| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bin Yang, Ri-Sheng Liang, Xi-Yao Wu, Yao-Jing Li. LncRNA TUG1 inhibits neuronal apoptosis in status epilepticus rats via targeting the miR-421/mTOR axis. Cellular signalling. vol 76. 2021-11-29. PMID:33007387. |
se rat model was established and intervened with tug1 to evaluate hippocampal neuronal apoptosis. |
2021-11-29 |
2023-08-13 |
human |
| Bin Yang, Ri-Sheng Liang, Xi-Yao Wu, Yao-Jing Li. LncRNA TUG1 inhibits neuronal apoptosis in status epilepticus rats via targeting the miR-421/mTOR axis. Cellular signalling. vol 76. 2021-11-29. PMID:33007387. |
inhibition of tug1 relieved pathological injury, oxidative stress and inflammation and reduced neuronal apoptosis in se rats, which were further verified in hippocampal neurons. |
2021-11-29 |
2023-08-13 |
human |
| Bin Yang, Ri-Sheng Liang, Xi-Yao Wu, Yao-Jing Li. LncRNA TUG1 inhibits neuronal apoptosis in status epilepticus rats via targeting the miR-421/mTOR axis. Cellular signalling. vol 76. 2021-11-29. PMID:33007387. |
overexpressed mir-421 inhibited hippocampal neuronal apoptosis. |
2021-11-29 |
2023-08-13 |
human |
| Bin Yang, Ri-Sheng Liang, Xi-Yao Wu, Yao-Jing Li. LncRNA TUG1 inhibits neuronal apoptosis in status epilepticus rats via targeting the miR-421/mTOR axis. Cellular signalling. vol 76. 2021-11-29. PMID:33007387. |
tug1 knockout inactivated the mtor pathway via the mir-421/timp2 axis to relieve neuronal apoptosis, oxidative stress and inflammation in se rats and hippocampal neurons. |
2021-11-29 |
2023-08-13 |
human |
| Bin Yang, Ri-Sheng Liang, Xi-Yao Wu, Yao-Jing Li. LncRNA TUG1 inhibits neuronal apoptosis in status epilepticus rats via targeting the miR-421/mTOR axis. Cellular signalling. vol 76. 2021-11-29. PMID:33007387. |
taken together, these findings showed that downregulation of lncrna tug1 inhibited apoptosis of hippocampal neurons in se rats, and attenuated oxidative stress and inflammation damage through regulating the mir-421/mtor axis. |
2021-11-29 |
2023-08-13 |
human |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Hye Sun Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. Journal of cellular physiology. vol 236. issue 10. 2021-11-29. PMID:33754353. |
stat3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. |
2021-11-29 |
2023-08-13 |
mouse |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Hye Sun Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. Journal of cellular physiology. vol 236. issue 10. 2021-11-29. PMID:33754353. |
using a streptozotocin-induced type 1 dm model, we showed enhanced hippocampal neuronal apoptosis that was associated with increased stat3 activation. |
2021-11-29 |
2023-08-13 |
mouse |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Hye Sun Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. Journal of cellular physiology. vol 236. issue 10. 2021-11-29. PMID:33754353. |
we also took advantage of mice lacking stat3 in microglia and demonstrated that depletion of microglial stat3 reduced neuronal apoptosis in the diabetic hippocampus. |
2021-11-29 |
2023-08-13 |
mouse |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Hye Sun Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. Journal of cellular physiology. vol 236. issue 10. 2021-11-29. PMID:33754353. |
taken together, these results suggest that stat3 activation in microglia plays an important role in hyperglycemia-induced neuronal apoptosis in the diabetic hippocampus and provide a potential therapeutic benefit of stat3 inhibition in microglia for preventing diabetic neuronal lesions. |
2021-11-29 |
2023-08-13 |
mouse |
| HuaiMing Wang, YiQuan Xu, Shuying Zhu, XueMing Li, HongWei Zhan. Post-Treatment Sevoflurane Protects Against Hypoxic-Ischemic Brain Injury in Neonatal Rats by Downregulating Histone Methyltransferase G9a and Upregulating Nuclear Factor Erythroid 2-Related Factor 2 (NRF2). Medical science monitor : international medical journal of experimental and clinical research. vol 27. 2021-11-29. PMID:34059615. |
histological stainings were performed to observe the area of cerebral infarction, record the number of neurons in the hippocampus, and assess neuron apoptosis. |
2021-11-29 |
2023-08-13 |
rat |
| Ganggang Li, Shiyue Zhang, Yating Cheng, Ye Lu, Zhixia Jia, Xiaohui Yang, Shaodan Zhang, Wenxiang Guo, Lin Pe. Baicalin suppresses neuron autophagy and apoptosis by regulating astrocyte polarization in pentylenetetrazol-induced epileptic rats and PC12 cells. Brain research. vol 1774. 2021-11-29. PMID:34780748. |
in conclusion, these findings suggest that bal can prevents cognitive and emotional disorders and has antiepileptic effects in rats, which may be associated with suppresses neuron autophagy and apoptosis in the hippocampus via regulate astrocyte phenotypes. |
2021-11-29 |
2023-08-13 |
rat |
| Yang Sun, Can Zhao, Yuan-Yuan Liu, Yue-Lin Sui, Jian-Zhong Zh. [Effects of spicy leaves on cognitive function and apoptosis of hippocampal neurons in diabetic rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 37. issue 6. 2021-11-26. PMID:34821098. |
[effects of spicy leaves on cognitive function and apoptosis of hippocampal neurons in diabetic rats]. |
2021-11-26 |
2023-08-13 |
rat |
| Wenyue Wei, Yuyin Wang, Jing Zhang, Qingfang Gu, Xiaoqin Liu, Lijuan Song, Zhi Chai, Minfang Guo, Jiezhong Yu, Cungen M. Fasudil ameliorates cognitive deficits, oxidative stress and neuronal apoptosis via inhibiting ROCK/MAPK and activating Nrf2 signalling pathways in APP/PS1 mice. Folia neuropathologica. vol 59. issue 1. 2021-11-25. PMID:33969676. |
data from the present study demonstrate that fasudil significantly restored cognitive function, restrained oxidative stress and reduced neuronal apoptosis in the hippocampus, probably by inhibiting rock/mapk and activating nrf2 signalling pathways in app/ps1 mice. |
2021-11-25 |
2023-08-13 |
mouse |
| Deming Xu, Changbi Zhou, Juanyun Lin, Wenhui Cai, Wei Li. MicroRNA-367-3p suppresses sevoflurane-induced adult rat astrocyte apoptosis by targeting BCL2L11. Experimental and therapeutic medicine. vol 23. issue 1. 2021-11-25. PMID:34815761. |
notably, mir-367-3p reduced the expression of bcl2l11, thereby inhibiting the apoptosis of astrocytes originating from the hippocampal area of adult rats induced by sevoflurane. |
2021-11-25 |
2023-08-13 |
rat |
| Wei Wei, Zhentao Sun, Shifeng He, Wanyue Zhang, Sai Che. Protective role of dexmedetomidine against sevoflurane-induced postoperative cognitive dysfunction via the microRNA-129/TLR4 axis. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 92. 2021-11-24. PMID:34509269. |
then, the damage of hippocampus and cortex, and apoptosis and activity of neurons were examined. |
2021-11-24 |
2023-08-13 |
rat |
| Min Li, Junwen Hu, Yucong Peng, Jingbo Li, Reng Re. CircPTK2-miR-181c-5p-HMGB1: a new regulatory pathway for microglia activation and hippocampal neuronal apoptosis induced by sepsis. Molecular medicine (Cambridge, Mass.). vol 27. issue 1. 2021-11-23. PMID:33952191. |
circptk2-mir-181c-5p-hmgb1: a new regulatory pathway for microglia activation and hippocampal neuronal apoptosis induced by sepsis. |
2021-11-23 |
2023-08-13 |
mouse |
| Wen-Chong Sun, Ling Pe. Dexmedetomidine attenuates propofol-induced apoptosis of neonatal hippocampal astrocytes by inhibiting the Bcl2l1 signalling pathway. The European journal of neuroscience. 2021-11-23. PMID:34734676. |
dexmedetomidine attenuates propofol-induced apoptosis of neonatal hippocampal astrocytes by inhibiting the bcl2l1 signalling pathway. |
2021-11-23 |
2023-08-13 |
Not clear |
| Thiago G Bassi, Elizabeth C Rohrs, Karl C Fernandez, Marlena Ornowska, Michelle Nicholas, Matt Gani, Doug Evans, Steven C Reynold. Brain injury after 50 h of lung-protective mechanical ventilation in a preclinical model. Scientific reports. vol 11. issue 1. 2021-11-22. PMID:33658581. |
our group wanted to explore the extent of brain injury after 50 h of mechanical ventilation, sedation and physical immobility, quantifying hippocampal apoptosis and inflammation, in a normal-lung porcine study. |
2021-11-22 |
2023-08-13 |
Not clear |
| Thiago G Bassi, Elizabeth C Rohrs, Karl C Fernandez, Marlena Ornowska, Michelle Nicholas, Matt Gani, Doug Evans, Steven C Reynold. Brain injury after 50 h of lung-protective mechanical ventilation in a preclinical model. Scientific reports. vol 11. issue 1. 2021-11-22. PMID:33658581. |
after 50 h of lung-protective mechanical ventilation, sedation and immobility, greater levels of hippocampal apoptosis and neuroinflammation were clearly observed in the mechanically ventilated group, in comparison to a never-ventilated group. |
2021-11-22 |
2023-08-13 |
Not clear |
| Liang Han, Yanhao Xu, Yuxiu Sh. Molecular Mechanism of the ATF6α/S1P/S2P Signaling Pathway in Hippocampal Neuronal Apoptosis in SPS Rats. Journal of molecular neuroscience : MN. vol 71. issue 12. 2021-11-19. PMID:33738762. |
molecular mechanism of the atf6α/s1p/s2p signaling pathway in hippocampal neuronal apoptosis in sps rats. |
2021-11-19 |
2023-08-13 |
rat |