| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seung-Chan Kim, Jae-Yong Park, Eun Mi Hwan. Caspase-dependent apoptosis induces reactivation and gliogenesis of astrocytes in adult mice. Frontiers in cellular neuroscience. vol 16. 2022-12-19. PMID:36531137. |
overall, transient hippocampal astrocyte depletion caused by apoptosis restored cell number and function within 2 weeks and did not induce significant neurotoxicity. |
2022-12-19 |
2023-08-14 |
mouse |
| Chenkang Wang, Yu Kang, Panwen Liu, Weiwei Liu, Wenhui Chen, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejim. Combined use of dasatinib and quercetin alleviates overtraining-induced deficits in learning and memory through eliminating senescent cells and reducing apoptotic cells in rat hippocampus. Behavioural brain research. 2022-12-19. PMID:36535433. |
interestingly, we observed elevated level of cleaved caspase 3, an apoptosis executor protein, in p21 positive hippocampus cells by d+q treatment in immunofluorescent staining, suggesting that senescent cells were induced to apoptosis in d+q-treated rats. |
2022-12-19 |
2023-08-14 |
rat |
| Cristini Escobar Viana, Vandreza Cardoso Bortolotto, Stífani Machado Araujo, Mustafa Munir Mustafa Dahleh, Franciéle Romero Machado, Adson de Souza Pereira, Byanca Pereira Moreira de Oliveira, Fernanda Vitória Leimann, Odinei Hess Gonçalves, Marina Prigol, Gustavo Petri Guerr. Lutein-loaded nanoparticles reverse oxidative stress, apoptosis, and autism spectrum disorder-like behaviors induced by prenatal valproic acid exposure in female rats. Neurotoxicology. 2022-12-17. PMID:36528186. |
the hippocampus was removed for the determination of oxidative stress indicators (ros; tbars; sod and nrf2) and apoptosis biomarkers (hsp-70; p38-mapk; bax and bcl-2). |
2022-12-17 |
2023-08-14 |
rat |
| Cristini Escobar Viana, Vandreza Cardoso Bortolotto, Stífani Machado Araujo, Mustafa Munir Mustafa Dahleh, Franciéle Romero Machado, Adson de Souza Pereira, Byanca Pereira Moreira de Oliveira, Fernanda Vitória Leimann, Odinei Hess Gonçalves, Marina Prigol, Gustavo Petri Guerr. Lutein-loaded nanoparticles reverse oxidative stress, apoptosis, and autism spectrum disorder-like behaviors induced by prenatal valproic acid exposure in female rats. Neurotoxicology. 2022-12-17. PMID:36528186. |
the exposure to lutein-loaded nanoparticles reversed sociability deficit, social memory deficit, and anxiety-like and repetitive behaviors induced by vpa, and restored the oxidative stress indicators and apoptosis biomarkers in the hippocampus. |
2022-12-17 |
2023-08-14 |
rat |
| Farzaneh Motafeghi, Abouzar Bagheri, Mohammad Seyedabadi, Fatemeh Shaki, Mohammad Shokrzade. Antidepressant-Like Effects of Edaravone and Minocycline: Investigation of Oxidative Stress, Neuroinflammation, Neurotrophic, and Apoptotic Pathways. Neurotoxicity research. 2022-12-15. PMID:36522510. |
the results showed that the separation of neonatal rats from their mothers induced depressive-like behaviors, weight loss, mitochondrial dysfunction, increased expression of genes involved in neuroinflammation, apoptosis, genes involved in the depressive process, and decreased expression of genes involved in mood in both the hippocampus and prefrontal cortex. |
2022-12-15 |
2023-08-14 |
rat |
| Yanan Zhang, Tingmin Guo, Yun Ding, Xin Wang, Ping Li. Taurine and deferiprone against Al-linked apoptosis in rat hippocampus. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 76. 2022-12-14. PMID:36516571. |
taurine and deferiprone against al-linked apoptosis in rat hippocampus. |
2022-12-14 |
2023-08-14 |
rat |
| Yanan Zhang, Tingmin Guo, Yun Ding, Xin Wang, Ping Li. Taurine and deferiprone against Al-linked apoptosis in rat hippocampus. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 76. 2022-12-14. PMID:36516571. |
in this study, we investigated the combined effect of taurine and dfp on al chelation and hippocampal apoptosis in al-exposed rats, as well as the underlying mechanisms of these effects to explore a possible therapy for ad. |
2022-12-14 |
2023-08-14 |
rat |
| Yan Meng, Shengxue Yu, Fang Zhao, Yu Liu, Yue Wang, Siqi Fan, Yuhong Su, Meili Lu, Hongxin Wan. Astragaloside IV Alleviates Brain Injury Induced by Hypoxia via the Calpain-1 Signaling Pathway. Neural plasticity. vol 2022. 2022-12-13. PMID:36510594. |
long-term hypoxia can induce oxidative stress and apoptosis in hippocampal neurons that can lead to brain injury diseases. |
2022-12-13 |
2023-08-14 |
mouse |
| Yan Meng, Shengxue Yu, Fang Zhao, Yu Liu, Yue Wang, Siqi Fan, Yuhong Su, Meili Lu, Hongxin Wan. Astragaloside IV Alleviates Brain Injury Induced by Hypoxia via the Calpain-1 Signaling Pathway. Neural plasticity. vol 2022. 2022-12-13. PMID:36510594. |
in this study, we investigated the effect of as-iv on hypoxia-induced oxidative stress and apoptosis in hippocampal neurons and explored its possible mechanism. |
2022-12-13 |
2023-08-14 |
mouse |
| Yaru Liu, Zhenyang Yan, Yafei Ren, Woyu Wang, Yinze Ke, Yifan Wang, Rongming Q. Electroacupuncture inhibits hippocampal neuronal apoptosis and improves cognitive dysfunction in mice with vascular dementia via the JNK signaling pathway. Acupuncture in medicine : journal of the British Medical Acupuncture Society. 2022-12-09. PMID:36482691. |
electroacupuncture inhibits hippocampal neuronal apoptosis and improves cognitive dysfunction in mice with vascular dementia via the jnk signaling pathway. |
2022-12-09 |
2023-08-14 |
mouse |
| Lei Li, Yanping Zhan, Haimei Xia, Yunkun Wu, Xiongzhi Wu, Shibiao Che. Sevoflurane protects against intracerebral hemorrhage via microRNA-133b/FOXO4/BCL2 axis. International immunopharmacology. vol 114. 2022-12-08. PMID:36476488. |
sev treatment attenuated ich and hippocampal neuronal apoptosis in mice by upregulating mir-133b. |
2022-12-08 |
2023-08-14 |
mouse |
| Lei Li, Yanping Zhan, Haimei Xia, Yunkun Wu, Xiongzhi Wu, Shibiao Che. Sevoflurane protects against intracerebral hemorrhage via microRNA-133b/FOXO4/BCL2 axis. International immunopharmacology. vol 114. 2022-12-08. PMID:36476488. |
mir-133b targeted foxo4 expression, and inhibition of foxo4 attenuated hippocampal neuronal apoptosis by increasing bcl2 expression. |
2022-12-08 |
2023-08-14 |
mouse |
| Zhangbi Wu, Jialin Huang, Xiaojie Bai, Qunan Wang, Fen Wang, Jun Xu, Huiping Tang, Chunying Yin, Yu Wang, Feng Yu, Hong Zhan. Ginsenoside-Rg1 mitigates cardiac arrest-induced cognitive damage by modulating neuroinflammation and hippocampal plasticity. European journal of pharmacology. 2022-12-04. PMID:36463944. |
in addition, ginsenoside-rg1 improved ca/cpr-induced hippocampal neuronal apoptosis, dendritic spines and synaptic ultrastructure defects as associated with the upregulation of the key synaptic regulatory proteins. |
2022-12-04 |
2023-08-14 |
rat |
| Titikorn Chunchai, Hiranya Pintana, Apiwan Arinno, Benjamin Ongnok, Patcharapong Pantiya, Thawatchai Khuanjing, Nanthip Prathumsap, Chayodom Maneechote, Nipon Chattipakorn, Siriporn C Chattipakor. Melatonin and Metformin Counteract Cognitive Dysfunction Equally in Male Rats with Doxorubicin-induced Chemobrain. Neurotoxicology. 2022-12-04. PMID:36463981. |
we aimed to investigate whether mel and met provide neuroprotective effects on glial dysmorphologies, brain inflammation, oxidative stress, brain mitochondrial dysfunction, apoptosis, necroptosis, neurogenesis, hippocampal dysplasticity, and cognitive dysfunction in rats with dox-induced chemobrain. |
2022-12-04 |
2023-08-14 |
rat |
| Titikorn Chunchai, Hiranya Pintana, Apiwan Arinno, Benjamin Ongnok, Patcharapong Pantiya, Thawatchai Khuanjing, Nanthip Prathumsap, Chayodom Maneechote, Nipon Chattipakorn, Siriporn C Chattipakor. Melatonin and Metformin Counteract Cognitive Dysfunction Equally in Male Rats with Doxorubicin-induced Chemobrain. Neurotoxicology. 2022-12-04. PMID:36463981. |
brain mitochondrial dysfunction, an increase in brain inflammation, oxidative stress, apoptosis and necroptosis, a decrease in the number of hippocampal dendritic spines and neurogenesis, and cognitive decline were also observed in dox-treated rats. |
2022-12-04 |
2023-08-14 |
rat |
| Titikorn Chunchai, Hiranya Pintana, Apiwan Arinno, Benjamin Ongnok, Patcharapong Pantiya, Thawatchai Khuanjing, Nanthip Prathumsap, Chayodom Maneechote, Nipon Chattipakorn, Siriporn C Chattipakor. Melatonin and Metformin Counteract Cognitive Dysfunction Equally in Male Rats with Doxorubicin-induced Chemobrain. Neurotoxicology. 2022-12-04. PMID:36463981. |
in conclusion, concomitant treatment with either mel or met counteract dox-induced chemobrain by preservation of glial morphology, brain inflammation, brain oxidative stress, brain mitochondrial function, hippocampal plasticity, and brain apoptosis. |
2022-12-04 |
2023-08-14 |
rat |
| Wanjing Xu, Zeyu Hu, Yanling Tang, Jingjing Zhang, Shangzhi Xu, Qiang Ni. Excessive Lysosomal Stress Response and Consequently Impaired Autophagy Contribute to Fluoride-Induced Developmental Neurotoxicity. Biological trace element research. 2022-12-04. PMID:36464725. |
we found that naf caused autophagic flux blockage and apoptosis in the rat hippocampus. |
2022-12-04 |
2023-08-14 |
human |
| Elif Funda Sener, Halime Dana, Reyhan Tahtasakal, Zuhal Hamurcu, Ahsen Guler, Esra Tufan, Zuleyha Doganyigit, Minoo Rassoulzadega. Partial changes in apoptotic pathways in hippocampus and hypothalamus of Cc2d1a heterozygous. Metabolic brain disease. 2022-12-01. PMID:36454503. |
the hippocampus and hypothalamus of cc2d1a ± mice were analyzed for the expression of apoptosis markers (caspase 3, 8 and 9). |
2022-12-01 |
2023-08-14 |
mouse |
| Yue Pan, Qinglan Zong, Guoxiang Li, Zhengcun Wu, Tingfu Du, Zhangqiong Huang, Ying Zhang, Kaili M. Nuclear localization of alpha-synuclein affects the cognitive and motor behavior of mice by inducing DNA damage and abnormal cell cycle of hippocampal neurons. Frontiers in molecular neuroscience. vol 15. 2022-11-28. PMID:36438187. |
it might be that nuclear overexpression of α-syn may cause dna damage of hippocampal neurons, thereby leading to activation and abnormal blocking of cell cycle, and further inducing apoptosis of hippocampal neurons and inflammatory reaction. |
2022-11-28 |
2023-08-14 |
mouse |
| Dawei Dong, Aihui Ren, Ying Yang, Jiayi Su, Libin Liu, Wenyan Zhuo, Yubin Lian. VX-765 Alleviates β-Amyloid Deposition and Secondary Degeneration in the Ipsilateral Hippocampus and Ameliorates Cognitive Decline after Focal Cortical Infarction in Rats. Journal of molecular neuroscience : MN. 2022-11-28. PMID:36441377. |
these findings revealed that vx-765 reduced aβ deposition, pyroptosis, and apoptosis in the ipsilateral hippocampus, which may be associated with reduced secondary degeneration and cognitive decline following focal cortical infarction. |
2022-11-28 |
2023-08-14 |
rat |