| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Changjian Wan, Lulu Shi, Yuying Lai, Zhuhong Wu, Mingzhe Zou, Zhibin Liu, Wei Meng, Songhua Wan. Long-term voluntary running improves cognitive ability in developing mice by modulating the cholinergic system, antioxidant ability, and BDNF/PI3K/Akt/CREB pathway. Neuroscience letters. 2024-06-18. PMID:38889879. |
moreover, it could also increase the hippocampal acetylcholine (ach) content and suppress the expression of neuronal apoptosis protein. |
2024-06-18 |
2024-06-21 |
mouse |
| Kwan Joong Kim, Zukhra Akhmedova, Ho Jin Heo, Dae-Ok Ki. Red Pine Bark Extract Alleviates Akt/GSK-3β Signaling Disruption in the Hippocampus of Streptozotocin-Induced Diabetic Sprague-Dawley Rats. Journal of microbiology and biotechnology. vol 34. issue 6. 2024-06-17. PMID:38881175. |
bark extract (pbe) can alleviate diabetes and abnormal apoptosis signaling pathways in the hippocampus of streptozotocin (stz)-induced diabetic sprague-dawley (sd) rats. |
2024-06-17 |
2024-06-19 |
rat |
| Ashrakt H Abdelhamid, Eman M Mantawy, Riham S Said, Ebtehal El-Demerdas. Neuroprotective effects of saxagliptin against radiation-induced cognitive impairment: Insights on Akt/CREB/SIRT1/BDNF signaling pathway. Toxicology and applied pharmacology. 2024-06-10. PMID:38857790. |
moreover, saxa abrogated radiation-induced hippocampal neuronal apoptosis through downregulating proapoptotic bcl-2 associated x-protein (bax) and upregulating antiapoptotic b-cell lymphoma 2 (bcl-2) expressions and eventually diminishing expression of cleaved caspase 3. |
2024-06-10 |
2024-06-14 |
rat |
| Ye Sun, Danmei Zhao, Qiuyan Song, Ting Cong, Liya Li, Haibo Wu, Zhaoyang Xia. NMT2 alleviates depression-like behavior in a rat model of chronic unpredictable stress: An integrated proteomic and phosphoproteomic analysis. Journal of psychiatric research. vol 176. 2024-06-09. PMID:38852542. |
importantly, inhibiting nmt2 was found to alleviate depression-like behavior and alleviate neuronal apoptosis in the hippocampus of cums rats. |
2024-06-09 |
2024-06-14 |
rat |
| Guangxi Lu, Zhibin Wen, Lu Yu, Chao Wang, Yang Ga. HIF1A overexpression caused by etomidate activates PGK1-induced oxidative stress in postoperative cognitive dysfunction. Brain research. 2024-06-09. PMID:38852658. |
a mouse model of eto-mediated pocd was established, and pathological changes, apoptosis, and inflammatory factors in mouse hippocampal tissues were analyzed by he staining, tunel assay, and elisa. |
2024-06-09 |
2024-06-14 |
mouse |
| Ayman Alzu'bi, Ejlal Abu-El-Rub, Fatimah Almahasneh, Lena Tahat, Rabaa Y Athamneh, Ramada Khasawneh, Hiba Alzoubi, Doaa S Ghorab, Rawan Almazari, Mazhar Salim Al Zoubi, Raed M Al-Zoub. Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice. Neurotoxicology. vol 103. 2024-06-08. PMID:38823587. |
these findings were found to be correlated with increased level of oxidative stress, neuroinflammation, and apoptosis markers, and reduced expression of brain-derived neurotrophic factor (bdnf), which plays an essential role in modulating synaptic plasticity integral for promoting learning and memory in the hippocampus. |
2024-06-08 |
2024-06-11 |
mouse |
| Qin Wang, Baijun Qin, Haichun Yu, Yueqiang Hu, Han Yu, Jie Zhong, Jinwen Liu, Chunyuan Yao, Jiawei Zeng, Jingjing Fan, Limei Dia. Advances in circular RNA in the pathogenesis of epilepsy. Neuroscience. 2024-06-06. PMID:38843987. |
this review provides an overview of circrnas considered to be playing regulatory roles in the process of epilepsy and to be involved in multiple biological epilepsy-related processes, such as hippocampal sclerosis, inflammatory response, cell apoptosis, synaptic remodeling, and cell proliferation and differentiation. |
2024-06-06 |
2024-06-10 |
Not clear |
| Tiantian Lu, Xiuling Chen, Qin Zhang, Kun Shang, Xiaogui Yang, Wei Xian. Vitamin D Relieves Epilepsy Symptoms and Neuroinflammation in Juvenile Mice by Activating the mTOR Signaling Pathway via RAF1: Insights from Network Pharmacology and Molecular Docking Studies. Neurochemical research. 2024-06-05. PMID:38837094. |
the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end-labeling (tunel) staining was used to analyze the apoptosis of hippocampal neurons. |
2024-06-05 |
2024-06-07 |
mouse |
| Xiaodong Zhang, Yanzhang Yang, Xinyi Ma, Huijuan Cao, Yingjie Su. Probiotics relieve perioperative postoperative cognitive dysfunction induced by cardiopulmonary bypass through the kynurenine metabolic pathway. Scientific reports. vol 14. issue 1. 2024-06-04. PMID:38834581. |
moreover, probiotics regulated inflammatory factors, meanwhile attenuated hippocampal neuronal apoptosis. |
2024-06-04 |
2024-06-07 |
rat |
| Di Yang, Minmin Wu, Nian Zou, Yiru Tang, Qing Tao, Lei Liu, Mengmeng Jin, Li Yu, Jian Du, Qingli Luo, Jilong Shen, Deyong Chu, Kunpeng Qi. Knockdown of DJ-1 Exacerbates Neuron Apoptosis Induced by TgCtwh3 through the NF-κB Pathway. Molecular neurobiology. 2024-06-03. PMID:38831169. |
therefore, this study aimed to investigate the expression of dj-1 in the hippocampus tissue of mice or in ht22 infected with t. gondii chinese 1 genotype wh3 strain (tgctwh3) and the effect of dj-1 knockdown on neuronal apoptosis induced by tgctwh3 tachyzoite, as well as the underlying mechanism at the cellular and molecular level. |
2024-06-03 |
2024-06-06 |
mouse |
| Di Yang, Minmin Wu, Nian Zou, Yiru Tang, Qing Tao, Lei Liu, Mengmeng Jin, Li Yu, Jian Du, Qingli Luo, Jilong Shen, Deyong Chu, Kunpeng Qi. Knockdown of DJ-1 Exacerbates Neuron Apoptosis Induced by TgCtwh3 through the NF-κB Pathway. Molecular neurobiology. 2024-06-03. PMID:38831169. |
firstly, we detected dj-1 protein expression and cell apoptosis in the hippocampal tissue of mice infected by tgctwh3. |
2024-06-03 |
2024-06-06 |
mouse |
| Di Yang, Minmin Wu, Nian Zou, Yiru Tang, Qing Tao, Lei Liu, Mengmeng Jin, Li Yu, Jian Du, Qingli Luo, Jilong Shen, Deyong Chu, Kunpeng Qi. Knockdown of DJ-1 Exacerbates Neuron Apoptosis Induced by TgCtwh3 through the NF-κB Pathway. Molecular neurobiology. 2024-06-03. PMID:38831169. |
our results showed that dj-1 expression was reduced and neurons underwent apoptosis in the hippocampus of mice infected with tgctwh3 tachyzoites. |
2024-06-03 |
2024-06-06 |
mouse |
| Yu-Hao Zhao, Tie-Feng Ji, Qi Luo, Jin-Lu Y. Retraction: Long non-coding RNA H19 induces hippocampal neuronal apoptosis Oncotarget. vol 15. 2024-06-03. PMID:38829612. |
retraction: long non-coding rna h19 induces hippocampal neuronal apoptosis |
2024-06-03 |
2024-06-05 |
Not clear |
| Jiangxia Cheng, Zhuo Wang, Hui Yu, Ye Chen, Zhengchao Wang, Liangcheng Zhang, Xiaohong Pen. The duration-dependent and sex-specific effects of neonatal sevoflurane exposure on cognitive function in rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 57. 2024-05-29. PMID:38808889. |
we found that neonatal exposure to sevoflurane promoted apoptosis in the hippocampus, and bax and caspase-3 were increased in a dose-dependent manner. |
2024-05-29 |
2024-06-02 |
rat |
| Jiaojiao Xie, Jiapin Yan, Keru Ji, Yuejun Guo, Sibei Xu, Danjie Shen, Chen Li, Hongchang Gao, Liangcai Zha. Fibroblast growth factor 21 enhances learning and memory performance in mice by regulating hippocampal L-lactate homeostasis. International journal of biological macromolecules. vol 271. issue Pt 2. 2024-05-29. PMID:38801850. |
the results showed that, compared to the vehicle group, the l-lactate-treated mice displayed learning and memory performance impairments, as well as reduced hippocampal atp and nadh levels, but increased oxidative stress, mitochondrial dysfunction, and apoptosis, which suggesting inhibited l-lactate-pyruvate conversion in the brain. |
2024-05-29 |
2024-05-31 |
mouse |
| Xi Liu, Jia Gu, Cheng Wang, Min Peng, Jilin Zhou, Xiyun Fei, Zhijun Zhong, Bo L. Ginsenoside Rg3 attenuates neuroinflammation and hippocampal neuronal damage after traumatic brain injury in mice by inactivating the NF-kB pathway via SIRT1 activation. Cell cycle (Georgetown, Tex.). 2024-05-26. PMID:38796716. |
cck-8 and tunel assays were employed to evaluate the viability and apoptosis of hippocampal neurons. |
2024-05-26 |
2024-05-31 |
mouse |
| Xi Liu, Jia Gu, Cheng Wang, Min Peng, Jilin Zhou, Xiyun Fei, Zhijun Zhong, Bo L. Ginsenoside Rg3 attenuates neuroinflammation and hippocampal neuronal damage after traumatic brain injury in mice by inactivating the NF-kB pathway via SIRT1 activation. Cell cycle (Georgetown, Tex.). 2024-05-26. PMID:38796716. |
hippocampal neurons cultured in a medium containing lps, ginsenoside rg3, and nam-treated microglia showed improved viability and reduced apoptosis compared to those cultured in a medium with lps and ginsenoside rg3-treated microglia alone. |
2024-05-26 |
2024-05-31 |
mouse |
| Huize Chen, Chujun Deng, Zeyu Meng, Mengting Zhu, Ruoyu Yang, Jing Yuan, Shengxi Men. Combined Catalpol and Tetramethylpyrazine Promote Axonal Plasticity in Alzheimer's Disease by Inducing Astrocytes to Secrete Exosomes Carrying CDK5 mRNA and Regulating STAT3 Phosphorylation. Molecular neurobiology. 2024-05-24. PMID:38789892. |
the viability, apoptosis, and expression levels of nf200 and gap-43 proteins in the hippocampal neurons of each group were compared. |
2024-05-24 |
2024-05-27 |
mouse |
| Xuejing Hou, Shanshan Xiao, Xiaohong Xu, Mingze Qin, Xuebing Cheng, Xiangping X. Glycoprotein non-metastatic melanoma protein B (GPNMB) protects against neuroinflammation and neuronal loss in pilocarpine-induced epilepsy via the regulation of microglial polarization. Neuroscience. 2024-05-23. PMID:38782114. |
gpnmb knockdown accelerated neuronal damage in the hippocampus, evidenced by increased neuron loss and neuronal cell apoptosis. |
2024-05-23 |
2024-05-27 |
rat |
| Xiang Li, Ning Liu, Di Wu, Shu Chang Li, Qing Wang, Dian-Wen Zhang, Lian-Lian Song, Min Huang, Xia Chen, Wei L. Hippocampal transcriptomic analyses reveal the potential antiapoptotic mechanism of a novel anticonvulsant agent Q808 on pentylenetetrazol-induced epilepsy in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 175. 2024-05-13. PMID:38739991. |
the morphological change and neuronal apoptosis in the hippocampus were detected by hematoxylin and eosin (he) and terminal deoxynucleotidyl transferase-mediated dutp nick end-labeling (tunel) staining, respectively. |
2024-05-13 |
2024-05-27 |
rat |