| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guang-Jun Hu, Xiao-Yang Jiang, Si-Yu Du, Kun Zhang, Zhuo Che. miR-107-5p ameliorates neurological damage, oxidative stress, and immune responses in mice with Alzheimer's disease by suppressing the Toll-like receptor 4 (TLR4)/nuclear factor-kappaB(NF-κB) pathway. The Kaohsiung journal of medical sciences. vol 40. issue 2. 2024-02-02. PMID:38305705. |
histopathological changes, hippocampal neuron distribution, and apoptosis were assessed using hematoxylin-eosin, nissl, and tunel staining. |
2024-02-02 |
2024-02-04 |
mouse |
| Micaela Gliozzi, Anna Rita Coppoletta, Antonio Cardamone, Vincenzo Musolino, Cristina Carresi, Saverio Nucera, Stefano Ruga, Federica Scarano, Francesca Bosco, Lorenza Guarnieri, Roberta Macrì, Rocco Mollace, Catherine Belzung, Vincenzo Mollac. The dangerous "West Coast Swing" by hyperglycaemia and chronic stress in the mouse hippocampus: role of kynurenine catabolism. Pharmacological research. 2024-02-01. PMID:38301816. |
our work demonstrates that kynurenine overproduction, leading to apoptosis in the hippocampus, is triggered in a different way depending on hyperglycaemia or chronic stress. |
2024-02-01 |
2024-02-04 |
mouse |
| Micaela Gliozzi, Anna Rita Coppoletta, Antonio Cardamone, Vincenzo Musolino, Cristina Carresi, Saverio Nucera, Stefano Ruga, Federica Scarano, Francesca Bosco, Lorenza Guarnieri, Roberta Macrì, Rocco Mollace, Catherine Belzung, Vincenzo Mollac. The dangerous "West Coast Swing" by hyperglycaemia and chronic stress in the mouse hippocampus: role of kynurenine catabolism. Pharmacological research. 2024-02-01. PMID:38301816. |
we demonstrated that the coexistence of hyperglycaemia and chronic stress worsened hippocampal damage through alternative mechanisms, such as glut-4 and bdnf down-expression, denoting mitochondrial dysfunction and apoptosis on one hand and evoking the compromission of neurogenesis on the other. |
2024-02-01 |
2024-02-04 |
mouse |
| Jianbin Zhu, Haixiang Wei, Minying Jiang, Ting Li, Ruizhu Wu, Hualiang Che. Effect of Dexmedetomidine on Apoptosis and Early Cognitive Dysfunction in Rats Following Propofol Anesthesia. Alternative therapies in health and medicine. 2024-01-30. PMID:38290461. |
to address the intricate interplay between surgical anesthesia, hippocampal apoptosis, and early cognitive dysfunction in rats, this study delves into the impact of dexmedetomidine (dex). |
2024-01-30 |
2024-02-02 |
rat |
| Mrunal Nannaware, Neelaambhigai Mayilswamy, Balasubramanian Kandasubramania. PFAS: exploration of neurotoxicity and environmental impact. Environmental science and pollution research international. 2024-01-26. PMID:38277101. |
animal studies reveal apoptosis and hippocampus dysfunction, resulting in memory loss and spatial learning issues. |
2024-01-26 |
2024-01-28 |
human |
| Lan Wu, Xiang-Jian Meng, Tian-Bao Xu, Xian-Cui Zhang, Yong Zhou, Zhu-Feng Tong, Jing-Han Jian. Berberine attenuates cognitive dysfunction and hippocampal apoptosis in rats with prediabetes. Chemical biology & drug design. vol 103. issue 1. 2024-01-17. PMID:38230770. |
in conclusion, berberine can alleviate the further development of diabetes in prediabetic rats, reduce oxidative stress and apoptosis in hippocampal tissue, and improve cognitive impairment in prediabetic rats. |
2024-01-17 |
2024-01-19 |
human |
| Lan Wu, Xiang-Jian Meng, Tian-Bao Xu, Xian-Cui Zhang, Yong Zhou, Zhu-Feng Tong, Jing-Han Jian. Berberine attenuates cognitive dysfunction and hippocampal apoptosis in rats with prediabetes. Chemical biology & drug design. vol 103. issue 1. 2024-01-17. PMID:38230770. |
berberine attenuates cognitive dysfunction and hippocampal apoptosis in rats with prediabetes. |
2024-01-17 |
2024-01-19 |
human |
| Lan Wu, Xiang-Jian Meng, Tian-Bao Xu, Xian-Cui Zhang, Yong Zhou, Zhu-Feng Tong, Jing-Han Jian. Berberine attenuates cognitive dysfunction and hippocampal apoptosis in rats with prediabetes. Chemical biology & drug design. vol 103. issue 1. 2024-01-17. PMID:38230770. |
however, after the administration of berberine, the blood glucose and lipid metabolism of prediabetic rats were significantly improved, and the oxidative stress level and apoptosis level of hippocampal tissue were significantly reduced. |
2024-01-17 |
2024-01-19 |
human |
| Yan Wang, Dai Li, Lan Zhang, Zhenyu Yin, Zhaoli Han, Xintong Ge, Meimei Li, Jing Zhao, Shishuang Zhang, Yan Zuo, Xiangyang Xiong, Han Gao, Qiang Liu, Fanglian Chen, Ping Le. Exosomes derived from microglia overexpressing miR-124-3p alleviate neuronal endoplasmic reticulum stress damage after repetitive mild traumatic brain injury. Neural regeneration research. vol 19. issue 9. 2024-01-16. PMID:38227530. |
finally, we delivered microglia-derived exosomes containing mir-124-3p intranasally to a mouse model of repetitive mild traumatic brain injury and found that endoplasmic reticulum stress and apoptosis levels in hippocampal neurons were significantly reduced. |
2024-01-16 |
2024-01-18 |
mouse |
| Huan Li, Yan Liu, Xiangmeng Wang, Chaoqun Xu, Xiaoyu Zhang, Jing Zhang, Li Lin, Qiao Ni. miR-128-3p is involved in aluminum-induced cognitive impairment by regulating the Sirt1-Keap1/Nrf2 pathway. Ecotoxicology and environmental safety. vol 271. 2024-01-14. PMID:38219620. |
we speculated that subchronic aluminum exposure may lead to the activation of mir-128-3p in rat hippocampus of rats, thereby inhibiting the sirt1-keap1/nrf2 pathway so that the sirt1-keap1/nrf2 pathway could not be activated to exert antioxidant capacity, resulting in an imbalance in the antioxidant system of rats and the apoptosis of neurons, which caused reduced cognitive impairment in rats. |
2024-01-14 |
2024-01-17 |
rat |
| Huizhen Sun, Shanshan Wei, Yanchun Gong, Kaizhi Ding, Shan Tang, Wei Sun, Chunhua Yuan, Liping Huang, Zhibing Liu, Chong Chen, Lihua Ya. Neuroprotective effects of cordycepin inhibit glutamate-induced apoptosis in hippocampal neurons. Cell stress & chaperones. 2024-01-14. PMID:38219840. |
neuroprotective effects of cordycepin inhibit glutamate-induced apoptosis in hippocampal neurons. |
2024-01-14 |
2024-01-17 |
Not clear |
| Xi Zhang, Hong Zheng, Zhitao Ni, Yuyin Shen, Die Wang, Wenqing Li, Liangcai Zhao, Chen Li, Hongchang Ga. Fibroblast growth factor 21 alleviates diabetes-induced cognitive decline. Cerebral cortex (New York, N.Y. : 1991). 2024-01-14. PMID:38220573. |
results revealed that i.c.v fgf21 infusion effectively improved learning and memory performance of dicd mice; neuron loss and apoptosis in hippocampus and cortex were significantly blocked, suggesting a potential neuroprotective role of fgf21 in dicd. |
2024-01-14 |
2024-01-17 |
mouse |
| Huina Ma, Hehua Huang, Chenyu Li, Shasha Li, Juefang Gan, Chunrong Lian, Yanwu Lin. The antidepressive mechanism of Longya Lilium combined with Fluoxetine in mice with depression-like behaviors. NPJ systems biology and applications. vol 10. issue 1. 2024-01-13. PMID:38218856. |
the underlying potential mechanism of this combination therapy was further explored based on in vitro and in vivo experiments to analyze the expression of cox-2, pge2, and il-22, activation of microglial cells, and neuron viability and apoptosis in the hippocampus. |
2024-01-13 |
2024-01-16 |
mouse |
| Charlene P Poore, Nurul A M N Hazalin, Shunhui Wei, See Wee Low, Bo Chen, Bernd Nilius, Zurina Hassan, Ping Lia. TRPM4 blocking antibody reduces neuronal excitotoxicity by specifically inhibiting glutamate-induced calcium influx under chronic hypoxia. Neurobiology of disease. 2024-01-10. PMID:38199274. |
using a rat model of chronic hypoxia with both common carotid arteries occluded, we found that m4p treatment could reduce apoptosis in the neurons within the hippocampus, attenuate long-term potentiation impairment and improve the functions of learning and memory in this rat model. |
2024-01-10 |
2024-01-13 |
rat |
| Ahmad Yahyazadeh, Feyza Başak, Mürşide Ayşe Demire. Efficacy of coenzyme Q10 and curcumin on antioxidant enzyme activity and hippocampal alteration following exposure to cyclophosphamide in male rat. Tissue & cell. vol 86. 2024-01-07. PMID:38184921. |
our findings showed that kq10 administration significantly mitigated the hippocampal alteration caused by sf through enhancing antioxidant enzyme activity and reducing apoptosis. |
2024-01-07 |
2024-01-10 |
rat |
| Li Sun, Yangyang Li, Daliang Wang, Xiaoya Hon. SESN2 attenuates sevoflurane-induced cognitive impairment and neuroinflammation in rats. Experimental brain research. 2023-12-21. PMID:38129329. |
neuronal apoptosis in the hippocampus was detected using tunel assay. |
2023-12-21 |
2023-12-24 |
rat |
| Li Sun, Yangyang Li, Daliang Wang, Xiaoya Hon. SESN2 attenuates sevoflurane-induced cognitive impairment and neuroinflammation in rats. Experimental brain research. 2023-12-21. PMID:38129329. |
importantly, overexpression of sesn2 alleviated sevoflurane-induced cognitive dysfunction and inhibited the production of pro-inflammatory factors, oxidative stress, and neuronal apoptosis in the hippocampus. |
2023-12-21 |
2023-12-24 |
rat |
| Xingyu Yang, Ziwei Yu, Li An, Xinyue Jing, Mengqian Yuan, Tiancheng Xu, Zhi Yu, Bin Xu, Mengjiang L. Electroacupuncture stimulation ameliorates cognitive impairment induced by long-term high-fat diet by regulating microglial BDNF. Brain research. vol 1825. 2023-12-17. PMID:38103878. |
overexcitation of peripheral inflammasome complexes induces hippocampal microglia apoptosis, which hinders the effects of es. |
2023-12-17 |
2023-12-21 |
mouse |
| Linlin Jing, Qingyue Da, Shuyu Zhang, Jie Zhang, Huiping Ma, Hongbo Lu. Nitronyl Nitroxide Ameliorates Hypobaric Hypoxia-Induced Cognitive Impairment in Mice by Suppressing the Oxidative Stress, Inflammatory Response and Apoptosis. Neurochemical research. 2023-12-16. PMID:38103103. |
the hippocampus cell apoptosis was detected by tunnel staining. |
2023-12-16 |
2023-12-18 |
mouse |
| Jing Zhang, Zhao Wang, Kun Cong, Jun Qi, Lining Su. Phoenixin-20 ameliorates Sevoflurane inhalation-induced post-operative cognitive dysfunction in rats via activation of the PKA/CREB signaling. Aging. vol 15. 2023-12-16. PMID:38103264. |
markedly increased escape latency and decreased time in the target quadrant in the morris water maze (mwm) test, and aggravated pathological changes and apoptosis in the hippocampus tissue were observed in sevoflurane-treated rats, which were markedly attenuated by pnx-20. |
2023-12-16 |
2023-12-19 |
rat |