| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hoo Young Lee, Suk-Young Song, Jihye Hwang, Ahreum Baek, Dawoon Baek, Sung Hoon Kim, Jung Hyun Park, Sungchul Choi, Soonil Pyo, Sung-Rae Ch. Very early environmental enrichment protects against apoptosis and improves functional recovery from hypoxic-ischemic brain injury. Frontiers in molecular neuroscience. vol 15. 2023-02-24. PMID:36824441. |
very early exposure to ee significantly downregulated fas/fasl-mediated apoptosis, decreased expression of fas, fas-associated death domain, cleaved caspase-8/caspase-8, cleaved caspase-3/caspase-3, as well as bax and bcl-2, in the cerebral cortex and the hippocampus. |
2023-02-24 |
2023-08-14 |
mouse |
| Abdelaziz M Hussein, Seham Ahmed Mahmoud, Khalid Mohammed Elazab, Ahmed F Abouelnaga, Marwa Abass, Ahmed A H Mosa, Mennatullah A M Hussein, Mohamed E G Elsaye. Possible Mechanisms of the Neuroprotective Actions of Date Palm Fruits Aqueous Extracts against Valproic Acid-Induced Autism in Rats. Current issues in molecular biology. vol 45. issue 2. 2023-02-24. PMID:36826050. |
at the end of the study, the expression of nrf2, heme oxygenase (ho-1), sirt-1, caspase-3 (a marker of apoptosis), lc3 (a marker of autophagy), and nfκb (inflammatory cytokines) were evaluated along with the oxidative stress in brain tissues and the histological changes in the cerebellum and hippocampus. |
2023-02-24 |
2023-08-14 |
rat |
| Chouhui Xuan, Haixia Cui, Zhengyong Jin, Yuyang Yue, Shuxia Cao, Songbiao Cui, Dongyuan X. Glutamine ameliorates hyperoxia-induced hippocampal damage by attenuating inflammation and apoptosis Frontiers in pharmacology. vol 14. 2023-02-23. PMID:36817145. |
glutamine ameliorates hyperoxia-induced hippocampal damage by attenuating inflammation and apoptosis glutamine (gln) is an immunomodulatory protein that mediates oxidative stress, inflammation, and apoptosis, but has not been reported in the treatment of hyperoxia (hyp)-induced brain injury. |
2023-02-23 |
2023-08-14 |
rat |
| Chouhui Xuan, Haixia Cui, Zhengyong Jin, Yuyang Yue, Shuxia Cao, Songbiao Cui, Dongyuan X. Glutamine ameliorates hyperoxia-induced hippocampal damage by attenuating inflammation and apoptosis Frontiers in pharmacology. vol 14. 2023-02-23. PMID:36817145. |
gln treatment significantly reduced brain tissue water content, oxidative stress levels, microglia activation and inflammatory factor expression, and attenuated tissue damage and apoptosis in the hippocampal region. |
2023-02-23 |
2023-08-14 |
rat |
| Gaoyou Pei, Liguo Xu, Wenhao Huang, Jianjun Yi. Retraction notice to "The protective role of microRNA-133b in restricting hippocampal neurons apoptosis and inflammatory injury in rats with depression by suppressing CTGF" [Int. Immunopharmacol. 78 (2020) 106076]. International immunopharmacology. vol 117. 2023-02-23. PMID:36822080. |
retraction notice to "the protective role of microrna-133b in restricting hippocampal neurons apoptosis and inflammatory injury in rats with depression by suppressing ctgf" [int. |
2023-02-23 |
2023-08-14 |
rat |
| Min Jeong Kim, Gee Euhn Choi, Chang Woo Chae, Jae Ryong Lim, Young Hyun Jung, Jee Hyeon Yoon, Ji Yong Park, Ho Jae Ha. Melatonin-mediated FKBP4 downregulation protects against stress-induced neuronal mitochondria dysfunctions by blocking nuclear translocation of GR. Cell death & disease. vol 14. issue 2. 2023-02-22. PMID:36810730. |
in this study, the effects of glucocorticoid on suppressing nix-mediated mitophagy, followed by mitochondrial dysfunction, neuronal cell apoptosis, and cognitive deficits were reversed by melatonin treatment by inhibiting the nuclear translocation of grs in both sh-sy5y cells and mouse hippocampal tissue. |
2023-02-22 |
2023-08-14 |
mouse |
| Yongjie Xu, Sijia Wei, Liying Zhu, Changyudong Huang, Tingting Yang, Shuang Wang, Yiqiong Zhang, Yunfeng Duan, Xing Li, Zhengrong Wang, Wei Pa. Low expression of the intestinal metabolite butyric acid and the corresponding memory pattern regulate HDAC4 to promote apoptosis in rat hippocampal neurons. Ecotoxicology and environmental safety. vol 253. 2023-02-22. PMID:36812872. |
low expression of the intestinal metabolite butyric acid and the corresponding memory pattern regulate hdac4 to promote apoptosis in rat hippocampal neurons. |
2023-02-22 |
2023-08-14 |
mouse |
| Yongjie Xu, Sijia Wei, Liying Zhu, Changyudong Huang, Tingting Yang, Shuang Wang, Yiqiong Zhang, Yunfeng Duan, Xing Li, Zhengrong Wang, Wei Pa. Low expression of the intestinal metabolite butyric acid and the corresponding memory pattern regulate HDAC4 to promote apoptosis in rat hippocampal neurons. Ecotoxicology and environmental safety. vol 253. 2023-02-22. PMID:36812872. |
microbiota transplantation has long been thought to reverse the behavioral changes in the brain caused by colony dysregulation, but in our study, microbiota transplantation seemed to improve only behavioral brain function, and there was no reasonable explanation for the high level of hippocampal neuron apoptosis that remained. |
2023-02-22 |
2023-08-14 |
mouse |
| Yongjie Xu, Sijia Wei, Liying Zhu, Changyudong Huang, Tingting Yang, Shuang Wang, Yiqiong Zhang, Yunfeng Duan, Xing Li, Zhengrong Wang, Wei Pa. Low expression of the intestinal metabolite butyric acid and the corresponding memory pattern regulate HDAC4 to promote apoptosis in rat hippocampal neurons. Ecotoxicology and environmental safety. vol 253. 2023-02-22. PMID:36812872. |
the results showed that disturbance of short-chain fatty acid metabolism led to high hdac4 expression in the hippocampus and regulated h4k8ac, h4k12ac, and h4k16ac to promote increased neuronal apoptosis. |
2023-02-22 |
2023-08-14 |
mouse |
| Yongjie Xu, Sijia Wei, Liying Zhu, Changyudong Huang, Tingting Yang, Shuang Wang, Yiqiong Zhang, Yunfeng Duan, Xing Li, Zhengrong Wang, Wei Pa. Low expression of the intestinal metabolite butyric acid and the corresponding memory pattern regulate HDAC4 to promote apoptosis in rat hippocampal neurons. Ecotoxicology and environmental safety. vol 253. 2023-02-22. PMID:36812872. |
however, microbiota transplantation did not change the pattern of low butyric acid expression, resulting in maintained high hdac4 expression in hippocampal neurons with continued neuronal apoptosis. |
2023-02-22 |
2023-08-14 |
mouse |
| Yongjie Xu, Sijia Wei, Liying Zhu, Changyudong Huang, Tingting Yang, Shuang Wang, Yiqiong Zhang, Yunfeng Duan, Xing Li, Zhengrong Wang, Wei Pa. Low expression of the intestinal metabolite butyric acid and the corresponding memory pattern regulate HDAC4 to promote apoptosis in rat hippocampal neurons. Ecotoxicology and environmental safety. vol 253. 2023-02-22. PMID:36812872. |
overall, our study shows that low levels of butyric acid in vivo can promote hdac4 expression through the gut-brain axis pathway, leading to hippocampal neuronal apoptosis, and demonstrates that butyric acid has great potential value for neuroprotection in the brain. |
2023-02-22 |
2023-08-14 |
mouse |
| Hongyu Yi, Yali Duan, Renjie Song, Yibo Zhou, Yating Cui, Chao Liu, Zhi Mao, Jie Hu, Feihu Zho. Activation of glucagon-like peptide-1 receptor in microglia exerts protective effects against sepsis-induced encephalopathy via attenuating endoplasmic reticulum stress-associated inflammation and apoptosis in a mouse model of sepsis. Experimental neurology. 2023-02-22. PMID:36813224. |
in vivo experiments confirmed the benefits of liraglutide in the regulation of microglial activation, er stress, inflammation, and apoptosis in the hippocampus of septic mice. |
2023-02-22 |
2023-08-14 |
mouse |
| Lei Gao, Fushun Liu, Ruilian Li. The Mechanism of Aerobic Exercise Regulating the PI3K/Akt-mTOR Signaling Pathway Intervenes in Hippocampal Neuronal Apoptosis in Vascular Dementia Rats. International journal of environmental research and public health. vol 20. issue 3. 2023-02-11. PMID:36767264. |
the mechanism of aerobic exercise regulating the pi3k/akt-mtor signaling pathway intervenes in hippocampal neuronal apoptosis in vascular dementia rats. |
2023-02-11 |
2023-08-14 |
rat |
| Lei Gao, Fushun Liu, Ruilian Li. The Mechanism of Aerobic Exercise Regulating the PI3K/Akt-mTOR Signaling Pathway Intervenes in Hippocampal Neuronal Apoptosis in Vascular Dementia Rats. International journal of environmental research and public health. vol 20. issue 3. 2023-02-11. PMID:36767264. |
the purpose of this paper is to explore the mechanism of aerobic exercise regulating autophagy through the pi3k/akt-mtor signaling pathway and its participation in apoptosis, to protect the hippocampal nerves from damage in vascular dementia rats. |
2023-02-11 |
2023-08-14 |
rat |
| Xuena Zhang, Mingying Li, Yun Yue, Ying Zhang, Anshi W. Luteoloside prevents sevoflurane-induced cognitive dysfunction in aged rats via maintaining mitochondrial function and dynamics in hippocampal neurons. Neuroscience. 2023-02-10. PMID:36764603. |
sevoflurane exposure led to hippocampal neuron apoptosis in vivo (n = 6) and in vitro (n = 3), while this injury was prevented by luteoloside in a dose-dependent manner. |
2023-02-10 |
2023-08-14 |
rat |
| Wenhui Yan, Tingli Guo, Na Liu, Xin Cui, Xiaotong Wei, Yuzhuo Sun, Hao Hu, Lina Che. Erythropoietin ameliorates cognitive deficits by improving hippocampal and synaptic damage in streptozotocin-induced diabetic mice. Cellular signalling. 2023-02-05. PMID:36739954. |
our findings revealed that epo impedes hippocampal and synaptic damage and neuronal apoptosis by regulating bdnf and psd-95 expression through nmda receptors, thereby ameliorating cognitive impairments in mice with t1dm. |
2023-02-05 |
2023-08-14 |
mouse |
| Asma B Salek, Emily T Claeboe, Ruchi Bansal, Nicolas F Berbari, Anthony J Baucu. Spinophilin dependent regulation of GluN2B-containing NMDAR-dependent calcium influx, GluN2B surface expression, and cleaved caspase expression. Synapse (New York, N.Y.). 2023-02-04. PMID:36738175. |
in hippocampal neurons isolated from spinophilin knockout animals there is an increase in cleaved caspase-3 levels, a marker of calcium-associated apoptosis, compared to wildtype mice. |
2023-02-04 |
2023-08-14 |
mouse |
| Xintong Wang, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Che. Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by sleep deprivation. Microbiome. vol 11. issue 1. 2023-02-01. PMID:36721179. |
here, we established fecal microbiota transplantation, aeromonas colonization and lps or butyrate supplementation tests to evaluate the role of the intestinal microbiota and its metabolites in melatonin in alleviating sd-induced memory impairment. results: transplantation of the sd-gut microbiota into normal mice induced microglia overactivation and neuronal apoptosis in the hippocampus, cognitive decline, and colonic microbiota disorder, manifesting as increased levels of aeromonas and lps and decreased levels of lachnospiraceae_nk4a136 and butyrate. |
2023-02-01 |
2023-08-14 |
mouse |
| Xintong Wang, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Che. Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by sleep deprivation. Microbiome. vol 11. issue 1. 2023-02-01. PMID:36721179. |
these changes lessen the inflammatory response and neuronal apoptosis in the hippocampus through crosstalk between the tlr4/nf-κb and mct1/ hdac3 signaling pathways. |
2023-02-01 |
2023-08-14 |
mouse |
| Qinglan Zong, Yue Pan, Yongfang Liu, Zhengcun Wu, Zhangqiong Huang, Ying Zhang, Kaili M. pNaktide mitigates inflammation-induced neuronal damage and behavioral deficits through the oxidative stress pathway. International immunopharmacology. vol 116. 2023-01-23. PMID:36689848. |
inhibition of autophagy and enhancement of apoptosis induced by lps were also alleviated by pnaktide, which restored lps-induced injury to newborn neurons in the hippocampus region. |
2023-01-23 |
2023-08-14 |
Not clear |