| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shanshan Liu, Qing Liu, Yanjie Ju, Lei Li. Downregulation of miR-383 reduces depression-like behavior through targeting Wnt family member 2 (Wnt2) in rats. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:33927285. |
downregulation of mir-383 significantly inhibited the apoptosis and inflammatory response of hippocampal neurons, and increased the expression levels of gfap, bdnf and creb which were impacted in depression, as well as neurotransmitters, then attenuated neural injury in rats induced by cums. |
2021-11-08 |
2023-08-13 |
rat |
| Shanshan Liu, Qing Liu, Yanjie Ju, Lei Li. Downregulation of miR-383 reduces depression-like behavior through targeting Wnt family member 2 (Wnt2) in rats. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:33927285. |
furthermore, wnt family member 2 (wnt2) was identified as a target of mir-383, and silencing of wnt2 obviously attenuated the protective effect of mir-383 inhibitor on the apoptosis and inflammatory response in hippocampal neurons, as well as neural injury in cums-induced rats. |
2021-11-08 |
2023-08-13 |
rat |
| Suchan Liao, Nattayaporn Apaijai, Ying Luo, Jun Wu, Titikorn Chunchai, Kodchanan Singhanat, Busarin Arunsak, Juthipong Benjanuwattra, Nipon Chattipakorn, Siriporn C Chattipakor. Cell death inhibitors protect against brain damage caused by cardiac ischemia/reperfusion injury. Cell death discovery. vol 7. issue 1. 2021-11-05. PMID:34689160. |
our data showed that cardiac i/r led to brain damage and only apoptosis occurred in the hippocampus after cardiac i/r injury. |
2021-11-05 |
2023-08-13 |
rat |
| Suchan Liao, Nattayaporn Apaijai, Ying Luo, Jun Wu, Titikorn Chunchai, Kodchanan Singhanat, Busarin Arunsak, Juthipong Benjanuwattra, Nipon Chattipakorn, Siriporn C Chattipakor. Cell death inhibitors protect against brain damage caused by cardiac ischemia/reperfusion injury. Cell death discovery. vol 7. issue 1. 2021-11-05. PMID:34689160. |
in the cardiac i/r group, treatment with m-z-vad and all doses of nec-1 decreased hippocampal apoptosis and amyloid beta aggregation, thereby reducing dendritic spine loss. |
2021-11-05 |
2023-08-13 |
rat |
| Yushan Cui, Bin Zhang, Zushan Zhang, Junyan Nie, Hongliang Li. Long-term repetitive exposure to excess iodine induces mitochondrial apoptosis, and alters monoamine neurotransmitters in hippocampus of rats of different genders. Toxicology research. vol 10. issue 5. 2021-11-05. PMID:34733482. |
long-term repetitive exposure to excess iodine induces mitochondrial apoptosis, and alters monoamine neurotransmitters in hippocampus of rats of different genders. |
2021-11-05 |
2023-08-13 |
human |
| Jing-Hua Zhang, Jin-Feng Zhang, Jun Song, Yu Bai, Lan Deng, Chun-Peng Feng, Xin-Yao Xu, Hong-Xia Guo, Yi Wang, Xin Gao, Yan Gu, Chuan Jin, Jun-Fu Zheng, Zhong Zhen, Hao S. Effects of Berberine on Diabetes and Cognitive Impairment in an Animal Model: The Mechanisms of Action. The American journal of Chinese medicine. vol 49. issue 6. 2021-11-04. PMID:34137676. |
the tunel assay confirmed that berberine reduced hippocampal neuronal apoptosis supported by tem. |
2021-11-04 |
2023-08-13 |
rat |
| Jing-Hua Zhang, Jin-Feng Zhang, Jun Song, Yu Bai, Lan Deng, Chun-Peng Feng, Xin-Yao Xu, Hong-Xia Guo, Yi Wang, Xin Gao, Yan Gu, Chuan Jin, Jun-Fu Zheng, Zhong Zhen, Hao S. Effects of Berberine on Diabetes and Cognitive Impairment in an Animal Model: The Mechanisms of Action. The American journal of Chinese medicine. vol 49. issue 6. 2021-11-04. PMID:34137676. |
the reduction of neuronal injury, a[formula: see text] deposition, abnormal phosphorylation of tau protein, and neuronal apoptosis in the hippocampus were observed as the related mechanisms of action. |
2021-11-04 |
2023-08-13 |
rat |
| Chang-Hai Fu, Xue-Yan Han, Lei Tong, Peng-Yin Nie, Yue-Dong Hu, Li-Li J. miR-142 downregulation alleviates the impairment of spatial learning and memory, reduces the level of apoptosis, and upregulates the expression of pCaMKII and BAI3 in the hippocampus of APP/PS1 transgenic mice. Behavioural brain research. vol 414. 2021-11-04. PMID:34302879. |
mir-142 downregulation alleviates the impairment of spatial learning and memory, reduces the level of apoptosis, and upregulates the expression of pcamkii and bai3 in the hippocampus of app/ps1 transgenic mice. |
2021-11-04 |
2023-08-13 |
mouse |
| Javad Mahmoudi, Leila Hosseini, Saeed Sadigh-Eteghad, Fereshteh Farajdokht, Seyed Mehdi Vatandoust, Mojtaba Ziae. Sericin Alleviates Thermal Stress Induced Anxiety-Like Behavior and Cognitive Impairment Through Regulation of Oxidative Stress, Apoptosis, and Heat-Shock Protein-70 in the Hippocampus. Neurochemical research. vol 46. issue 9. 2021-11-03. PMID:34089443. |
sericin alleviates thermal stress induced anxiety-like behavior and cognitive impairment through regulation of oxidative stress, apoptosis, and heat-shock protein-70 in the hippocampus. |
2021-11-03 |
2023-08-13 |
mouse |
| Javad Mahmoudi, Leila Hosseini, Saeed Sadigh-Eteghad, Fereshteh Farajdokht, Seyed Mehdi Vatandoust, Mojtaba Ziae. Sericin Alleviates Thermal Stress Induced Anxiety-Like Behavior and Cognitive Impairment Through Regulation of Oxidative Stress, Apoptosis, and Heat-Shock Protein-70 in the Hippocampus. Neurochemical research. vol 46. issue 9. 2021-11-03. PMID:34089443. |
sericin administration decreased serum corticosterone and enhanced hippocampal antioxidant defense and attenuated apoptosis and hsp-70 levels. |
2021-11-03 |
2023-08-13 |
mouse |
| Xiumin Liu, Chenkang Wang, Weiwei Liu, Siaoyu Song, Jianing Fu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejim. Oral Administration of Silibinin Ameliorates Cognitive Deficits of Parkinson's Disease Mouse Model by Restoring Mitochondrial Disorders in Hippocampus. Neurochemical research. vol 46. issue 9. 2021-11-03. PMID:34097239. |
however, these mice were protected by oral administration of silibinin, accompanying reduction in the cell apoptosis in the hippocampus. |
2021-11-03 |
2023-08-13 |
mouse |
| Jingxiong Zhang, Mingsheng Zhu, Jie Zhan. Pachypodol protects newborn rats from anaesthesia-induced apoptosis in the developing brain by regulating the JNK/ERK pathway. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 81. issue 7. 2021-11-02. PMID:34198359. |
additionally, a terminal deoxynucleotidyl transferase dutp nick-end labelling (tunel) assay was performed to assess neuronal cell apoptosis in several regions of the hippocampus. |
2021-11-02 |
2023-08-13 |
rat |
| Sayad Kocahan, Kubra Akillioglu, Leman Sencar, Leyla Sahin, Ozge Selin Cevik, Eylem Taskin, Celal Guven, Ayper Boga, Sait Pola. Living with female rats exposed to restraint stress during pregnancy caused depressive-like behavior in male rats and stress-induced apoptosis. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 81. issue 7. 2021-11-02. PMID:34228828. |
the purpose of this study investigates emotional behavior and hippocampal apoptosis alterations of the male live with a postpartum depressed female. |
2021-11-02 |
2023-08-13 |
rat |
| Retraction. Journal of cellular biochemistry. vol 122 Suppl 1. 2021-11-01. PMID:34191317. |
retraction: "rna interference-mediated silencing of s100b improves nerve function recovery and inhibits hippocampal cell apoptosis in rat models of ischemic stroke," by jin-hua zhang, jiang-kun li, li-li ma, ji-yu lou, j cell biochem. |
2021-11-01 |
2023-08-13 |
rat |
| Caitlin A Finney, Artur Shvetcov, R Frederick Westbrook, Margaret J Morris, Nicole M Jone. The selective estrogen receptor modulator tamoxifen protects against subtle cognitive decline and early markers of injury 24 h after hippocampal silent infarct in male Sprague-Dawley rats. Hormones and behavior. vol 134. 2021-11-01. PMID:34242875. |
si did not lead to detectable hippocampal cell loss but increased apoptosis, astrogliosis, microgliosis and inflammation. |
2021-11-01 |
2023-08-13 |
rat |
| Caitlin A Finney, Artur Shvetcov, R Frederick Westbrook, Margaret J Morris, Nicole M Jone. The selective estrogen receptor modulator tamoxifen protects against subtle cognitive decline and early markers of injury 24 h after hippocampal silent infarct in male Sprague-Dawley rats. Hormones and behavior. vol 134. 2021-11-01. PMID:34242875. |
tamoxifen mitigates apoptosis, gliosis, and inflammation and normalization of er levels in the ca1, leading to improved cognitive outcomes after hippocampal si. |
2021-11-01 |
2023-08-13 |
rat |
| Xing Ge, Yong Zuo, Jinhong Xie, Xincheng Li, Yan Li, Anand Thirupathi, Peng Yu, Guofen Gao, Changhao Zhou, Yanzhong Chang, Zhenhua Sh. A new mechanism of POCD caused by sevoflurane in mice: cognitive impairment induced by cross-dysfunction of iron and glucose metabolism. Aging. vol 13. issue 18. 2021-11-01. PMID:34547719. |
the cross-dysfunction of iron and glucose metabolism caused the apoptosis in the cortex and hippocampus through bcl2/bax pathway. |
2021-11-01 |
2023-08-13 |
mouse |
| Ying Zhou, Qiuyun Tian, Chenfei Zheng, Jinge Yang, Junming Fan, Yangping Shent. Myocardial infarction-induced anxiety-like behavior is associated with epigenetic alterations in the hippocampus of rat. Brain research bulletin. vol 164. 2021-10-29. PMID:32871241. |
in addition, mi not only increased levels of il-1β, bax, and cleaved-caspase 3, but also increased iba-1 and gfap expression in the hippocampus, as compared to those in controls, suggesting a promotion of neuro-inflammation and apoptosis in hippocampus. |
2021-10-29 |
2023-08-13 |
rat |
| Luting Poh, David Y Fann, Peiyan Wong, Hong Meng Lim, Sok Lin Foo, Sung-Wook Kang, Vismitha Rajeev, Sharmelee Selvaraji, Vinaya Rajagopal Iyer, Nageiswari Parathy, Mohammad Badruzzaman Khan, David C Hess, Dong-Gyu Jo, Grant R Drummond, Christopher G Sobey, Mitchell K P Lai, Christopher Li-Hsian Chen, Lina H K Lim, Thiruma V Arumuga. AIM2 inflammasome mediates hallmark neuropathological alterations and cognitive impairment in a mouse model of vascular dementia. Molecular psychiatry. vol 26. issue 8. 2021-10-28. PMID:33299135. |
moreover, in aim2 knockout mice we observed attenuated inflammasome-mediated production of proinflammatory cytokines, apoptosis, and pyroptosis, as well as resistance to chronic microglial activation, myelin breakdown, hippocampal neuronal loss, and behavioral and cognitive deficits following bcas. |
2021-10-28 |
2023-08-13 |
mouse |
| Yunhai Tao, Kerun Gao, Bianhong Shen, Kaiyuan Zhang, Zhiwen Zhang, Chengpeng Wan. MicroRNA-135b-5p Downregulation Causes Antidepressant Effects by Regulating SIRT1 Expression. Biochemical genetics. vol 59. issue 6. 2021-10-28. PMID:33999341. |
concomitantly, the results indicated that the mir-135b-5p inhibitor inhibited cums-induced hippocampal cell apoptosis and significantly reduced the expression levels of cleaved caspase-3 and the ratio of cleaved caspase-3/caspase-3. |
2021-10-28 |
2023-08-13 |
mouse |