| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fatemeh Panahzadeh, Rahim Mirnasouri, Masoud Rahmat. Exercise and Syzygium aromaticum reverse memory deficits, apoptosis and mitochondrial dysfunction of the hippocampus in Alzheimer's disease. Journal of ethnopharmacology. 2021-12-02. PMID:34856360. |
exercise and syzygium aromaticum reverse memory deficits, apoptosis and mitochondrial dysfunction of the hippocampus in alzheimer's disease. |
2021-12-02 |
2023-08-13 |
Not clear |
| Reza Yakhkeshi, Fatemeh Roshani, Kobra Akhoundzadeh, Sakineh Shafi. Effect of treadmill exercise on serum corticosterone, serum and hippocampal BDNF, hippocampal apoptosis and anxiety behavior in an ovariectomized rat model of post-traumatic stress disorder (PTSD). Physiology & behavior. vol 243. 2021-11-30. PMID:34743976. |
effect of treadmill exercise on serum corticosterone, serum and hippocampal bdnf, hippocampal apoptosis and anxiety behavior in an ovariectomized rat model of post-traumatic stress disorder (ptsd). |
2021-11-30 |
2023-08-13 |
rat |
| Yuting Cui, Yue Xiong, Hua Li, Mengqi Zeng, Yan Wang, Yuan Li, Xuan Zou, Weiqiang Lv, Jing Gao, Ruijun Cao, Lingjie Meng, Jiangang Long, Jiankang Liu, Zhihui Fen. Chalcone-Derived Nrf2 Activator Protects Cognitive Function via Maintaining Neuronal Redox Status. Antioxidants (Basel, Switzerland). vol 10. issue 11. 2021-11-30. PMID:34829682. |
in addition, consistent benefits are also observed in an energy stress mouse model under a high-fat diet, as the administration of tak remarkably increases akt signaling-mediated antioxidative enzyme expression and prevents hippocampal neuronal apoptosis without significant effect on the mouse metabolic status. |
2021-11-30 |
2023-08-13 |
mouse |
| Bin Yang, Ri-Sheng Liang, Xi-Yao Wu, Yao-Jing Li. LncRNA TUG1 inhibits neuronal apoptosis in status epilepticus rats via targeting the miR-421/mTOR axis. Cellular signalling. vol 76. 2021-11-29. PMID:33007387. |
status epilepticus (se) induces apoptosis of hippocampal neurons. |
2021-11-29 |
2023-08-13 |
human |
| Bin Yang, Ri-Sheng Liang, Xi-Yao Wu, Yao-Jing Li. LncRNA TUG1 inhibits neuronal apoptosis in status epilepticus rats via targeting the miR-421/mTOR axis. Cellular signalling. vol 76. 2021-11-29. PMID:33007387. |
in present study, we aimed to investigate whether lncrna tug1 induces apoptosis of hippocampal neurons in se rat models. |
2021-11-29 |
2023-08-13 |
human |
| Bin Yang, Ri-Sheng Liang, Xi-Yao Wu, Yao-Jing Li. LncRNA TUG1 inhibits neuronal apoptosis in status epilepticus rats via targeting the miR-421/mTOR axis. Cellular signalling. vol 76. 2021-11-29. PMID:33007387. |
se rat model was established and intervened with tug1 to evaluate hippocampal neuronal apoptosis. |
2021-11-29 |
2023-08-13 |
human |
| Bin Yang, Ri-Sheng Liang, Xi-Yao Wu, Yao-Jing Li. LncRNA TUG1 inhibits neuronal apoptosis in status epilepticus rats via targeting the miR-421/mTOR axis. Cellular signalling. vol 76. 2021-11-29. PMID:33007387. |
inhibition of tug1 relieved pathological injury, oxidative stress and inflammation and reduced neuronal apoptosis in se rats, which were further verified in hippocampal neurons. |
2021-11-29 |
2023-08-13 |
human |
| Bin Yang, Ri-Sheng Liang, Xi-Yao Wu, Yao-Jing Li. LncRNA TUG1 inhibits neuronal apoptosis in status epilepticus rats via targeting the miR-421/mTOR axis. Cellular signalling. vol 76. 2021-11-29. PMID:33007387. |
overexpressed mir-421 inhibited hippocampal neuronal apoptosis. |
2021-11-29 |
2023-08-13 |
human |
| Bin Yang, Ri-Sheng Liang, Xi-Yao Wu, Yao-Jing Li. LncRNA TUG1 inhibits neuronal apoptosis in status epilepticus rats via targeting the miR-421/mTOR axis. Cellular signalling. vol 76. 2021-11-29. PMID:33007387. |
tug1 knockout inactivated the mtor pathway via the mir-421/timp2 axis to relieve neuronal apoptosis, oxidative stress and inflammation in se rats and hippocampal neurons. |
2021-11-29 |
2023-08-13 |
human |
| Bin Yang, Ri-Sheng Liang, Xi-Yao Wu, Yao-Jing Li. LncRNA TUG1 inhibits neuronal apoptosis in status epilepticus rats via targeting the miR-421/mTOR axis. Cellular signalling. vol 76. 2021-11-29. PMID:33007387. |
taken together, these findings showed that downregulation of lncrna tug1 inhibited apoptosis of hippocampal neurons in se rats, and attenuated oxidative stress and inflammation damage through regulating the mir-421/mtor axis. |
2021-11-29 |
2023-08-13 |
human |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Hye Sun Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. Journal of cellular physiology. vol 236. issue 10. 2021-11-29. PMID:33754353. |
stat3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. |
2021-11-29 |
2023-08-13 |
mouse |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Hye Sun Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. Journal of cellular physiology. vol 236. issue 10. 2021-11-29. PMID:33754353. |
using a streptozotocin-induced type 1 dm model, we showed enhanced hippocampal neuronal apoptosis that was associated with increased stat3 activation. |
2021-11-29 |
2023-08-13 |
mouse |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Hye Sun Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. Journal of cellular physiology. vol 236. issue 10. 2021-11-29. PMID:33754353. |
we also took advantage of mice lacking stat3 in microglia and demonstrated that depletion of microglial stat3 reduced neuronal apoptosis in the diabetic hippocampus. |
2021-11-29 |
2023-08-13 |
mouse |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Hye Sun Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. Journal of cellular physiology. vol 236. issue 10. 2021-11-29. PMID:33754353. |
taken together, these results suggest that stat3 activation in microglia plays an important role in hyperglycemia-induced neuronal apoptosis in the diabetic hippocampus and provide a potential therapeutic benefit of stat3 inhibition in microglia for preventing diabetic neuronal lesions. |
2021-11-29 |
2023-08-13 |
mouse |
| HuaiMing Wang, YiQuan Xu, Shuying Zhu, XueMing Li, HongWei Zhan. Post-Treatment Sevoflurane Protects Against Hypoxic-Ischemic Brain Injury in Neonatal Rats by Downregulating Histone Methyltransferase G9a and Upregulating Nuclear Factor Erythroid 2-Related Factor 2 (NRF2). Medical science monitor : international medical journal of experimental and clinical research. vol 27. 2021-11-29. PMID:34059615. |
histological stainings were performed to observe the area of cerebral infarction, record the number of neurons in the hippocampus, and assess neuron apoptosis. |
2021-11-29 |
2023-08-13 |
rat |
| Ganggang Li, Shiyue Zhang, Yating Cheng, Ye Lu, Zhixia Jia, Xiaohui Yang, Shaodan Zhang, Wenxiang Guo, Lin Pe. Baicalin suppresses neuron autophagy and apoptosis by regulating astrocyte polarization in pentylenetetrazol-induced epileptic rats and PC12 cells. Brain research. vol 1774. 2021-11-29. PMID:34780748. |
in conclusion, these findings suggest that bal can prevents cognitive and emotional disorders and has antiepileptic effects in rats, which may be associated with suppresses neuron autophagy and apoptosis in the hippocampus via regulate astrocyte phenotypes. |
2021-11-29 |
2023-08-13 |
rat |
| Yang Sun, Can Zhao, Yuan-Yuan Liu, Yue-Lin Sui, Jian-Zhong Zh. [Effects of spicy leaves on cognitive function and apoptosis of hippocampal neurons in diabetic rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 37. issue 6. 2021-11-26. PMID:34821098. |
[effects of spicy leaves on cognitive function and apoptosis of hippocampal neurons in diabetic rats]. |
2021-11-26 |
2023-08-13 |
rat |
| Wenyue Wei, Yuyin Wang, Jing Zhang, Qingfang Gu, Xiaoqin Liu, Lijuan Song, Zhi Chai, Minfang Guo, Jiezhong Yu, Cungen M. Fasudil ameliorates cognitive deficits, oxidative stress and neuronal apoptosis via inhibiting ROCK/MAPK and activating Nrf2 signalling pathways in APP/PS1 mice. Folia neuropathologica. vol 59. issue 1. 2021-11-25. PMID:33969676. |
data from the present study demonstrate that fasudil significantly restored cognitive function, restrained oxidative stress and reduced neuronal apoptosis in the hippocampus, probably by inhibiting rock/mapk and activating nrf2 signalling pathways in app/ps1 mice. |
2021-11-25 |
2023-08-13 |
mouse |
| Deming Xu, Changbi Zhou, Juanyun Lin, Wenhui Cai, Wei Li. MicroRNA-367-3p suppresses sevoflurane-induced adult rat astrocyte apoptosis by targeting BCL2L11. Experimental and therapeutic medicine. vol 23. issue 1. 2021-11-25. PMID:34815761. |
notably, mir-367-3p reduced the expression of bcl2l11, thereby inhibiting the apoptosis of astrocytes originating from the hippocampal area of adult rats induced by sevoflurane. |
2021-11-25 |
2023-08-13 |
rat |
| Wei Wei, Zhentao Sun, Shifeng He, Wanyue Zhang, Sai Che. Protective role of dexmedetomidine against sevoflurane-induced postoperative cognitive dysfunction via the microRNA-129/TLR4 axis. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 92. 2021-11-24. PMID:34509269. |
then, the damage of hippocampus and cortex, and apoptosis and activity of neurons were examined. |
2021-11-24 |
2023-08-13 |
rat |