| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L J Lin, C H Zhu, B Yan, P X Yu, L Yang, W Huang, J R Che. Gynosaponin ameliorates sevoflurane anesthesia-induced cognitive dysfunction and neuronal apoptosis in rats through modulation of the phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin pathway. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 75. issue 5. 2024-12-09. PMID:39652900. |
the apoptosis of hippocampal neurons was observed using hematoxylin-eosin (he staining and tunel assay. |
2024-12-09 |
2024-12-12 |
rat |
| L J Lin, C H Zhu, B Yan, P X Yu, L Yang, W Huang, J R Che. Gynosaponin ameliorates sevoflurane anesthesia-induced cognitive dysfunction and neuronal apoptosis in rats through modulation of the phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin pathway. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 75. issue 5. 2024-12-09. PMID:39652900. |
viability and apoptosis of hippocampal neurons were detected by cell counting kit-8 and flow cytometry. |
2024-12-09 |
2024-12-12 |
rat |
| Hong Zhang, Jian Guo, Jiayi Chu, Huanhuan Yu, Jialin Zhang, Siman Ma, Ge Jin, Yingshan Jiang, Jiao Xiao, Yutong Hou, Minyan Li, Shiliang Yi. Deferoxamine-induced neurotoxicity: Role of chaperone-mediated autophagy dysfunction in neuronal apoptosis in the hippocampus. Chemico-biological interactions. 2024-12-06. PMID:39643152. |
deferoxamine-induced neurotoxicity: role of chaperone-mediated autophagy dysfunction in neuronal apoptosis in the hippocampus. |
2024-12-06 |
2024-12-10 |
mouse |
| Qin Zhang, Hai-Jin Huang, Jing-Ling Zhang, Ying Tian, Ying H. E3 ubiquitination ligase XIAP lightens diabetes-induced cognitive impairment by inactivating TXNIP-ERS-mediated neuronal injury. The Kaohsiung journal of medical sciences. 2024-12-04. PMID:39629879. |
this study aims to elucidate the role and mechanisms of the x-linked inhibitor of apoptosis protein (xiap)/thioredoxin-interacting protein (txnip) in hippocampal neuron cell death and cognitive function within dcd models. |
2024-12-04 |
2024-12-06 |
rat |
| Lin Yang, Yan Cheng, Yanlong Jia, Zhen Cao, Zerui Zhuang, Xiaolei Zhang, Jitian Guan, Rongzhi Cai, Yan Lin, Renhua W. Visualization of Unconjugated Bilirubin In Vivo with a Novel Approach Using Chemical Exchange Saturation Transfer Magnetic Resonance Imaging in a Rat Model. ACS chemical neuroscience. 2024-11-30. PMID:39614805. |
compared with the vehicle group, the ucb group had more hippocampal neuronal apoptosis and worse cognitive function. |
2024-11-30 |
2024-12-06 |
rat |
| Yuyan Chen, Jie Huang, Zhiying Zhou, Jiaping Zhang, Chaohui Jin, Xiansi Zeng, Jinjing Jia, Li L. Noise exposure-induced the cerebral alterations: From emerging evidence to antioxidant-mediated prevention and treatment. Ecotoxicology and environmental safety. vol 288. 2024-11-26. PMID:39591731. |
in this review, we summarized that noise exposure led to cerebral changes through breaking the redox balance, inducing neuroinflammation and neuronal apoptosis and altering the neurotransmission in numerous brain areas, including cortex, thalamus, hippocampus, amygdala, striatum and cerebellum. |
2024-11-26 |
2024-11-29 |
human |
| Zuo Hao Lee, Wong Siew Tung, Kabileshvaran A/L Jana Santhiran, Huma Shahzad, Nelli Giribabu, Naguib Salle. Estrogen hindrance escalates inflammation and neurodegeneration in the hippocampal regions of collagen-induced arthritis female Sprague-Dawley rats. Pflugers Archiv : European journal of physiology. 2024-11-21. PMID:39570400. |
additionally, oxidative stress, inflammatory, and apoptosis markers' levels in the hippocampus were analyzed by qpcr, elisa, and immunohistochemistry techniques. |
2024-11-21 |
2024-11-23 |
rat |
| Zuo Hao Lee, Wong Siew Tung, Kabileshvaran A/L Jana Santhiran, Huma Shahzad, Nelli Giribabu, Naguib Salle. Estrogen hindrance escalates inflammation and neurodegeneration in the hippocampal regions of collagen-induced arthritis female Sprague-Dawley rats. Pflugers Archiv : European journal of physiology. 2024-11-21. PMID:39570400. |
estrogen hindrance exaggerated oxidative stress, inflammation, and apoptosis which resulted in neuronal degeneration in the hippocampal regions in rheumatoid arthritis. |
2024-11-21 |
2024-11-23 |
rat |
| Soraya Kaewngam, Ram Prajit, Tanaporn Anosri, Kornrawee Suwannakot, Rasa Saenno, Nataya Sritawan, Anusara Aranarochana, Apiwat Sirichoat, Wanassanun Pannangrong, Peter Wigmore, Jariya Umka Welba. The effects of hesperidin on valproic acid-induced reduction in hippocampal neurogenesis through the antioxidant and apoptotic pathways in adult rats. Scientific reports. vol 14. issue 1. 2024-11-21. PMID:39572680. |
because brain function and memory are reliant on hippocampal neurogenesis, this work is planned to elucidate the effects of hsd on the vpa-induced alterations in hippocampal neurogenesis and apoptosis via oxidative damage. |
2024-11-21 |
2024-11-24 |
rat |
| Zhaoyan Chen, Fei Ruan, Di Wu, Xiaoping Yu, Yaqing Jiang, Wei Bao, Haicheng Wen, Jing Hu, Haidi Bi, Liping Chen, Kai L. Quercetin alleviates neonatal hypoxic-ischaemic brain injury by rebalancing microglial M1/M2 polarization through silent information regulator 1/ high mobility group box-1 signalling. Inflammopharmacology. 2024-11-20. PMID:39565473. |
in vivo experiments have shown that quercetin can significantly improve the performance of hi mice in behavioural tests, such as the morris water maze, rotarod test and pole climbing test, and reduce hi insult-induced structural brain damage, cell apoptosis and hippocampal neuron loss. |
2024-11-20 |
2024-11-23 |
mouse |
| Hong Zhu, Ting Zhang, Ruomeng Li, Dan Ren, Jiangxi Xu, Lan Xia. Bushen Huoxue acupuncture ameliorates Alzheimer's disease by upregulating MARCHF3 to induce NLRP3 ubiquitination and inhibit caspase-1-dependent pyroptosis. Metabolic brain disease. vol 40. issue 1. 2024-11-18. PMID:39556273. |
terminal deoxynucleotidyl transferase mediated dutp nick end labeling (tunel) staining was used for observing hippocampal neuronal apoptosis. |
2024-11-18 |
2024-11-22 |
mouse |
| Haiying Shen, Junjie Nie, Guangqing Li, Hongyan Tian, Jun Zhang, Xiaofeng Luo, Da Xu, Jie Sun, Dongfang Zhang, Hong Zhang, Guifang Zhao, Weiyao Wang, Zhonghua Zheng, Shuyan Yang, Yuji Ji. Stem cell factor restrains endoplasmic reticulum stress-associated apoptosis through c-Kit receptor activation of JAK2/STAT3 axis in hippocampal neuronal cells. PloS one. vol 19. issue 11. 2024-11-16. PMID:39546459. |
stem cell factor restrains endoplasmic reticulum stress-associated apoptosis through c-kit receptor activation of jak2/stat3 axis in hippocampal neuronal cells. |
2024-11-16 |
2024-11-18 |
Not clear |
| Mina Gholami, Daniel J Klionsky, Majid Motaghineja. Preventive Effects of Crocin, a Key Carotenoid Component in Saffron, Against Nicotine-Triggered Neurodegeneration in Rat Hippocampus: Possible Role of Autophagy and Apoptosis. International journal of preventive medicine. vol 15. 2024-11-14. PMID:39539579. |
preventive effects of crocin, a key carotenoid component in saffron, against nicotine-triggered neurodegeneration in rat hippocampus: possible role of autophagy and apoptosis. |
2024-11-14 |
2024-11-17 |
rat |
| Mina Gholami, Daniel J Klionsky, Majid Motaghineja. Preventive Effects of Crocin, a Key Carotenoid Component in Saffron, Against Nicotine-Triggered Neurodegeneration in Rat Hippocampus: Possible Role of Autophagy and Apoptosis. International journal of preventive medicine. vol 15. 2024-11-14. PMID:39539579. |
the aim of the current study is to investigate crocin's neuroprotective effects against nicotine-triggered neuro-inflammation, apoptosis, and autophagy in rat hippocampus. |
2024-11-14 |
2024-11-17 |
rat |
| Wenyan Shi, Xingyan Wu, Chengdong Yuan, Tao Kuang, Xiangfan Xie, Wenlu Gong, Fujia Li, Lechen Shen, Yi Zhang, Xiaoli Lian. Effect of remimazolam toluene sulfonate on the cognitive function of juveniles and its mechanism of action. European journal of medical research. vol 29. issue 1. 2024-11-13. PMID:39533344. |
tunel staining was used to observe the apoptosis of neurons in hippocampus, western blotting was used to detect the expression changes of related proteins, and the changes of ltp were observed by recording the activity of neurons through electrical stimulation. |
2024-11-13 |
2024-11-17 |
mouse |
| Wenyan Shi, Xingyan Wu, Chengdong Yuan, Tao Kuang, Xiangfan Xie, Wenlu Gong, Fujia Li, Lechen Shen, Yi Zhang, Xiaoli Lian. Effect of remimazolam toluene sulfonate on the cognitive function of juveniles and its mechanism of action. European journal of medical research. vol 29. issue 1. 2024-11-13. PMID:39533344. |
concurrently, the extent of caspase-3 upregulation, the number of neuronal apoptosis in ca1 and ca3 regions, a downward trend of psd95 and bdnf in the hippocampus, and the inhibition of ltp were highly consistent with the behavior of short-term memory impairment. |
2024-11-13 |
2024-11-17 |
mouse |
| In Gyoung Ju, Joo Hee Lee, Jae-Min Lee, Hyeri Im, Hyeyoon Eo, Minho Moon, Min Kyung Song, Yoon-Seong Kim, Myung Sook Oh, Youn-Jung Ki. NXP031 restores memory function by dual effects degrading Aβ accumulation and facilitating antioxidant pathway in Alzheimer's disease models. Free radical biology & medicine. 2024-11-09. PMID:39521153. |
additionally, the neuroprotective effects of nxp031 were confirmed in a dose-dependent manner when administered to intrahippocampal aβ-injected mice, as nxp031 attenuated memory decline, neuronal apoptosis, synaptic degeneration, and excessive glial activation, and reduced nox-2 expression in the hippocampus. |
2024-11-09 |
2024-11-17 |
mouse |
| Rongchen Zhu, Xuewen Tong, Yuhan Du, Jiahua Liu, Xuefei Xu, Yang He, Liankui Wen, Zhitong Wan. Improvement of chlorpyrifos-induced cognitive impairment by mountain grape anthocyanins based on PI3K/Akt signaling pathway. Pesticide biochemistry and physiology. vol 205. 2024-10-30. PMID:39477625. |
morris water maze, histopathological, elisa and western blot analyses showed that anthocyanins effectively ameliorated cpf-induced spatial learning memory impairment in mice by ameliorating cpf-induced ache inhibition, oxidative stress, and neuroinflammation and by modulating the levels of apoptosis (caspase-3, caspase-9) and autophagy (lc3ii/ lc3i, beclin1, p62, mtor) biomarkers, in order to restore damaged hippocampal tissue morphology, neuron and synapse structures. |
2024-10-30 |
2024-11-02 |
mouse |
| Abdulfatah M Alayoubi, Fatima Alfadhli, Mehnaz, Alia M Albalawi, Khushnooda Ramzan, Musharraf Jelani, Sulman Basi. A homozygous variant in ARHGAP39 is associated with lethal cerebellar vermis hypoplasia in a consanguineous Saudi family. Scientific reports. vol 14. issue 1. 2024-10-26. PMID:39455833. |
arhgap39 is a rho gtpase-activating protein 39 and has been known to regulate apoptosis, cell migration, neurogenesis, and cerebral and hippocampal dendritic spine morphology. |
2024-10-26 |
2024-10-29 |
mouse |
| Jianlian Guo, Yong Xu, Jie Liu, Xueqi Ho. The involvement of lidocaine in amyloid-β1-42-dependent mitochondrial dysfunction and apoptosis in hippocampal neurons via nerve growth factor-protein kinase B pathway. Neuroreport. 2024-10-24. PMID:39445521. |
the involvement of lidocaine in amyloid-β1-42-dependent mitochondrial dysfunction and apoptosis in hippocampal neurons via nerve growth factor-protein kinase b pathway. |
2024-10-24 |
2024-10-26 |
mouse |