65. 2012-10-03. PMID:22847388. |
fusion of mitochondria, on the other hand, leads to sharing of matrix proteins, solutes, mtdna and the electrochemical gradient, and also seems to prevent progression to apoptosis. |
2012-10-03 |
2023-08-12 |
human |
| Herman Yeger, Bernard Perba. The CCN family of genes: a perspective on CCN biology and therapeutic potential. Journal of cell communication and signaling. vol 1. issue 3-4. 2012-10-02. PMID:18568428. |
ccn proteins are involved in mitosis, adhesion, apoptosis, extracellular matrix production, growth arrest and migration of multiple cell types. |
2012-10-02 |
2023-08-12 |
Not clear |
| K Lalithakumari, A V Krishnaraju, K Sengupta, G V Subbaraju, A Chatterje. Safety and Toxicological Evaluation of a Novel, Standardized 3-O-Acetyl-11-keto-beta-Boswellic Acid (AKBA)-Enriched Boswellia serrata Extract (5-Loxin(R)). Toxicology mechanisms and methods. vol 16. issue 4. 2012-10-02. PMID:20021046. |
5-loxin(r) significantly prevented the tnfalpha-induced expression of matrix metalloproteinases and adhesion molecules (icam-1 and vcam-1), and inducible expression of the mediators of apoptosis. |
2012-10-02 |
2023-08-12 |
human |
| Bixiu He, Chengping Hu, Shuo Liang, Xuebing L. [Effects of matrix metalloproteinase-9 antisense oligonucleotide on the apoptosis and metastasis of the human lung adenocarcinoma cell]. Zhongguo fei ai za zhi = Chinese journal of lung cancer. vol 10. issue 5. 2012-10-02. PMID:21126399. |
[effects of matrix metalloproteinase-9 antisense oligonucleotide on the apoptosis and metastasis of the human lung adenocarcinoma cell]. |
2012-10-02 |
2023-08-12 |
human |
| Erawan Borkham-Kamphorst, Claudia R van Roeyen, Eddy Van de Leur, Jürgen Floege, Ralf Weiskirche. CCN3/NOV small interfering RNA enhances fibrogenic gene expression in primary hepatic stellate cells and cirrhotic fat storing cell line CFSC. Journal of cell communication and signaling. vol 6. issue 1. 2012-10-02. PMID:21748432. |
ccn proteins are involved in the regulation of mitosis, adhesion, apoptosis, extracellular matrix production, growth arrest and migration in multiple cell types. |
2012-10-02 |
2023-08-12 |
rat |
| Hiromitsu Hayashi, Takao Saka. Biological Significance of Local TGF-β Activation in Liver Diseases. Frontiers in physiology. vol 3. 2012-10-02. PMID:22363291. |
the cytokine transforming growth factor-β (tgf-β) plays a pivotal role in a diverse range of cellular responses, including cell proliferation, apoptosis, differentiation, migration, adhesion, angiogenesis, stimulation of extracellular matrix (ecm) synthesis, and downregulation of ecm degradation. |
2012-10-02 |
2023-08-12 |
Not clear |
| Paolo Luraghi, Florian Schelter, Achim Krüger, Carla Boccacci. The MET Oncogene as a Therapeutical Target in Cancer Invasive Growth. Frontiers in pharmacology. vol 3. 2012-10-02. PMID:22973229. |
the met proto-oncogene, encoding the tyrosine kinase receptor for hepatocyte growth factor (hgf) regulates invasive growth, a genetic program that associates control of cell proliferation with invasion of the extracellular matrix and protection from apoptosis. |
2012-10-02 |
2023-08-12 |
human |
| Xiang Li, Zexuan Liu, Zeen Cheng, Xianwu Chen. Cysteinyl cathepsins: multifunctional enzymes in cardiovascular disease. Chonnam medical journal. vol 48. issue 2. 2012-10-02. PMID:22977747. |
although the precise mechanisms are unknown, data from animal studies suggest that members of the cathepsin family, like other extracellular proteases, contribute to extracellular matrix protein remodeling and interstitial matrix degradation, as well as to cell signaling and cell apoptosis in heart disease. |
2012-10-02 |
2023-08-12 |
Not clear |
| Xiaoqing Yu, Xiaoqi Zheng, Taigang Liu, Yongchao Dou, Jun Wan. Predicting subcellular location of apoptosis proteins with pseudo amino acid composition: approach from amino acid substitution matrix and auto covariance transformation. Amino acids. vol 42. issue 5. 2012-10-01. PMID:21344173. |
predicting subcellular location of apoptosis proteins with pseudo amino acid composition: approach from amino acid substitution matrix and auto covariance transformation. |
2012-10-01 |
2023-08-12 |
Not clear |