| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiangxia Cheng, Zhuo Wang, Hui Yu, Ye Chen, Zhengchao Wang, Liangcheng Zhang, Xiaohong Pen. The duration-dependent and sex-specific effects of neonatal sevoflurane exposure on cognitive function in rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 57. 2024-05-29. PMID:38808889. |
we found that neonatal exposure to sevoflurane promoted apoptosis in the hippocampus, and bax and caspase-3 were increased in a dose-dependent manner. |
2024-05-29 |
2024-06-02 |
rat |
| Jiaojiao Xie, Jiapin Yan, Keru Ji, Yuejun Guo, Sibei Xu, Danjie Shen, Chen Li, Hongchang Gao, Liangcai Zha. Fibroblast growth factor 21 enhances learning and memory performance in mice by regulating hippocampal L-lactate homeostasis. International journal of biological macromolecules. vol 271. issue Pt 2. 2024-05-29. PMID:38801850. |
the results showed that, compared to the vehicle group, the l-lactate-treated mice displayed learning and memory performance impairments, as well as reduced hippocampal atp and nadh levels, but increased oxidative stress, mitochondrial dysfunction, and apoptosis, which suggesting inhibited l-lactate-pyruvate conversion in the brain. |
2024-05-29 |
2024-05-31 |
mouse |
| Xi Liu, Jia Gu, Cheng Wang, Min Peng, Jilin Zhou, Xiyun Fei, Zhijun Zhong, Bo L. Ginsenoside Rg3 attenuates neuroinflammation and hippocampal neuronal damage after traumatic brain injury in mice by inactivating the NF-kB pathway via SIRT1 activation. Cell cycle (Georgetown, Tex.). 2024-05-26. PMID:38796716. |
cck-8 and tunel assays were employed to evaluate the viability and apoptosis of hippocampal neurons. |
2024-05-26 |
2024-05-31 |
mouse |
| Xi Liu, Jia Gu, Cheng Wang, Min Peng, Jilin Zhou, Xiyun Fei, Zhijun Zhong, Bo L. Ginsenoside Rg3 attenuates neuroinflammation and hippocampal neuronal damage after traumatic brain injury in mice by inactivating the NF-kB pathway via SIRT1 activation. Cell cycle (Georgetown, Tex.). 2024-05-26. PMID:38796716. |
hippocampal neurons cultured in a medium containing lps, ginsenoside rg3, and nam-treated microglia showed improved viability and reduced apoptosis compared to those cultured in a medium with lps and ginsenoside rg3-treated microglia alone. |
2024-05-26 |
2024-05-31 |
mouse |
| Huize Chen, Chujun Deng, Zeyu Meng, Mengting Zhu, Ruoyu Yang, Jing Yuan, Shengxi Men. Combined Catalpol and Tetramethylpyrazine Promote Axonal Plasticity in Alzheimer's Disease by Inducing Astrocytes to Secrete Exosomes Carrying CDK5 mRNA and Regulating STAT3 Phosphorylation. Molecular neurobiology. 2024-05-24. PMID:38789892. |
the viability, apoptosis, and expression levels of nf200 and gap-43 proteins in the hippocampal neurons of each group were compared. |
2024-05-24 |
2024-05-27 |
mouse |
| Xuejing Hou, Shanshan Xiao, Xiaohong Xu, Mingze Qin, Xuebing Cheng, Xiangping X. Glycoprotein non-metastatic melanoma protein B (GPNMB) protects against neuroinflammation and neuronal loss in pilocarpine-induced epilepsy via the regulation of microglial polarization. Neuroscience. 2024-05-23. PMID:38782114. |
gpnmb knockdown accelerated neuronal damage in the hippocampus, evidenced by increased neuron loss and neuronal cell apoptosis. |
2024-05-23 |
2024-05-27 |
rat |
| Xiang Li, Ning Liu, Di Wu, Shu Chang Li, Qing Wang, Dian-Wen Zhang, Lian-Lian Song, Min Huang, Xia Chen, Wei L. Hippocampal transcriptomic analyses reveal the potential antiapoptotic mechanism of a novel anticonvulsant agent Q808 on pentylenetetrazol-induced epilepsy in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 175. 2024-05-13. PMID:38739991. |
the morphological change and neuronal apoptosis in the hippocampus were detected by hematoxylin and eosin (he) and terminal deoxynucleotidyl transferase-mediated dutp nick end-labeling (tunel) staining, respectively. |
2024-05-13 |
2024-05-27 |
rat |
| Xu Zhao, Jiancong Lu, Jingyi Zhang, Ce Liu, Huijun Wang, Yan Wang, Qingfeng D. Sleep restriction promotes brain oxidative stress and inflammation, and aggravates cognitive impairment in insulin-resistant mice. Psychoneuroendocrinology. vol 166. 2024-05-08. PMID:38718616. |
compared with control group, ir mice showed impaired cognitive capacity, meanwhile, sr not only promoted bax/bcl2-induced hippocampal neuronal cell apoptosis and nrf2/ho1- induced oxidative stress, but also increased microglia activation and inflammatory factor levels and bbb permeability, thus aggravating the cognitive impairment in ir mice. |
2024-05-08 |
2024-05-27 |
mouse |
| Mengjiao Gao, Yu Song, Yaqi Liu, Yuqing Miao, Yanwu Guo, Huihui Cha. TNF-α/TNFR1 activated astrocytes exacerbate depression-like behavior in CUMS mice. Cell death discovery. vol 10. issue 1. 2024-05-08. PMID:38710713. |
tnfr1 expression was significantly increased in the hippocampus of depression-like mice, with increased astrocytes activation and neuronal apoptosis. |
2024-05-08 |
2024-05-27 |
mouse |
| Jingshu Hong, Yue Li, Lei Chen, Dengyang Han, Yitong Li, Xinning Mi, Kaixi Liu, Qian Wang, Yanan Song, Taotao Liu, Ning Yang, Yajie Liu, Zhengqian Li, Xiangyang Gu. A53T α-synuclein mutation increases susceptibility to postoperative delayed neurocognitive recovery via hippocampal Ang-(1-7)/MasR axis. Biochemical pharmacology. 2024-05-05. PMID:38705534. |
we respectively examined molecular changes at 6 h, 1 day, and 2 days after partial hepatectomy and observed that cognitive changes were accompanied by weakened angiotensin-(1-7)/mas receptor [ang-(1-7)/masr] axis, increased alpha-synuclein (α-syn) expression and phosphorylation, decreased methylated protein phosphatase-2a (me-pp2a), and prompted microglia m1 polarization and neuronal apoptosis in the hippocampus at 1 day after surgery. |
2024-05-05 |
2024-05-08 |
mouse |
| Majid Motaghinejad, Manijeh Motevalian, Fatemeh Babalouei, Mohammad Abdollahi, Mansour Heidari, Zahra Madj. Retraction Notice to "Possible involvement of CREB/BDNF signaling pathway in neuroprotective effects of topiramate against methylphenidate induced apoptosis, oxidative stress and inflammation in hippocampus of rats: Molecular, biochemical and histological evidences" [Brain. Res. Bull. 132 (2017) 82-98]. Brain research bulletin. 2024-04-28. PMID:38679545. |
retraction notice to "possible involvement of creb/bdnf signaling pathway in neuroprotective effects of topiramate against methylphenidate induced apoptosis, oxidative stress and inflammation in hippocampus of rats: molecular, biochemical and histological evidences" [brain. |
2024-04-28 |
2024-05-01 |
rat |
| Xuerui Kong, Gaohe Dai, Zhong Zeng, Yi Zhang, Jiarong Gu, Teng Ma, Nina Wang, Jinhai Gu, Yin Wan. Integrating Proteomics and Transcriptomics Reveals the Potential Pathways of Hippocampal Neuron Apoptosis in Dravet Syndrome Model Mice. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38674042. |
integrating proteomics and transcriptomics reveals the potential pathways of hippocampal neuron apoptosis in dravet syndrome model mice. |
2024-04-27 |
2024-04-29 |
mouse |
| Hamed Ghazvini, Fatemeh Tirgar, Mehdi Khodamoradi, Seyedeh Masoumeh Seyedhosseini Tamijani, Saba Niknamfar, Esmaeil Akbari, Mohammad Nekahi, Nabiollah Tarjani, Hossein Ghalehnoei, Motahareh Rouhi Ardeshir. Investigating Facilitatory Effects of Lithium on Methamphetamine-induced Spatial Memory Impairments in Rat. Basic and clinical neuroscience. vol 14. issue 5. 2024-04-17. PMID:38628835. |
in current study the effects of lithium on spatial memory, hippocampal apoptosis and brain edema in meth-exposed rats are investigated. |
2024-04-17 |
2024-04-19 |
rat |
| Yuhai Xu, Xin Xin, Tianzhu Ta. Decoding the Neurotoxic Effects of Propofol: Insights into the RARα-Snhg1-Bdnf Regulatory Cascade. American journal of physiology. Cell physiology. 2024-04-15. PMID:38618701. |
the findings draw a clear link between propofol-induced neurotoxicity and the amplification of rar signaling pathways, impacting hippocampal development and apoptosis and leading to increased rarα and snhg1 and decreased bdnf. |
2024-04-15 |
2024-04-17 |
Not clear |
| Xinbo Ma, Yang Liu, Bo Ding, Siqi Lu, Bangyao Ni, Yuting Chen, Liu Yang, Yanan Liu, Yuchen Zhang, Yuxi Wang, Yanmei Yang, Xiaona Li. Anthocyanins from blueberry ameliorated arsenic-induced memory impairment, oxidative stress, and mitochondrial-biosynthesis imbalance in rat hippocampal neurons. Cellular signalling. 2024-04-15. PMID:38621470. |
arsenic exposure resulted in elevated levels of oxidative stress, decreased antioxidant capacity and increased apoptosis in rat hippocampal brain tissue and mitochondria. |
2024-04-15 |
2024-04-18 |
rat |
| Xiyong Xiang, Siyu Xia, Shan Li, Yirong Zeng, Lixuan Wang, Yan Zho. Study on the role and mechanism of Tan IIA in Alzheimer's disease based on CREB-BDNF-TrkB pathway. Neuroscience letters. 2024-04-14. PMID:38616003. |
the results of the water maze experiment showed that after tan iia treatment, the escape latency of ad rats was shortened and the number of platform crossings increased; in the new object recognition experiment, the discrimination index of ad rats significantly increased after treatment; nissl staining and tunel staining results showed that tan iia increased the number of surviving neurons in the hippocampus of cognitively impaired rats and reduced neuronal apoptosis; bielschowsky silver staining results showed that tan iia reduced neurofibrillary tangles (nfts) in the ad rats; tan iia can reduce the inflammatory response and oxidative stress reaction in the hippocampus of ad rats, and at the same time reduce the activity of acetylcholinesterase. |
2024-04-14 |
2024-04-17 |
rat |
| Xiyong Xiang, Siyu Xia, Shan Li, Yirong Zeng, Lixuan Wang, Yan Zho. Study on the role and mechanism of Tan IIA in Alzheimer's disease based on CREB-BDNF-TrkB pathway. Neuroscience letters. 2024-04-14. PMID:38616003. |
these data suggest that tan iia may upregulate the expression of the creb-bdnf-trkb signaling pathway in the hippocampus of brain tissue, produce anti-neuroinflammatory, antioxidant stress, inhibit neuronal apoptosis effects, and improve cholinergic neurotransmitter disorder induced by stz, reduce the neuronal damage and learning and memory impairment caused by stz in rats, and improve the cognitive function of rats. |
2024-04-14 |
2024-04-17 |
rat |
| Daniela Giovannini, Francesca Antonelli, Arianna Casciati, Cinzia De Angelis, Maria Denise Astorino, Giulia Bazzano, Emiliano Fratini, Alessandro Ampollini, Monia Vadrucci, Evaristo Cisbani, Paolo Nenzi, Luigi Picardi, Anna Saran, Carmela Marino, Mariateresa Mancuso, Concetta Ronsivalle, Simonetta Pazzagli. Comparing the effects of irradiation with protons or photons on neonatal mouse brain: Apoptosis, oncogenesis and hippocampal alterations. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 2024-04-13. PMID:38614282. |
comparing the effects of irradiation with protons or photons on neonatal mouse brain: apoptosis, oncogenesis and hippocampal alterations. |
2024-04-13 |
2024-04-16 |
mouse |
| Fahaid H Al-Hashem, Salah O Bashir, Amal F Dawood, Moutasem S Aboonq, Ismaeel Bin-Jaliah, Abdulaiziz M Al-Garni, Mohamed D Mors. Vanillylacetone attenuates cadmium chloride-induced hippocampal damage and memory loss through up-regulation of nuclear factor erythroid 2-related factor 2 gene and protein expression. Neural regeneration research. vol 19. issue 12. 2024-04-10. PMID:38595292. |
additionally, vanillylacetone markedly decreased the hippocampal tissue levels of inflammatory biomarkers (interleukin-6, tumor necrosis factor-α, intracellular cell adhesive molecules) and apoptosis biomarkers (bax and cleaved caspase-3). |
2024-04-10 |
2024-04-12 |
rat |
| Zhiheng Zhang, Wenhan Liu, Meilun Shen, Xiangying Ma, Rouqian Li, Xiaodi Jin, Hui Bai, Li Ga. Correction to: Protective Effect of GM1 Attenuates Hippocampus and Cortex Apoptosis After Ketamine Exposure in Neonatal Rat via PI3K/AKT/GSK3β Pathway. Molecular neurobiology. 2024-04-09. PMID:38592588. |
correction to: protective effect of gm1 attenuates hippocampus and cortex apoptosis after ketamine exposure in neonatal rat via pi3k/akt/gsk3β pathway. |
2024-04-09 |
2024-04-11 |
rat |