| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dan-Hong Xu, Jian-Kui Du, Shi-Yu Liu, Hui Zhang, Lu Yang, Xiao-Yan Zhu, Yu-Jian Li. Upregulation of KLK8 contributes to CUMS-induced hippocampal neuronal apoptosis by cleaving NCAM1. Cell death & disease. vol 14. issue 4. 2023-04-19. PMID:37076499. |
in ht22 murine hippocampal neuronal cells and primary hippocampal neurons, adenovirus-mediated overexpression of klk8 (ad-klk8) was sufficient to induce neuron apoptosis. |
2023-04-19 |
2023-08-14 |
mouse |
| Yingjun Zhu, Min Zhang, Jiayu Wang, Qingxiu Wan. Knocking down Trim47 ameliorated sevoflurane-induced neuronal cell injury and cognitive impairment in rats. Experimental brain research. 2023-04-17. PMID:37067562. |
the mrna and protein expression of tnf-α, il-1β and il-6 in the cells, along with the neuronal apoptosis in the hippocampus of rats in each group were studied by tunel or wb. |
2023-04-17 |
2023-08-14 |
rat |
| Yingjun Zhu, Min Zhang, Jiayu Wang, Qingxiu Wan. Knocking down Trim47 ameliorated sevoflurane-induced neuronal cell injury and cognitive impairment in rats. Experimental brain research. 2023-04-17. PMID:37067562. |
the results showed that, knockdown of trim47 ameliorated sev-induced neurological damage and cognitive deficits, inflammation and neuronal cell apoptosis in rats, and promoted hippocampal neuronal activity. |
2023-04-17 |
2023-08-14 |
rat |
| Caio Matheus Santos da Silva Calado, Raul Manhães-de-Castro, Sabrina da Conceição, Pereira, Vanessa da Silva Souza, Diego Bulcão Visco, Beatriz Souza de Silveira, Sandra Lopes de Souza, Ana Elisa Toscan. Therapeutic advances for treating memory impairments in perinatal brain injuries with implications for cerebral palsy: A systematic review and meta-analysis of preclinical studies. Experimental neurology. 2023-04-17. PMID:37068620. |
these were reported to cause a reduction in the number of neurons and the volume of the hippocampus, in addition to an increase in astrogliosis and apoptosis of neurons and difficulties in forming new memories similar to those that occur in children with cp. |
2023-04-17 |
2023-08-14 |
Not clear |
| Haijing Zhang, Chao Zhang, Donggang Xu, Qin Wang, Dongqun X. Effects of subchronic exposure of perfluorooctane sulfonate on cognitive function of mice and its mechanism. Environmental pollution (Barking, Essex : 1987). 2023-04-16. PMID:37062406. |
the apoptosis of neurons and astrocytes in the cortex and hippocampus was analyzed, as well as the potential apoptotic signaling pathways. |
2023-04-16 |
2023-08-14 |
mouse |
| Fang-Fang Zhang, Liang Zhang, Lin Zhao, Yu Lu, Xin Dong, Yan-Qi Liu, Yu Li, Shuang Guo, Si-Yuan Zheng, Ying Xiao, Yu-Zhu Jian. The circular RNA Neural regeneration research. vol 18. issue 10. 2023-04-14. PMID:37056143. |
hoxa5 expression was low in the hippocampus of a mouse model of acute ischemia and in ht22-ais cells, and inhibited ht22-ais cell apoptosis. |
2023-04-14 |
2023-08-14 |
mouse |
| Cheng-Long Zhu, Jian Xie, Qiang Liu, Yi Wang, Hui-Ru Li, Chang-Meng Yu, Peng Li, Xiao-Ming Deng, Jin-Jun Bian, Jia-Feng Wan. PD-L1 promotes GSDMD-mediated NET release by maintaining the transcriptional activity of Stat3 in sepsis-associated encephalopathy. International journal of biological sciences. vol 19. issue 5. 2023-04-14. PMID:37056920. |
here, we firstly show that in murine sepsis model, neutrophils and nets promote blood-brain barrier (bbb) disruption, neuronal apoptosis and microglia activation in hippocampus and induce hippocampus-dependent memory impairment. |
2023-04-14 |
2023-08-14 |
human |
| Houman Kamranian, Hadi Asoudeh, Roya Kamrani Sharif, Fereshteh Taheri, A Wallace Hayes, Mina Gholami, Ahmad Alavi, Majid Motaghineja. Neuroprotective Potential of Trimetazidine Against Tramadol-Induced Neurotoxicity: Role of PI3K/Akt/mTOR Signaling Pathways. Toxicology mechanisms and methods. 2023-04-13. PMID:37051630. |
hippocampal neurodegenerative, mitochondrial quadruple complex enzymes, phosphatidylinositol-3-kinases (pi3ks)/protein kinase b levels, oxidative stress, inflammatory, apoptosis, autophagy, and histopathology were evaluated. |
2023-04-13 |
2023-08-14 |
rat |
| Su Jiang, Ying Xiong, Xinyan Wan. Engeletin ameliorates sevoflurane-induced cognitive impairment by activating PPAR-gamma in neonatal mice. Neuropathology : official journal of the Japanese Society of Neuropathology. 2023-04-10. PMID:37037475. |
the treatment of engeletin dramatically suppressed the activation of microglia and apoptosis induced by sev in the hippocampus of neonatal mice. |
2023-04-10 |
2023-08-14 |
mouse |
| Fatih Mete, Signem Eyuboglu, Ayca Vitrinel, Ulkan Kilic, Cihan Suleyman Erdogan, Ertugrul Kilic, Bayram Yilma. Hyperthermia alters neurobehavior by affecting cell proliferation and neuronal survival in young male rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2023-04-08. PMID:37029601. |
neuronal survival, apoptosis, and cell proliferation were investigated in cortex, hippocampal dentate gyrus (dg) and ca1 regions, and corpus callosum (cc). |
2023-04-08 |
2023-08-14 |
rat |
| Yan-Li Jia, Wei Wang, Ning Han, Hong-Liang Sun, Fang-Ming Dong, Ya-Xue Song, Rong-Fang Feng, Jian-Hua Wan. The mitochondria-targeted small molecule SS31 delays progression of behavioral deficits by attenuating β-amyloid plaque formation and mitochondrial/synaptic deterioration in APP/PS1 mice. Biochemical and biophysical research communications. vol 658. 2023-04-05. PMID:37018887. |
the app/ps1 transgenic mice exhibited elevated expression of aβ40/aβ42 and mitochondrial fission protein dlp1 and reduced expression of synaptophysin (syn) and postsynaptic density protein 95 (psd95) reductions, as well as increased levels of neuronal apoptosis and ros in the hippocampus, and long-term treatment with ss31 reversed these effects. |
2023-04-05 |
2023-08-14 |
mouse |
| Zhonglan Dong, Lili Jia, Wenhui Han, Yidan Wang, Mingwei Sheng, Yinghui Ren, Yiqi Weng, Hongxia Li, Wenli Y. The protective effect of lncRNA NEAT1/miR-122-5p/Wnt1 axis on hippocampal damage in hepatic ischemic reperfusion young mice. Cellular signalling. 2023-04-02. PMID:37004832. |
upregulated expression of mir-122-5p reduces the viability of neuronal cells and promotes the development of apoptosis, thereby aggravating the damage of hippocampal tissue in hir young mice. |
2023-04-02 |
2023-08-14 |
mouse |
| Nataya Sritawan, Apiwat Sirichoat, Anusara Aranarochana, Wanassanan Pannangrong, Peter Wigmore, Jariya Umka Welba. Protective effect of metformin on methotrexate induced reduction of rat hippocampal neural stem cells and neurogenesis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 162. 2023-03-31. PMID:37001179. |
in this study, we focus to investigate neural stem cells, biomarkers of apoptosis, and the protein for synaptogenesis, which involves in the transcription factors of the hippocampus in rats that received metformin and mtx. |
2023-03-31 |
2023-08-14 |
rat |
| Junjie Liang, Shanshan Han, Chao Ye, Haimeng Zhu, Jiajun Wu, Yunjuan Nie, Gaoshang Chai, Peng Zhao, Dengxin Zhan. Minocycline Attenuates Sevoflurane-Induced Postoperative Cognitive Dysfunction in Aged Mice by Suppressing Hippocampal Apoptosis and the Notch Signaling Pathway-Mediated Neuroinflammation. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979321. |
minocycline attenuates sevoflurane-induced postoperative cognitive dysfunction in aged mice by suppressing hippocampal apoptosis and the notch signaling pathway-mediated neuroinflammation. |
2023-03-29 |
2023-08-14 |
mouse |
| Christina Magdy Wadie, Radwa Hassan Ali, Abd El-Hamid A Mohamed, Jolly M W Labib, Abdel Rhman Sabaa, Hossam Eldin Ahmed Awad, Doaa Ahmed Abou-Bak. A comparative study of acetyl-l-carnitine and caloric restriction impact on hippocampal autophagy, apoptosis, neurogenesis, and astroglial function in AlCl Canadian journal of physiology and pharmacology. 2023-03-29. PMID:36988119. |
a comparative study of acetyl-l-carnitine and caloric restriction impact on hippocampal autophagy, apoptosis, neurogenesis, and astroglial function in alcl alzheimer's disease (ad) is a worldwide chronic progressive neurodegenerative disease. |
2023-03-29 |
2023-08-14 |
Not clear |
| Meng Cheng, Caihua Ye, Chunxiao Tian, Dongju Zhao, Haonan Li, Zuhao Sun, Yuyang Miao, Qiang Zhang, Junping Wang, Yan Do. Engineered macrophage-biomimetic versatile nanoantidotes for inflammation-targeted therapy against Alzheimer's disease by neurotoxin neutralization and immune recognition suppression. Bioactive materials. vol 26. 2023-03-23. PMID:36950153. |
benefiting from this two-pronged immunosuppressive strategy, ot-lipo@m exhibits outstanding therapeutic effects on ameliorating cognitive deficits, inhibiting neuronal apoptosis, and enhancing synaptic plasticity in ad mice, accompanied by the delayed hippocampal atrophy and brain microstructural disruption by |
2023-03-23 |
2023-08-14 |
mouse |
| Mohamed Taha, Omar Mohsen Eldemerdash, Ismail Mohamed Elshaffei, Einas Mohamed Yousef, Ayman S Soliman, Mahmoud Ahmed Senous. Apigenin Attenuates Hippocampal Microglial Activation and Restores Cognitive Function in Methotrexate-Treated Rats: Targeting the miR-15a/ROCK-1/ERK1/2 Pathway. Molecular neurobiology. 2023-03-21. PMID:36943623. |
this was accompanied by neuroinflammation, oxidative stress, and enhanced apoptosis manifested by elevated hippocampal interleukin-1β, malondialdehyde, and caspase-3, and decreased reduced glutathione levels. |
2023-03-21 |
2023-08-14 |
rat |
| Mohamed Taha, Omar Mohsen Eldemerdash, Ismail Mohamed Elshaffei, Einas Mohamed Yousef, Ayman S Soliman, Mahmoud Ahmed Senous. Apigenin Attenuates Hippocampal Microglial Activation and Restores Cognitive Function in Methotrexate-Treated Rats: Targeting the miR-15a/ROCK-1/ERK1/2 Pathway. Molecular neurobiology. 2023-03-21. PMID:36943623. |
on the left, methotrexate (mtx) administration to rats resulted in hippocampal mir-15a downregulation, which triggered an enhanced expression of its target rock-1, consequently inhibiting the downstream erk1/2/creb/bdnf pathway, instigating a state of microglial activation, neuroinflammation, oxidative stress, and apoptosis. |
2023-03-21 |
2023-08-14 |
rat |
| Mohamed Taha, Omar Mohsen Eldemerdash, Ismail Mohamed Elshaffei, Einas Mohamed Yousef, Ayman S Soliman, Mahmoud Ahmed Senous. Apigenin Attenuates Hippocampal Microglial Activation and Restores Cognitive Function in Methotrexate-Treated Rats: Targeting the miR-15a/ROCK-1/ERK1/2 Pathway. Molecular neurobiology. 2023-03-21. PMID:36943623. |
on the other hand, apigenin (api) co-treatment restored mir-15a, inhibited rock-1 expression, and activated the erk1/2/creb/bdnf pathway, leading to diminished hippocampal microglial activation, neuroinflammation, and apoptosis, and restoration of the redox balance, along with improvement in memory and cognitive function of the mtx-treated rats. |
2023-03-21 |
2023-08-14 |
rat |
| Shengliang Peng, Yun Yu, Juan Li, Danling Jiang, Guohai Xu, Lidong Wu, Jialing H. Hsp22 pretreatment protection against LPS-induced hippocampal injury by alleviating neuroinflammation and apoptosis by regulating the NLRP3/Caspase1/IL-1β signaling pathway in mice. Aging. vol 15. 2023-03-19. PMID:36934348. |
hsp22 pretreatment protection against lps-induced hippocampal injury by alleviating neuroinflammation and apoptosis by regulating the nlrp3/caspase1/il-1β signaling pathway in mice. |
2023-03-19 |
2023-08-14 |
mouse |