| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun Huang, Wentao Jiang, Junping Pan, Xuetao X. Correlation of sLOX-1 and CSF1 with the pathological progression of hypoxic-ischemic encephalopathy in neonatal rats. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 10. 2023-11-13. PMID:37953571. |
the model group showed more severe pathological damage of the hippocampus and higher neuronal apoptosis than the control group. |
2023-11-13 |
2023-11-20 |
rat |
| Jun Huang, Wentao Jiang, Junping Pan, Xuetao X. Correlation of sLOX-1 and CSF1 with the pathological progression of hypoxic-ischemic encephalopathy in neonatal rats. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 10. 2023-11-13. PMID:37953571. |
compared with the blank group, slox-1-si and csf1-si groups showed significantly alleviated hippocampal damage, inhibited neuronal apoptosis, reduced 5-ht, da, ne, bax, and cl-caspase-3, and increased bcl-2 (p<0.05). |
2023-11-13 |
2023-11-20 |
rat |
| Zhengda Sun, Jiqing Song, Qijun Song, Lin Li, Xinxin Tian, Lijun Wan. Recombinant human erythropoietin protects against immature brain damage induced by hypoxic/ischemia insult. Neuroreport. vol 34. issue 17. 2023-11-08. PMID:37938927. |
on pd10, damage of brain tissue was examined by hematoxylin-eosin (he) staining, observation of neuronal apoptosis in the hippocampus and cortex using immunofluorescence assay (marker: tunel). |
2023-11-08 |
2023-11-20 |
human |
| Jinling Zhang, Ruiqing Li, Yang Yu, Weijia Sun, Chengshi Zhang, Haijun Wan. Network pharmacology-and molecular docking-based investigation of Danggui blood-supplementing decoction in ischaemic stroke. Growth factors (Chur, Switzerland). 2023-11-07. PMID:37932893. |
cell experiments confirmed the involvement of kng1 and sphingolipid signalling pathway in hippocampal neuronal cell apoptosis. |
2023-11-07 |
2023-11-08 |
Not clear |
| J Zhang, J He, X Mi, X Xu, Y Tian, R Ya. [High homocysteine level promotes autophagy and apoptosis of mouse hippocampal HT22 cells through the Notch1/Hes1 signaling pathway]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 43. issue 10. 2023-11-07. PMID:37933657. |
[high homocysteine level promotes autophagy and apoptosis of mouse hippocampal ht22 cells through the notch1/hes1 signaling pathway]. |
2023-11-07 |
2023-11-08 |
mouse |
| Zhizhuan Guo, Wenwen Zhong, Zhengshou Zo. miR-98-5p Prevents Hippocampal Neurons from Oxidative Stress and Apoptosis by Targeting STAT3 in Epilepsy in vitro. Neuropsychiatric disease and treatment. vol 19. 2023-11-06. PMID:37928166. |
mir-98-5p prevents hippocampal neurons from oxidative stress and apoptosis by targeting stat3 in epilepsy in vitro. |
2023-11-06 |
2023-11-08 |
Not clear |
| Hui Chen, Wei Zhang, Song Luo, Yanshu Li, Qian Zhu, Yongli Xia, Hong Tan, Ying Bian, Yaobing Li, Jianmin Ma, Wei Chen, Xietian Luo, Gaochun Zh. Lead exposure induces neuronal apoptosis via NFκB p65/RBBP4/Survivin signaling pathway. Toxicology. vol 499. 2023-11-05. PMID:37866543. |
the results of tunel showed that lead exposure promoted the onset of apoptosis in cells and hippocampus. |
2023-11-05 |
2023-11-08 |
rat |
| Kai Yang, Jue Wu, Shang Li, Shan Wang, Jing Zhang, Yi-Peng Wang, You-Sheng Yan, Hua-Ying Hu, Ming-Fang Xiong, Chao-Bo Bai, Yong-Qing Sun, Wen-Qi Chen, Yang Zeng, Jun-Liang Yuan, Cheng-Hong Yi. NTRK1 knockdown induces mouse cognitive impairment and hippocampal neuronal damage through mitophagy suppression via inactivating the AMPK/ULK1/FUNDC1 pathway. Cell death discovery. vol 9. issue 1. 2023-11-01. PMID:37907480. |
next, an in vitro analysis was conducted using the cck-8 assay, tunel assay, neun if staining, dcfh-da staining, jc-1 staining, atp content test, mrfp-egfp-lc3 assay, and lc3-ii if staining to elucidate the effect of ntrk1 on mouse hippocampal neuronal activity, apoptosis, damage, mitochondrial function, and autophagy. |
2023-11-01 |
2023-11-08 |
mouse |
| Kai Yang, Jue Wu, Shang Li, Shan Wang, Jing Zhang, Yi-Peng Wang, You-Sheng Yan, Hua-Ying Hu, Ming-Fang Xiong, Chao-Bo Bai, Yong-Qing Sun, Wen-Qi Chen, Yang Zeng, Jun-Liang Yuan, Cheng-Hong Yi. NTRK1 knockdown induces mouse cognitive impairment and hippocampal neuronal damage through mitophagy suppression via inactivating the AMPK/ULK1/FUNDC1 pathway. Cell death discovery. vol 9. issue 1. 2023-11-01. PMID:37907480. |
the results of in vitro analysis indicated that ntrk1 knockdown attenuated viability, neun expression, atp production, mitochondrial membrane potential, and mitophagy, while enhancing apoptosis and ros production in mouse hippocampal neurons. |
2023-11-01 |
2023-11-08 |
mouse |
| Thalita Mázala-de-Oliveira, Bruna Teixeira Silva, Paula Campello-Costa, Vinicius Frias Carvalh. The Role of the Adrenal-Gut-Brain Axis on Comorbid Depressive Disorder Development in Diabetes. Biomolecules. vol 13. issue 10. 2023-10-30. PMID:37892186. |
in this context, we propose here that hypercortisolism, in association with gut dysbiosis, leads to an exacerbation of hippocampal neuroinflammation, glutamatergic transmission, and neuronal apoptosis, leading to the development and aggravation of depression and to resistance to treatment of this mood disorder in diabetic patients. |
2023-10-30 |
2023-11-08 |
mouse |
| Maaly A Abd Elmaaboud, Remon S Estfanous, Aliaa Atef, Ahmed M Kabel, Khalid A Alnemari, Tamer M Naguib, Shuruq E Alsufyani, Hany W Darwish, Hany H Ara. Dapagliflozin/Hesperidin Combination Mitigates Lipopolysaccharide-Induced Alzheimer's Disease in Rats. Pharmaceuticals (Basel, Switzerland). vol 16. issue 10. 2023-10-30. PMID:37895841. |
in conclusion, inhibition of the hippocampal hmgb1/tlr4/rage signaling, the pro-inflammatory axis, and apoptosis alongside augmentation of the antioxidant defenses and autophagy can be regarded as beneficial effects by which dapagliflozin/hesperidin combination may combat lps-triggered ad. |
2023-10-30 |
2023-11-08 |
rat |
| Narjes Ebrahimnezhad, Shila Nayebifar, Zahra Soltani, Kayvan Khoramipou. High-intensity interval training reduced oxidative stress and apoptosis in the hippocampus of male rats with type 2 diabetes: The role of the PGC1α-Keap1-Nrf2 signaling pathway. Iranian journal of basic medical sciences. vol 26. issue 11. 2023-10-27. PMID:37885999. |
high-intensity interval training reduced oxidative stress and apoptosis in the hippocampus of male rats with type 2 diabetes: the role of the pgc1α-keap1-nrf2 signaling pathway. |
2023-10-27 |
2023-11-08 |
rat |
| Narjes Ebrahimnezhad, Shila Nayebifar, Zahra Soltani, Kayvan Khoramipou. High-intensity interval training reduced oxidative stress and apoptosis in the hippocampus of male rats with type 2 diabetes: The role of the PGC1α-Keap1-Nrf2 signaling pathway. Iranian journal of basic medical sciences. vol 26. issue 11. 2023-10-27. PMID:37885999. |
this study aimed to determine the effect of 8-week high-intensity interval training (hiit) on oxidative stress and apoptosis in the hippocampus of male rats with type 2 diabetes (t2d). |
2023-10-27 |
2023-11-08 |
rat |
| Züleyha Doğanyiğit, Aslı Okan, Enes Akyüz, Seher Yılmaz, Şükrü Ateş, Serpil Taheri, Zeynep Yılmaz, Mohd Farooq Shaik. Can endoplasmic reticulum stress observed in the PTZ-kindling model seizures be prevented with TUDCA and 4-PBA? European journal of pharmacology. vol 960. 2023-10-22. PMID:37852571. |
er stress, apoptosis, and oxidative stress were determined in the hippocampus tissues of animals in all groups. |
2023-10-22 |
2023-11-08 |
rat |
| Fen-Fang Chen, Jian-Feng Liu, Di-Mi Zho. SIRT3 enhances the protective effect of Xyloketal B on seizure-induced brain injury by regulating AMPK/mTOR signaling-mediated autophagy. The Kaohsiung journal of medical sciences. 2023-10-18. PMID:37850727. |
in this article, we constructed a rat developmental convulsion model and a primary hippocampal neuronal cell convulsion model, through which we studied hippocampal neuronal morphology and neuronal apoptosis using h&e staining and tunel staining, respectively. |
2023-10-18 |
2023-11-08 |
rat |
| Tong Li, DaJing Su, HuaWen Lu, YunQing Gao, YongGang Liu, ShaoHua Wang, YuTing Hou, KeMin Qin, XianTing Que, XiaoPing Chen, BaiLing Qin, ZiJun Wang, Yan Den. Recombinant human brain natriuretic peptide attenuates ischemic brain injury in mice by inhibiting oxidative stress and cell apoptosis via activation of PI3K/AKT/Nrf2/HO-1 pathway. Experimental brain research. 2023-10-17. PMID:37847304. |
cell apoptosis in hippocampus tissues was examined by tunel staining. |
2023-10-17 |
2023-11-08 |
mouse |
| Tong Li, DaJing Su, HuaWen Lu, YunQing Gao, YongGang Liu, ShaoHua Wang, YuTing Hou, KeMin Qin, XianTing Que, XiaoPing Chen, BaiLing Qin, ZiJun Wang, Yan Den. Recombinant human brain natriuretic peptide attenuates ischemic brain injury in mice by inhibiting oxidative stress and cell apoptosis via activation of PI3K/AKT/Nrf2/HO-1 pathway. Experimental brain research. 2023-10-17. PMID:37847304. |
cell apoptosis in hippocampus tissues of model mice was inhibited by rhbnp which was shown as the reduced tunel-positive cells, the decreased bax, cleaved caspase-3, and cleaved caspase-9 protein levels, and the enhanced bcl-2 protein level. |
2023-10-17 |
2023-11-08 |
mouse |
| Afsaneh Soltani, Uliana Y Chugaeva, Montather F Ramadan, Ebraheem Abdu Musad Saleh, Shaker Shanawa Al-Hasnawi, Rosario Mireya Romero-Parra, Ali Alsaalamy, Yasser Fakri Mustafa, Mohammad Yasin Zamanian, Maryam Golmohammad. A narrative review of the effects of dexamethasone on traumatic brain injury in clinical and animal studies: focusing on inflammation. Inflammopharmacology. 2023-10-16. PMID:37843641. |
considering the outcomes of this research, some of the effects of dxm on tbi include: (1) dxm-loaded hydrogels reduce apoptosis, neuroinflammation, and lesion volume and improves neuronal cell survival and motor performance, (2) dxm treatment elevates the levels of ndufs2, gria3, maob, and ndufv2 in the hippocampus following tbi, (3) dxm decreases the quantity of circulating endothelial progenitor cells, (4) dxm reduces the expression of il1, (5) dxm suppresses the infiltration of rhoa + cells into primary lesions of tbi and (6) dxm treatment led to an increase in fractional anisotropy values and a decrease in apparent diffusion coefficient values, indicating improved white matter integrity. |
2023-10-16 |
2023-11-08 |
Not clear |
| Ahmad H Alhowai. Pioglitazone ameliorates DOX-induced cognitive impairment by mitigating inflammation, oxidative stress, and apoptosis of hippocampal neurons in rats. Behavioural brain research. 2023-10-14. PMID:37838244. |
pioglitazone ameliorates dox-induced cognitive impairment by mitigating inflammation, oxidative stress, and apoptosis of hippocampal neurons in rats. |
2023-10-14 |
2023-11-08 |
rat |
| Zhenzhong Liu, Li Wang, Yue Wang, Siya Wu, Caiting Peng, Yu Wang, Ming Huang, Li Che, Rongjing Sun, Xi Zhao, Zuo Du, Wenhu Li. Quantitative Proteomics Reveals the Neurotoxicity of Trimethyltin Chloride on Mitochondria in the Hippocampus of Mice. Neurotoxicology. 2023-10-14. PMID:37838251. |
in conclusion, our findings suggest that impairment of mitochondrial respiratory chain transport and promotion of apoptosis are the potential mechanisms of tmt induced hippocampus toxicity in mice. |
2023-10-14 |
2023-11-08 |
mouse |