| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lan Wu, Xiang-Jian Meng, Tian-Bao Xu, Xian-Cui Zhang, Yong Zhou, Zhu-Feng Tong, Jing-Han Jian. Berberine attenuates cognitive dysfunction and hippocampal apoptosis in rats with prediabetes. Chemical biology & drug design. vol 103. issue 1. 2024-01-17. PMID:38230770. |
however, after the administration of berberine, the blood glucose and lipid metabolism of prediabetic rats were significantly improved, and the oxidative stress level and apoptosis level of hippocampal tissue were significantly reduced. |
2024-01-17 |
2024-01-19 |
human |
| Lan Wu, Xiang-Jian Meng, Tian-Bao Xu, Xian-Cui Zhang, Yong Zhou, Zhu-Feng Tong, Jing-Han Jian. Berberine attenuates cognitive dysfunction and hippocampal apoptosis in rats with prediabetes. Chemical biology & drug design. vol 103. issue 1. 2024-01-17. PMID:38230770. |
in conclusion, berberine can alleviate the further development of diabetes in prediabetic rats, reduce oxidative stress and apoptosis in hippocampal tissue, and improve cognitive impairment in prediabetic rats. |
2024-01-17 |
2024-01-19 |
human |
| Yan Wang, Dai Li, Lan Zhang, Zhenyu Yin, Zhaoli Han, Xintong Ge, Meimei Li, Jing Zhao, Shishuang Zhang, Yan Zuo, Xiangyang Xiong, Han Gao, Qiang Liu, Fanglian Chen, Ping Le. Exosomes derived from microglia overexpressing miR-124-3p alleviate neuronal endoplasmic reticulum stress damage after repetitive mild traumatic brain injury. Neural regeneration research. vol 19. issue 9. 2024-01-16. PMID:38227530. |
finally, we delivered microglia-derived exosomes containing mir-124-3p intranasally to a mouse model of repetitive mild traumatic brain injury and found that endoplasmic reticulum stress and apoptosis levels in hippocampal neurons were significantly reduced. |
2024-01-16 |
2024-01-18 |
mouse |
| Huan Li, Yan Liu, Xiangmeng Wang, Chaoqun Xu, Xiaoyu Zhang, Jing Zhang, Li Lin, Qiao Ni. miR-128-3p is involved in aluminum-induced cognitive impairment by regulating the Sirt1-Keap1/Nrf2 pathway. Ecotoxicology and environmental safety. vol 271. 2024-01-14. PMID:38219620. |
we speculated that subchronic aluminum exposure may lead to the activation of mir-128-3p in rat hippocampus of rats, thereby inhibiting the sirt1-keap1/nrf2 pathway so that the sirt1-keap1/nrf2 pathway could not be activated to exert antioxidant capacity, resulting in an imbalance in the antioxidant system of rats and the apoptosis of neurons, which caused reduced cognitive impairment in rats. |
2024-01-14 |
2024-01-17 |
rat |
| Huizhen Sun, Shanshan Wei, Yanchun Gong, Kaizhi Ding, Shan Tang, Wei Sun, Chunhua Yuan, Liping Huang, Zhibing Liu, Chong Chen, Lihua Ya. Neuroprotective effects of cordycepin inhibit glutamate-induced apoptosis in hippocampal neurons. Cell stress & chaperones. 2024-01-14. PMID:38219840. |
neuroprotective effects of cordycepin inhibit glutamate-induced apoptosis in hippocampal neurons. |
2024-01-14 |
2024-01-17 |
Not clear |
| Xi Zhang, Hong Zheng, Zhitao Ni, Yuyin Shen, Die Wang, Wenqing Li, Liangcai Zhao, Chen Li, Hongchang Ga. Fibroblast growth factor 21 alleviates diabetes-induced cognitive decline. Cerebral cortex (New York, N.Y. : 1991). 2024-01-14. PMID:38220573. |
results revealed that i.c.v fgf21 infusion effectively improved learning and memory performance of dicd mice; neuron loss and apoptosis in hippocampus and cortex were significantly blocked, suggesting a potential neuroprotective role of fgf21 in dicd. |
2024-01-14 |
2024-01-17 |
mouse |
| Huina Ma, Hehua Huang, Chenyu Li, Shasha Li, Juefang Gan, Chunrong Lian, Yanwu Lin. The antidepressive mechanism of Longya Lilium combined with Fluoxetine in mice with depression-like behaviors. NPJ systems biology and applications. vol 10. issue 1. 2024-01-13. PMID:38218856. |
the underlying potential mechanism of this combination therapy was further explored based on in vitro and in vivo experiments to analyze the expression of cox-2, pge2, and il-22, activation of microglial cells, and neuron viability and apoptosis in the hippocampus. |
2024-01-13 |
2024-01-16 |
mouse |
| Charlene P Poore, Nurul A M N Hazalin, Shunhui Wei, See Wee Low, Bo Chen, Bernd Nilius, Zurina Hassan, Ping Lia. TRPM4 blocking antibody reduces neuronal excitotoxicity by specifically inhibiting glutamate-induced calcium influx under chronic hypoxia. Neurobiology of disease. 2024-01-10. PMID:38199274. |
using a rat model of chronic hypoxia with both common carotid arteries occluded, we found that m4p treatment could reduce apoptosis in the neurons within the hippocampus, attenuate long-term potentiation impairment and improve the functions of learning and memory in this rat model. |
2024-01-10 |
2024-01-13 |
rat |
| Ahmad Yahyazadeh, Feyza Başak, Mürşide Ayşe Demire. Efficacy of coenzyme Q10 and curcumin on antioxidant enzyme activity and hippocampal alteration following exposure to cyclophosphamide in male rat. Tissue & cell. vol 86. 2024-01-07. PMID:38184921. |
our findings showed that kq10 administration significantly mitigated the hippocampal alteration caused by sf through enhancing antioxidant enzyme activity and reducing apoptosis. |
2024-01-07 |
2024-01-10 |
rat |
| Li Sun, Yangyang Li, Daliang Wang, Xiaoya Hon. SESN2 attenuates sevoflurane-induced cognitive impairment and neuroinflammation in rats. Experimental brain research. 2023-12-21. PMID:38129329. |
neuronal apoptosis in the hippocampus was detected using tunel assay. |
2023-12-21 |
2023-12-24 |
rat |
| Li Sun, Yangyang Li, Daliang Wang, Xiaoya Hon. SESN2 attenuates sevoflurane-induced cognitive impairment and neuroinflammation in rats. Experimental brain research. 2023-12-21. PMID:38129329. |
importantly, overexpression of sesn2 alleviated sevoflurane-induced cognitive dysfunction and inhibited the production of pro-inflammatory factors, oxidative stress, and neuronal apoptosis in the hippocampus. |
2023-12-21 |
2023-12-24 |
rat |
| Xingyu Yang, Ziwei Yu, Li An, Xinyue Jing, Mengqian Yuan, Tiancheng Xu, Zhi Yu, Bin Xu, Mengjiang L. Electroacupuncture stimulation ameliorates cognitive impairment induced by long-term high-fat diet by regulating microglial BDNF. Brain research. vol 1825. 2023-12-17. PMID:38103878. |
overexcitation of peripheral inflammasome complexes induces hippocampal microglia apoptosis, which hinders the effects of es. |
2023-12-17 |
2023-12-21 |
mouse |
| Linlin Jing, Qingyue Da, Shuyu Zhang, Jie Zhang, Huiping Ma, Hongbo Lu. Nitronyl Nitroxide Ameliorates Hypobaric Hypoxia-Induced Cognitive Impairment in Mice by Suppressing the Oxidative Stress, Inflammatory Response and Apoptosis. Neurochemical research. 2023-12-16. PMID:38103103. |
the hippocampus cell apoptosis was detected by tunnel staining. |
2023-12-16 |
2023-12-18 |
mouse |
| Jing Zhang, Zhao Wang, Kun Cong, Jun Qi, Lining Su. Phoenixin-20 ameliorates Sevoflurane inhalation-induced post-operative cognitive dysfunction in rats via activation of the PKA/CREB signaling. Aging. vol 15. 2023-12-16. PMID:38103264. |
markedly increased escape latency and decreased time in the target quadrant in the morris water maze (mwm) test, and aggravated pathological changes and apoptosis in the hippocampus tissue were observed in sevoflurane-treated rats, which were markedly attenuated by pnx-20. |
2023-12-16 |
2023-12-19 |
rat |
| Huixia Geng, Qihang An, Jie Song, Dongling He, Huimin Han, Lai Wan. Cadmium-induced global DNA hypermethylation promoting mitochondrial dynamics dysregulation in hippocampal neurons. Environmental toxicology. 2023-12-14. PMID:38095104. |
this study used hippocampal neurons cultured in vitro to observe the impact of cadmium exposure on mitochondrial dynamics and apoptosis. |
2023-12-14 |
2023-12-17 |
Not clear |
| Huixia Geng, Qihang An, Jie Song, Dongling He, Huimin Han, Lai Wan. Cadmium-induced global DNA hypermethylation promoting mitochondrial dynamics dysregulation in hippocampal neurons. Environmental toxicology. 2023-12-14. PMID:38095104. |
exposure to 5 μm cadmium causes degradation of hippocampal neuron cell bodies and axons, morphological destruction, low cell viability, and apoptosis increase. |
2023-12-14 |
2023-12-17 |
Not clear |
| Ling Lei, Yong Luo, Dongkun Kang, Fumin Yang, Dongli Meng, Jian-Zhi Wang, Rong Liu, Xiaochuan Wang, Hong-Lian L. Gypenoside IX restores Akt/GSK-3β pathway and alleviates Alzheimer's disease-like neuropathology and cognitive deficits. Aging. vol 15. 2023-12-14. PMID:38095632. |
in the current study, we used staurosporine (stp), an inducer of apoptosis and causing tau hyperphosphorylation, to mimic ad models, and explored the role and mechanism of gypenoside ix (one of the extracts of gynostemma, gp for short name in our experiments) in stp treated primary hippocampal neurons and rats. |
2023-12-14 |
2023-12-17 |
rat |
| Zhujing Ye, Jin Wang, Wenyu Shi, Zhou Zhou, Yarui Zhang, Jingdong Wang, Hongying Yan. Reprimo (RPRM) as a Potential Preventive and Therapeutic Target for Radiation-Induced Brain Injury via Multiple Mechanisms. International journal of molecular sciences. vol 24. issue 23. 2023-12-09. PMID:38069378. |
specifically, rprm knockout significantly reduced hippocampal dna damage and apoptosis shortly after mice were exposed to whole-brain irradiation (wbi). |
2023-12-09 |
2023-12-17 |
mouse |
| Chao Song, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Che. Hesperetin protects hippocampal neurons from the neurotoxicity of Aflatoxin B1 in mice. Ecotoxicology and environmental safety. vol 269. 2023-12-06. PMID:38056121. |
this study confirmed that afb1 caused endoplasmic reticulum stress (er stress) and apoptosis in hippocampal neurons using c57bl/6 j mice and ht22 cells as models. |
2023-12-06 |
2023-12-10 |
mouse |
| Enhua Wei, Aiying Gao, Xiaofei Mu, Songlin Qu, Caixing Yang, Fengling Li, Shujing Li, Xuehuan Liu, Chunhong Song, Yinghui Gu. Paeonol ameliorates hippocampal neuronal damage by inhibiting GRM5/GABBR2/β-arrestin2 and activating the cAMP-PKA signaling pathway in premenstrual irritability rats. Brain research bulletin. 2023-11-30. PMID:38036272. |
in addition, we found that paeonol significantly reduced the serum corticosterone (cort) level, improved hippocampal morphological structure and neuron number, and reduced hippocampal neuron apoptosis in pmdd rats. |
2023-11-30 |
2023-12-10 |
rat |