| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu Zhang, Cheng-Jun Xing, Xiao Liu, Ya-Hong Li, Jing Jia, Jian-Guo Feng, Cheng-Jie Yang, Ye Chen, Jun Zho. Thioredoxin-Interacting Protein (TXNIP) Knockdown Protects against Sepsis-Induced Brain Injury and Cognitive Decline in Mice by Suppressing Oxidative Stress and Neuroinflammation. Oxidative medicine and cellular longevity. vol 2022. 2022-05-16. PMID:35571246. |
furthermore, the alterations in microglial activity, oxidative response, proinflammatory factors, apoptosis, protein levels (txnip and nlrp3 inflammasome), and apoptosis were examined in the hippocampal tissues. |
2022-05-16 |
2023-08-13 |
mouse |
| Chen Chen, Bo Li, Haotian Chen, Yuhui Qin, Junying Cheng, Bo He, Yixuan Wan, Dongyong Zhu, Fabao Ga. Epigallocatechin-3-Gallate Ameliorated Iron Accumulation and Apoptosis and Promoted Neuronal Regeneration and Memory/Cognitive Functions in the Hippocampus Induced by Exposure to a Chronic High-Altitude Hypoxia Environment. Neurochemical research. 2022-05-13. PMID:35552996. |
epigallocatechin-3-gallate ameliorated iron accumulation and apoptosis and promoted neuronal regeneration and memory/cognitive functions in the hippocampus induced by exposure to a chronic high-altitude hypoxia environment. |
2022-05-13 |
2023-08-13 |
rat |
| Bristi Poude. Rescuing Behavioral Impairment after Doxorubicin Chemotherapy in Rats. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35553240. |
doxorubicin is a reactive oxygen species-producing antineoplastic anthracycline agent that adversely affects hippocampal neurogenesis, causes neuro-inflammation, and induces apoptosis. |
2022-05-13 |
2023-08-13 |
rat |
| Jin Zheng, Jianguo Qi, Quan Zou, Zhenzhong Zhan. Construction of PLGA/JNK3-shRNA nanoparticles and their protective role in hippocampal neuron apoptosis induced by oxygen and glucose deprivation. RSC advances. vol 8. issue 36. 2022-05-11. PMID:35541669. |
construction of plga/jnk3-shrna nanoparticles and their protective role in hippocampal neuron apoptosis induced by oxygen and glucose deprivation. |
2022-05-11 |
2023-08-13 |
Not clear |
| Ashif Iqubal, Mohammad Kashif Iqubal, Sumit Sharma, Mohd Wasim, Mohamed A Alfaleh, Shadab Md, Sanjula Baboota, Javed Ali, Syed Ehtaishamul Haqu. Pathogenic mechanisms and therapeutic promise of phytochemicals and nanocarriers based drug delivery against radiotherapy-induced neurotoxic manifestations. Drug delivery. vol 29. issue 1. 2022-05-11. PMID:35543534. |
based on the preclinical and clinical investigations, the profound role of increased oxidative stress, nuclear translocation of nf-kb, production of proinflammatory cytokines such as tnf-α, il-6, il-β, increased level of mmps, increased apoptosis, reduced angiogenesis, neurogenesis, and histological aberrations in ca1, ca2, ca3 and dg region of the hippocampus have been reported. |
2022-05-11 |
2023-08-13 |
Not clear |
| Jun Xu, Qian Li, Chen-Yu Xu, Shan Mao, Jia-Jia Jin, Wei Gu, Ying Shi, Chun-Fang Zou, Liang Y. Obstructive sleep apnea aggravates neuroinflammation and pyroptosis in early brain injury following subarachnoid hemorrhage via ASC/HIF-1α pathway. Neural regeneration research. vol 17. issue 11. 2022-05-10. PMID:35535908. |
we found that sleep apnea aggravated brain edema, increased hippocampal neuron apoptosis, and worsened neurological function in this mouse model of subarachnoid hemorrhage. |
2022-05-10 |
2023-08-13 |
mouse |
| Xing Wang, Fei Yang, Liling Deng, Di Qiu, Yao Liu, Yang Kan. Liraglutide Is Protective against Brain Injury in Mice with Febrile Seizures by Inhibiting Inflammatory Factors. Computational and mathematical methods in medicine. vol 2022. 2022-05-09. PMID:35529274. |
the behavioral score was performed on mice with racine grading, and nerve cells in apoptosis in the hippocampus were determined by tunel. |
2022-05-09 |
2023-08-13 |
mouse |
| Qian Chen, Yichen Cai, Xiaoyu Zhu, Jing Wang, Feng Gao, Mingfeng Yang, Leilei Mao, Zongyong Zhang, Baoliang Su. Edaravone Dexborneol Treatment Attenuates Neuronal Apoptosis and Improves Neurological Function by Suppressing 4-HNE-Associated Oxidative Stress After Subarachnoid Hemorrhage. Frontiers in pharmacology. vol 13. 2022-05-09. PMID:35529450. |
our results showed that a post-sah therapeutic regimen with edaravone dexborneol helped improve neurological function up to 21 days after sah surgery and demonstrated a greater beneficial effect than edaravone alone, accompanied by an obvious inhibition of neuronal apoptosis in the ca1 hippocampus and basal cortex regions. |
2022-05-09 |
2023-08-13 |
human |
| Zheng Liu, Wenwei Gao, Yuanqin X. Eleutheroside E alleviates cerebral ischemia-reperfusion injury in a 5-hydroxytryptamine receptor 2C (Htr2c)-dependent manner in rats. Bioengineered. vol 13. issue 5. 2022-05-03. PMID:35502892. |
here, we demonstrated that ee significantly alleviated the cerebral i/r injury and reduced the apoptosis of hippocampal neuron cells in rats. |
2022-05-03 |
2023-08-13 |
rat |
| Zheng Liu, Wenwei Gao, Yuanqin X. Eleutheroside E alleviates cerebral ischemia-reperfusion injury in a 5-hydroxytryptamine receptor 2C (Htr2c)-dependent manner in rats. Bioengineered. vol 13. issue 5. 2022-05-03. PMID:35502892. |
silencing htr2c expression dramatically weakened the protective effect of ee on i/r-induced apoptosis of rat hippocampal neuron. |
2022-05-03 |
2023-08-13 |
rat |
| Qin Wu, Jiajun Dong, Xinying Bai, Yuan Jiang, Jinjin Li, Shiqi Fan, Yahong Cheng, Gaofeng Jian. Propionate ameliorates diabetes-induced neurological dysfunction through regulating the PI3K/Akt/eNOS signaling pathway. European journal of pharmacology. 2022-05-01. PMID:35490725. |
in a diabetic mouse model, propionate reduces cerebral microcirculation, hippocampus apoptosis, and neurological impairment. |
2022-05-01 |
2023-08-13 |
mouse |
| Jinxu Wang, Yueyang Xin, Tiantian Chu, Cheng Liu, Aijun X. Dexmedetomidine attenuates perioperative neurocognitive disorders by suppressing hippocampal neuroinflammation and HMGB1/RAGE/NF-κB signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 150. 2022-04-29. PMID:35486975. |
nissl, immunohistochemistry and tunel-neun staining results indicated that dex reduced hippocampus damage and neuronal apoptosis caused by surgery. |
2022-04-29 |
2023-08-13 |
rat |
| Yuan Meng, Zhao Yang, Taoguang Huo, Hong Jian. Realgar facilitates the Nrf2-Keap1-p62 positive feedback signaling axis via MAPKs and AKT to interfere with autophagy-induced apoptosis and oxidative stress in the hippocampus. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 150. 2022-04-23. PMID:35461089. |
realgar facilitates the nrf2-keap1-p62 positive feedback signaling axis via mapks and akt to interfere with autophagy-induced apoptosis and oxidative stress in the hippocampus. |
2022-04-23 |
2023-08-13 |
rat |
| W W Yan, G H Li, J J Zhao, Y M Jia, Y Lou, X Y Ga. [Mechanism of paeoniflorin inhibiting apoptosis of hippocampal neurons of rats induced by lead acetate]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. vol 40. issue 3. 2022-04-19. PMID:35439856. |
[mechanism of paeoniflorin inhibiting apoptosis of hippocampal neurons of rats induced by lead acetate]. |
2022-04-19 |
2023-08-13 |
rat |
| Xie Han, Yanling Tang, Yuanli Zhang, Jingjing Zhang, Zeyu Hu, Wanjing Xu, Shangzhi Xu, Qiang Ni. Impaired V-ATPase leads to increased lysosomal pH, results in disrupted lysosomal degradation and autophagic flux blockage, contributes to fluoride-induced developmental neurotoxicity. Ecotoxicology and environmental safety. vol 236. 2022-04-14. PMID:35421827. |
in addition, naf reduced v-atpase expression, diminished lysosomal degradation capacity and blocked autophagic flux, and increased apoptosis in the hippocampus of offspring. |
2022-04-14 |
2023-08-13 |
rat |
| Yang Xu, Zejie Liu, Shuting Xu, Chengxian Li, Manrui Li, Shuqiang Cao, Yuwen Sun, Hao Dai, Yadong Guo, Xiameng Chen, Weibo Lian. Scientific Evidences of Calorie Restriction and Intermittent Fasting for Neuroprotection in Traumatic Brain Injury Animal Models: A Review of the Literature. Nutrients. vol 14. issue 7. 2022-04-12. PMID:35406044. |
this recovery is believed to be achieved by alleviating mitochondrial dysfunction, promoting hippocampal neurogenesis, inhibiting glial cell responses, shaping neural cell plasticity, as well as targeting apoptosis and autophagy. |
2022-04-12 |
2023-08-13 |
Not clear |
| Xiucui Li, Huiya Ying, Zilong Zhang, Zijing Yang, Cancan You, Xiaohong Cai, Zhongdong Lin, Yanfeng Xia. Sulforaphane Attenuates Chronic Intermittent Hypoxia-Induced Brain Damage in Mice Frontiers in cellular neuroscience. vol 16. 2022-04-11. PMID:35401114. |
also, sfn effectively alleviated apoptosis of hippocampal neurons following cih by decreased tunel-positive cells, downregulated cleaved parp, cleaved caspase 3, and upregulated bcl-2. |
2022-04-11 |
2023-08-13 |
mouse |
| Xiucui Li, Huiya Ying, Zilong Zhang, Zijing Yang, Cancan You, Xiaohong Cai, Zhongdong Lin, Yanfeng Xia. Sulforaphane Attenuates Chronic Intermittent Hypoxia-Induced Brain Damage in Mice Frontiers in cellular neuroscience. vol 16. 2022-04-11. PMID:35401114. |
in addition, we found that sfn enhanced nrf2 nuclear translocation to hold an antioxidative function on cih-induced neuronal apoptosis in hippocampus. |
2022-04-11 |
2023-08-13 |
mouse |
| Xiucui Li, Huiya Ying, Zilong Zhang, Zijing Yang, Cancan You, Xiaohong Cai, Zhongdong Lin, Yanfeng Xia. Sulforaphane Attenuates Chronic Intermittent Hypoxia-Induced Brain Damage in Mice Frontiers in cellular neuroscience. vol 16. 2022-04-11. PMID:35401114. |
overall, our findings indicated that sfn reduced the apoptosis of hippocampal neurons through antioxidant effect of nrf2 and autophagy in cih-induced brain damage, which highlights the potential of sfn as a novel therapy for osahs-related neurocognitive dysfunction. |
2022-04-11 |
2023-08-13 |
mouse |
| Razie Mirjalili, Elahe Shokouh, Niloufar Sayah Dehkordi, Reza Afsari, Sakineh Shafia, Ali Rashidy-Pou. Prior short-term exercise prevents behavioral and biochemical abnormalities induced by single prolonged stress in a rat model of posttraumatic stress disorder. Behavioural brain research. 2022-04-11. PMID:35405172. |
after testing anxiety-like behaviours in the elevated plus maze, the levels of corticosterone and bdnf in serum and bdnf and apoptosis markers (bax, bcl-2, and caspase) in hippocampus were measured. |
2022-04-11 |
2023-08-13 |
rat |