| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xuncui Wang, Wen Xu, Hejuntao Chen, Weizu Li, Weiping Li, Guoqi Zh. Astragaloside IV prevents Aβ Brain research. vol 1747. 2021-10-07. PMID:32739157. |
in vivo data further revealed that as-iv improved aβo-induced memory impairment and reduced apoptosis of hippocampal neurons. |
2021-10-07 |
2023-08-13 |
Not clear |
| Xuncui Wang, Wen Xu, Hejuntao Chen, Weizu Li, Weiping Li, Guoqi Zh. Astragaloside IV prevents Aβ Brain research. vol 1747. 2021-10-07. PMID:32739157. |
taken together, these results indicate that as-iv prevents aβo-induced memory impairment and hippocampal neuronal apoptosis, probably by promoting the pparγ/bdnf signaling pathway. |
2021-10-07 |
2023-08-13 |
Not clear |
| Peng-Yin Nie, Lei Tong, Ming-Da Li, Chang-Hai Fu, Jun-Bo Peng, Li-Li J. miR-142 downregulation alleviates rat PTSD-like behaviors, reduces the level of inflammatory cytokine expression and apoptosis in hippocampus, and upregulates the expression of fragile X mental retardation protein. Journal of neuroinflammation. vol 18. issue 1. 2021-10-07. PMID:33407653. |
mir-142 downregulation alleviates rat ptsd-like behaviors, reduces the level of inflammatory cytokine expression and apoptosis in hippocampus, and upregulates the expression of fragile x mental retardation protein. |
2021-10-07 |
2023-08-13 |
rat |
| Xia Niu, Hai-Ling Zhu, Qian Liu, Jing-Fen Yan, Mei-Lian L. MiR-194-5p serves as a potential biomarker and regulates the proliferation and apoptosis of hippocampus neuron in children with temporal lobe epilepsy. Journal of the Chinese Medical Association : JCMA. vol 84. issue 5. 2021-10-07. PMID:33742994. |
mir-194-5p serves as a potential biomarker and regulates the proliferation and apoptosis of hippocampus neuron in children with temporal lobe epilepsy. |
2021-10-07 |
2023-08-13 |
Not clear |
| Hamid Soltani Zangbar, Parviz Shahabi, Manouchehr Seyedi Vafaee, Tahereh Ghadiri, Abbas Ebrahimi Kalan, Solmaz Fallahi, Meysam Ghorbani, Mohsen Jafarzadehgharehziaaddi. Hippocampal neurodegeneration and rhythms mirror each other during acute spinal cord injury in male rats. Brain research bulletin. vol 172. 2021-10-07. PMID:33848614. |
our study demonstrated that acute sci, alters the power and max-frequency of hippocampal rhythms parallel with changes in the hippocampal neurogenesis, apoptosis, and receptors expression. |
2021-10-07 |
2023-08-13 |
rat |
| Parul, Akanksha Mishra, Sonu Singh, Seema Singh, Virendra Tiwari, Swati Chaturvedi, Muhammad Wahajuddin, Gautam Palit, Shubha Shukl. Chronic unpredictable stress negatively regulates hippocampal neurogenesis and promote anxious depression-like behavior via upregulating apoptosis and inflammatory signals in adult rats. Brain research bulletin. vol 172. 2021-10-07. PMID:33895271. |
chronic unpredictable stress negatively regulates hippocampal neurogenesis and promote anxious depression-like behavior via upregulating apoptosis and inflammatory signals in adult rats. |
2021-10-07 |
2023-08-13 |
rat |
| Parul, Akanksha Mishra, Sonu Singh, Seema Singh, Virendra Tiwari, Swati Chaturvedi, Muhammad Wahajuddin, Gautam Palit, Shubha Shukl. Chronic unpredictable stress negatively regulates hippocampal neurogenesis and promote anxious depression-like behavior via upregulating apoptosis and inflammatory signals in adult rats. Brain research bulletin. vol 172. 2021-10-07. PMID:33895271. |
additionally, cus altered adult hippocampal neurogenesis, increased gliosis and neuronal apoptosis in cerebral cortex and hippocampus which might be associated with reduced akt and increased erk signaling, as seen in the rat brain tissue. |
2021-10-07 |
2023-08-13 |
rat |
| Fei Zhu, Ermin Luo, Fei Yi, Jianzhong Xiong, Chun Huang, Runying L. LncRNA ITSN1-2 knockdown inhibits OGD/R-induced inflammation and apoptosis in mouse hippocampal neurons via sponging miR-195-5p. Neuroreport. vol 32. issue 16. 2021-10-07. PMID:34554938. |
lncrna itsn1-2 knockdown inhibits ogd/r-induced inflammation and apoptosis in mouse hippocampal neurons via sponging mir-195-5p. |
2021-10-07 |
2023-08-13 |
mouse |
| Dong-Xia Li, Chang-Nan Wang, Yan Wang, Chang-Lin Ye, Lai Jiang, Xiao-Yan Zhu, Yu-Jian Li. NLRP3 inflammasome-dependent pyroptosis and apoptosis in hippocampus neurons mediates depressive-like behavior in diabetic mice. Behavioural brain research. vol 391. 2021-10-05. PMID:32454054. |
nlrp3 inflammasome-dependent pyroptosis and apoptosis in hippocampus neurons mediates depressive-like behavior in diabetic mice. |
2021-10-05 |
2023-08-13 |
mouse |
| Dong-Xia Li, Chang-Nan Wang, Yan Wang, Chang-Lin Ye, Lai Jiang, Xiao-Yan Zhu, Yu-Jian Li. NLRP3 inflammasome-dependent pyroptosis and apoptosis in hippocampus neurons mediates depressive-like behavior in diabetic mice. Behavioural brain research. vol 391. 2021-10-05. PMID:32454054. |
our results suggest that hyperglycemia results in apoptosis and pyroptosis of hippocampal neuron cells in a nlrp3-dependent manner, which was associated with the depressive phenotypes evoked by stz-induced diabetes. |
2021-10-05 |
2023-08-13 |
mouse |
| Nasser Rahmani, Mola Mohammadi, Homa Manaheji, Nader Maghsoudi, Hermann Katinger, Mansoureh Baniasadi, Jalal Zaringhala. Carbamylated erythropoietin improves recognition memory by modulating microglia in a rat model of pain. Behavioural brain research. vol 416. 2021-10-05. PMID:34506840. |
additionally, cepo-fc noticeably decreased the hippocampal microglial expression, production of hippocampal il-1β, and hippocampal apoptosis and necroptosis induced by the inflammatory pain. |
2021-10-05 |
2023-08-13 |
rat |
| Yang Yu, Wei Zhang, Dengyan Zhu, Haitao Wang, Hua Shao, Yue Zhan. LncRNA Rian ameliorates sevoflurane anesthesia-induced cognitive dysfunction through regulation of miR-143-3p/LIMK1 axis. Human cell. vol 34. issue 3. 2021-10-04. PMID:33616869. |
moreover, transfection with ad-rian also protected isolated primary hippocampal neurons against sevoflurane-induced decrease of cell viability and increase of lactic acid dehydrogenase (ldh) and apoptosis. |
2021-10-04 |
2023-08-13 |
mouse |
| Patricia Soriano Roque, Mehdi Hooshmandi, Laura Neagu-Lund, Shelly Yin, Noosha Yousefpour, Hiroaki Sato, Tamaki Sato, Yosuke Nakadate, Akiko Kawakami, Soroush Tahmasebi, Alfredo Ribeiro-da-Silva, Christos G Gkogkas, Masha Prager-Khoutorsky, Thomas Schricker, Linda Wykes, Arkady Khoutorsk. Intranasal insulin rescues repeated anesthesia-induced deficits in synaptic plasticity and memory and prevents apoptosis in neonatal mice via mTORC1. Scientific reports. vol 11. issue 1. 2021-10-04. PMID:34326413. |
moreover, intranasal insulin prevented anesthesia-induced apoptosis of hippocampal cells, which is thought to underlie cognitive impairment. |
2021-10-04 |
2023-08-13 |
mouse |
| Patricia Soriano Roque, Mehdi Hooshmandi, Laura Neagu-Lund, Shelly Yin, Noosha Yousefpour, Hiroaki Sato, Tamaki Sato, Yosuke Nakadate, Akiko Kawakami, Soroush Tahmasebi, Alfredo Ribeiro-da-Silva, Christos G Gkogkas, Masha Prager-Khoutorsky, Thomas Schricker, Linda Wykes, Arkady Khoutorsk. Intranasal insulin rescues repeated anesthesia-induced deficits in synaptic plasticity and memory and prevents apoptosis in neonatal mice via mTORC1. Scientific reports. vol 11. issue 1. 2021-10-04. PMID:34326413. |
our study demonstrates that intranasal insulin prevents general anesthesia-induced apoptosis of hippocampal cells, and deficits in synaptic plasticity and memory, and suggests that the rescue effect is mediated via mtorc1/4e-bp2 signaling. |
2021-10-04 |
2023-08-13 |
mouse |
| Mingliang Xu, Jianguo Feng, Mingxi Tang, Qingxi Guo, Jian Zhan, Fuzu Zhu, Hong Lei, Qingmei Kan. Blocking retrograde axonal transport of autophagosomes contributes to sevoflurane-induced neuron apoptosis in APP/PS1 mice. Acta neurologica Belgica. vol 121. issue 5. 2021-10-02. PMID:32385796. |
sevoflurane impaired acquisition learning and memory function, promoted the apoptosis of hippocampal neurons in appswe/ps1Δe9 double-transgenic mice, and the mechanism might be related to the activation of autophagy along with the disruption of autophagosomes retrograde transport in axons. |
2021-10-02 |
2023-08-13 |
mouse |
| Mohammadmehdi Hadipour, Gholam Hossein Meftahi, Mohammad Reza Afarinesh, Gila Pirzad Jahromi, Boshra Hate. Crocin attenuates the granular cells damages on the dentate gyrus and pyramidal neurons in the CA3 regions of the hippocampus and frontal cortex in the rat model of Alzheimer's disease. Journal of chemical neuroanatomy. vol 113. 2021-10-01. PMID:32534024. |
amyloid β-peptides (aβ) are considered as a major hallmark of alzheimer's disease (ad) that can induce synaptic loss and apoptosis in brain regions, particularly in the cortex and the hippocampus. |
2021-10-01 |
2023-08-13 |
rat |
| Cheng Zhu, Li Hui, Ke Zheng, Linjing Liu, Jiahong Liu, Wei L. Silencing of RGS2 enhances hippocampal neuron regeneration and rescues depression-like behavioral impairments through activation of cAMP pathway. Brain research. vol 1746. 2021-10-01. PMID:32679115. |
furthermore, regeneration was enhanced and apoptosis was repressed in mouse hippocampal neurons in the presence of rgs2 knockdown and forskolin. |
2021-10-01 |
2023-08-13 |
mouse |
| Tiyasha Sarkar, Nisha Patro, Ishan Kumar Patr. Neuronal changes and cognitive deficits in a multi-hit rat model following cumulative impact of early life stressors. Biology open. vol 9. issue 9. 2021-10-01. PMID:32878878. |
hippocampal cellular apoptosis, β iii tubulin catastrophe, altered neuronal profiling and spatial memory impairments were assessed at pnd 180, using specific immunohistochemical markers (active caspase 3, β iii tubulin, doublecortin), golgi studies and cognitive mazes (morris water maze and t maze). |
2021-10-01 |
2023-08-13 |
rat |
| Bruna Ferrary Deniz, Heloísa Deola Confortim, Patrícia Maidana Miguel, Loise Bronauth, Isabela R Fernandes, Alysson R Muotri, Lenir Orlandi Pereir. High gestational folic acid supplementation prevents hypoxia-ischemia-induced caspase-3 augmenting without changing synapsin and H3 methylation levels in the rat hippocampus. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 81. issue 6. 2021-10-01. PMID:34021639. |
considering that fa supplementation is already used in pregnant women and that hi occurs in the peripartum period, this study was designated to evaluate how gestational fa supplementation and neonatal hi affect: apoptosis (caspase-3) and expression of synaptic proteins (synapsin and psd-95) and the methylation of histone h3 lysine (k) 4 and 27 in the rat hippocampus. |
2021-10-01 |
2023-08-13 |
rat |
| Manish Shukla, Kumar Vyonkesh Mani, Deepshikha, Sangeeta Shukla, Neeru Kapoo. Moderate noise associated oxidative stress with concomitant memory impairment, neuro-inflammation and neurodegeneration. Brain, behavior, & immunity - health. vol 5. 2021-10-01. PMID:34589861. |
further, the underlying mechanism pertaining to apoptosis was investigated by immuno-histological studies through assessment of caspase-3 and tunel assay as well as morphological parameters, namely nissl bodies in ca1, ca3 and dg regions of hippocampus. |
2021-10-01 |
2023-08-13 |
rat |