| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rita Chaaya, Joel R Steele, Brian G Oliver, Hui Chen, Rita Machaalan. Effects of e-vapour and high-fat diet on the immunohistochemical staining of nicotinic acetylcholine receptors, apoptosis, microglia and astrocytes in the adult male mouse hippocampus. Journal of chemical neuroanatomy. 2023-06-21. PMID:37343645. |
this study, using a mouse model, investigated the effects of exposure to e-vapour (± nicotine) and hfd (43% fat) consumption, on the expression of nicotinic acetylcholine receptor (nachr) subunits α3, α4, α7 and β2, apoptosis markers caspase-3 and tunel, microglial marker iba-1, and astrocyte marker gfap, in hippocampal subregions of dentate gyrus (dg) and cornu ammonis (ca) 1-3. |
2023-06-21 |
2023-08-14 |
mouse |
| Rita Chaaya, Joel R Steele, Brian G Oliver, Hui Chen, Rita Machaalan. Effects of e-vapour and high-fat diet on the immunohistochemical staining of nicotinic acetylcholine receptors, apoptosis, microglia and astrocytes in the adult male mouse hippocampus. Journal of chemical neuroanatomy. 2023-06-21. PMID:37343645. |
these findings highlight that e-vapour itself alters nachrs, particularly in the ca2 subregion, associated with a decrease in neuroinflammatory response (iba-1) across the whole hippocampus, and the addition of nicotine increases cell apoptosis across the whole hippocampus. |
2023-06-21 |
2023-08-14 |
mouse |
| Qun Zhang, Xiwu Wang, Yuan Lin, Zhaoting Lv, Shuangda Miao, Yi Lu, Yiren Fan, Xiuchun Li, Yuanyuan Fang, Xuyi Pan, Zirun Chen, Hui Wang, Jia Li, Ying Wang, Jianliang Su. Virgin coconut oil attenuates lipopolysaccharide-induced depression-like behaviors: Integrating network pharmacology analysis and molecular mechanism evaluation. Neuroscience letters. 2023-06-16. PMID:37327854. |
we assessed the effects of vco on depression and the related mechanisms by performing network pharmacology analysis and evaluating depressive-like behaviors in rat model and found that vco-treatment alleviated the depressive-like behaviors, inhibited microglial and astrocytic activation and reduced neuronal loss in the hippocampus, possibly by decreasing neuronal apoptosis. |
2023-06-16 |
2023-08-14 |
rat |
| Xiao-Bo Bi, Xia Zhang, Ji-Peng Wen, Wei Ding, Jin L. [Effects of repeated sevoflurane exposure on hippocampal cell apoptosis and long-term learning and memory ability in neonatal rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 38. issue 6. 2023-06-12. PMID:37308440. |
[effects of repeated sevoflurane exposure on hippocampal cell apoptosis and long-term learning and memory ability in neonatal rats]. |
2023-06-12 |
2023-08-14 |
rat |
| Naomi Lomeli, Diana C Pearre, Maureen Cruz, Kaijun Di, Daniela A Bot. Cisplatin Induces BDNF Downregulation in Middle-Aged Female Rat Model while BDNF Enhancement Attenuates Cisplatin Neurotoxicity. bioRxiv : the preprint server for biology. 2023-06-09. PMID:37293048. |
our previous crci rodent studies have shown that cisplatin reduces hippocampal neurogenesis and bdnf expression and increases hippocampal apoptosis, which is associated with cognitive impairments. |
2023-06-09 |
2023-08-14 |
rat |
| Junzi Chen, Yu Wang, Cong Chen, Qingyang Zhang, Shuang Wang, Yi Wang, Jiajia Fang, Ying Wan. Activation of medial septum cholinergic neurons restores cognitive function in temporal lobe epilepsy. Neural regeneration research. vol 18. issue 11. 2023-06-07. PMID:37282477. |
furthermore, selective apoptosis of medial septum cholinergic neurons mimicked the cognitive deficits in epileptic mice, and activation of medial septum cholinergic neurons enhanced hippocampal acetylcholine release and restored cognitive function in both kainic acid- and kindling-induced epilepsy models. |
2023-06-07 |
2023-08-14 |
mouse |
| Xiuqin Li, Shaopeng Chen, Guiming Zheng, Yanyan Yang, Nan Yin, Xiaoli Niu, Lixia Yao, Peiyuan L. Atorvastatin calcium ameliorates cognitive deficits through the AMPK/mTOR pathway in rats with vascular dementia. Combinatorial chemistry & high throughput screening. 2023-06-07. PMID:37282650. |
results ac decreased apoptosis, increased autophagy, and alleviated oxidative stress in primary hippocampal neurons. |
2023-06-07 |
2023-08-14 |
mouse |
| Yan Xu, Dong-Guang Liu, Ting-Bo Ning, Jian-Guo Zhu, Ru Yao, Xue Meng, Jing-Chun Yao, Wen-Xue Zha. [Antidepressant mechanism of Shenling Kaixin Granules based on BDNF/TrkB/CREB pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 8. 2023-06-07. PMID:37282906. |
in conclusion, slkx might regulate the nrf2 nucleus translocation by activating bdnf/trkb/creb pathway, lower oxidative stress damage in hippocampus, inhibit caspase-3 activity, and reduce apoptosis of hippocampal nerve cells, thereby playing an antidepressant role. |
2023-06-07 |
2023-08-14 |
rat |
| Guo-Hua Wu, Que-Hui Guo, Xiao-Dong Xu, Jian-Chang Lin, Gui-Ting You, Cai-Hou Lin, Liang-Cheng Zhan. Ketamine exerts dual effects on the apoptosis of primary cultured hippocampal neurons from fetal rats in vitro. Metabolic brain disease. 2023-06-05. PMID:37273081. |
ketamine exerts dual effects on the apoptosis of primary cultured hippocampal neurons from fetal rats in vitro. |
2023-06-05 |
2023-08-14 |
rat |
| Guo-Hua Wu, Que-Hui Guo, Xiao-Dong Xu, Jian-Chang Lin, Gui-Ting You, Cai-Hou Lin, Liang-Cheng Zhan. Ketamine exerts dual effects on the apoptosis of primary cultured hippocampal neurons from fetal rats in vitro. Metabolic brain disease. 2023-06-05. PMID:37273081. |
our findings indicate that ketamine exerts a dual effect on the apoptosis of primary cultured fetal rat hippocampal neurons in vitro and that the neurotoxic effects of ketamine are related to activation of the p38 mapk signaling pathway. |
2023-06-05 |
2023-08-14 |
rat |
| Zi Ye, Xiaomin Guan, Wenyuan Shan, Baojun M. OIP5-AS1 accelerates apoptosis of hippocampal neurons in cell models of epilepsy by modulating MiR-128-3p/BAX axis. Preventive medicine. 2023-06-02. PMID:37268172. |
oip5-as1 accelerates apoptosis of hippocampal neurons in cell models of epilepsy by modulating mir-128-3p/bax axis. |
2023-06-02 |
2023-08-14 |
Not clear |
| Zi Ye, Xiaomin Guan, Wenyuan Shan, Baojun M. OIP5-AS1 accelerates apoptosis of hippocampal neurons in cell models of epilepsy by modulating MiR-128-3p/BAX axis. Preventive medicine. 2023-06-02. PMID:37268172. |
oip5-as1 interacts with mir-128-3p to overexpress bcl2-associated x (bax), thereby modulating cell apoptosis in ep cell models.oip5-as1 accelerates apoptosis of hippocampal neurons in cell models of ep by modulating mir-128-3p/bax axis. |
2023-06-02 |
2023-08-14 |
Not clear |
| Zhaofei Dong, Fuli Min, Sai Zhang, Huili Zhang, Tao Zen. EGR1-Driven METTL3 Activation Curtails VIM-Mediated Neuron Injury in Epilepsy. Neurochemical research. 2023-06-02. PMID:37268752. |
the mice were rendered epileptic using the kainic acid protocol, followed by measurement of seizure severity, high amplitude and frequency, pathological changes of hippocampal tissues and neuron apoptosis. |
2023-06-02 |
2023-08-14 |
mouse |
| Zhaofei Dong, Fuli Min, Sai Zhang, Huili Zhang, Tao Zen. EGR1-Driven METTL3 Activation Curtails VIM-Mediated Neuron Injury in Epilepsy. Neurochemical research. 2023-06-02. PMID:37268752. |
however, its knockdown reduced hippocampal neuron injury and apoptosis. |
2023-06-02 |
2023-08-14 |
mouse |
| Zhaofei Dong, Fuli Min, Sai Zhang, Huili Zhang, Tao Zen. EGR1-Driven METTL3 Activation Curtails VIM-Mediated Neuron Injury in Epilepsy. Neurochemical research. 2023-06-02. PMID:37268752. |
egr1 activated mettl3 and reduced vim expression, thereby impairing hippocampal neuron injury and apoptosis, preventing epilepsy progression. |
2023-06-02 |
2023-08-14 |
mouse |
| Yinli Cao, Yazhou Sun, Qingyang Cui, Xiaojing He, Zhenzhen L. [Artesunate alleviates hypoxic-ischemic brain damage in neonatal rats by inhibiting NLRP3 inflammasome activation and inflammatory cytokine secretion]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 5. 2023-05-30. PMID:37248835. |
results compared with the model group, the neurological deficit score was decreased; the pathological damage of brain tissues was relieved; the brain water content was significantly reduced; the apoptosis number of hippocampal neurons was decreased significantly; the levels of il-1β, il-6 and tnf-α in brain tissues and peripheral blood were significantly reduced; the protein expression levels of nlrp3, asc and caspase-1 were significantly lowered in the middle-dose and high-dose artesunate groups and the dexamethasone group. |
2023-05-30 |
2023-08-14 |
rat |
| Yu Gao, Haoxin Liu, Jiejie Zhou, Min Guo, Jie Sun, Manlin Dua. THE PROTECTIVE EFFECT OF C23 IN A RAT MODEL OF CARDIAC ARREST AND RESUSCITATION. Shock (Augusta, Ga.). vol 59. issue 6. 2023-05-25. PMID:36930651. |
in addition, c23 treatment can reduce the apoptosis of hippocampus neurons ( p < 0.05). |
2023-05-25 |
2023-09-07 |
rat |
| Jiming Xie, Shijun Hong, Xiufeng Zhang, Yuwen Li, Runfang Xi. Inhibition of glycolysis prevents behavioural changes in mice with MK801-induced SCZ model by alleviating lactate accumulation and lactylation. Brain research. 2023-05-19. PMID:37207839. |
apoptosis was evaluated in hmgb1-treated hippocampal neurons by flow cytometry. |
2023-05-19 |
2023-08-14 |
mouse |
| Jiming Xie, Shijun Hong, Xiufeng Zhang, Yuwen Li, Runfang Xi. Inhibition of glycolysis prevents behavioural changes in mice with MK801-induced SCZ model by alleviating lactate accumulation and lactylation. Brain research. 2023-05-19. PMID:37207839. |
in addition, the level of hmgb1 increased in the medium and induced apoptosis in primary hippocampal neurons. |
2023-05-19 |
2023-08-14 |
mouse |
| Jiming Xie, Shijun Hong, Xiufeng Zhang, Yuwen Li, Runfang Xi. Inhibition of glycolysis prevents behavioural changes in mice with MK801-induced SCZ model by alleviating lactate accumulation and lactylation. Brain research. 2023-05-19. PMID:37207839. |
glycolytic related hmgb1 upregulation may induce apoptosis in hippocampal neurons downstream. |
2023-05-19 |
2023-08-14 |
mouse |