| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohamed Taha, Omar Mohsen Eldemerdash, Ismail Mohamed Elshaffei, Einas Mohamed Yousef, Ayman S Soliman, Mahmoud Ahmed Senous. Apigenin Attenuates Hippocampal Microglial Activation and Restores Cognitive Function in Methotrexate-Treated Rats: Targeting the miR-15a/ROCK-1/ERK1/2 Pathway. Molecular neurobiology. 2023-03-21. PMID:36943623. |
on the left, methotrexate (mtx) administration to rats resulted in hippocampal mir-15a downregulation, which triggered an enhanced expression of its target rock-1, consequently inhibiting the downstream erk1/2/creb/bdnf pathway, instigating a state of microglial activation, neuroinflammation, oxidative stress, and apoptosis. |
2023-03-21 |
2023-08-14 |
rat |
| Mohamed Taha, Omar Mohsen Eldemerdash, Ismail Mohamed Elshaffei, Einas Mohamed Yousef, Ayman S Soliman, Mahmoud Ahmed Senous. Apigenin Attenuates Hippocampal Microglial Activation and Restores Cognitive Function in Methotrexate-Treated Rats: Targeting the miR-15a/ROCK-1/ERK1/2 Pathway. Molecular neurobiology. 2023-03-21. PMID:36943623. |
on the other hand, apigenin (api) co-treatment restored mir-15a, inhibited rock-1 expression, and activated the erk1/2/creb/bdnf pathway, leading to diminished hippocampal microglial activation, neuroinflammation, and apoptosis, and restoration of the redox balance, along with improvement in memory and cognitive function of the mtx-treated rats. |
2023-03-21 |
2023-08-14 |
rat |
| Shengliang Peng, Yun Yu, Juan Li, Danling Jiang, Guohai Xu, Lidong Wu, Jialing H. Hsp22 pretreatment protection against LPS-induced hippocampal injury by alleviating neuroinflammation and apoptosis by regulating the NLRP3/Caspase1/IL-1β signaling pathway in mice. Aging. vol 15. 2023-03-19. PMID:36934348. |
hsp22 pretreatment protection against lps-induced hippocampal injury by alleviating neuroinflammation and apoptosis by regulating the nlrp3/caspase1/il-1β signaling pathway in mice. |
2023-03-19 |
2023-08-14 |
mouse |
| Shengliang Peng, Yun Yu, Juan Li, Danling Jiang, Guohai Xu, Lidong Wu, Jialing H. Hsp22 pretreatment protection against LPS-induced hippocampal injury by alleviating neuroinflammation and apoptosis by regulating the NLRP3/Caspase1/IL-1β signaling pathway in mice. Aging. vol 15. 2023-03-19. PMID:36934348. |
preconditioning with the hsp22-overexpressing lentivirus attenuated lps-induced activation of hippocampal microglia, the expression of inflammatory factors and pathway proteins, and apoptosis, and improved cognitive impairment in mice. |
2023-03-19 |
2023-08-14 |
mouse |
| Tingting Gu, Chang Xu, Xiaozhou Meng, Dapeng Gao, Guanghao Jiang, Anqi Yin, Qingzhen Liu, Lidong Zhan. Sevoflurane Preconditioning Alleviates Posttraumatic Stress Disorder-Induced Apoptosis in the Hippocampus via the EZH2-Regulated Akt/mTOR Axis and Improves Synaptic Plasticity. Journal of molecular neuroscience : MN. 2023-03-17. PMID:36930428. |
sevoflurane preconditioning alleviates posttraumatic stress disorder-induced apoptosis in the hippocampus via the ezh2-regulated akt/mtor axis and improves synaptic plasticity. |
2023-03-17 |
2023-08-14 |
rat |
| Qianyin Lou, Xue-Er Meng, Chongqi Wei, Jiaxiang Tong, Yang Chen, Mengting Li, Qingqing Wang, Sheng Guo, Jin-Ao Duan, Er-Xin Shang, Yue Zh. Jian-Yan-Ling capsules ameliorate cognitive impairment in mice with D-galactose-induced senescence and inhibit the oxidation-induced apoptosis of HT22 hippocampal cells by regulating the Nrf2-HO1 signaling pathway. Journal of ethnopharmacology. 2023-03-16. PMID:36924864. |
jian-yan-ling capsules ameliorate cognitive impairment in mice with d-galactose-induced senescence and inhibit the oxidation-induced apoptosis of ht22 hippocampal cells by regulating the nrf2-ho1 signaling pathway. |
2023-03-16 |
2023-08-14 |
mouse |
| Sohir M Zohny, Mohamed Z Habib, Magda I Mohamad, Wael M Elayat, Reham M Elhossiny, Mohamed F Abd El-Salam, Ghada A M Hassan, Sawsan Aboul-Fotou. Memantine/Aripiprazole Combination Alleviates Cognitive Dysfunction in Valproic Acid Rat Model of Autism: Hippocampal CREB/BDNF Signaling and Glutamate Homeostasis. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2023-03-15. PMID:36918475. |
these were accompanied by the appearance of numerous neurofibrillary tangles (nfts) with enhanced apoptosis in hippocampal sections. |
2023-03-15 |
2023-08-14 |
human |
| Sohir M Zohny, Mohamed Z Habib, Magda I Mohamad, Wael M Elayat, Reham M Elhossiny, Mohamed F Abd El-Salam, Ghada A M Hassan, Sawsan Aboul-Fotou. Memantine/Aripiprazole Combination Alleviates Cognitive Dysfunction in Valproic Acid Rat Model of Autism: Hippocampal CREB/BDNF Signaling and Glutamate Homeostasis. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2023-03-15. PMID:36918475. |
this study draws attention to the favorable cognitive effects of memantine/aripiprazole combination in autistic subjects which could be mediated via enhancing creb/bdnf signaling with increased expression of astrocytic glt-1 and restoration of gaba/glutamate balance, leading to inhibition of hippocampal nfts formation and neuronal apoptosis. |
2023-03-15 |
2023-08-14 |
human |
| Aolei Lin, Yi Guo, Hui Zhang, Peijia Lin, Kaiyan Tao, Li Jiang, Demei Xu, Bo Che. GSDMD knockdown exacerbates hippocampal damage and seizure susceptibility by crosstalk between pyroptosis and apoptosis in kainic acid-induced temporal lobe epilepsy. Biochimica et biophysica acta. Molecular basis of disease. 2023-03-15. PMID:36921736. |
gsdmd knockdown exacerbates hippocampal damage and seizure susceptibility by crosstalk between pyroptosis and apoptosis in kainic acid-induced temporal lobe epilepsy. |
2023-03-15 |
2023-08-14 |
Not clear |
| Saeedeh Fahimi, Shahrbanoo Oryan, Ramesh Ahmadi, Akram Eid. Downregulation of Iranian journal of pharmaceutical research : IJPR. vol 21. issue 1. 2023-03-14. PMID:36915407. |
downregulation of apoptosis is proposed as a possible mechanism for diabetes-induced hippocampal neuronal cell death. |
2023-03-14 |
2023-08-14 |
Not clear |
| Nellysha Namela Muhammad Abdul Kadar, Fairus Ahmad, Seong Lin Teoh, Mohamad Fairuz Yahay. Comparable Benefits of Stingless Bee Honey and Caffeic Acid in Mitigating the Negative Effects of Metabolic Syndrome on the Brain. Antioxidants (Basel, Switzerland). vol 11. issue 11. 2023-03-08. PMID:36358526. |
immunohistochemistry investigations of neurogenesis (edu) and apoptosis (tunel) on the cornu ammonis 1 (ca1) and dentate gyrus (dg) areas of the hippocampus showed no changes with sbh and ca supplementation compared to the control. |
2023-03-08 |
2023-08-16 |
rat |
| Bin Xi, Jieping Fu, Dengfeng Wan, Zhiping Xi. Ginsenoside Rg1 attenuation of neurogenesis disorder and neuronal apoptosis in the rat hippocampus after spinal cord injury may involve brain-derived neurotrophic factor/extracellular signal-regulated kinase signaling. Neuroreport. vol 34. issue 5. 2023-03-07. PMID:36881751. |
ginsenoside rg1 attenuation of neurogenesis disorder and neuronal apoptosis in the rat hippocampus after spinal cord injury may involve brain-derived neurotrophic factor/extracellular signal-regulated kinase signaling. |
2023-03-07 |
2023-08-14 |
rat |
| Sepideh Ghazvineh, Morteza Salimi, Samaneh Dehghan, Azam Asemi-Rad, Kolsoum Dehdar, Alireza Salimi, Hamidreza Jamaati, Mohammad Reza Raouf. Stimulating olfactory epithelium mitigates mechanical ventilation-induced hippocampal inflammation and apoptosis. Hippocampus. 2023-03-03. PMID:36864704. |
stimulating olfactory epithelium mitigates mechanical ventilation-induced hippocampal inflammation and apoptosis. |
2023-03-03 |
2023-08-14 |
rat |
| Sepideh Ghazvineh, Morteza Salimi, Samaneh Dehghan, Azam Asemi-Rad, Kolsoum Dehdar, Alireza Salimi, Hamidreza Jamaati, Mohammad Reza Raouf. Stimulating olfactory epithelium mitigates mechanical ventilation-induced hippocampal inflammation and apoptosis. Hippocampus. 2023-03-03. PMID:36864704. |
since diversion of breathing route to the tracheal tube diminishes brain activity entrained by physiological nasal breathing, we hypothesized that simulating nasal breathing using rhythmic air-puff (ap) into the nasal cavity of mechanically ventilated rats can reduce hippocampal inflammation and apoptosis in association with restoring respiration-coupled oscillations. |
2023-03-03 |
2023-08-14 |
rat |
| Sepideh Ghazvineh, Morteza Salimi, Samaneh Dehghan, Azam Asemi-Rad, Kolsoum Dehdar, Alireza Salimi, Hamidreza Jamaati, Mohammad Reza Raouf. Stimulating olfactory epithelium mitigates mechanical ventilation-induced hippocampal inflammation and apoptosis. Hippocampus. 2023-03-03. PMID:36864704. |
we found that stimulating olfactory epithelium through applying rhythmic nasal ap, in association with reviving respiration-coupled brain rhythm, mitigates mv-induced hippocampal apoptosis and inflammation involving microglia and astrocytes. |
2023-03-03 |
2023-08-14 |
rat |
| Le-le Zhang, Ai-Hong Yuan, Jun Yang, Bi-Xiang Zha, Guang Gu, Yin-Qiu Fan, Yu-Song Yang, Wen-Jing Ka. [Moxibustion improves learning-memory ability by regulating apoptosis related proteins of hippocampus in diabetic rats with cognitive impairment]. Zhen ci yan jiu = Acupuncture research. vol 48. issue 2. 2023-03-01. PMID:36858415. |
[moxibustion improves learning-memory ability by regulating apoptosis related proteins of hippocampus in diabetic rats with cognitive impairment]. |
2023-03-01 |
2023-08-14 |
rat |
| Le-le Zhang, Ai-Hong Yuan, Jun Yang, Bi-Xiang Zha, Guang Gu, Yin-Qiu Fan, Yu-Song Yang, Wen-Jing Ka. [Moxibustion improves learning-memory ability by regulating apoptosis related proteins of hippocampus in diabetic rats with cognitive impairment]. Zhen ci yan jiu = Acupuncture research. vol 48. issue 2. 2023-03-01. PMID:36858415. |
to investigate the effect of moxibustion on the proteins related with apoptosis and nuclear transcription factor kappa b (nf-κb) in hippocampus of diabetic rats with cognitive impairment (ci), so as to explore its mechanism underlying improvement of learning-memory ability. |
2023-03-01 |
2023-08-14 |
rat |
| Simon W So, Joshua P Nixon, David A Bernlohr, Tammy A Butteric. RNAseq Analysis of FABP4 Knockout Mouse Hippocampal Transcriptome Suggests a Role for WNT/β-Catenin in Preventing Obesity-Induced Cognitive Impairment. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834799. |
results showed that hfd-fed fabp4 knockout mice have a hippocampal transcriptome consistent with neuroprotection, including associations with decreased proinflammatory signaling, er stress, apoptosis, and cognitive decline. |
2023-02-25 |
2023-08-14 |
mouse |
| Paria Hashemi, Shamseddin Ahmad. Alpha-Pinene Exerts Antiseizure Effects by Preventing Oxidative Stress and Apoptosis in the Hippocampus in a Rat Model of Temporal Lobe Epilepsy Induced by Kainate. Molecular neurobiology. 2023-02-25. PMID:36840843. |
alpha-pinene exerts antiseizure effects by preventing oxidative stress and apoptosis in the hippocampus in a rat model of temporal lobe epilepsy induced by kainate. |
2023-02-25 |
2023-08-14 |
rat |
| Hoo Young Lee, Suk-Young Song, Jihye Hwang, Ahreum Baek, Dawoon Baek, Sung Hoon Kim, Jung Hyun Park, Sungchul Choi, Soonil Pyo, Sung-Rae Ch. Very early environmental enrichment protects against apoptosis and improves functional recovery from hypoxic-ischemic brain injury. Frontiers in molecular neuroscience. vol 15. 2023-02-24. PMID:36824441. |
very early exposure to ee significantly downregulated fas/fasl-mediated apoptosis, decreased expression of fas, fas-associated death domain, cleaved caspase-8/caspase-8, cleaved caspase-3/caspase-3, as well as bax and bcl-2, in the cerebral cortex and the hippocampus. |
2023-02-24 |
2023-08-14 |
mouse |