| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jian Liu, Lin Liu, Yuan-Shan Han, Jian Yi, Chun Guo, Hong-Qing Zhao, Jia Ling, Yu-Hong Wan. The molecular mechanism underlying mitophagy-mediated hippocampal neuron apoptosis in diabetes-related depression. Journal of cellular and molecular medicine. vol 25. issue 15. 2021-10-15. PMID:34213839. |
our previous studies indicated that glutamate (glu) and hippocampal neuron apoptosis are key signal and direct factor leading to diabetes-related depression, respectively. |
2021-10-15 |
2023-08-13 |
rat |
| Jian Liu, Lin Liu, Yuan-Shan Han, Jian Yi, Chun Guo, Hong-Qing Zhao, Jia Ling, Yu-Hong Wan. The molecular mechanism underlying mitophagy-mediated hippocampal neuron apoptosis in diabetes-related depression. Journal of cellular and molecular medicine. vol 25. issue 15. 2021-10-15. PMID:34213839. |
we hypothesized that diabetes-related depression might be associated with the mitophagy-mediated hippocampal neuron apoptosis, triggered by aberrant glu-glutamate receptor2 (glur2)-parkin pathway. |
2021-10-15 |
2023-08-13 |
rat |
| Jian Liu, Lin Liu, Yuan-Shan Han, Jian Yi, Chun Guo, Hong-Qing Zhao, Jia Ling, Yu-Hong Wan. The molecular mechanism underlying mitophagy-mediated hippocampal neuron apoptosis in diabetes-related depression. Journal of cellular and molecular medicine. vol 25. issue 15. 2021-10-15. PMID:34213839. |
we found that dd rats exhibit an elevated glutamate levels followed by monoamine neurotransmitter deficiency and depressive-like behaviour, and dd modelling promoted autophagosome formation and caused mitochondrial impairment, eventually leading to hippocampal neuron apoptosis via aberrant glu-glur2-parkin pathway. |
2021-10-15 |
2023-08-13 |
rat |
| Jian Liu, Lin Liu, Yuan-Shan Han, Jian Yi, Chun Guo, Hong-Qing Zhao, Jia Ling, Yu-Hong Wan. The molecular mechanism underlying mitophagy-mediated hippocampal neuron apoptosis in diabetes-related depression. Journal of cellular and molecular medicine. vol 25. issue 15. 2021-10-15. PMID:34213839. |
interestingly, both glur2 and mammalian target of rapamycin (mtor) receptor blocker aggravated mitophagy-induced hippocampal neuron apoptosis and abnormal expression of apoptotic protein. |
2021-10-15 |
2023-08-13 |
rat |
| Jian Liu, Lin Liu, Yuan-Shan Han, Jian Yi, Chun Guo, Hong-Qing Zhao, Jia Ling, Yu-Hong Wan. The molecular mechanism underlying mitophagy-mediated hippocampal neuron apoptosis in diabetes-related depression. Journal of cellular and molecular medicine. vol 25. issue 15. 2021-10-15. PMID:34213839. |
our findings revealed that mitophagy-mediated hippocampal neuron apoptosis, triggered by aberrant glu-glur2-parkin pathway, is responsible for depressive-like behaviour and monoamine neurotransmitter deficiency in dd rats. |
2021-10-15 |
2023-08-13 |
rat |
| Fan Zhao, Chenyiyu Zhang, Dong Xiao, Weihua Zhang, Liping Zhou, Simeng Gu, Rong Q. Radix Scutellariae Ameliorates Stress-Induced Depressive-Like Behaviors via Protecting Neurons through the TGF Neural plasticity. vol 2020. 2021-10-14. PMID:33273910. |
radix scutellariae ameliorates stress-induced depressive-like behaviors via protecting neurons through the tgf chronic stress can impair hippocampal neurogenesis, increase neuronal apoptosis, and cause depressive-like behaviors. |
2021-10-14 |
2023-08-13 |
mouse |
| Kerstin Killer, Oanh Le, Christian Beauséjou. The Intracerebroventricular Injection of Murine Mesenchymal Stromal Cells Engineered to Secrete Epidermal Growth Factor Does Not Prevent Loss of Neurogenesis in Irradiated Mice. Radiation research. vol 196. issue 3. 2021-10-14. PMID:34107047. |
using transgenic mouse models, we previously showed that abrogation of radiation-induced senescence, or apoptosis, can partially rescue neurogenesis in the subventricular and hippocampus regions. |
2021-10-14 |
2023-08-13 |
mouse |
| Juhi Mishra, Jitendra Vishwakarma, Rafat Malik, Keerti Gupta, Rukmani Pandey, Shailendra Kumar Maurya, Asmita Garg, Manoj Shukla, Naibedya Chattopadhyay, Sanghamitra Bandyopadhya. Hypothyroidism Induces Interleukin-1-Dependent Autophagy Mechanism as a Key Mediator of Hippocampal Neuronal Apoptosis and Cognitive Decline in Postnatal Rats. Molecular neurobiology. vol 58. issue 3. 2021-10-13. PMID:33106949. |
hypothyroidism induces interleukin-1-dependent autophagy mechanism as a key mediator of hippocampal neuronal apoptosis and cognitive decline in postnatal rats. |
2021-10-13 |
2023-08-13 |
rat |
| Juhi Mishra, Jitendra Vishwakarma, Rafat Malik, Keerti Gupta, Rukmani Pandey, Shailendra Kumar Maurya, Asmita Garg, Manoj Shukla, Naibedya Chattopadhyay, Sanghamitra Bandyopadhya. Hypothyroidism Induces Interleukin-1-Dependent Autophagy Mechanism as a Key Mediator of Hippocampal Neuronal Apoptosis and Cognitive Decline in Postnatal Rats. Molecular neurobiology. vol 58. issue 3. 2021-10-13. PMID:33106949. |
here, we examined the molecular mechanism, hypothesizing the involvement of a deregulated autophagy and apoptosis pathway in hippocampal neurons that regulate cognitive functions. |
2021-10-13 |
2023-08-13 |
rat |
| Juhi Mishra, Jitendra Vishwakarma, Rafat Malik, Keerti Gupta, Rukmani Pandey, Shailendra Kumar Maurya, Asmita Garg, Manoj Shukla, Naibedya Chattopadhyay, Sanghamitra Bandyopadhya. Hypothyroidism Induces Interleukin-1-Dependent Autophagy Mechanism as a Key Mediator of Hippocampal Neuronal Apoptosis and Cognitive Decline in Postnatal Rats. Molecular neurobiology. vol 58. issue 3. 2021-10-13. PMID:33106949. |
we then linked these events with hypothyroidism-induced apoptosis and loss of hippocampal neurons, where we observed that like thyroxine, il-1ra and autophagy inhibitor, 3-methyladenine, reduced the cleaved caspase-3 and tunel-stained apoptotic neurons and enhanced nissl-stained neuronal count in methimazole-treated rats. |
2021-10-13 |
2023-08-13 |
rat |
| Zhi-Meng Wang, Cong Liu, Ying-Ying Wang, Yu-Sen Deng, Xuan-Cheng He, Hong-Zhen Du, Chang-Mei Liu, Zhao-Qian Ten. SerpinA3N deficiency deteriorates impairments of learning and memory in mice following hippocampal stab injury. Cell death discovery. vol 6. issue 1. 2021-10-13. PMID:34535636. |
here, we report that the serine protease inhibitor serpina3n is upregulated in hippocampal neurons in the early stage of hippocampal stab injury (hsi), while its deficiency causes a greater degree of neuronal apoptosis and severer impairments of spatial learning and memory in mice after hsi. |
2021-10-13 |
2023-08-13 |
mouse |
| M D Morsy, M A Alsaleem, M S Aboonq, S O Bashir, H A Al-Dahe. Acylated Ghrelin Administration Inhibits Sleeve Gastrectomy-Induced Hippocampal Oxidative Stress, Apoptosis and Tau-Hyperphosphorylation by Activating the PI3K/Akt Pathway. Folia biologica. vol 67. issue 2. 2021-10-12. PMID:34624937. |
acylated ghrelin administration inhibits sleeve gastrectomy-induced hippocampal oxidative stress, apoptosis and tau-hyperphosphorylation by activating the pi3k/akt pathway. |
2021-10-12 |
2023-08-13 |
rat |
| Li-Ling He, Yun-Cui Wang, Ya-Ting Ai, Ling Wang, Si-Meng Gu, Ping Wang, Qing-Hua Long, Hui H. Qiangji Decoction Alleviates Neurodegenerative Changes and Hippocampal Neuron Apoptosis Induced by D-Galactose Frontiers in pharmacology. vol 12. 2021-10-12. PMID:34630111. |
qiangji decoction alleviates neurodegenerative changes and hippocampal neuron apoptosis induced by d-galactose qiangji decoction (qjd), a classic formula, has been widely used to treat brain aging-related neurodegenerative diseases. |
2021-10-12 |
2023-08-13 |
mouse |
| Li-Ling He, Yun-Cui Wang, Ya-Ting Ai, Ling Wang, Si-Meng Gu, Ping Wang, Qing-Hua Long, Hui H. Qiangji Decoction Alleviates Neurodegenerative Changes and Hippocampal Neuron Apoptosis Induced by D-Galactose Frontiers in pharmacology. vol 12. 2021-10-12. PMID:34630111. |
next, we investigated qjd's effect on cognitive function of the model of brain aging and the mechanisms that qjd suppressing neuroinflammation as well as improving neurodegenerative changes and hippocampal neuron apoptosis. |
2021-10-12 |
2023-08-13 |
mouse |
| Li-Ling He, Yun-Cui Wang, Ya-Ting Ai, Ling Wang, Si-Meng Gu, Ping Wang, Qing-Hua Long, Hui H. Qiangji Decoction Alleviates Neurodegenerative Changes and Hippocampal Neuron Apoptosis Induced by D-Galactose Frontiers in pharmacology. vol 12. 2021-10-12. PMID:34630111. |
nissl staining and tunel staining were employed to detect the hippocampal neuron apoptosis. |
2021-10-12 |
2023-08-13 |
mouse |
| Li-Ling He, Yun-Cui Wang, Ya-Ting Ai, Ling Wang, Si-Meng Gu, Ping Wang, Qing-Hua Long, Hui H. Qiangji Decoction Alleviates Neurodegenerative Changes and Hippocampal Neuron Apoptosis Induced by D-Galactose Frontiers in pharmacology. vol 12. 2021-10-12. PMID:34630111. |
our findings showed that the qjd-treated groups, especially the m-qjd group, mitigated learning and memory impairments of the model of brain aging as well as the improvement of neurodegenerative changes and hippocampal neuron apoptosis. |
2021-10-12 |
2023-08-13 |
mouse |
| Li-Ling He, Yun-Cui Wang, Ya-Ting Ai, Ling Wang, Si-Meng Gu, Ping Wang, Qing-Hua Long, Hui H. Qiangji Decoction Alleviates Neurodegenerative Changes and Hippocampal Neuron Apoptosis Induced by D-Galactose Frontiers in pharmacology. vol 12. 2021-10-12. PMID:34630111. |
taken together, qjd alleviated neurodegenerative changes and hippocampal neuron apoptosis in the model of brain aging via regulating the ampk/sirt1/nf-κb signaling pathway. |
2021-10-12 |
2023-08-13 |
mouse |
| Yi-Liang Wang, Ying Zhang, Da-Sheng Ca. Dexmedetomidine Ameliorates Postoperative Cognitive Dysfunction via the MicroRNA-381-Mediated EGR1/p53 Axis. Molecular neurobiology. vol 58. issue 10. 2021-10-08. PMID:34245441. |
dex administration attenuated hippocampal neuron apoptosis, neuroinflammation, dna damage, and cognitive impairment in aged mice. |
2021-10-08 |
2023-08-13 |
mouse |
| Yi-Liang Wang, Ying Zhang, Da-Sheng Ca. Dexmedetomidine Ameliorates Postoperative Cognitive Dysfunction via the MicroRNA-381-Mediated EGR1/p53 Axis. Molecular neurobiology. vol 58. issue 10. 2021-10-08. PMID:34245441. |
mir-381 targeted egr1 and disrupted its interaction with p53, leading to a decline in hippocampal neuron apoptosis, dna damage, neuroinflammation, and cognitive impairment. |
2021-10-08 |
2023-08-13 |
mouse |
| Xuncui Wang, Wen Xu, Hejuntao Chen, Weizu Li, Weiping Li, Guoqi Zh. Astragaloside IV prevents Aβ Brain research. vol 1747. 2021-10-07. PMID:32739157. |
in vivo data further revealed that as-iv improved aβo-induced memory impairment and reduced apoptosis of hippocampal neurons. |
2021-10-07 |
2023-08-13 |
Not clear |