| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nazanin Mozafari, Jalal Hassanshahi, Hamid Ostadebrahimi, Ali Shamsizadeh, Fatemeh Ayoobi, Elham Hakimizadeh, Mohammad Pak-Hashemi, Ayat Kaeid. Neuroprotective effect of Achillea millefolium aqueous extract against oxidative stress and apoptosis induced by chronic morphine in rat hippocampal CA1 neurons. Acta neurobiologiae experimentalis. vol 82. issue 2. 2022-07-14. PMID:35833817. |
this study evaluates the neuroprotective effect of achillea millefolium (ach) on chronic morphine‑induced learning and memory impairment, oxidative stress, and neuronal apoptosis in the ca1 region of the rat hippocampus. |
2022-07-14 |
2023-08-14 |
human |
| Xiaoyan Ren, Jiangang Yu, Lili Guo, Zaili Zhan. CDGSH iron sulfur domain 2 mitigates apoptosis, oxidative stress and inflammatory response caused by oxygen-glucose deprivation/reoxygenation in HT22 hippocampal neurons by Akt-Nrf2-activated pathway. Metabolic brain disease. 2022-07-12. PMID:35819709. |
cdgsh iron sulfur domain 2 mitigates apoptosis, oxidative stress and inflammatory response caused by oxygen-glucose deprivation/reoxygenation in ht22 hippocampal neurons by akt-nrf2-activated pathway. |
2022-07-12 |
2023-08-14 |
Not clear |
| Saereh Hosseindoost, Ardeshir Akbarabadi, Mitra-Sadat Sadat-Shirazi, Seyed M Mousavi, Solmaz Khalifeh, Azarakhsh Mokri, Mahmoudreza Hadjighassem, Mohammad-Reza Zarrindas. Effect of tramadol on apoptosis and synaptogenesis in hippocampal neurons: The possible role of µ-opioid receptor. Drug development research. 2022-07-09. PMID:35808942. |
effect of tramadol on apoptosis and synaptogenesis in hippocampal neurons: the possible role of µ-opioid receptor. |
2022-07-09 |
2023-08-14 |
rat |
| Saereh Hosseindoost, Ardeshir Akbarabadi, Mitra-Sadat Sadat-Shirazi, Seyed M Mousavi, Solmaz Khalifeh, Azarakhsh Mokri, Mahmoudreza Hadjighassem, Mohammad-Reza Zarrindas. Effect of tramadol on apoptosis and synaptogenesis in hippocampal neurons: The possible role of µ-opioid receptor. Drug development research. 2022-07-09. PMID:35808942. |
here, we examine the effect of tramadol on apoptosis and synaptogenesis of hippocampal neuronal in vitro. |
2022-07-09 |
2023-08-14 |
rat |
| Mina Ranjbaran, Reyhaneh Vaali, Zahra Yaghoobi, Fardin Sehati, Vida Jashn, Sevda Mahdipour Kolur, Fariba Akhondzadeh, Ghorbangol Ashab. Adipose-derived mesenchymal stem cells reduced transient cerebral ischemia injury by modulation of inflammatory factors and AMPK signaling. Behavioural brain research. 2022-07-09. PMID:35809694. |
data proposed that adipose-derived mscs inhibit pro-inflammatory factors such as il-6 and tnf-α, consequently decreasing apoptosis in the hippocampus of ccao rats. |
2022-07-09 |
2023-08-14 |
rat |
| Lin Wang, Bi-Qiang Zhou, Ying-Hong Li, Qian-Qian Jiang, Wei-Hong Cong, Ke-Ji Chen, Xiao-Min Wen, Zheng-Zhi W. Lactoferrin modification of berberine nanoliposomes enhances the neuroprotective effects in a mouse model of Alzheimer's disease. Neural regeneration research. vol 18. issue 1. 2022-07-08. PMID:35799547. |
lactoferrin-modified berberine nanoliposomes inhibited acetylcholinesterase activity and apoptosis in the hippocampus, reduced tau over-phosphorylation in the cerebral cortex, and improved mouse behavior. |
2022-07-08 |
2023-08-14 |
mouse |
| Xiaoding Shi, Xuelai Zhong, Lin Deng, Xiaohong Wu, Pinyi Zhang, Xin Zhang, Guonian Wan. Mesenchymal stem cell-derived extracellular vesicle-enclosed miR-93 prevents hypoxic-ischemic brain damage in rats. Neuroscience. 2022-07-08. PMID:35803492. |
furthermore, hdac4 overexpression, through inhibiting bcl-2 via deacetylation, promoted the infarct volume and pathological changes in hippocampal tissues and neuron apoptosis, and impaired neurobehavioral ability of mcao rats. |
2022-07-08 |
2023-08-14 |
rat |
| Xiaoding Shi, Xuelai Zhong, Lin Deng, Xiaohong Wu, Pinyi Zhang, Xin Zhang, Guonian Wan. Mesenchymal stem cell-derived extracellular vesicle-enclosed miR-93 prevents hypoxic-ischemic brain damage in rats. Neuroscience. 2022-07-08. PMID:35803492. |
importantly, msc-derived evs overexpressing mir-93 suppressed hdac4 expression and subsequently impeded the apoptosis of ogd-exposed hippocampal neurons in vitro, and also ameliorated hibd in vivo. |
2022-07-08 |
2023-08-14 |
rat |
| Xiaoding Shi, Xuelai Zhong, Lin Deng, Xiaohong Wu, Pinyi Zhang, Xin Zhang, Guonian Wan. Mesenchymal stem cell-derived extracellular vesicle-enclosed miR-93 prevents hypoxic-ischemic brain damage in rats. Neuroscience. 2022-07-08. PMID:35803492. |
taken together, mir-93 delivered by msc-derived evs can ameliorate hibd by suppressing hippocampal neuron apoptosis through targeting the hdac4/bcl-2 axis, a finding which may be of great significance in the treatment of hibd. |
2022-07-08 |
2023-08-14 |
rat |
| Xin Jin, Xingjuan Liao, Longfei Wu, Jianling Huang, Zhimin Li, Yali Li, Fan Gu. FOXO4 alleviates hippocampal neuronal damage in epileptic mice via the miR-138-5p/ROCK2 axis. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 2022-07-07. PMID:35796190. |
foxo4 overexpression alleviated hippocampal neuronal damage in ep mice and improved ht-22 cell viability and inhibited apoptosis, and decreased oxidative stress and inflammation in hippocampal tissue and ht-22 cells. |
2022-07-07 |
2023-08-14 |
mouse |
| Qing Li, Xianjie Zhang, Siyuan Li, Wen Li, Yunpeng Teng, Yukai Zhou, Hongfei Xion. Carnosol alleviates sevoflurane-induced cognitive dysfunction by mediating NF-κB pathway in aged rats. Drug development research. 2022-07-05. PMID:35781309. |
the effects of carnosol on the expression of inflammatory factors in rat hippocampus mediated by sev were determined by enzyme-linked immunoassay and polymerase chain reaction experiments; the effects of carnosol on the expressions of iba-1 and glial fibrillary acidic protein after sev-mediated activation of rat microglia were clarified by immunofluorescence and western blotting (wb); the effects of carnosol on sev-mediated neuronal apoptosis were studied by terminal deoxynucleotidyl transferase dutp nick end labeling and wb; the specific signaling pathways regulated by carnosol were elucidated by wb. |
2022-07-05 |
2023-08-14 |
rat |
| Haichao Ju, Zhimin Yan. H19 silencing decreases kainic acid-induced hippocampus neuron injury via activating the PI3K/AKT pathway via the H19/miR-206 axis. Experimental brain research. 2022-07-05. PMID:35781830. |
functionally, both h19 knockdown and mir-206 overexpression weakened ka-induced apoptosis, autophagy, inflammatory response, and oxidative stress in hippocampus neurons. |
2022-07-05 |
2023-08-14 |
rat |
| Haichao Ju, Zhimin Yan. H19 silencing decreases kainic acid-induced hippocampus neuron injury via activating the PI3K/AKT pathway via the H19/miR-206 axis. Experimental brain research. 2022-07-05. PMID:35781830. |
knockdown of h19 suppressed hippocampus neuronal apoptosis, autophagy and inflammatory response presumably through directly upregulating mir-206 and activating the pi3k/akt signaling pathway. |
2022-07-05 |
2023-08-14 |
rat |
| Chongqi Wei, Ziqiang Zhu, Jia-Ni Zheng, Yunqing Lu, Cheng Cao, Suchen Qu, Mengqiu Liu, Xue-Er Meng, Qianyin Lou, Qingqing Wang, Jin-Ao Duan, Er-Xin Shang, Zhenxiang Han, Yue Zh. Chinese Medicine, Succinum, Ameliorates Cognitive Impairment of Carotid Artery Ligation Rats and Inhibits Apoptosis of HT22 Hippocampal Cells Frontiers in pharmacology. vol 13. 2022-07-05. PMID:35784758. |
chinese medicine, succinum, ameliorates cognitive impairment of carotid artery ligation rats and inhibits apoptosis of ht22 hippocampal cells succinum is an organic mineral formed from the resin of ancient coniferous and leguminous plants, which is applied for tranquilizing mood, promoting blood circulation, and removing blood stasis in chinese medicine. |
2022-07-05 |
2023-08-14 |
mouse |
| Chongqi Wei, Ziqiang Zhu, Jia-Ni Zheng, Yunqing Lu, Cheng Cao, Suchen Qu, Mengqiu Liu, Xue-Er Meng, Qianyin Lou, Qingqing Wang, Jin-Ao Duan, Er-Xin Shang, Zhenxiang Han, Yue Zh. Chinese Medicine, Succinum, Ameliorates Cognitive Impairment of Carotid Artery Ligation Rats and Inhibits Apoptosis of HT22 Hippocampal Cells Frontiers in pharmacology. vol 13. 2022-07-05. PMID:35784758. |
it was found that ethyl acetate extracts of succinum significantly improved the learning and memory abilities of model rats and inhibited neuronal apoptosis in the hippocampus. |
2022-07-05 |
2023-08-14 |
mouse |
| Chongqi Wei, Ziqiang Zhu, Jia-Ni Zheng, Yunqing Lu, Cheng Cao, Suchen Qu, Mengqiu Liu, Xue-Er Meng, Qianyin Lou, Qingqing Wang, Jin-Ao Duan, Er-Xin Shang, Zhenxiang Han, Yue Zh. Chinese Medicine, Succinum, Ameliorates Cognitive Impairment of Carotid Artery Ligation Rats and Inhibits Apoptosis of HT22 Hippocampal Cells Frontiers in pharmacology. vol 13. 2022-07-05. PMID:35784758. |
on a mice hippocampal neuronal cell line (ht22), ethyl acetate extracts of succinum also exerted better action trend in inhibiting cell apoptosis induced by oxygen glucose deprivation (ogd). |
2022-07-05 |
2023-08-14 |
mouse |
| Manar Mohammed El Tabaa, Maram Mohammed El Tabaa, Anis Anis, Rehab Mohamed Elgharabawy, Nermeen Borai El-Bora. GLP-1 mediates the neuroprotective action of crocin against cigarette smoking-induced cognitive disorders via suppressing HMGB1-RAGE/TLR4-NF-κB pathway. International immunopharmacology. vol 110. 2022-07-05. PMID:35785730. |
histopathologically, cro lessened neuronal apoptosis by lowering bax/bcl-2 ratio at hippocampal ca2 region. |
2022-07-05 |
2023-08-14 |
rat |
| Peirong Liu, Juan Wang, Sheng Peng, Dan Zhang, Lin Zhuang, Chunliang Liu, Yu Zhang, Xiaowei Sh. Suppression of phosphodiesterase IV enzyme by Roflumilast ameliorates cognitive dysfunction in aged rats after sevoflurane anesthesia via PKA-CREB and MEK/ERK pathways. The European journal of neuroscience. 2022-06-29. PMID:35767003. |
loss-of-function assay indicated that pka-creb and mek/erk signaling impairment reduced camp levels and promoted apoptosis and ros in rat hippocampus and neurons. |
2022-06-29 |
2023-08-14 |
rat |
| Yoko Hirata, Ruidai Okazaki, Mina Sato, Kentaro Oh-Hashi, Hiroshi Takemori, Kyoji Furut. Effect of ferroptosis inhibitors oxindole-curcumin hybrid compound and N,N-dimethylaniline derivatives on rotenone-induced oxidative stress. European journal of pharmacology. 2022-06-26. PMID:35753403. |
treatment of mouse hippocampal ht22 cells with the mitochondrial transport chain inhibitor rotenone for 24 h reduced mitochondrial membrane potential, increased reactive oxygen species production, promoted nuclear fragmentation, and ultimately impaired cell viability, consistent with apoptosis. |
2022-06-26 |
2023-08-14 |
mouse |
| Zengmian Wang, Zhimin Na, Ying Cui, Chunjie Wei, Shuqiu Wan. LncRNA ZFAS1 regulates the hippocampal neurons injury in epilepsy through the miR-15a-5p/OXSR1/NF-κB pathway. Metabolic brain disease. 2022-06-25. PMID:35751788. |
silenced zfas1 promoted viability, while inhibited inflammation, apoptosis and oxidative stress in se-induced hippocampal neurons. |
2022-06-25 |
2023-08-14 |
mouse |