| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qi Zhang, Yanan Li, Xupeng Wang, Chunping Yin, Qi Zhou, Junfei Guo, Juan Zhao, Xiaohui Xian, Zhiyong Hou, Qiujun Wan. Sevoflurane exposure causes neuronal apoptosis and cognitive dysfunction by inducing ER stress Frontiers in aging neuroscience. vol 14. 2022-11-07. PMID:36337694. |
therefore, in this study, we investigated the role of the ip3r in endoplasmic reticulum (er) stress and hippocampal neuronal apoptosis induced by sevoflurane in aged rats and isolated hippocampal neurons using both |
2022-11-07 |
2023-08-14 |
rat |
| Fang Chen, Xiaofeng Wu, Jiayong Yang, Xuben Yu, Bili Liu, Zhiwen Ya. Hippocampal Galectin-3 knockdown alleviates lipopolysaccharide-induced neurotoxicity and cognitive deficits by inhibiting TLR4/NF-кB signaling in aged mice. European journal of pharmacology. 2022-11-06. PMID:36336009. |
to determine the effects of hippocampal gal-3 knockdown on neuroinflammatory response and neuronal apoptosis, we assessed the effects of gal-3 silencing on the levels of pro-inflammatory cytokines, microglial activation, and apoptosis in the hippocampus of lps-exposed aged mice. |
2022-11-06 |
2023-08-14 |
mouse |
| Fang Chen, Xiaofeng Wu, Jiayong Yang, Xuben Yu, Bili Liu, Zhiwen Ya. Hippocampal Galectin-3 knockdown alleviates lipopolysaccharide-induced neurotoxicity and cognitive deficits by inhibiting TLR4/NF-кB signaling in aged mice. European journal of pharmacology. 2022-11-06. PMID:36336009. |
these analyses showed that hippocampal gal-3 knockdown attenuated neuroinflammation and neuronal apoptosis in the hippocampus of lps-challenged aged mice, and this was associated with improved cognitive function. |
2022-11-06 |
2023-08-14 |
mouse |
| Yi Tian, Meihui Li, Shanshan Zhang, Juntao Hu, Haoran Wu, Mitchell Wan, Jingxin Xue, Leilei Wang, Honglei Xiao, Guomin Zhou, Kaidi Wang, Qiong Li. Microglia activation in the hippocampus mediates retinal degeneration-induced depressive-like behaviors via the NLRP3/IL-1β pathway. Brain research bulletin. 2022-11-04. PMID:36332880. |
excessive neuroinflammation has been shown to participate in glaucoma-induced retinal degeneration and hippocampal neural apoptosis in depression. |
2022-11-04 |
2023-08-14 |
mouse |
| Yue Ming, Zhihui Deng, Xianhua Tian, Yuerong Jia, Meng Ning, Shuhua Chen. m6A Methyltransferase METTL3 Reduces Hippocampal Neuron Apoptosis in a Mouse Model of Autism Through the MALAT1/SFRP2/Wnt/β-catenin Axis. Psychiatry investigation. vol 19. issue 10. 2022-11-03. PMID:36327957. |
m6a methyltransferase mettl3 reduces hippocampal neuron apoptosis in a mouse model of autism through the malat1/sfrp2/wnt/β-catenin axis. |
2022-11-03 |
2023-08-14 |
mouse |
| Yue Ming, Zhihui Deng, Xianhua Tian, Yuerong Jia, Meng Ning, Shuhua Chen. m6A Methyltransferase METTL3 Reduces Hippocampal Neuron Apoptosis in a Mouse Model of Autism Through the MALAT1/SFRP2/Wnt/β-catenin Axis. Psychiatry investigation. vol 19. issue 10. 2022-11-03. PMID:36327957. |
hippocampal neuron apoptosis contributes to autism, while mettl3 has been documented to possess great potentials in neuron apoptosis. |
2022-11-03 |
2023-08-14 |
mouse |
| Zhujun Mei, LinLing Huang, Wei Ra. CircNUFIP2 overexpression induces GDF11 to ameliorate oxygen-glucose deprivation-induced hippocampal neuron cell apoptosis and oxidative stress after cerebral ischemia. Neurological research. 2022-11-03. PMID:36328251. |
circnufip2 overexpression induces gdf11 to ameliorate oxygen-glucose deprivation-induced hippocampal neuron cell apoptosis and oxidative stress after cerebral ischemia. |
2022-11-03 |
2023-08-14 |
mouse |
| Yingjun Zhu, Min Zhang, Jiayu Wang, Qingxiu Wan. Lin28A Reduced Sevoflurane-Induced Nerve Injury and Cognitive Dysfunction by Inhibiting Tau Acetylation and Phosphorylation via Activating SIRT1 in Elderly Rats. Neurotoxicity research. 2022-11-02. PMID:36322362. |
learning and memory abilities were assessed by morris water maze (mwm) trainings; pathological alterations in hippocampal region were assessed by he staining; neuronal apoptosis was assessed by tunel; related protein expression was analyzed by immunofluorescence, immunohistochemistry, and western blotting. |
2022-11-02 |
2023-08-14 |
rat |
| Chih-Hung Wang, Chien-Hua Huang, Min-Shan Tsai, Chan-Chi Wang, Wei-Tien Chang, Shing-Hwa Liu, Wen-Jone Che. Inhaled Carbon Dioxide Improves Neurological Outcomes by Downregulating Hippocampal Autophagy and Apoptosis in an Asphyxia-Induced Cardiac Arrest and Resuscitation Rat Model. Journal of the American Heart Association. 2022-10-31. PMID:36314493. |
inhaled carbon dioxide improves neurological outcomes by downregulating hippocampal autophagy and apoptosis in an asphyxia-induced cardiac arrest and resuscitation rat model. |
2022-10-31 |
2023-08-14 |
rat |
| Bo Li, Ying Lu, Rong Wang, Tao Xu, Xiaolu Lei, Huan Jin, Xiaohong Gao, Ye Xie, Xiaohong Liu, Junwei Zen. MiR-29c Inhibits TNF-α-Induced ROS Production and Apoptosis in Mouse Hippocampal HT22 Cell Line. Neurochemical research. 2022-10-30. PMID:36309937. |
mir-29c inhibits tnf-α-induced ros production and apoptosis in mouse hippocampal ht22 cell line. |
2022-10-30 |
2023-08-14 |
mouse |
| Xintong Zhang, Yuan Cui, Xiaopeng Song, Xiaodi Jin, Xuanbo Sheng, Xinyu Xu, Ting Li, Hong Chen, Li Ga. Curcumin alleviates ketamine-induced oxidative stress and apoptosis via Nrf2 signaling pathway in rats' cerebral cortex and hippocampus. Environmental toxicology. 2022-10-28. PMID:36305173. |
curcumin alleviates ketamine-induced oxidative stress and apoptosis via nrf2 signaling pathway in rats' cerebral cortex and hippocampus. |
2022-10-28 |
2023-08-14 |
rat |
| Jingjing Shao, Xiaoxuan Ma, Linlin Qu, Pei Ma, Rong Huang, Daidi Fa. Ginsenoside Rh4 remodels the periphery microenvironment by targeting the brain-gut axis to alleviate depression-like behaviors. Food chemistry. vol 404. issue Pt B. 2022-10-25. PMID:36283312. |
concurrently, rh4 inhibits hippocampal neuronal apoptosis and synaptic structural damage due to the overexpression of proinflammatory cytokines and overactivation of microglia and astrocytes by inhibiting the immune-inflammatory response and signaling molecular interaction pathways. |
2022-10-25 |
2023-08-14 |
mouse |
| Expression of concern: Up-regulation of microRNA-223 inhibits brain injury and hippocampal neuron apoptosis of rats after febrile seizure through the NLRP3-Caspase-1 signaling pathway [Biomedicine & Pharmacotherapy 114 (2019) 108683]. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 155. 2022-10-22. PMID:36271529. |
expression of concern: up-regulation of microrna-223 inhibits brain injury and hippocampal neuron apoptosis of rats after febrile seizure through the nlrp3-caspase-1 signaling pathway [biomedicine & pharmacotherapy 114 (2019) 108683]. |
2022-10-22 |
2023-08-14 |
rat |
| Hua Xu, Yingpeng Ding, Xinyang Qi, Zhi-Jun Zhang, Jianhua S. Ameliorated Neurogenesis Deficits in Dentate Gyrus May Underly the Pronounced Antidepressant Effect of TREK-1 Potassium Channel Blockade in Rats with Depressive-like Behavior. ACS chemical neuroscience. 2022-10-21. PMID:36269040. |
antidepressant treatment restored the adult hippocampal neurodegeneration, which was impaired by chronic unpredicted mild stress displaying decreased proliferation and neuronal differentiation but increased apoptosis of newly formed neurons in dentate gyrus. |
2022-10-21 |
2023-08-14 |
rat |
| Yueh-Ting Tsai, Shung-Te Kao, Chin-Yi Chen. Medicinal Herbs and Their Derived Ingredients Protect against Cognitive Decline in In Vivo Models of Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232612. |
therefore, mhdis listed in this review protect against aβ-induced cognitive decline by inhibiting aβ accumulation, oxidative stress, tau hyperphosphorylation, inflammation, synaptic damage, and neuronal apoptosis in the cortex and hippocampus during the early and late ad phases. |
2022-10-14 |
2023-08-14 |
Not clear |
| Zijian Ma, Yang Ma, Xuefeng Cao, Yunpeng Zhang, Tieying Son. Avenanthramide-C Activates Nrf2/ARE Pathway and Inhibiting Ferroptosis Pathway to Improve Cognitive Dysfunction in Aging Rats. Neurochemical research. 2022-10-12. PMID:36222956. |
repeated propofol anesthesia could severely impair spatial learning ability, memory and cognitive function, and could promote hippocampal apoptosis, oxidative stress injury, neuroinflammation and ferroptosis in aging rats. |
2022-10-12 |
2023-08-14 |
rat |
| Zijian Ma, Yang Ma, Xuefeng Cao, Yunpeng Zhang, Tieying Son. Avenanthramide-C Activates Nrf2/ARE Pathway and Inhibiting Ferroptosis Pathway to Improve Cognitive Dysfunction in Aging Rats. Neurochemical research. 2022-10-12. PMID:36222956. |
in addition, avc not only improved cognitive dysfunction, but also significantly inhibited apoptosis, neuroinflammatory response, ferroptosis and oxidative stress level in the hippocampus of aging rats induced by repeated anesthesia. |
2022-10-12 |
2023-08-14 |
rat |
| Alessandra Borsini, Blair Merrick, Jonathan Edgeworth, Gargi Mandal, Deepak P Srivastava, Anthony C Vernon, Gaia Nebbia, Sandrine Thuret, Carmine M Pariant. Neurogenesis is disrupted in human hippocampal progenitor cells upon exposure to serum samples from hospitalized COVID-19 patients with neurological symptoms. Molecular psychiatry. 2022-10-04. PMID:36195636. |
moreover, increased concentration of il6 in serum samples from delirium patients stimulated the hippocampal cells to produce il12 and il13, and treatment with an antibody against il12 or il13 also prevented the decreased cell proliferation and neurogenesis, and the increased apoptosis. |
2022-10-04 |
2023-08-14 |
human |
| Lingang Wanga, Hui Zhang, Chenyao Xi. Down-regulation of miR-204-5p ameliorates sevoflurane-induced brain injury in neonatal rats through targeting VCAM1. Toxicology mechanisms and methods. 2022-09-30. PMID:36177783. |
these results suggest that down-regulation of mir-204-5p ameliorates sevoflurane-induced cognitive impairment and hippocampal pathology and inhibits neuronal autophagy and apoptosis by targeting vcam1. |
2022-09-30 |
2023-08-14 |
rat |
| Zhongyuan Zhou, Meng Wang, Chengyu Huang, Yan Li, Lin Gao, Yandong Zhu, Changjiang Ying, Xiaoyan Zho. Treadmill exercise training alleviates diabetes-induced depressive-like behavior and cognitive impairment by improving hippocampal CA1 neurons injury in db/db mice. Brain research bulletin. 2022-09-29. PMID:36174874. |
in summary, the results indicated that treadmill exercise training significantly ameliorates hippocampus injury by suppressing oxidative stress-induced apoptosis and nlrp3 inflammasome activation, consequently ameliorating diabetes-induced depressive-like behavior and cognitive impairment in db/db mice. |
2022-09-29 |
2023-08-14 |
mouse |