| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhujing Ye, Jin Wang, Wenyu Shi, Zhou Zhou, Yarui Zhang, Jingdong Wang, Hongying Yan. Reprimo (RPRM) as a Potential Preventive and Therapeutic Target for Radiation-Induced Brain Injury via Multiple Mechanisms. International journal of molecular sciences. vol 24. issue 23. 2023-12-09. PMID:38069378. |
specifically, rprm knockout significantly reduced hippocampal dna damage and apoptosis shortly after mice were exposed to whole-brain irradiation (wbi). |
2023-12-09 |
2023-12-17 |
mouse |
| Chao Song, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Che. Hesperetin protects hippocampal neurons from the neurotoxicity of Aflatoxin B1 in mice. Ecotoxicology and environmental safety. vol 269. 2023-12-06. PMID:38056121. |
this study confirmed that afb1 caused endoplasmic reticulum stress (er stress) and apoptosis in hippocampal neurons using c57bl/6 j mice and ht22 cells as models. |
2023-12-06 |
2023-12-10 |
mouse |
| Enhua Wei, Aiying Gao, Xiaofei Mu, Songlin Qu, Caixing Yang, Fengling Li, Shujing Li, Xuehuan Liu, Chunhong Song, Yinghui Gu. Paeonol ameliorates hippocampal neuronal damage by inhibiting GRM5/GABBR2/β-arrestin2 and activating the cAMP-PKA signaling pathway in premenstrual irritability rats. Brain research bulletin. 2023-11-30. PMID:38036272. |
in addition, we found that paeonol significantly reduced the serum corticosterone (cort) level, improved hippocampal morphological structure and neuron number, and reduced hippocampal neuron apoptosis in pmdd rats. |
2023-11-30 |
2023-12-10 |
rat |
| Siming Huo, Xuliang Zhang, Jinyu Xu, Jian Zhang, Jiayu Du, Bo Li, Miao Song, Bing Shao, Yanfei Li, Feibo X. Corrigendum to "Parkin-mediated mitophagy protects against aluminum trichloride-induced hippocampal apoptosis in mice via the mtROS-NLRP3 pathway" [Ecotoxicol. Environ. Saf. 2023 Oct 1:264:115459.]. Ecotoxicology and environmental safety. vol 269. 2023-11-28. PMID:38016194. |
corrigendum to "parkin-mediated mitophagy protects against aluminum trichloride-induced hippocampal apoptosis in mice via the mtros-nlrp3 pathway" [ecotoxicol. |
2023-11-28 |
2023-12-07 |
mouse |
| Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Sing. S1PR2 inhibition mitigates cognitive deficit in diabetic mice by modulating microglial activation via Akt-p53-TIGAR pathway. International immunopharmacology. vol 126. 2023-11-27. PMID:38011768. |
s1pr2 inhibition increased p-akt and tigar levels and reduced the levels of p53 in the pfc and hippocampus of type 2 diabetic mice, thereby decreasing apoptosis. |
2023-11-27 |
2023-11-29 |
mouse |
| Kewei Chang, Liyan Lin, Tingting Cui, Hao Zhao, Jiaxin Li, Chang Liu, Dan Gao, Shemin L. Zinc-a2-Glycoprotein Acts as a Component of PNN to Protect Hippocampal Neurons from Apoptosis. Molecular neurobiology. 2023-11-24. PMID:38001359. |
zinc-a2-glycoprotein acts as a component of pnn to protect hippocampal neurons from apoptosis. |
2023-11-24 |
2023-11-28 |
mouse |
| Xiao-Yan Zhang, Xie Wang, Ting Ye, Nan Shao, Jie Wang, Biao Cai, Dao-Jun Xi. Network pharmacology-based approach to understand the effect and mechanism of chrysophanol against cognitive impairment in Wilson disease. Metabolic brain disease. 2023-11-24. PMID:37999884. |
the experiments showed that chr could reduce the copper content in liver, increase the copper content in 24-h urine, improve the ability of the learning and memory, alleviate the damage and apoptosis level of hippocampal neurons, down-regulate the expression of bax, cleaved caspase-3, and up-regulate the expressions of bcl-2, p-pi3k/pi3k, p-akt/akt. |
2023-11-24 |
2023-11-29 |
human |
| Jie Gao, Huiping Zhang, Leiying Zhou, Jiaqi Liu, Enba Zhuo, Yujun Shen, Xuesheng Liu, Qiying She. MANF Alleviates Sevoflurane-Induced Cognitive Impairment in Neonatal Mice by Modulating Microglial Activation and Polarization. Molecular neurobiology. 2023-11-22. PMID:37989984. |
finally, the recombinant human manf (rhmanf, 20 μg) protein was intraperitoneally administrated to neonatal mice before the sevoflurane anesthesia and the cognitive function, levels of pro-inflammatory cytokine and synapse-associated protein psd95, the status of neural apoptosis, microglia activation and oxidative stress in hippocampus of the mice were investigated. |
2023-11-22 |
2023-11-29 |
mouse |
| Jie Gao, Huiping Zhang, Leiying Zhou, Jiaqi Liu, Enba Zhuo, Yujun Shen, Xuesheng Liu, Qiying She. MANF Alleviates Sevoflurane-Induced Cognitive Impairment in Neonatal Mice by Modulating Microglial Activation and Polarization. Molecular neurobiology. 2023-11-22. PMID:37989984. |
mko upregulated the expression of tumor necrosis factor-α (tnf-α), accelerated the neural apoptosis and the activation of microglia in hippocampus in young mice. |
2023-11-22 |
2023-11-29 |
mouse |
| Yinli Shi, Pei Sheng, Yun Zhao, Xu Wang, Xiru Xu, Sifan Su. Based on Bioinformatics to Explore the Mechanism of "Tangzhiqing" Decoction Alleviating Type 2 Diabetes-associated Cognitive Dysfunction in Mice by Regulating Hippocampal Neuron Apoptosis and Autophagy. Combinatorial chemistry & high throughput screening. 2023-11-22. PMID:37990900. |
based on bioinformatics to explore the mechanism of "tangzhiqing" decoction alleviating type 2 diabetes-associated cognitive dysfunction in mice by regulating hippocampal neuron apoptosis and autophagy. |
2023-11-22 |
2023-11-29 |
mouse |
| Wen-Yuan Zhang, Cui-Mei Zhao, Chang-Shui Wang, Xin Xie, Yu-Qi Li, Bei-Bei Chen, Lei Feng, Pei Jian. Methylglyoxal accumulation contributes to accelerated brain aging in spontaneously hypertensive rats. Free radical biology & medicine. 2023-11-20. PMID:37984752. |
finally, nac was observed to inhibit apoptosis in the hippocampus of shrs. |
2023-11-20 |
2023-11-29 |
rat |
| Chunsheng Bao, Guge Wuyun Sure, Yufeng Ga. [Mongolian medicine Zhenbao Pill (Eridon Uril) inhibits inflammation and apoptosis in hippocampal neuronal cells of oxyglucose deprived/reoxygenated mice through activation of SIRT1/NF-κB pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 11. 2023-11-19. PMID:37980552. |
[mongolian medicine zhenbao pill (eridon uril) inhibits inflammation and apoptosis in hippocampal neuronal cells of oxyglucose deprived/reoxygenated mice through activation of sirt1/nf-κb pathway]. |
2023-11-19 |
2023-11-20 |
mouse |
| Chunsheng Bao, Guge Wuyun Sure, Yufeng Ga. [Mongolian medicine Zhenbao Pill (Eridon Uril) inhibits inflammation and apoptosis in hippocampal neuronal cells of oxyglucose deprived/reoxygenated mice through activation of SIRT1/NF-κB pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 11. 2023-11-19. PMID:37980552. |
objective to observe the effect of mongolian medicine zhenbao pill (eridon uril, eu) on inflammation and apoptosis of ht22 mouse hippocampal neurons cells under oxygen glucose deprivation/reoxygenation (ogd/r), and to explore its potential mechanism. |
2023-11-19 |
2023-11-20 |
mouse |
| Chunsheng Bao, Guge Wuyun Sure, Yufeng Ga. [Mongolian medicine Zhenbao Pill (Eridon Uril) inhibits inflammation and apoptosis in hippocampal neuronal cells of oxyglucose deprived/reoxygenated mice through activation of SIRT1/NF-κB pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 11. 2023-11-19. PMID:37980552. |
conclusion eu significantly reduces the inflammatory response and apoptosis in ogd/r-induced mouse hippocampal neurons, which is associated with the activation of sirt1/nf-κb signal pathway. |
2023-11-19 |
2023-11-20 |
mouse |
| Huifang Zhang, Yudan Zhang, Kaixuan Xu, Lawen Wang, Xin Zhou, Mingge Yang, Jiangli Xie, Hui L. Inhibition of FLT1 Attenuates Neurodevelopmental Abnormalities and Cognitive Impairment in Offspring Caused by Maternal Prenatal Stress. Applied biochemistry and biotechnology. 2023-11-18. PMID:37979086. |
the apoptosis level of hippocampal neurons and the expression of nmdars were detected by mtt assay, tunel assay, and western blot. |
2023-11-18 |
2023-11-20 |
rat |
| Huifang Zhang, Yudan Zhang, Kaixuan Xu, Lawen Wang, Xin Zhou, Mingge Yang, Jiangli Xie, Hui L. Inhibition of FLT1 Attenuates Neurodevelopmental Abnormalities and Cognitive Impairment in Offspring Caused by Maternal Prenatal Stress. Applied biochemistry and biotechnology. 2023-11-18. PMID:37979086. |
inhibition of ftl1 reduced hippocampal neuronal apoptosis and increased the expression of nmdars in ps progeny. |
2023-11-18 |
2023-11-20 |
rat |
| Wenjun Wan, Ying Wang, Lei Li, Chaoyang Ma, Yanfu Wang, Fei Yo. Electroacupuncture Improves Learning and Memory Abilities via Activating AMPK/mTOR-Induced Autophagy in APP/PS1 Mice. Biochemical genetics. 2023-11-18. PMID:37980310. |
ea treatment improved the cognitive impairments, reduced amyloid-beta (aβ) deposition, and alleviated neuronal apoptosis in the hippocampal tissues of app/ps1 mice. |
2023-11-18 |
2023-11-20 |
mouse |
| Yanhua Tian, Sanchun Wang, Weifang Tong, Hongyan Wang, Yating Zhang, Bo Ten. Pseudoginsenoside GQ mitigates chronic intermittent hypoxia-induced cognitive damage by modulating microglia polarization. International immunopharmacology. vol 126. 2023-11-17. PMID:37977071. |
we found that pgq significantly ameliorated cih-induced spatial learning deficits, and inhibited microglial activation, pro-inflammatory cytokine release, and neuronal apoptosis in the hippocampus of cih mice. |
2023-11-17 |
2023-11-20 |
mouse |
| Mengjiao Zhu, Si Long, Yizhi Tao, Zhifa Zhang, Zhiqiang Zhou, Xueren Wang, Wei Che. The P38MAPK/ATF2 signaling pathway is involved in PND in mice. Experimental brain research. 2023-11-16. PMID:37973625. |
inhibition of the p38mapk/atf2 signaling pathway attenuates hippocampal neuroinflammation and neuronal apoptosis in aged mice with pnd, thus improving the perioperative cognitive function of the mice. |
2023-11-16 |
2023-11-20 |
mouse |
| Xiaoxiao Pan, Xiaoqian Gong, Lili Pan, Liyu L. Erythropoietin relieves neuronal apoptosis in epilepsy rats via TGF-β/Smad signaling pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 10. 2023-11-13. PMID:37953557. |
the results of the tunel assay showed that the intervention with rhuepo could remarkably reduce the number of ptz-induced apoptotic neurons in the hippocampus, while sb431542 inhibitor could attenuate the protective effect of rhuepo against neuronal apoptosis (p<0.05). |
2023-11-13 |
2023-11-20 |
human |