| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elif Funda Sener, Halime Dana, Reyhan Tahtasakal, Zuhal Hamurcu, Ahsen Guler, Esra Tufan, Zuleyha Doganyigit, Minoo Rassoulzadega. Partial changes in apoptotic pathways in hippocampus and hypothalamus of Cc2d1a heterozygous. Metabolic brain disease. 2022-12-01. PMID:36454503. |
the hippocampus and hypothalamus of cc2d1a ± mice were analyzed for the expression of apoptosis markers (caspase 3, 8 and 9). |
2022-12-01 |
2023-08-14 |
mouse |
| Yue Pan, Qinglan Zong, Guoxiang Li, Zhengcun Wu, Tingfu Du, Zhangqiong Huang, Ying Zhang, Kaili M. Nuclear localization of alpha-synuclein affects the cognitive and motor behavior of mice by inducing DNA damage and abnormal cell cycle of hippocampal neurons. Frontiers in molecular neuroscience. vol 15. 2022-11-28. PMID:36438187. |
it might be that nuclear overexpression of α-syn may cause dna damage of hippocampal neurons, thereby leading to activation and abnormal blocking of cell cycle, and further inducing apoptosis of hippocampal neurons and inflammatory reaction. |
2022-11-28 |
2023-08-14 |
mouse |
| Dawei Dong, Aihui Ren, Ying Yang, Jiayi Su, Libin Liu, Wenyan Zhuo, Yubin Lian. VX-765 Alleviates β-Amyloid Deposition and Secondary Degeneration in the Ipsilateral Hippocampus and Ameliorates Cognitive Decline after Focal Cortical Infarction in Rats. Journal of molecular neuroscience : MN. 2022-11-28. PMID:36441377. |
these findings revealed that vx-765 reduced aβ deposition, pyroptosis, and apoptosis in the ipsilateral hippocampus, which may be associated with reduced secondary degeneration and cognitive decline following focal cortical infarction. |
2022-11-28 |
2023-08-14 |
rat |
| M A Gruden, T V Davydova, A M Ratmirov, R D E Sewel. Cerebral Expression of the Neuregulin-1 Gene NRG1 during Induced Spatial Memory Impairment and Its Reversal in Aging Mice. Bulletin of experimental biology and medicine. 2022-11-27. PMID:36437318. |
we studied the effects of chronic intranasal administration of amyloidogenic fibrils of the proinflammatory protein s100a9 alone or in combination with glutamate antibodies on the expression of the neuregulin-1 gene (nrg1), a regulator of various physiological processes, in particular, regulation of neurogenesis and apoptosis, in the hippocampus, prefrontal cortex, and cerebellum of aging c57bl/6 mice under conditions of long-term memory disturbances. |
2022-11-27 |
2023-08-14 |
mouse |
| Bina Lee, Ingabire Ines, Jihyun Je, Eun Jung Park, Hyemin Seong, Min Gi Jo, Hwajin Kim, Seon-Hee Kim, Seong Jae Kim, Hye Jung Kim, Minkyeong Kim, Sang Won Park, Seung Pil Yu. Effect of Renal Ischemia Reperfusion on Brain Neuroinflammation. Biomedicines. vol 10. issue 11. 2022-11-26. PMID:36428560. |
the activation of astrocytes and microglia in the hippocampus and cerebral cortex, which are responsible for important functions, including memory, learning, concentration, and language, can trigger nerve cell apoptosis. |
2022-11-26 |
2023-08-14 |
Not clear |
| Shingo Enomoto, Masahiro Ohgidani, Noriaki Sagata, Shogo Inamine, Takahiro A Kat. Preliminary analysis of hippocampus synaptic apoptosis and microglial phagocytosis induced by severe restraint stress. Neuropsychopharmacology reports. 2022-11-24. PMID:36419367. |
preliminary analysis of hippocampus synaptic apoptosis and microglial phagocytosis induced by severe restraint stress. |
2022-11-24 |
2023-08-14 |
mouse |
| Shingo Enomoto, Masahiro Ohgidani, Noriaki Sagata, Shogo Inamine, Takahiro A Kat. Preliminary analysis of hippocampus synaptic apoptosis and microglial phagocytosis induced by severe restraint stress. Neuropsychopharmacology reports. 2022-11-24. PMID:36419367. |
in this micro-report, we aimed to preliminary examine local synaptic apoptosis in the mouse hippocampus following severe restraint stress, and its effect on microglial phagocytosis. |
2022-11-24 |
2023-08-14 |
mouse |
| Nini Li, Dongdong Zhang, Hena Guo, Qian Yang, Peng Li, Yifan H. Inhibition of circ_0004381 improves cognitive function via miR-647/PSEN1 axis in an Alzheimer disease mouse model. Journal of neuropathology and experimental neurology. 2022-11-21. PMID:36409993. |
knockdown of circ_0004381 attenuated aβ1-42-induced apoptosis, oxidative stress, and mitochondrial dysfunction in hippocampal neurons. |
2022-11-21 |
2023-08-14 |
mouse |
| Seyed Hamidreza Rastegar-Moghaddam, Fatemeh Alipour, Mahmoud Hosseini, Alireza Ebrahimzadeh-Bideska. Anti-apoptotic and neurogenic properties in the hippocampus as possible mechanisms for learning and memory improving impacts of vitamin D in hypothyroid rats during the growth period. Life sciences. 2022-11-21. PMID:36410409. |
the current study was designed to investigate the protective effects of vitamin d (vd) on hippocampal neurogenesis, apoptosis, and subsequent hippocampal-dependent learning and memory performance in hypothyroid juvenile rats. |
2022-11-21 |
2023-08-14 |
rat |
| Seyed Hamidreza Rastegar-Moghaddam, Fatemeh Alipour, Mahmoud Hosseini, Alireza Ebrahimzadeh-Bideska. Anti-apoptotic and neurogenic properties in the hippocampus as possible mechanisms for learning and memory improving impacts of vitamin D in hypothyroid rats during the growth period. Life sciences. 2022-11-21. PMID:36410409. |
at the end of treatment, morris water maze (mwm) was carried out and evaluated hippocampal neurogenesis, apoptosis, and dark neurons (dns). |
2022-11-21 |
2023-08-14 |
rat |
| Seyed Hamidreza Rastegar-Moghaddam, Fatemeh Alipour, Mahmoud Hosseini, Alireza Ebrahimzadeh-Bideska. Anti-apoptotic and neurogenic properties in the hippocampus as possible mechanisms for learning and memory improving impacts of vitamin D in hypothyroid rats during the growth period. Life sciences. 2022-11-21. PMID:36410409. |
in conclusion, these results support a role for vd in the restoring hippocampal neurogenesis impairment, reducing neuronal apoptosis, and dns in hypothyroid rats as well as raise the possibility that vd may contribute as a therapeutic approach to improve the learning and memory deficits associated with hypothyroidism. |
2022-11-21 |
2023-08-14 |
rat |
| Patricia Soriano Roque, Carolina Thörn Perez, Mehdi Hooshmandi, Calvin Wong, Mohammad Javad Eslamizade, Shilan Heshmati, Nicole Brown, Vijendra Sharma, Kevin C Lister, Vanessa Magalie Goyon, Laura E Neagu-Lund, Cathy Shen, Nicolas Daccache, Hiroaki Sato, Tamaki Sato, Jeffrey S Mogil, Karim Nader, Christos G Gkogkas, Mihaela D Iordanova, Masha Prager-Khoutorsky, Heidi M McBride, Jean-Claude Lacaille, Linda Wykes, Thomas Schricker, Arkady Khoutorsk. Parvalbumin interneuron loss mediates repeated anesthesia-induced memory deficits in mice. The Journal of clinical investigation. 2022-11-17. PMID:36394958. |
here we showed that repeated general anesthesia in postnatal mice induces preferential apoptosis and subsequent loss of parvalbumin-positive inhibitory interneurons in the hippocampus. |
2022-11-17 |
2023-08-14 |
mouse |
| Jinxiu Cui, Qianqian Ma, Chenxu Zhang, Yuanzhe Li, Juan Liu, Kangning Xie, Erping Luo, Mingming Zhai, Chi Tan. Krt18 depletion as a possible mechanism for the induction of apoptosis and ferroptosis in the rat hippocampus after hypobaric hypoxia. Neuroscience. 2022-11-17. PMID:36395917. |
krt18 depletion as a possible mechanism for the induction of apoptosis and ferroptosis in the rat hippocampus after hypobaric hypoxia. |
2022-11-17 |
2023-08-14 |
rat |
| Jinxiu Cui, Qianqian Ma, Chenxu Zhang, Yuanzhe Li, Juan Liu, Kangning Xie, Erping Luo, Mingming Zhai, Chi Tan. Krt18 depletion as a possible mechanism for the induction of apoptosis and ferroptosis in the rat hippocampus after hypobaric hypoxia. Neuroscience. 2022-11-17. PMID:36395917. |
emerging evidence indicates crosstalk between apoptosis and ferroptosis, while the crosstalk between hh-induced apoptosis and ferroptosis in the hippocampus has not been clarified. |
2022-11-17 |
2023-08-14 |
rat |
| Jinxiu Cui, Qianqian Ma, Chenxu Zhang, Yuanzhe Li, Juan Liu, Kangning Xie, Erping Luo, Mingming Zhai, Chi Tan. Krt18 depletion as a possible mechanism for the induction of apoptosis and ferroptosis in the rat hippocampus after hypobaric hypoxia. Neuroscience. 2022-11-17. PMID:36395917. |
then, we conducted morphological observations that showed that apoptosis and ferroptosis coexisted in the rat hippocampus after hh exposure. |
2022-11-17 |
2023-08-14 |
rat |
| Jinxiu Cui, Qianqian Ma, Chenxu Zhang, Yuanzhe Li, Juan Liu, Kangning Xie, Erping Luo, Mingming Zhai, Chi Tan. Krt18 depletion as a possible mechanism for the induction of apoptosis and ferroptosis in the rat hippocampus after hypobaric hypoxia. Neuroscience. 2022-11-17. PMID:36395917. |
in conclusion, krt18 may regulate apoptosis and ferroptosis simultaneously, possibly via the jnk signaling pathway, which might provide a potential central target for apoptosis and ferroptosis in hippocampal injury after hh exposure. |
2022-11-17 |
2023-08-14 |
rat |
| Xiaohui Chen, Dongtai Chen, Pinzhong Chen, Andi Chen, Jianhui Deng, Jianjie Wei, Weian Zeng, Xiaochun Zhen. Dexmedetomidine Attenuates Apoptosis and Neurological Deficits by Modulating Neuronal NADPH Oxidase 2-Derived Oxidative Stress in Neonates Following Hypoxic Brain Injury. Antioxidants (Basel, Switzerland). vol 11. issue 11. 2022-11-11. PMID:36358571. |
our results showed that pre- or post-treatment with dex improved the neurological deficits and alleviated the hippocampal neuronal damage and apoptosis caused by neonatal hypoxia. |
2022-11-11 |
2023-08-14 |
mouse |
| Chuanxing Feng, Yuge Jiang, Shiying Li, Yueting Ge, Yonghui Shi, Xue Tang, Guowei L. Methionine Restriction Improves Cognitive Ability by Alleviating Hippocampal Neuronal Apoptosis through H19 in Middle-Aged Insulin-Resistant Mice. Nutrients. vol 14. issue 21. 2022-11-11. PMID:36364766. |
methionine restriction improves cognitive ability by alleviating hippocampal neuronal apoptosis through h19 in middle-aged insulin-resistant mice. |
2022-11-11 |
2023-08-14 |
mouse |
| Chuanxing Feng, Yuge Jiang, Shiying Li, Yueting Ge, Yonghui Shi, Xue Tang, Guowei L. Methionine Restriction Improves Cognitive Ability by Alleviating Hippocampal Neuronal Apoptosis through H19 in Middle-Aged Insulin-Resistant Mice. Nutrients. vol 14. issue 21. 2022-11-11. PMID:36364766. |
hippocampal neuron apoptosis damages cognitive ability. |
2022-11-11 |
2023-08-14 |
mouse |
| Chuanxing Feng, Yuge Jiang, Shiying Li, Yueting Ge, Yonghui Shi, Xue Tang, Guowei L. Methionine Restriction Improves Cognitive Ability by Alleviating Hippocampal Neuronal Apoptosis through H19 in Middle-Aged Insulin-Resistant Mice. Nutrients. vol 14. issue 21. 2022-11-11. PMID:36364766. |
however, the effect of mr on hippocampal neuronal apoptosis induced by a high-fat diet (hfd) in middle-aged mice remains unclear. |
2022-11-11 |
2023-08-14 |
mouse |