| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alessandra Borsini, Blair Merrick, Jonathan Edgeworth, Gargi Mandal, Deepak P Srivastava, Anthony C Vernon, Gaia Nebbia, Sandrine Thuret, Carmine M Pariant. Neurogenesis is disrupted in human hippocampal progenitor cells upon exposure to serum samples from hospitalized COVID-19 patients with neurological symptoms. Molecular psychiatry. 2022-10-04. PMID:36195636. |
moreover, increased concentration of il6 in serum samples from delirium patients stimulated the hippocampal cells to produce il12 and il13, and treatment with an antibody against il12 or il13 also prevented the decreased cell proliferation and neurogenesis, and the increased apoptosis. |
2022-10-04 |
2023-08-14 |
human |
| Lingang Wanga, Hui Zhang, Chenyao Xi. Down-regulation of miR-204-5p ameliorates sevoflurane-induced brain injury in neonatal rats through targeting VCAM1. Toxicology mechanisms and methods. 2022-09-30. PMID:36177783. |
these results suggest that down-regulation of mir-204-5p ameliorates sevoflurane-induced cognitive impairment and hippocampal pathology and inhibits neuronal autophagy and apoptosis by targeting vcam1. |
2022-09-30 |
2023-08-14 |
rat |
| Zhongyuan Zhou, Meng Wang, Chengyu Huang, Yan Li, Lin Gao, Yandong Zhu, Changjiang Ying, Xiaoyan Zho. Treadmill exercise training alleviates diabetes-induced depressive-like behavior and cognitive impairment by improving hippocampal CA1 neurons injury in db/db mice. Brain research bulletin. 2022-09-29. PMID:36174874. |
in summary, the results indicated that treadmill exercise training significantly ameliorates hippocampus injury by suppressing oxidative stress-induced apoptosis and nlrp3 inflammasome activation, consequently ameliorating diabetes-induced depressive-like behavior and cognitive impairment in db/db mice. |
2022-09-29 |
2023-08-14 |
mouse |
| Hongyan Pei, Jianning Zeng, Zhongmei He, Ying Zong, Yan Zhao, Jianming Li, Weijia Chen, Rui D. Palmatine ameliorates LPS-induced HT-22 cells and mouse models of depression by regulating apoptosis and oxidative stress. Journal of biochemical and molecular toxicology. 2022-09-28. PMID:36169195. |
more importantly, palmatine improved neuronal apoptosis in the hippocampus, and depression through bax/bcl-2 and nrf2/ho-1 signaling pathways. |
2022-09-28 |
2023-08-14 |
mouse |
| Zi-Ang Zhang, Yafei Sun, Ziyan Yuan, Lei Wang, Qian Dong, Yang Zhou, Gang Zheng, Michael Aschner, Yuankang Zou, Wenjing Lu. Insight into the Effects of High-Altitude Hypoxic Exposure on Learning and Memory. Oxidative medicine and cellular longevity. vol 2022. 2022-09-26. PMID:36160703. |
based on these points, this review thoroughly discussed the relationship between high-altitude hypoxia and l&m impairment, in terms of hippocampal neuron apoptosis and dysfunction, neuronal oxidative stress disorder, neurotransmitters and related receptors, and nerve cell energy metabolism disorder, which is of great significance to find potential targets for medical intervention. |
2022-09-26 |
2023-08-14 |
Not clear |
| Haiyang Zhang, Mian Wei, Ning Sun, Hui Wang, Honggang Fa. Melatonin attenuates chronic stress-induced hippocampal inflammatory response and apoptosis by inhibiting ADAM17/TNF-α axis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-09-26. PMID:36162616. |
melatonin attenuates chronic stress-induced hippocampal inflammatory response and apoptosis by inhibiting adam17/tnf-α axis. |
2022-09-26 |
2023-08-14 |
rat |
| Haiyang Zhang, Mian Wei, Ning Sun, Hui Wang, Honggang Fa. Melatonin attenuates chronic stress-induced hippocampal inflammatory response and apoptosis by inhibiting ADAM17/TNF-α axis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-09-26. PMID:36162616. |
our results indicated that melatonin alleviated chronic restraint stress (crs)-induced inflammatory response and apoptosis, thus improving hippocampal structural damage and subsequent depression-like behaviors in rats. |
2022-09-26 |
2023-08-14 |
rat |
| Haiyang Zhang, Mian Wei, Ning Sun, Hui Wang, Honggang Fa. Melatonin attenuates chronic stress-induced hippocampal inflammatory response and apoptosis by inhibiting ADAM17/TNF-α axis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-09-26. PMID:36162616. |
analogously, both adam17 inhibitor tmi-1 and tnf-α inhibitor thalidomide relieved the effects of crs on adam17/tnf-α axis and its downstream proteins phosphorylation, hippocampal apoptosis, hippocampal inflammatory response, and depression-like behaviors in rats. |
2022-09-26 |
2023-08-14 |
rat |
| Bao-Dong He, Chang-Mei Liu, Zhao-Qian Ten. A Mouse Model of Neurodegeneration Induced by Blade Penetrating Stab Wound to the Hippocampus. Biology. vol 11. issue 9. 2022-09-23. PMID:36138848. |
mice with a hippocampal blade stab injury (hbsi) displayed the activation of microglia and astrocytes, inflammation, neuronal apoptosis, and deficits in spatial learning and memory. |
2022-09-23 |
2023-08-14 |
mouse |
| Sahar Askari, Pegah Javadpour, Fatemeh Sadat Rashidi, Leila Dargahi, Khosrow Kashfi, Rasoul Ghasem. Behavioral and Molecular Effects of Thapsigargin-Induced Brain ER- Stress: Encompassing Inflammation, MAPK, and Insulin Signaling Pathway. Life (Basel, Switzerland). vol 12. issue 9. 2022-09-23. PMID:36143409. |
meanwhile, molecular results showed a concurrent increment of hippocampal upr markers, apoptosis, p38 activity, and tnf-α. |
2022-09-23 |
2023-08-14 |
rat |
| Yan Peng, Rui Chi, Gang Liu, Weijie Tian, Jun Zhang, Rihui Zhan. Aerobic Exercise Regulates Apoptosis through the PI3K/Akt/GSK-3 Neural plasticity. vol 2022. 2022-09-20. PMID:36124291. |
therefore, this study investigated whether an 8-week running table exercise intervention could reduce apoptosis and improve cognitive function in the hippocampal neurons of ad model mice. |
2022-09-20 |
2023-08-14 |
mouse |
| Junsha An, Huali Fan, Mingyu Han, Cheng Peng, Jie Xie, Fu Pen. Exploring the mechanisms of neurotoxicity caused by fuzi using network pharmacology and molecular docking. Frontiers in pharmacology. vol 13. 2022-09-16. PMID:36110545. |
what's more, this study confirmed that aconitine could produce neurotoxicity by promoting apoptosis of hippocampus neuron and decreasing its quantity through nissl staining and tunel assay. |
2022-09-16 |
2023-08-14 |
Not clear |
| Ying Liu, Xiaoning Qu, Mengjun Yan, Dalei Li, Rong Zo. Tricin attenuates cerebral ischemia/reperfusion injury through inhibiting nerve cell autophagy, apoptosis and inflammation by regulating the PI3K/Akt pathway. Human & experimental toxicology. vol 41. 2022-09-16. PMID:36113040. |
apoptosis and autophagy were assessed in the nerve cells of hippocampus tissue, and the levels of inflammatory markers within animal serum were detected. |
2022-09-16 |
2023-08-14 |
mouse |
| Lingyun Zhi, Fuping Zhang, Huanhuan Liu, Xinhui Jiang, Yunfei Zhang, Qianling Yang, Xinyue Zhang, Mengke Liu, Zhaohui Zhang, Jinggui Son. CRS induces depression-like behavior after MCAO in rats possibly by activating p38 MAPK. Behavioural brain research. 2022-09-13. PMID:36100011. |
our data indicated that crs combined with mcao could induce depression-like and anxiety-like behaviors, which led to neuronal damage, apoptosis, and cellular loss in the left parietal cortex and left hippocampus. |
2022-09-13 |
2023-08-14 |
rat |
| Xi Fang, Qiang Han, Shiyong Li, Ailin Lu. Melatonin attenuates spatial learning and memory dysfunction in developing rats by suppressing isoflurane-induced endoplasmic reticulum stress via the SIRT1/Mfn2/PERK signaling pathway. Heliyon. vol 8. issue 9. 2022-09-12. PMID:36091956. |
the hippocampal tissue and serum were collected to determine the levels of sirt1, mfn2, perk, and other proteins or cytokines related to er stress, apoptosis, and neuroinflammation. |
2022-09-12 |
2023-08-14 |
rat |
| Yinna Zhang, Yajun Lian, Xiaolei Lian, Haifeng Zhang, Yuan Chen, Hanqing Sheng, Rui Fen. FUNDC1 Mediated Mitophagy in Epileptic Hippocampal Neuronal Injury Induced by Magnesium-Free Fluid. Neurochemical research. 2022-09-12. PMID:36094682. |
in this study, we investigated the role of fundc1 in mitophagy and neuronal apoptosis using a hippocampal neuronal culture model of acquired epilepsy (ae) in vitro. |
2022-09-12 |
2023-08-14 |
Not clear |
| Yinna Zhang, Yajun Lian, Xiaolei Lian, Haifeng Zhang, Yuan Chen, Hanqing Sheng, Rui Fen. FUNDC1 Mediated Mitophagy in Epileptic Hippocampal Neuronal Injury Induced by Magnesium-Free Fluid. Neurochemical research. 2022-09-12. PMID:36094682. |
overexpression of fundc1 significantly decreased ae-induced superoxide anion, enhanced cell viability, reduced oxidative stress, and reduced neuronal apoptosis in epileptic hippocampus, while fundc1 down-regulation caused the opposite effect. |
2022-09-12 |
2023-08-14 |
Not clear |
| Yongjie Xu, Haizhi Li, Gang Chen, Liying Zhu, Hairong Lin, Changyudong Huang, Sijia Wei, Tingting Yang, Wen Qian, Xing Li, Shuyun Zhao, Wei Pa. Radix polygoni multiflori protects against hippocampal neuronal apoptosis in diabetic encephalopathy by inhibiting the HDAC4/JNK pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 153. 2022-09-09. PMID:36076547. |
radix polygoni multiflori protects against hippocampal neuronal apoptosis in diabetic encephalopathy by inhibiting the hdac4/jnk pathway. |
2022-09-09 |
2023-08-14 |
rat |
| Yongjie Xu, Haizhi Li, Gang Chen, Liying Zhu, Hairong Lin, Changyudong Huang, Sijia Wei, Tingting Yang, Wen Qian, Xing Li, Shuyun Zhao, Wei Pa. Radix polygoni multiflori protects against hippocampal neuronal apoptosis in diabetic encephalopathy by inhibiting the HDAC4/JNK pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 153. 2022-09-09. PMID:36076547. |
our finds indicates that rpm and emodin would inhibit hdac4 expression, curb the activation of the jnk pathway, reduce hippocampal neuron apoptosis and ultimately meliorate the cognitive function from diabetes. |
2022-09-09 |
2023-08-14 |
rat |
| Chong Song, Wei Wei, Tong Wang, Min Zhou, Yunshi Li, Bing Xiao, Dongyi Huang, Junwei Gu, Linyong Shi, Junjie Peng, Dianshi Ji. Microglial infiltration mediates cognitive dysfunction in rat models of hypothalamic obesity Frontiers in cellular neuroscience. vol 16. 2022-09-08. PMID:36072565. |
furthermore, neuronal apoptosis and activated microglia in the downstream of the lesion area (the lha) induced microglial infiltration into the intact hippocampus |
2022-09-08 |
2023-08-14 |
rat |