| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zichen Zhang, Liuyi Chen, Yi Guo, Dan Li, Jingyu Zhang, Ling Liu, Wen Fan, Tao Guo, Siru Qin, Yadan Zhao, Zhifang Xu, Zelin Che. The neuroprotective and neural circuit mechanisms of acupoint stimulation for cognitive impairment. Chinese medicine. vol 18. issue 1. 2023-01-20. PMID:36670425. |
the common mechanism may be that acupoint stimulation protects hippocampal neurons by preventing apoptosis and scavenging toxic proteins. |
2023-01-20 |
2023-08-14 |
Not clear |
| Gouri Patil, Shabda Kulsange, Rubina Kazi, Tejas Chirmade, Vaikhari Kale, Chandrashekhar Mote, Manoj Aswar, Santosh Koratkar, Sachin Agawane, Mahesh Kulkarn. Behavioral and Proteomic Studies Reveal Methylglyoxal Activate Pathways Associated with Alzheimer's Disease. ACS pharmacology & translational science. vol 6. issue 1. 2023-01-19. PMID:36654748. |
further, hippocampal proteomics demonstrated that mgo treated rats differentially regulate proteins involved in calcium homeostasis, mitochondrial functioning, and apoptosis, which may affect neurotransmission and neuronal plasticity. |
2023-01-19 |
2023-08-14 |
rat |
| Ting-Ting Yi, Li-Mei Zhang, Xiang-Nan Huan. Glycyrrhizic acid protects against temporal lobe epilepsy in young rats by regulating neuronal ferroptosis through the miR-194-5p/PTGS2 axis. The Kaohsiung journal of medical sciences. 2023-01-17. PMID:36647717. |
briefly, different doses of ga (20, 40, and 60 mg/kg) reduced the epileptic score, frequency, and duration in tle young rats, along with reductions in iron content, lipid peroxidation, neuronal injury, and apoptosis in the hippocampus. |
2023-01-17 |
2023-08-14 |
rat |
| Zhongxuan Ma, Dingding Feng, Wenjuan Rui, Zhiqing Wan. Baicalin attenuates chronic unpredictable mild stress-induced hippocampal neuronal apoptosis through regulating SIRT1/PARP1 signaling pathway. Behavioural brain research. 2023-01-15. PMID:36642102. |
baicalin attenuates chronic unpredictable mild stress-induced hippocampal neuronal apoptosis through regulating sirt1/parp1 signaling pathway. |
2023-01-15 |
2023-08-14 |
mouse |
| Zhongxuan Ma, Dingding Feng, Wenjuan Rui, Zhiqing Wan. Baicalin attenuates chronic unpredictable mild stress-induced hippocampal neuronal apoptosis through regulating SIRT1/PARP1 signaling pathway. Behavioural brain research. 2023-01-15. PMID:36642102. |
in primary hippocampal neurons (phns), ba abrogated the neuronal apoptosis caused by parp1 overexpression. |
2023-01-15 |
2023-08-14 |
mouse |
| Zhongxuan Ma, Dingding Feng, Wenjuan Rui, Zhiqing Wan. Baicalin attenuates chronic unpredictable mild stress-induced hippocampal neuronal apoptosis through regulating SIRT1/PARP1 signaling pathway. Behavioural brain research. 2023-01-15. PMID:36642102. |
overall, our results indicated that ba attenuated the cums-induced hippocampal neuronal apoptosis through regulating the sirt1/parp1 signaling pathway. |
2023-01-15 |
2023-08-14 |
mouse |
| Abdulla M A Mahmoud, Eman M Mantawy, Sara A Wahdan, Ramy M Ammar, Ebtehal El-Demerdas. Vildagliptin restores cognitive function and mitigates hippocampal neuronal apoptosis in cisplatin-induced chemo-brain: Imperative roles of AMPK/Akt/CREB/ BDNF signaling cascades. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 159. 2023-01-14. PMID:36640673. |
vildagliptin restores cognitive function and mitigates hippocampal neuronal apoptosis in cisplatin-induced chemo-brain: imperative roles of ampk/akt/creb/ bdnf signaling cascades. |
2023-01-14 |
2023-08-14 |
human |
| Abdulla M A Mahmoud, Eman M Mantawy, Sara A Wahdan, Ramy M Ammar, Ebtehal El-Demerdas. Vildagliptin restores cognitive function and mitigates hippocampal neuronal apoptosis in cisplatin-induced chemo-brain: Imperative roles of AMPK/Akt/CREB/ BDNF signaling cascades. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 159. 2023-01-14. PMID:36640673. |
in addition, the neuroprotective mechanisms of vilda include diminishing oxidative stress by reducing mda levels while raising gsh levels and sod activity, repressing neuronal apoptosis as shown by elevated bcl-2 levels together with diminished bax and caspase-3 expressions, inhibiting neuroinflammation as shown by decreased gfap expression, and finally boosting hippocampal neurogenesis and survival by upregulating expressions of bdnf and pcna. |
2023-01-14 |
2023-08-14 |
human |
| Hana Yamamoto, Nanami Shimomura, Kazuma Oura, Yasushi Hasegaw. Nacre Extract from Pearl Oyster Shell Prevents D-Galactose-Induced Brain and Skin Aging. Marine biotechnology (New York, N.Y.). 2023-01-11. PMID:36629944. |
a histological study showed that nacre extract suppressed d-galactose-induced neuronal cell death and the expression of b cell lymphoma 2 (bcl-2)-associated x protein (bax), which causes apoptosis in the hippocampus. |
2023-01-11 |
2023-08-14 |
mouse |
| Bingjie Xue, Bo Ma, Yaoyao Yao, Aimei Zhao, Ying Gao, Jianxun Li. BYHW Decoction Improves Cognitive Impairments in Rats with Cerebral Microinfarcts via Activation of the PKA/CREB Pathway. Oxidative medicine and cellular longevity. vol 2022. 2023-01-09. PMID:36620084. |
we then used the morris water maze, quantitative proteomics, immunohistochemistry, and other molecular assays and found that activation of the pka/creb pathway by byhw decoction treatment may reverse mitochondrial dysfunction, inhibit apoptosis of hippocampal neurons, and ameliorate cmi-induced cognitive impairments in rats. |
2023-01-09 |
2023-08-14 |
rat |
| Thiago G Bassi, Elizabeth C Rohrs, Mr Karl C Fernandez, Ms Marlena Ornowska, Ms Michelle Nicholas, Ms Jessica Wittmann, Mr Matt Gani, Mr Doug Evans, Steven C Reynold. Diaphragm Neurostimulation Mitigates Ventilation-Associated Brain Injury in a Preclinical Acute Respiratory Distress Syndrome Model. Critical care explorations. vol 4. issue 12. 2023-01-05. PMID:36601565. |
in a porcine healthy lung model, temporary transvenous diaphragm neurostimulation (ttdn) for 50 hours mitigated hippocampal apoptosis and inflammation associated with mechanical ventilation (mv). |
2023-01-05 |
2023-08-14 |
Not clear |
| Huiya Ying, Zilong Zhang, Wei Wang, Zijing Yang, Cancan You, Yuanai Li, Xiaohong Cai, Xiucui L. Inhibition of Calcium-Sensing Receptor Alleviates Chronic Intermittent Hypoxia-Induced Cognitive Dysfunction via CaSR-PKC-ERK1/2 Pathway. Molecular neurobiology. 2023-01-04. PMID:36600080. |
calcium-sensing receptor (casr) mediates the apoptosis of hippocampal neurons in various diseases. |
2023-01-04 |
2023-08-14 |
mouse |
| Huiya Ying, Zilong Zhang, Wei Wang, Zijing Yang, Cancan You, Yuanai Li, Xiaohong Cai, Xiucui L. Inhibition of Calcium-Sensing Receptor Alleviates Chronic Intermittent Hypoxia-Induced Cognitive Dysfunction via CaSR-PKC-ERK1/2 Pathway. Molecular neurobiology. 2023-01-04. PMID:36600080. |
cih accelerated apoptosis of hippocampal neurons and resulted in the synaptic plasticity deficit via downregulated synaptophysin (syn) protein level. |
2023-01-04 |
2023-08-14 |
mouse |
| Huiya Ying, Zilong Zhang, Wei Wang, Zijing Yang, Cancan You, Yuanai Li, Xiaohong Cai, Xiucui L. Inhibition of Calcium-Sensing Receptor Alleviates Chronic Intermittent Hypoxia-Induced Cognitive Dysfunction via CaSR-PKC-ERK1/2 Pathway. Molecular neurobiology. 2023-01-04. PMID:36600080. |
the mice were intraperitoneally injected with casr inhibitor (nps2143) 30 min before cih exposure and the results demonstrated casr inhibitor alleviated the apoptosis and synaptic plasticity deficit in the hippocampus of cih mice. |
2023-01-04 |
2023-08-14 |
mouse |
| Huiya Ying, Zilong Zhang, Wei Wang, Zijing Yang, Cancan You, Yuanai Li, Xiaohong Cai, Xiucui L. Inhibition of Calcium-Sensing Receptor Alleviates Chronic Intermittent Hypoxia-Induced Cognitive Dysfunction via CaSR-PKC-ERK1/2 Pathway. Molecular neurobiology. 2023-01-04. PMID:36600080. |
overall, our findings revealed that casr held a critical function on cih-induced cognitive dysfunction in mice by accelerating hippocampal neuronal apoptosis and reducing synaptic plasticity via augmenting casr-pkc-erk1/2 pathway; otherwise, inhibition of casr alleviated cih-induced cognitive dysfunction. |
2023-01-04 |
2023-08-14 |
mouse |
| Ye Li, Zhi Liang, Shuyan Lei, Xiaoning Wu, Tao Yuan, Kai Ma, Kui Ch. Sevoflurane Preconditioning Downregulates GRIA1 Expression to Attenuate Cerebral Ischemia-Reperfusion-Induced Neuronal Injury. Neurotoxicity research. 2023-01-03. PMID:36595163. |
moreover, sev pretreatment ameliorated neurobehavioral deficits induced by i/r treatment, reduced brain infarct volume, and decreased apoptosis of neurons in hippocampal tissues. |
2023-01-03 |
2023-08-14 |
rat |
| Qi Liu, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Che. Insulin ameliorates dim blue light at night-induced apoptosis in hippocampal neurons via the IR/IRS1/AKT/GSK3β/β-catenin signaling pathway. Ecotoxicology and environmental safety. vol 250. 2022-12-31. PMID:36586168. |
insulin ameliorates dim blue light at night-induced apoptosis in hippocampal neurons via the ir/irs1/akt/gsk3β/β-catenin signaling pathway. |
2022-12-31 |
2023-08-14 |
mouse |
| Manal A Othman, Raouf Fadel, Yasin Tayem, Ahmed Jaradat, Aisha Rashid, Ayesha Fatima, Ali E Al-Mahameed, Wael Amin Nasr El-Di. Caffeine protects against hippocampal alterations in type 2 diabetic rats via modulation of gliosis, inflammation and apoptosis. Cell and tissue research. 2022-12-28. PMID:36577880. |
caffeine protects against hippocampal alterations in type 2 diabetic rats via modulation of gliosis, inflammation and apoptosis. |
2022-12-28 |
2023-08-14 |
rat |
| Momoko Hirano, Kazuhisa Sugai, Masahiko Fujisawa, Eiji Kobayashi, Yoshinori Katsumata, Yoji Hakamata, Motoaki San. Pharmacokinetics of hydrogen administered intraperitoneally as hydrogen-rich saline and its effect on ischemic neuronal cell death in the brain in gerbils. PloS one. vol 17. issue 12. 2022-12-27. PMID:36574398. |
on day 3 of ischemia/reperfusion, the number of neurons undergoing apoptosis in the cortex was significantly lower in the h2-rich saline group than in the saline group, and on day 7, the number of viable neurons in the hippocampus and cerebral cortex was significantly higher in the h2-rich saline group. |
2022-12-27 |
2023-08-14 |
Not clear |
| Titikorn Chunchai, Nattayaporn Apaijai, Juthipong Benjanuwattra, Hiranya Pintana, Kodchanan Singhanat, Busarin Arunsak, Nipon Chattipakorn, Siriporn C Chattipakor. Erythropoietin administration exerted neuroprotective effects against cardiac ischemia/reperfusion injury. Current research in pharmacology and drug discovery. vol 3. 2022-12-26. PMID:36568264. |
we hypothesized that the administration of epo attenuates brain damage caused by cardiac i/r injury through decreasing peripheral and brain oxidative stress, preserving microglial morphology, attenuating hippocampal necroptosis, and decreasing hippocampal apoptosis, and hippocampal dysplasticity. |
2022-12-26 |
2023-08-14 |
rat |