| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xueying Zhang, Rui Gao, Changteng Zhang, Yi Teng, Hai Chen, Qi Li, Changliang Liu, Jiahui Wu, Liuxing Wei, Liyun Deng, Lining Wu, Shixin Ye-Lehmann, Xiaobo Mao, Jin Liu, Tao Zhu, Chan Che. Extracellular RNAs-TLR3 signaling contributes to cognitive impairment after chronic neuropathic pain in mice. Signal transduction and targeted therapy. vol 8. issue 1. 2023-08-06. PMID:37544956. |
importantly, compared to the wild-type (wt) mice, tlr3 knockout (ko) mice and tlr3-specific neuronal knockdown mice both displayed improved cognitive function, reduced levels of inflammatory cytokines and neuronal apoptosis and attenuated injury to hippocampal neuroplasticity. |
2023-08-06 |
2023-08-14 |
mouse |
| Pei-Pei Liu, Shi-Ping Lu, Xiao Li, Gang-Bin Tang, Xiao Liu, Shang-Kun Dai, Lin-Fei Jiao, Xi-Wen Lin, Xing-Guo Li, Baoyang Hu, Jianwei Jiao, Zhao-Qian Teng, Chun-Sheng Han, Chang-Mei Li. Abnormal chromatin remodeling caused by ARID1A deletion leads to malformation of the dentate gyrus. Cell death and differentiation. 2023-08-05. PMID:37543710. |
disruption of arid1a in mouse forebrain significantly decreases neural stem/progenitor cells (nspcs) proliferation and differentiation to neurons within the dentate gyrus (dg), increasing perinatal and postnatal apoptosis, leading to reduced hippocampus size. |
2023-08-05 |
2023-08-14 |
mouse |
| Shuang Peng, Xuling Wu, Qian Zheng, Jianwei Xu, Dongjun Xie, Mengyun Zhou, Mingwei Wang, Yongran Cheng, Lan Ye, Xiangang Mo, Zhanhui Fen. Downregulating NHE-1 decreases the apoptosis of hippocampal cells in epileptic model rats based on the NHE-1/calpain1 pathway. Heliyon. vol 9. issue 7. 2023-08-04. PMID:37539113. |
downregulating nhe-1 decreases the apoptosis of hippocampal cells in epileptic model rats based on the nhe-1/calpain1 pathway. |
2023-08-04 |
2023-08-14 |
rat |
| Shuang Peng, Xuling Wu, Qian Zheng, Jianwei Xu, Dongjun Xie, Mengyun Zhou, Mingwei Wang, Yongran Cheng, Lan Ye, Xiangang Mo, Zhanhui Fen. Downregulating NHE-1 decreases the apoptosis of hippocampal cells in epileptic model rats based on the NHE-1/calpain1 pathway. Heliyon. vol 9. issue 7. 2023-08-04. PMID:37539113. |
seizure is associated with pathological changes of hippocampus, but the mechanism by which hippocampal neuronal apoptosis promotes epilepsy is unclear. |
2023-08-04 |
2023-08-14 |
rat |
| Shuang Peng, Xuling Wu, Qian Zheng, Jianwei Xu, Dongjun Xie, Mengyun Zhou, Mingwei Wang, Yongran Cheng, Lan Ye, Xiangang Mo, Zhanhui Fen. Downregulating NHE-1 decreases the apoptosis of hippocampal cells in epileptic model rats based on the NHE-1/calpain1 pathway. Heliyon. vol 9. issue 7. 2023-08-04. PMID:37539113. |
therefore, this study further explores the effect of nhe-1 on hippocampal cells apoptosis and seizure in lithium chloride-pilocarpine epileptic model rats. |
2023-08-04 |
2023-08-14 |
rat |
| Shuang Peng, Xuling Wu, Qian Zheng, Jianwei Xu, Dongjun Xie, Mengyun Zhou, Mingwei Wang, Yongran Cheng, Lan Ye, Xiangang Mo, Zhanhui Fen. Downregulating NHE-1 decreases the apoptosis of hippocampal cells in epileptic model rats based on the NHE-1/calpain1 pathway. Heliyon. vol 9. issue 7. 2023-08-04. PMID:37539113. |
first, we established a lithium chloride-pilocarpine induced epileptic rat model and detected the expression of nhe-1, calpain1 and apoptosis in the hippocampus. |
2023-08-04 |
2023-08-14 |
rat |
| Shuang Peng, Xuling Wu, Qian Zheng, Jianwei Xu, Dongjun Xie, Mengyun Zhou, Mingwei Wang, Yongran Cheng, Lan Ye, Xiangang Mo, Zhanhui Fen. Downregulating NHE-1 decreases the apoptosis of hippocampal cells in epileptic model rats based on the NHE-1/calpain1 pathway. Heliyon. vol 9. issue 7. 2023-08-04. PMID:37539113. |
then, we further down-regulated nhe-1 to observe the expression of calpain1 and apoptosis in the hippocampus, as well as its effect on seizures in rats. |
2023-08-04 |
2023-08-14 |
rat |
| Shuang Peng, Xuling Wu, Qian Zheng, Jianwei Xu, Dongjun Xie, Mengyun Zhou, Mingwei Wang, Yongran Cheng, Lan Ye, Xiangang Mo, Zhanhui Fen. Downregulating NHE-1 decreases the apoptosis of hippocampal cells in epileptic model rats based on the NHE-1/calpain1 pathway. Heliyon. vol 9. issue 7. 2023-08-04. PMID:37539113. |
we found that the expression of nhe-1 and calpain1 and apoptosis in the hippocampus was significant increased in the model group. |
2023-08-04 |
2023-08-14 |
rat |
| Shuang Peng, Xuling Wu, Qian Zheng, Jianwei Xu, Dongjun Xie, Mengyun Zhou, Mingwei Wang, Yongran Cheng, Lan Ye, Xiangang Mo, Zhanhui Fen. Downregulating NHE-1 decreases the apoptosis of hippocampal cells in epileptic model rats based on the NHE-1/calpain1 pathway. Heliyon. vol 9. issue 7. 2023-08-04. PMID:37539113. |
after down-regulating nhe-1, the expression of calpain1 was decreased, and hippocampal cell apoptosis was alleviated. |
2023-08-04 |
2023-08-14 |
rat |
| Shuang Peng, Xuling Wu, Qian Zheng, Jianwei Xu, Dongjun Xie, Mengyun Zhou, Mingwei Wang, Yongran Cheng, Lan Ye, Xiangang Mo, Zhanhui Fen. Downregulating NHE-1 decreases the apoptosis of hippocampal cells in epileptic model rats based on the NHE-1/calpain1 pathway. Heliyon. vol 9. issue 7. 2023-08-04. PMID:37539113. |
therefore, hippocampal nhe-1 overexpression is closely related to the development of neuronal apoptosis in a rat model of epilepsy, and downregulating nhe-1 expression can reduce cell apoptosis. |
2023-08-04 |
2023-08-14 |
rat |
| Shuang Peng, Xuling Wu, Qian Zheng, Jianwei Xu, Dongjun Xie, Mengyun Zhou, Mingwei Wang, Yongran Cheng, Lan Ye, Xiangang Mo, Zhanhui Fen. Downregulating NHE-1 decreases the apoptosis of hippocampal cells in epileptic model rats based on the NHE-1/calpain1 pathway. Heliyon. vol 9. issue 7. 2023-08-04. PMID:37539113. |
moreover, the nhe-1/calpain1 signaling pathway may be an important mechanism leading to hippocampal cell apoptosis. |
2023-08-04 |
2023-08-14 |
rat |
| K G Akbulut, A Keskin-Aktan, S A Abgarmi, H Akbulu. The role of SIRT2 inhibition on the aging process of brain in male rats. Aging brain. vol 4. 2023-07-31. PMID:37519449. |
though the exact mechanisms regarding brain aging and its relation to neurodegenerative disorders are not precise, oxidative stress, the key regulators of apoptosis and autophagy, such as bcl-2 and beclin 1, seem to be the potential players in the aging of the cerebral cortex and hippocampus. |
2023-07-31 |
2023-08-14 |
rat |
| Pu Yang, Haiyan Chen, Tian Wang, Ling Li, Hong Su, Jing Li, Yujun He, Shengyong S. Electroacupuncture Attenuates Chronic Inflammatory Pain And Depression Comorbidity by Inhibiting Hippocampal Neuronal Apoptosis via the PI3K/Akt Signaling Pathway. Neuroscience letters. 2023-07-29. PMID:37516346. |
electroacupuncture attenuates chronic inflammatory pain and depression comorbidity by inhibiting hippocampal neuronal apoptosis via the pi3k/akt signaling pathway. |
2023-07-29 |
2023-08-14 |
rat |
| Pu Yang, Haiyan Chen, Tian Wang, Ling Li, Hong Su, Jing Li, Yujun He, Shengyong S. Electroacupuncture Attenuates Chronic Inflammatory Pain And Depression Comorbidity by Inhibiting Hippocampal Neuronal Apoptosis via the PI3K/Akt Signaling Pathway. Neuroscience letters. 2023-07-29. PMID:37516346. |
this study aimed to investigate the effects of ea on hippocampal neuronal apoptosis in rats with cip and depression. |
2023-07-29 |
2023-08-14 |
rat |
| Pu Yang, Haiyan Chen, Tian Wang, Ling Li, Hong Su, Jing Li, Yujun He, Shengyong S. Electroacupuncture Attenuates Chronic Inflammatory Pain And Depression Comorbidity by Inhibiting Hippocampal Neuronal Apoptosis via the PI3K/Akt Signaling Pathway. Neuroscience letters. 2023-07-29. PMID:37516346. |
overall, our study suggests that ea holds the potential to improve pain and depressive behaviors in rats with cip and depression comorbidity, potentially mediated through the activation of the pi3k/akt pathway, leading to a reduction in hippocampal neuronal apoptosis. |
2023-07-29 |
2023-08-14 |
rat |
| Lulu Xie, Jiaxin Qin, Tingting Wang, Shuai Zhang, Mingcui Luo, Xuelei Cheng, Xinrui Cao, Hui Wang, Baozhen Yao, Dan Xu, Biwen Pen. Impact of Prenatal Acetaminophen Exposure for Hippocampal Development Disorder on Mice. Molecular neurobiology. 2023-07-29. PMID:37516664. |
furthermore, exposure to high doses, multiple-treatment courses, and late pregnancy induced pathological changes, such as wrinkling and vacuolation, inhibited hippocampal proliferation and increased apoptosis. |
2023-07-29 |
2023-08-14 |
mouse |
| Kaiming Guo, Wenting Huang, Kun Chen, Pengkai Huang, Wenshuo Peng, Ruiqing Shi, Tao He, Mulan Zhang, Hao Wang, Jian Hu, Xinshi Wang, Yangping Shentu, Huiqin Xu, Li Li. Fibroblast growth factor 10 ameliorates neurodegeneration in mouse and cellular models of Alzheimer's disease via reducing tau hyperphosphorylation and neuronal apoptosis. Aging cell. 2023-07-28. PMID:37503695. |
additionally, fgf10 treatment reduced tau hyperphosphorylation and neuronal apoptosis, thereby mitigating neuronal cell damage and synaptic deficits in the cortex and hippocampus of 3xtg-ad mice, as well as appswe-transfected ht22 cells. |
2023-07-28 |
2023-08-14 |
mouse |
| Kaiming Guo, Wenting Huang, Kun Chen, Pengkai Huang, Wenshuo Peng, Ruiqing Shi, Tao He, Mulan Zhang, Hao Wang, Jian Hu, Xinshi Wang, Yangping Shentu, Huiqin Xu, Li Li. Fibroblast growth factor 10 ameliorates neurodegeneration in mouse and cellular models of Alzheimer's disease via reducing tau hyperphosphorylation and neuronal apoptosis. Aging cell. 2023-07-28. PMID:37503695. |
similarly, endogenous fgf10 overexpression ameliorated tau hyperphosphorylation and neuronal apoptosis in the cortex and hippocampus of 3xtg-ad mice. |
2023-07-28 |
2023-08-14 |
mouse |
| Chen Jiang, Jun Shen, Chun Wang, Yongjie Huang, Linbo Wang, Yiran Yang, Wen Hu, Ping Li, Haiying W. Mechanism of aconitine mediated neuronal apoptosis induced by mitochondrial calcium overload caused by MCU. Toxicology letters. 2023-07-28. PMID:37506855. |
the results showed that after treatment with 400μmol/l aconitine, mitochondrial energy metabolism was abnormal in rat hippocampal neuron cells, the expression of mcu in mitochondria was up-regulated, calcium overload in mitochondria, atp production decreased, and mitochondrial membrane potential changes, increased expression of the apoptosis gene cleaved-caspase-3. |
2023-07-28 |
2023-08-14 |
rat |
| Yao Chen, Xudan Liu, Qianhui Zhang, Huanhuan Wang, Ruo Zhang, Yanhong Ge, Huning Liang, Wanying Li, Juanjun Fan, Huimin Liu, Zhengyang Lv, Wenting Dou, Yi Wang, Xin L. Arsenic induced autophagy-dependent apoptosis in hippocampal neurons via AMPK/mTOR signaling pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-07-22. PMID:37481228. |
our findings suggested that arsenic-induced pgam5 activation played a role in ampk-mtor dependent autophagy and arsenic induced autophagy-dependent apoptosis in hippocampal neurons via ampk/mtor signaling pathway. |
2023-07-22 |
2023-08-14 |
Not clear |