| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kuo-Jen Wu, Tsai-Wei Hung, Yu-Syuan Wang, Yun-Hsiang Chen, Eun-Kyung Bae, Seong-Jin Y. Prosaposin PS18 reduces dopaminergic neurodegeneration in a 6-hydroxydopamine rat model of Parkinson's disease. Scientific reports. vol 13. issue 1. 2023-05-19. PMID:37208379. |
prosaposin or its analog prosaposin-derived 18-mer peptide (ps18) reduced neuronal damage in hippocampus and apoptosis in stroke brain. |
2023-05-19 |
2023-08-14 |
rat |
| Hui-Ru Li, Qiang Liu, Cheng-Long Zhu, Xiao-Yang Sun, Chen-Yan Sun, Chang-Meng Yu, Peng Li, Xiao-Ming Deng, Jia-Feng Wan. β-Nicotinamide mononucleotide activates NAD+/SIRT1 pathway and attenuates inflammatory and oxidative responses in the hippocampus regions of septic mice. Redox biology. vol 63. 2023-05-18. PMID:37201414. |
apoptosis, inflammatory and oxidative responses in the hippocampus of septic mice were attenuated significantly after nmn administration. |
2023-05-18 |
2023-08-14 |
mouse |
| Nan Yan, Shuai Wang, Haotian Gao, Jiaqi Chen, Jiahui Cao, Pengsheng Wei, Xue Li, Ying Yu, Yan Wang, Yalin Niu, Yijie Wang, Shuyuan Liu, Ge Ji. Neuroprotective effect of aloe emodin against Huntington's disease-like symptoms in R6/1 transgenic mice. Food & function. 2023-05-16. PMID:37191091. |
aloe emodin could also inhibit neuronal apoptosis in the hippocampus of r6/1 mice. |
2023-05-16 |
2023-08-14 |
mouse |
| Luwen Zhang, Yang Li, Dan Tao, Liu Yang, Yue Zhang, Hua Zhang, Chun Xi. The miR-34b-5p-negative target Gnai2 aggravates fluorine combined with aluminum-induced apoptosis of rat offspring hippocampal neurons and NG108-15 cells. Environmental science and pollution research international. 2023-05-15. PMID:37186186. |
the mir-34b-5p-negative target gnai2 aggravates fluorine combined with aluminum-induced apoptosis of rat offspring hippocampal neurons and ng108-15 cells. |
2023-05-15 |
2023-08-14 |
rat |
| Luwen Zhang, Yang Li, Dan Tao, Liu Yang, Yue Zhang, Hua Zhang, Chun Xi. The miR-34b-5p-negative target Gnai2 aggravates fluorine combined with aluminum-induced apoptosis of rat offspring hippocampal neurons and NG108-15 cells. Environmental science and pollution research international. 2023-05-15. PMID:37186186. |
learning memory damage is implicated in excessive hippocampal neuron apoptosis, and mir-34b-5p participates in regulating the hippocampal neuron apoptosis. |
2023-05-15 |
2023-08-14 |
rat |
| Luwen Zhang, Yang Li, Dan Tao, Liu Yang, Yue Zhang, Hua Zhang, Chun Xi. The miR-34b-5p-negative target Gnai2 aggravates fluorine combined with aluminum-induced apoptosis of rat offspring hippocampal neurons and NG108-15 cells. Environmental science and pollution research international. 2023-05-15. PMID:37186186. |
we found that fa triggered apoptosis of rat hippocampal neurons and ng108-15 cells, increased mir-34b-5p expression, and decreased gnai2, pka, erk and creb expression. |
2023-05-15 |
2023-08-14 |
rat |
| Xiaoru Chang, Shuyan Niu, Mengting Shang, Jiangyan Li, Menghao Guo, Wenli Zhang, Zuoyi Sun, Yunjing Li, Rui Zhang, Xin Shen, Meng Tang, Yuying Xu. ROS-Drp1-mediated mitochondria fission contributes to hippocampal HT22 cell apoptosis induced by silver nanoparticles. Redox biology. vol 63. 2023-05-15. PMID:37187014. |
ros-drp1-mediated mitochondria fission contributes to hippocampal ht22 cell apoptosis induced by silver nanoparticles. |
2023-05-15 |
2023-08-14 |
mouse |
| Xiaoru Chang, Shuyan Niu, Mengting Shang, Jiangyan Li, Menghao Guo, Wenli Zhang, Zuoyi Sun, Yunjing Li, Rui Zhang, Xin Shen, Meng Tang, Yuying Xu. ROS-Drp1-mediated mitochondria fission contributes to hippocampal HT22 cell apoptosis induced by silver nanoparticles. Redox biology. vol 63. 2023-05-15. PMID:37187014. |
this study aimed to investigate the molecular mechanisms of mitochondrial damage and apoptosis in mouse hippocampal ht22 cells and further to explore role of reactive oxygen species (ros) and gtpase dynamin-related protein 1 (drp1) in agnps-induced neurotoxicity. |
2023-05-15 |
2023-08-14 |
mouse |
| Yihan Zhao, Wenying Zhao, Ying Ha. Inhibition of mTORC2 improves brain injury in epileptic rats by promoting chaperone-mediated autophagy. Epilepsy research. vol 193. 2023-05-10. PMID:37163909. |
our research results show that the levels of apoptosis in cortical and hippocampal neurons were upregulated in epileptic rats (f = 32.15, 30.96; both p < 0.01), and epilepsy caused neuronal damage (f = 8.13, 9.43; both p < 0.01). |
2023-05-10 |
2023-08-14 |
rat |
| Yihan Zhao, Wenying Zhao, Ying Ha. Inhibition of mTORC2 improves brain injury in epileptic rats by promoting chaperone-mediated autophagy. Epilepsy research. vol 193. 2023-05-10. PMID:37163909. |
inhibition of mtorc2 resulted in decreased levels of apoptosis and reduced neuronal damage in the cortex and hippocampus of epileptic rats. |
2023-05-10 |
2023-08-14 |
rat |
| Yinpei Huang, Zhili Liu, Xin Wang, Yaoxu Li, Lian Liu, Bing L. TGF-β3 Protects Neurons Against Intermittent Hypoxia-Induced Oxidative Stress and Apoptosis Through Activation of the Nrf-2/KEAP1/HO-1 Pathway via Binding to TGF-βRI. Neurochemical research. 2023-05-04. PMID:37140776. |
second-generation sequencing (rna-seq) and subsequent experiments supported that ih decreased tgf-β3 expression and stimulated reactive oxygen species (ros)-induced oxidative stress and apoptosis in rat hippocampus. |
2023-05-04 |
2023-08-14 |
human |
| Zhijing Zhang, Lideng Guo, Fei Yang, Shanpan Peng, Di Wang, Xiawei Lai, Baiqin Su, Haihui Xi. Adiponectin Attenuates Splenectomy-Induced Cognitive Deficits by Neuroinflammation and Oxidative Stress via TLR4/MyD88/NF-κb Signaling Pathway in Aged Rats. ACS chemical neuroscience. 2023-05-04. PMID:37141577. |
further experiments indicated that apn could inhibit the toll-like receptor 4 (tlr4)/myeloid differentiation factor 88 (myd88)/nuclear factor kappa b (nf-κb) p65 pathway to decrease the degree of oxidative damage (malondialdehyde (mda) and superoxide dismutase (sod)), microglia-mediated neuroinflammation (ionized calcium binding adapter molecule 1 (iba1), caspase-1, tumor necrosis factor (tnf)-α, interleukin-1β (il-1β), and interleukin-6 (il-6)), and apoptosis (p53, bcl2, bax, and caspase 3) in hippocampus. |
2023-05-04 |
2023-08-14 |
rat |
| Hamid Soltani Zangbar, Solmaz Fallahi, Leila Hosseini, Meysam Ghorbani, Mohsen Jafarzadehgharehziaaddin, Parviz Shahab. Spinal cord injury leads to more neurodegeneration in the hippocampus of aged male rats compared to young rats. Experimental brain research. 2023-05-02. PMID:37129669. |
the locomotion, hippocampal apoptosis, hippocampal rhythms (delta, theta, beta, gamma) max frequency (max.rf) and power, hippocampal neurogenesis, and hippocampal receptors (nmda, gaba a, muscarinic1/m1), which are important in the generation of rhythms and neurogenesis, were compared in aged rats in contrast to young rats. |
2023-05-02 |
2023-08-14 |
human |
| Fankai Gao, Rui Chen, Shuo Li, An Li, Bo Bai, Rulin Mi, Guofang Xu. (+)-Borneol exerts neuroprotective effects via suppressing the NF-κB pathway in the pilocarpine-induced epileptogenesis rat model. Brain research. 2023-05-01. PMID:37127175. |
furthermore, we examined the effects of 12 mg/kg (+)-borneol on neuronal damage, glial cell activation, and apoptosis in the hippocampus at different time points (1, 3, and 7 days) after se. |
2023-05-01 |
2023-08-14 |
rat |
| Bin Wang, Xiangke Cao, Jie Lin, Qingqiang Qian, Ling Yu, Qingzeng Qia. Retraction notice to "Up-regulation of microRNA-223 inhibits brain injury and hippocampal neuron apoptosis of rats after febrile seizure through the NLRP3-Caspase-1 signaling pathway" [Biomedi. Pharmacother. 114 (2019) 108683]. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023-04-22. PMID:37087337. |
retraction notice to "up-regulation of microrna-223 inhibits brain injury and hippocampal neuron apoptosis of rats after febrile seizure through the nlrp3-caspase-1 signaling pathway" [biomedi. |
2023-04-22 |
2023-08-14 |
rat |
| Zohre Aghaei, Narges Karbalaei, Mohammad Reza Namavar, Masoud Haghani, Mahboobeh Razmkhah, Mahdi Khorsand Ghaffari, Marzieh Nemat. Neuroprotective Effect of Wharton's Jelly-Derived Mesenchymal Stem Cell-Conditioned Medium (WJMSC-CM) on Diabetes-Associated Cognitive Impairment by Improving Oxidative Stress, Neuroinflammation, and Apoptosis. Stem cells international. vol 2023. 2023-04-21. PMID:37081849. |
in the current study, we aimed to examine the effects of wharton's jelly-derived mesenchymal stem cell-conditioned medium (wjmsc-cm) on learning and memory, oxidative stress, apoptosis, and histological changes in the hippocampus of diabetic rats. |
2023-04-21 |
2023-08-14 |
rat |
| Yuanping Zhong, Pengcheng Zhao, Chao Zhang, Zhenyu Wu, Xu Fang, Zhaoqiong Zh. NUDT21 relieves sevoflurane-induced neurological damage in rats by down-regulating LIMK2. Open life sciences. vol 18. issue 1. 2023-04-20. PMID:37077345. |
in addition, tunel assay results indicated that enhanced nudt21 alleviated sevoflurane-induced apoptosis of hippocampal neurons. |
2023-04-20 |
2023-08-14 |
rat |
| Dan-Hong Xu, Jian-Kui Du, Shi-Yu Liu, Hui Zhang, Lu Yang, Xiao-Yan Zhu, Yu-Jian Li. Upregulation of KLK8 contributes to CUMS-induced hippocampal neuronal apoptosis by cleaving NCAM1. Cell death & disease. vol 14. issue 4. 2023-04-19. PMID:37076499. |
upregulation of klk8 contributes to cums-induced hippocampal neuronal apoptosis by cleaving ncam1. |
2023-04-19 |
2023-08-14 |
mouse |
| Dan-Hong Xu, Jian-Kui Du, Shi-Yu Liu, Hui Zhang, Lu Yang, Xiao-Yan Zhu, Yu-Jian Li. Upregulation of KLK8 contributes to CUMS-induced hippocampal neuronal apoptosis by cleaving NCAM1. Cell death & disease. vol 14. issue 4. 2023-04-19. PMID:37076499. |
the present study aimed to explore the potential function of klk8 in hippocampal neuronal cell apoptosis associated with depressive disorders in rodent models of chronic unpredictable mild stress (cums)-induced depression. |
2023-04-19 |
2023-08-14 |
mouse |
| Dan-Hong Xu, Jian-Kui Du, Shi-Yu Liu, Hui Zhang, Lu Yang, Xiao-Yan Zhu, Yu-Jian Li. Upregulation of KLK8 contributes to CUMS-induced hippocampal neuronal apoptosis by cleaving NCAM1. Cell death & disease. vol 14. issue 4. 2023-04-19. PMID:37076499. |
transgenic overexpression of klk8 exacerbated, whereas klk8 deficiency attenuated cums-induced depression-like behaviors and hippocampal neuronal apoptosis. |
2023-04-19 |
2023-08-14 |
mouse |