| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yang Xu, Zejie Liu, Shuting Xu, Chengxian Li, Manrui Li, Shuqiang Cao, Yuwen Sun, Hao Dai, Yadong Guo, Xiameng Chen, Weibo Lian. Scientific Evidences of Calorie Restriction and Intermittent Fasting for Neuroprotection in Traumatic Brain Injury Animal Models: A Review of the Literature. Nutrients. vol 14. issue 7. 2022-04-12. PMID:35406044. |
this recovery is believed to be achieved by alleviating mitochondrial dysfunction, promoting hippocampal neurogenesis, inhibiting glial cell responses, shaping neural cell plasticity, as well as targeting apoptosis and autophagy. |
2022-04-12 |
2023-08-13 |
Not clear |
| Xiucui Li, Huiya Ying, Zilong Zhang, Zijing Yang, Cancan You, Xiaohong Cai, Zhongdong Lin, Yanfeng Xia. Sulforaphane Attenuates Chronic Intermittent Hypoxia-Induced Brain Damage in Mice Frontiers in cellular neuroscience. vol 16. 2022-04-11. PMID:35401114. |
also, sfn effectively alleviated apoptosis of hippocampal neurons following cih by decreased tunel-positive cells, downregulated cleaved parp, cleaved caspase 3, and upregulated bcl-2. |
2022-04-11 |
2023-08-13 |
mouse |
| Xiucui Li, Huiya Ying, Zilong Zhang, Zijing Yang, Cancan You, Xiaohong Cai, Zhongdong Lin, Yanfeng Xia. Sulforaphane Attenuates Chronic Intermittent Hypoxia-Induced Brain Damage in Mice Frontiers in cellular neuroscience. vol 16. 2022-04-11. PMID:35401114. |
in addition, we found that sfn enhanced nrf2 nuclear translocation to hold an antioxidative function on cih-induced neuronal apoptosis in hippocampus. |
2022-04-11 |
2023-08-13 |
mouse |
| Xiucui Li, Huiya Ying, Zilong Zhang, Zijing Yang, Cancan You, Xiaohong Cai, Zhongdong Lin, Yanfeng Xia. Sulforaphane Attenuates Chronic Intermittent Hypoxia-Induced Brain Damage in Mice Frontiers in cellular neuroscience. vol 16. 2022-04-11. PMID:35401114. |
overall, our findings indicated that sfn reduced the apoptosis of hippocampal neurons through antioxidant effect of nrf2 and autophagy in cih-induced brain damage, which highlights the potential of sfn as a novel therapy for osahs-related neurocognitive dysfunction. |
2022-04-11 |
2023-08-13 |
mouse |
| Razie Mirjalili, Elahe Shokouh, Niloufar Sayah Dehkordi, Reza Afsari, Sakineh Shafia, Ali Rashidy-Pou. Prior short-term exercise prevents behavioral and biochemical abnormalities induced by single prolonged stress in a rat model of posttraumatic stress disorder. Behavioural brain research. 2022-04-11. PMID:35405172. |
after testing anxiety-like behaviours in the elevated plus maze, the levels of corticosterone and bdnf in serum and bdnf and apoptosis markers (bax, bcl-2, and caspase) in hippocampus were measured. |
2022-04-11 |
2023-08-13 |
rat |
| Razie Mirjalili, Elahe Shokouh, Niloufar Sayah Dehkordi, Reza Afsari, Sakineh Shafia, Ali Rashidy-Pou. Prior short-term exercise prevents behavioral and biochemical abnormalities induced by single prolonged stress in a rat model of posttraumatic stress disorder. Behavioural brain research. 2022-04-11. PMID:35405172. |
sedentary male and female sps rats significantly (ps ranging <0.05 to <0.0001) exhibited increased anxiety levels in the elevated plus maze, enhanced serum corticosterone, reduced serum and hippocampal bdnf and enhanced hippocampal apoptosis than the corresponding control group. |
2022-04-11 |
2023-08-13 |
rat |
| Maryam Sabzali, Akram Eidi, Mehdi Khaksari, Hossein Khasta. Anti-inflammatory, Antioxidant, and Antiapoptotic Action of Metformin Attenuates Ethanol Neurotoxicity in the Animal Model of Fetal Alcohol Spectrum Disorders. Neurotoxicity research. 2022-04-07. PMID:35386022. |
in this study, we evaluated the protective effects of metformin on ethanol-related neuroinflammation, as well as neuron apoptosis in the hippocampus of adult male rat in animal model of fetal alcohol spectrum disorders. |
2022-04-07 |
2023-08-13 |
rat |
| Maryam Sabzali, Akram Eidi, Mehdi Khaksari, Hossein Khasta. Anti-inflammatory, Antioxidant, and Antiapoptotic Action of Metformin Attenuates Ethanol Neurotoxicity in the Animal Model of Fetal Alcohol Spectrum Disorders. Neurotoxicity research. 2022-04-07. PMID:35386022. |
in the metformin group, there was a reduction in cell apoptosis in the hippocampus, as well as gfap-positive cells (p < 0.01). |
2022-04-07 |
2023-08-13 |
rat |
| Xiaofang Wei, Juan Tan, Hui Ga. Role of sirtuin 1 in the brain development in congenital hypothyroidism rats via the regulation of p53 signaling pathway. Bioengineered. vol 13. issue 4. 2022-04-06. PMID:35383535. |
moreover, overexpression of sirt1 in the hippocampal tissues of rats with ch and improved rat behavior, while reducing the ch-induced nerve cell apoptosis. |
2022-04-06 |
2023-08-13 |
rat |
| Canelif Yilmaz, Thanasis Rogdakis, Alessia Latorrata, Evangelia Thanou, Eleftheria Karadima, Eleni Papadimitriou, Eleni Siapi, Ka Wan Li, Theodora Katsila, Theodora Calogeropoulou, Ioannis Charalampopoulos, Vasileia Ismini Alexak. ENT-A010, a Novel Steroid Derivative, Displays Neuroprotective Functions and Modulates Microglial Responses. Biomolecules. vol 12. issue 3. 2022-03-25. PMID:35327616. |
ent-a010 protected pc12 cells against serum starvation-induced cell death, dorsal root ganglia (drg) neurons against ngf deprivation-induced apoptosis and hippocampal neurons against aβ-induced apoptosis. |
2022-03-25 |
2023-08-13 |
mouse |
| Yamei Li, Bo Peng, Yi Li, Airu Huang, Yinian Peng, Qian Yu, Yufeng L. MiR-203a-3p/153-3p improves cognitive impairments induced by ischemia/reperfusion via blockade of SRC-mediated MAPK signaling pathway in ischemic stroke. Chemico-biological interactions. 2022-03-20. PMID:35305977. |
moreover, mir-203a-3p and mir-153-3p relieved the apoptosis, decreases nlrp3 inflammasome activity, decreases oxidative stress and inflammation in hippocampal neuron through targeting src. |
2022-03-20 |
2023-08-13 |
rat |
| Statement of Retraction: NF-κB signaling pathway inhibition suppresses hippocampal neuronal apoptosis and cognitive impairment via RCAN1 in neonatal rats with hypoxic-ischemic brain damage. Cell cycle (Georgetown, Tex.). 2022-03-17. PMID:35297309. |
statement of retraction: nf-κb signaling pathway inhibition suppresses hippocampal neuronal apoptosis and cognitive impairment via rcan1 in neonatal rats with hypoxic-ischemic brain damage. |
2022-03-17 |
2023-08-13 |
rat |
| Saeed Samarghandian, Fahimeh Ghasemi, Hamed Aramjoo, Fariborz Samini, Michael Aschner, Babak Roshanravan, Tahereh Farkhonde. Effects of exposure Toxicology reports. vol 9. 2022-03-14. PMID:35284239. |
our study indicated that bup may potentiate antioxidant system and inhibit apoptosis and oxidative stress in the hippocampus of neonates received this drug during the fetal stage. |
2022-03-14 |
2023-08-13 |
rat |
| Shi-Rong Lin, Qing-Ming Lin, Yu-Jia Lin, Xin Qian, Xiao-Ping Wang, Zheng Gong, Feng Chen, Bin Son. Bradykinin postconditioning protects rat hippocampal neurons after restoration of spontaneous circulation following cardiac arrest via activation of the AMPK/mTOR signaling pathway. Neural regeneration research. vol 17. issue 10. 2022-03-09. PMID:35259843. |
we found that bk postconditioning effectively promoted the recovery of rat neurological function after rosc following cardiac arrest, increased the amount of autophagosomes in the hippocampal tissue, inhibited neuronal cell apoptosis, up-regulated the expression of autophagy-related proteins lc3 and nbr1 and down-regulated p62, inhibited the expression of the brain injury marker s100β and apoptosis-related protein caspase-3, and affected the expression of adenosine monophosphate-activated protein kinase/mechanistic target of rapamycin pathway-related proteins. |
2022-03-09 |
2023-08-13 |
rat |
| Qi Zhang, Yanan Li, Chunping Yin, Jiaxu Yu, Juan Zhao, Lirong Yan, Qiujun Wan. Electro-Acupuncture Pretreatment Ameliorates Anesthesia and Surgery-Induced Cognitive Dysfunction Via Inhibiting Mitochondrial Injury and nEuroapoptosis in Aged Rats. Neurochemical research. 2022-03-08. PMID:35258777. |
then hippocampal tissues were stripped and hippocampal neuronal amount, expression level of cleaved caspase-9 level, cytochrome c (cyt c), cleaved caspase-3 level, bcl-2, bax, ros expression level, apoptosis rate, mitochondrial membrane potential (mmp), cytosolic calcium concentration ([ca |
2022-03-08 |
2023-08-13 |
rat |
| Yu-Lu Chen, Lei Tong, Yao Chen, Chang-Hai Fu, Jun-Bo Peng, Li-Li J. MiR-153 downregulation alleviates PTSD-like behaviors and reduces cell apoptosis by upregulating the Sigma-1 receptor in the hippocampus of rats exposed to single-prolonged stress. Experimental neurology. 2022-03-08. PMID:35259352. |
mir-153 downregulation alleviates ptsd-like behaviors and reduces cell apoptosis by upregulating the sigma-1 receptor in the hippocampus of rats exposed to single-prolonged stress. |
2022-03-08 |
2023-08-13 |
rat |
| Yu-Lu Chen, Lei Tong, Yao Chen, Chang-Hai Fu, Jun-Bo Peng, Li-Li J. MiR-153 downregulation alleviates PTSD-like behaviors and reduces cell apoptosis by upregulating the Sigma-1 receptor in the hippocampus of rats exposed to single-prolonged stress. Experimental neurology. 2022-03-08. PMID:35259352. |
furthermore, anti-mir-153 could also increase the dendritic spine density and reduce cell apoptosis in the hippocampus of sps rats. |
2022-03-08 |
2023-08-13 |
rat |
| Yu-Lu Chen, Lei Tong, Yao Chen, Chang-Hai Fu, Jun-Bo Peng, Li-Li J. MiR-153 downregulation alleviates PTSD-like behaviors and reduces cell apoptosis by upregulating the Sigma-1 receptor in the hippocampus of rats exposed to single-prolonged stress. Experimental neurology. 2022-03-08. PMID:35259352. |
the results of this study indicated that mir-153 might alleviate ptsd-like behaviors by regulating cell morphology and reducing cell apoptosis in the hippocampus of rats exposed to sps by targeting σ-1r, which might be related to the mtor signaling pathway. |
2022-03-08 |
2023-08-13 |
rat |
| Yujiao Yang, Debo Yun, Biqian Dong, Yuan Geng, Yong Wa. VIP alleviates sepsis-induced cognitive dysfunction as the TLR-4/NF-κB signaling pathway is inhibited in the hippocampus of rats. Journal of molecular histology. 2022-03-03. PMID:35239068. |
additionally, we examined apoptosis and inflammation in rats' hippocampus. |
2022-03-03 |
2023-08-13 |
rat |
| Yujiao Yang, Debo Yun, Biqian Dong, Yuan Geng, Yong Wa. VIP alleviates sepsis-induced cognitive dysfunction as the TLR-4/NF-κB signaling pathway is inhibited in the hippocampus of rats. Journal of molecular histology. 2022-03-03. PMID:35239068. |
it is worth noting that vip inhibited the apoptosis in the hippocampus and reduced the productions of proinflammatory cytokines tnf-α, il-6 and il-1β. |
2022-03-03 |
2023-08-13 |
rat |