| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Moechars, K Lorent, B De Strooper, I Dewachter, F Van Leuve. Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice. The EMBO journal. vol 15. issue 6. 1996-07-11. PMID:8635459. |
in the brain, the observed neuropathological changes included necrosis, apoptosis and astrogliosis in the hippocampus, cortex and other areas. |
1996-07-11 |
2023-08-12 |
mouse |
| S a Johnson, C S Young-Chan, N J Laping, C E Finc. Perforant path transection induces complement C9 deposition in hippocampus. Experimental neurology. vol 138. issue 2. 1996-06-18. PMID:8620918. |
apoptosis of ec layer ii neurons was seen and was presumably due to severing of their axonal projections to the hippocampus by the transection lesion. |
1996-06-18 |
2023-08-12 |
rat |
| M van Lookeren Campagne, P J Lucassen, J P Vermeulen, R Baláz. NMDA and kainate induce internucleosomal DNA cleavage associated with both apoptotic and necrotic cell death in the neonatal rat brain. The European journal of neuroscience. vol 7. issue 7. 1995-11-07. PMID:7551189. |
agarose gel electrophoresis of dna extracted from the ipsilateral striatum, cerebral cortex and hippocampus clearly showed breakdown of dna into oligonucleosome-sized fragments, indicative of apoptosis, 12 h post-nmda injection. |
1995-11-07 |
2023-08-12 |
rat |
| P Hamet, L Richard, T V Dam, E Teiger, S N Orlov, L Gaboury, F Gossard, J Trembla. Apoptosis in target organs of hypertension. Hypertension (Dallas, Tex. : 1979). vol 26. issue 4. 1995-11-07. PMID:7558225. |
the present report provides the first evidence of increased apoptosis in whole organs of genetically hypertensive rat and mouse strains: in the heart of spontaneously hypertensive rats (shr) and in the heart (ventricular cardiomyocytes), kidney (inner cortex and medulla), and brain (cortex, striatum, hippocampus, and thalamus) of spontaneously hypertensive mice, with a higher effect of apoptotic inducers in cultured aortic smooth muscle cells derived from shr. |
1995-11-07 |
2023-08-12 |
mouse |
| G Smale, N R Nichols, D R Brady, C E Finch, W E Horto. Evidence for apoptotic cell death in Alzheimer's disease. Experimental neurology. vol 133. issue 2. 1995-09-22. PMID:7544290. |
sections from the hippocampus of alzheimer-diseased (ad) brains and non-ad brains were examined for apoptosis. |
1995-09-22 |
2023-08-12 |
Not clear |
| T Nitatori, N Sato, S Waguri, Y Karasawa, H Araki, K Shibanai, E Kominami, Y Uchiyam. Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 2. 1995-03-29. PMID:7869078. |
delayed neuronal death in the ca1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis. |
1995-03-29 |
2023-08-12 |
Not clear |
| J A Watt, C J Pike, A J Walencewicz-Wasserman, C W Cotma. Ultrastructural analysis of beta-amyloid-induced apoptosis in cultured hippocampal neurons. Brain research. vol 661. issue 1-2. 1995-03-01. PMID:7834365. |
ultrastructural analysis of beta-amyloid-induced apoptosis in cultured hippocampal neurons. |
1995-03-01 |
2023-08-12 |
Not clear |
| C D Hornsby, E R de Kloe. Dexamethasone does not prevent apoptosis in the hippocampus of the rat. Annals of the New York Academy of Sciences. vol 746. 1995-02-16. PMID:7825917. |
dexamethasone does not prevent apoptosis in the hippocampus of the rat. |
1995-02-16 |
2023-08-12 |
rat |
| J P MacManus, A M Buchan, I E Hill, I Rasquinha, E Presto. Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain. Neuroscience letters. vol 164. issue 1-2. 1994-05-09. PMID:8152622. |
laddered dna indicative of apoptosis was observed in the ca1 layer of hippocampus and in dorsolateral striatum following a global cerebral ischemic insult produced by transient two vessel occlusion in rats. |
1994-05-09 |
2023-08-12 |
rat |
| Y Enokido, H Hatanak. Apoptotic cell death occurs in hippocampal neurons cultured in a high oxygen atmosphere. Neuroscience. vol 57. issue 4. 1994-03-17. PMID:8309555. |
these results indicate that increased levels of oxygen activate an apoptotic mechanism in the cultured hippocampal neurons, and suggest that neuronal activity may protect the neurons from oxygen-induced apoptosis. |
1994-03-17 |
2023-08-12 |
rat |
| J M Roberts-Lewis, V R Marcy, Y Zhao, J L Vaught, R Siman, M E Lewi. Aurintricarboxylic acid protects hippocampal neurons from NMDA- and ischemia-induced toxicity in vivo. Journal of neurochemistry. vol 61. issue 1. 1993-07-22. PMID:8515286. |
as a biochemical marker of neuronal death, spectrin proteolysis, which is mediated by activation of calpain i, was measured in hippocampus after 24 h. ata treatment resulted in a profound reduction of both nmda- and ischemia-induced spectrin proteolysis, consistent with the possibility of some common mechanism in apoptosis and other forms of neuronal death in vivo. |
1993-07-22 |
2023-08-12 |
rat |
| R S Sloviter, A L Sollas, E Dean, S Neubor. Adrenalectomy-induced granule cell degeneration in the rat hippocampal dentate gyrus: characterization of an in vivo model of controlled neuronal death. The Journal of comparative neurology. vol 330. issue 3. 1993-05-11. PMID:8468409. |
taken together, these results indicate that adrenalectomy reliably initiates an immediate, highly selective, and long-continuing process of hippocampal granule cell degeneration that exhibits morphological features characteristic of apoptosis, rather than necrosis. |
1993-05-11 |
2023-08-12 |
human |
| R S Sloviter, E Dean, S Neubor. Electron microscopic analysis of adrenalectomy-induced hippocampal granule cell degeneration in the rat: apoptosis in the adult central nervous system. The Journal of comparative neurology. vol 330. issue 3. 1993-05-11. PMID:8468410. |
electron microscopic analysis of adrenalectomy-induced hippocampal granule cell degeneration in the rat: apoptosis in the adult central nervous system. |
1993-05-11 |
2023-08-12 |
rat |
| E Ignatowicz, A M Vezzani, M Rizzi, M D'Incalc. Nerve cell death induced in vivo by kainic acid and quinolinic acid does not involve apoptosis. Neuroreport. vol 2. issue 11. 1992-06-03. PMID:1839770. |
no typical 'ladder' of dna fragments (multimers of approximately 200 kb) which characterizes apoptosis was seen in hippocampal cells after toxic doses of kainic or quinolinic acid, as assessed by agarose gel electrophoresis. |
1992-06-03 |
2023-08-11 |
mouse |
| E Ignatowicz, A M Vezzani, M Rizzi, M D'Incalc. Nerve cell death induced in vivo by kainic acid and quinolinic acid does not involve apoptosis. Neuroreport. vol 2. issue 11. 1992-06-03. PMID:1839770. |
this suggests that hippocampal nerve cell death induced in vivo by the excitotoxins is not mediated by apoptosis. |
1992-06-03 |
2023-08-11 |
mouse |
| J N Masters, C E Finch, R M Sapolsk. Glucocorticoid endangerment of hippocampal neurons does not involve deoxyribonucleic acid cleavage. Endocrinology. vol 124. issue 6. 1989-06-28. PMID:2721459. |
these observations suggest that gcs endanger hippocampal neurons through a different mechanism, one that seems likely to be less sterotyped and simple than this cascade of apoptosis in lymphocytes. |
1989-06-28 |
2023-08-11 |
Not clear |