| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F W Holtsberg, M R Steiner, A J Bruce-Keller, J N Keller, M P Mattson, J C Moyers, S M Steine. Lysophosphatidic acid and apoptosis of nerve growth factor-differentiated PC12 cells. Journal of neuroscience research. vol 53. issue 6. 1998-12-22. PMID:9753197. |
the lipid biomediator lysophosphatidic acid (lpa) elicits a unique response in hippocampal neurons, lpa induces neuronal apoptosis. |
1998-12-22 |
2023-08-12 |
Not clear |
| M P Mattson, J Partin, J G Begle. Amyloid beta-peptide induces apoptosis-related events in synapses and dendrites. Brain research. vol 807. issue 1-2. 1998-12-10. PMID:9757026. |
a caspase inhibitor prevented abeta-induced mitochondrial membrane depolarization in synaptosomes, and mitochondrial membrane depolarization and nuclear apoptosis in cultured hippocampal neurons. |
1998-12-10 |
2023-08-12 |
Not clear |
| W Y Chan, D T Ye. Apoptosis and Bcl-2 oncoprotein expression in the human fetal central nervous system. The Anatomical record. vol 252. issue 2. 1998-12-09. PMID:9776071. |
an inverse correlation between apoptosis and bcl-2 oncoprotein expression was found in visual, sensory, and motor cortices but not in the frontal cortex and hippocampus. |
1998-12-09 |
2023-08-12 |
human |
| X Xie, Y Gu, T Fox, J T Coll, M A Fleming, W Markland, P R Caron, K P Wilson, M S S. Crystal structure of JNK3: a kinase implicated in neuronal apoptosis. Structure (London, England : 1993). vol 6. issue 8. 1998-12-08. PMID:9739089. |
knockout mice lacking jnk3 showed reduced apoptosis of hippocampal neurons and reduced seizure induced by kainic acid, a glutamate-receptor agonist. |
1998-12-08 |
2023-08-12 |
mouse |
| Y F Li. Expression of polyglutamine-expanded Huntingtin activates the SEK1-JNK pathway and induces apoptosis in a hippocampal neuronal cell line. The Journal of biological chemistry. vol 273. issue 44. 1998-12-01. PMID:9786889. |
expression of polyglutamine-expanded huntingtin activates the sek1-jnk pathway and induces apoptosis in a hippocampal neuronal cell line. |
1998-12-01 |
2023-08-12 |
rat |
| T Adayev, R Estephan, S Meserole, B Mazza, E J Yurkow, P Banerje. Externalization of phosphatidylserine may not be an early signal of apoptosis in neuronal cells, but only the phosphatidylserine-displaying apoptotic cells are phagocytosed by microglia. Journal of neurochemistry. vol 71. issue 5. 1998-11-30. PMID:9798909. |
in this study, the applicability of these parameters to cns-derived neuronal cells was tested using hippocampal hn2-5, cells that undergo apoptosis under anoxia. |
1998-11-30 |
2023-08-12 |
mouse |
| A Gerth, C G Hatalski, S Avishai-Eliner, T Z Bara. Corticotropin releasing hormone antagonist does not prevent adrenalectomy-induced apoptosis in the dentate gyrus of the rat hippocampus. Stress (Amsterdam, Netherlands). vol 2. issue 3. 1998-11-20. PMID:9787264. |
corticotropin releasing hormone antagonist does not prevent adrenalectomy-induced apoptosis in the dentate gyrus of the rat hippocampus. |
1998-11-20 |
2023-08-12 |
rat |
| A J Krohn, E Preis, J H Preh. Staurosporine-induced apoptosis of cultured rat hippocampal neurons involves caspase-1-like proteases as upstream initiators and increased production of superoxide as a main downstream effector. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 20. 1998-10-23. PMID:9763465. |
staurosporine-induced apoptosis of cultured rat hippocampal neurons involves caspase-1-like proteases as upstream initiators and increased production of superoxide as a main downstream effector. |
1998-10-23 |
2023-08-12 |
rat |
| A J Krohn, E Preis, J H Preh. Staurosporine-induced apoptosis of cultured rat hippocampal neurons involves caspase-1-like proteases as upstream initiators and increased production of superoxide as a main downstream effector. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 20. 1998-10-23. PMID:9763465. |
we induced apoptosis in cultured rat hippocampal neurons by exposure to the protein kinase inhibitor staurosporine (30 nm, 24 hr). |
1998-10-23 |
2023-08-12 |
rat |
| M Kawata, K Yuri, H Ozawa, M Nishi, T Ito, Z Hu, H Lu, M Yoshid. Steroid hormones and their receptors in the brain. The Journal of steroid biochemistry and molecular biology. vol 65. issue 1-6. 1998-08-27. PMID:9699881. |
second biphasic effects of glucocorticoid on the hippocampus was described and particular emphasis was given on the apoptosis. |
1998-08-27 |
2023-08-12 |
Not clear |
| A Hara, M Niwa, M Nakashima, T Iwai, T Uematsu, N Yoshimi, H Mor. Protective effect of apoptosis-inhibitory agent, N-tosyl-L-phenylalanyl chloromethyl ketone against ischemia-induced hippocampal neuronal damage. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 18. issue 8. 1998-08-21. PMID:9701342. |
we show here that an inhibitor of proteolytic process of apoptosis, n-tosyl-l-phenylalanyl chloromethyl ketone (tpck), protected hippocampal neuronal damage by inhibition of the dna fragmentation in a dose-dependent manner and that tpck induced an apoptosis-regulating molecule, bcl-2 protein, in the surviving neurons. |
1998-08-21 |
2023-08-12 |
Not clear |
| B Viviani, E Corsini, C L Galli, M Marinovic. Glia increase degeneration of hippocampal neurons through release of tumor necrosis factor-alpha. Toxicology and applied pharmacology. vol 150. issue 2. 1998-08-05. PMID:9653057. |
exposure of a 98% pure culture of rat hippocampal neurons to 0.1-1 microm trimethyltin for 24 h caused neural cell death and nuclear changes typical of apoptosis; at these doses glial cells viability was not affected but the cells released significant amounts of tumor necrosis factor-alpha (tnf-alpha). |
1998-08-05 |
2023-08-12 |
rat |
| B Viviani, E Corsini, C L Galli, M Marinovic. Glia increase degeneration of hippocampal neurons through release of tumor necrosis factor-alpha. Toxicology and applied pharmacology. vol 150. issue 2. 1998-08-05. PMID:9653057. |
treatment of a neuron-glia co-culture with tnf-alpha antibody prevented the increase in neuronal apoptosis, and tnf-alpha administration induced apoptosis in hippocampal cells. |
1998-08-05 |
2023-08-12 |
rat |
| G C Chan, T R Hinds, S Impey, D R Stor. Hippocampal neurotoxicity of Delta9-tetrahydrocannabinol. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 14. 1998-07-27. PMID:9651215. |
treatment of cultured neurons or hippocampal slices with thc caused shrinkage of neuronal cell bodies and nuclei as well as genomic dna strand breaks, hallmarks of neuronal apoptosis. |
1998-07-27 |
2023-08-12 |
Not clear |
| S A Bennett, M Tenniswood, J H Chen, C M Davidson, M T Keyes, T Fortin, B A Pappa. Chronic cerebral hypoperfusion elicits neuronal apoptosis and behavioral impairment. Neuroreport. vol 9. issue 1. 1998-07-08. PMID:9592069. |
to assess whether chronic cerebrovascular insufficiency elicits neuronal apoptosis, apoptotic cell death in the hippocampus was quantitated in a rat model of permanent carotid occlusion. |
1998-07-08 |
2023-08-12 |
rat |
| C Stadelmann, W Brück, C Bancher, K Jellinger, H Lassman. Alzheimer disease: DNA fragmentation indicates increased neuronal vulnerability, but not apoptosis. Journal of neuropathology and experimental neurology. vol 57. issue 5. 1998-06-04. PMID:9596416. |
despite the large numbers of cells with dna fragmentation identified in the hippocampus of ad brains, only exceptional cells displayed the morphological characteristics of apoptosis or labeled for the asp. |
1998-06-04 |
2023-08-12 |
human |
| E M Eves, W Xiong, A Bellacosa, S G Kennedy, P N Tsichlis, M R Rosner, N Ha. Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line. Molecular and cellular biology. vol 18. issue 4. 1998-05-21. PMID:9528786. |
consistent with this possibility, apoptosis of conditionally (simian virus 40 tts) immortalized rat hippocampal h19-7 neuronal cells was increased in response to wortmannin, an inhibitor of pi 3-kinase. |
1998-05-21 |
2023-08-12 |
rat |
| K W Yoon, T Fuse, P T Shah, S Nguyen, M L Klei. Indirect glutamate neurotoxicity. Journal of neurotrauma. vol 15. issue 2. 1998-05-08. PMID:9512089. |
this neurotoxin induced both apoptosis and necrosis in cultured rat hippocampal cells. |
1998-05-08 |
2023-08-12 |
rat |
| A C Jackson, H Par. Apoptotic cell death in experimental rabies in suckling mice. Acta neuropathologica. vol 95. issue 2. 1998-04-14. PMID:9498051. |
the brains of cvs-infected mice showed widespread morphologic changes of apoptosis, which were particularly prominent in pyramidal neurons of the hippocampus and in the cerebral cortex. |
1998-04-14 |
2023-08-12 |
mouse |
| S Nonaka, C J Hough, D M Chuan. Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N-methyl-D-aspartate receptor-mediated calcium influx. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 5. 1998-04-09. PMID:9482940. |
we found that long-term exposure to lithium chloride dramatically protects cultured rat cerebellar, cerebral cortical, and hippocampal neurons against glutamate-induced excitotoxicity, which involves apoptosis mediated by n-methyl-d-aspartate (nmda) receptors. |
1998-04-09 |
2023-08-12 |
rat |