| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eva C Bunk, Hans-Georg König, Jochen H M Prehn, Brian P Kirb. p53 upregulated mediator of apoptosis (Puma) deficiency increases survival of adult neural stem cells generated physiologically in the hippocampus, but does not protect stem cells generated in surplus after an excitotoxic lesion. Journal of basic and clinical physiology and pharmacology. vol 32. issue 2. 2021-10-27. PMID:33155994. |
p53 upregulated mediator of apoptosis (puma) deficiency increases survival of adult neural stem cells generated physiologically in the hippocampus, but does not protect stem cells generated in surplus after an excitotoxic lesion. |
2021-10-27 |
2023-08-13 |
mouse |
| Eva C Bunk, Hans-Georg König, Jochen H M Prehn, Brian P Kirb. p53 upregulated mediator of apoptosis (Puma) deficiency increases survival of adult neural stem cells generated physiologically in the hippocampus, but does not protect stem cells generated in surplus after an excitotoxic lesion. Journal of basic and clinical physiology and pharmacology. vol 32. issue 2. 2021-10-27. PMID:33155994. |
previously, we demonstrated that the bh3-only protein p53-upregulated mediator of apoptosis (puma) controls the physiological rate of apoptosis of neural precursor cells in the adult mouse hippocampus. |
2021-10-27 |
2023-08-13 |
mouse |
| Tao Yu, Hui Fu, Jing-Jing Sun, Dan-Rui Ding, Hua Wan. miR-106b-5p upregulation is associated with microglial activation and inflammation in the mouse hippocampus following status epilepticus. Experimental brain research. vol 239. issue 11. 2021-10-26. PMID:34476536. |
unlike in the dentate gyrus, immunohistochemical staining revealed prominent neuronal swelling at 6 h, significant neuronal loss and apoptosis on day 3, and recovery by day 14 in the hippocampal cornu ammonis (ca)1 and ca3 pyramidal cells in se mice. |
2021-10-26 |
2023-08-13 |
mouse |
| Sakthi Jothi Muthu, Prakash Seppa. Apoptosis in hippocampal tissue induced by oxidative stress in testosterone deprived male rats. The aging male : the official journal of the International Society for the Study of the Aging Male. vol 23. issue 5. 2021-10-25. PMID:33691594. |
apoptosis in hippocampal tissue induced by oxidative stress in testosterone deprived male rats. |
2021-10-25 |
2023-08-13 |
rat |
| Ameer Alrubaye, Majid Motovali-Bashi, Mehran Miroliae. Rosmarinic acid inhibits DNA glycation and modulates the expression of Akt1 and Akt3 partially in the hippocampus of diabetic rats. Scientific reports. vol 11. issue 1. 2021-10-23. PMID:34663861. |
the expression of akt genes (inhibitors of apoptosis) in the hippocampus was evaluated using rt-qpcr. |
2021-10-23 |
2023-08-13 |
human |
| Ameer Alrubaye, Majid Motovali-Bashi, Mehran Miroliae. Rosmarinic acid inhibits DNA glycation and modulates the expression of Akt1 and Akt3 partially in the hippocampus of diabetic rats. Scientific reports. vol 11. issue 1. 2021-10-23. PMID:34663861. |
past studies have shown that diabetes induces apoptosis in the hippocampal neurons. |
2021-10-23 |
2023-08-13 |
human |
| Ameer Alrubaye, Majid Motovali-Bashi, Mehran Miroliae. Rosmarinic acid inhibits DNA glycation and modulates the expression of Akt1 and Akt3 partially in the hippocampus of diabetic rats. Scientific reports. vol 11. issue 1. 2021-10-23. PMID:34663861. |
given that glycation changes the genes expression and causes cell death, apoptosis of the hippocampal neurons can be due to the glycation of dna. |
2021-10-23 |
2023-08-13 |
human |
| Huahui Lu, Huijun Zhang, Ying Cong, Wenjun Li, Juan Zhou, Chuang Wu, Fulong Liang, Ying L. Propane-2-sulfonic acid octadec-9-enyl-amide, a novel PPARα/γ dual agonist, reverses neuroinflammation in lipopolysaccharide-induced mice. Neuroreport. vol 31. issue 15. 2021-10-22. PMID:32881774. |
we found that n15 decreased the mrna expression of the proinflammatory cytokines il-1β, il-6, tnfα, inducible nitric oxide synthase and cyclooxygenase-2; inhibited microglial activation; and ameliorated neuronal apoptosis in the hippocampus and cortex of lps-induced mice. |
2021-10-22 |
2023-08-13 |
mouse |
| Yi-Qiang Pang, Jing Yang, Chun-Mei Jia, Rui Zhang, Qi Pan. Hypoxic preconditioning reduces NLRP3 inflammasome expression and protects against cerebral ischemia/reperfusion injury. Neural regeneration research. vol 17. issue 2. 2021-10-22. PMID:34269215. |
compared with control mice, mice with cerebral ischemia/reperfusion injury showed increased bederson neurological function scores, significantly increased cerebral infarction volume, obvious pathological damage to the hippocampus, significantly increased apoptosis; upregulated interleukin-1β, interleukin-6, and interleukin-8 levels in brain tissue; and increased expression levels of nod-like receptor family pyrin domain containing 3 (nlrp3), nlrp inflammasome-related protein caspase-1, and gasdermin d. however, hypoxic preconditioning significantly inhibited the above phenomena. |
2021-10-22 |
2023-08-13 |
mouse |
| Qiang Lu, Ying Zhang, Chao Zhao, Hu Zhang, Yuepu Pu, Lihong Yi. Copper induces oxidative stress and apoptosis of hippocampal neuron via pCREB/BDNF/ and Nrf2/HO-1/NQO1 pathway. Journal of applied toxicology : JAT. 2021-10-22. PMID:34676557. |
copper induces oxidative stress and apoptosis of hippocampal neuron via pcreb/bdnf/ and nrf2/ho-1/nqo1 pathway. |
2021-10-22 |
2023-08-13 |
Not clear |
| Qiang Lu, Ying Zhang, Chao Zhao, Hu Zhang, Yuepu Pu, Lihong Yi. Copper induces oxidative stress and apoptosis of hippocampal neuron via pCREB/BDNF/ and Nrf2/HO-1/NQO1 pathway. Journal of applied toxicology : JAT. 2021-10-22. PMID:34676557. |
this might link to copper-induced hippocampal neuronal apoptosis and decrease in neurons viability. |
2021-10-22 |
2023-08-13 |
Not clear |
| Qiang Lu, Ying Zhang, Chao Zhao, Hu Zhang, Yuepu Pu, Lihong Yi. Copper induces oxidative stress and apoptosis of hippocampal neuron via pCREB/BDNF/ and Nrf2/HO-1/NQO1 pathway. Journal of applied toxicology : JAT. 2021-10-22. PMID:34676557. |
our vitro experiment showed copper exposure induced oxidative stress and promoted apoptosis of ht22 murine hippocampal neuronal cell. |
2021-10-22 |
2023-08-13 |
Not clear |
| Rui Chen, Junyu Wang, Bing Jiang, Xin Wan, Hongwei Liu, Huan Liu, Xiaosheng Yang, Xiaobing Wu, Qin Zou, Wenren Yan. Study of cell apoptosis in the hippocampus and thalamencephalon in a ventricular fluid impact model. Experimental and therapeutic medicine. vol 6. issue 6. 2021-10-21. PMID:24255676. |
study of cell apoptosis in the hippocampus and thalamencephalon in a ventricular fluid impact model. |
2021-10-21 |
2023-08-12 |
rabbit |
| Rui Chen, Junyu Wang, Bing Jiang, Xin Wan, Hongwei Liu, Huan Liu, Xiaosheng Yang, Xiaobing Wu, Qin Zou, Wenren Yan. Study of cell apoptosis in the hippocampus and thalamencephalon in a ventricular fluid impact model. Experimental and therapeutic medicine. vol 6. issue 6. 2021-10-21. PMID:24255676. |
the aim of this study was to investigate the apoptosis of nerve cells in the hippocampal and thalamencephalon regions using a rabbit model of ventricular fluid impact. |
2021-10-21 |
2023-08-12 |
rabbit |
| Rui Chen, Junyu Wang, Bing Jiang, Xin Wan, Hongwei Liu, Huan Liu, Xiaosheng Yang, Xiaobing Wu, Qin Zou, Wenren Yan. Study of cell apoptosis in the hippocampus and thalamencephalon in a ventricular fluid impact model. Experimental and therapeutic medicine. vol 6. issue 6. 2021-10-21. PMID:24255676. |
furthermore, h&e staining showed that pathological changes, such as hemorrhage and necrosis, occurred in the hippocampal and thalamencephalon regions at an early stage subsequent to trauma, while tunel staining showed that neuronal apoptosis occurred in the various injury groups. |
2021-10-21 |
2023-08-12 |
rabbit |
| Tobias Engel, David C Henshal. Apoptosis, Bcl-2 family proteins and caspases: the ABCs of seizure-damage and epileptogenesis? International journal of physiology, pathophysiology and pharmacology. vol 1. issue 2. 2021-10-20. PMID:21383882. |
biochemical hallmarks associated with apoptosis have been identified in hippocampal and neocortical material removed from patients with pharmacoresistant epilepsy: altered expression of pro-apoptotic bcl-2 family genes and increased expression of caspases and the presence of their cleaved forms. |
2021-10-20 |
2023-08-12 |
Not clear |
| Tobias Engel, David C Henshal. Apoptosis, Bcl-2 family proteins and caspases: the ABCs of seizure-damage and epileptogenesis? International journal of physiology, pathophysiology and pharmacology. vol 1. issue 2. 2021-10-20. PMID:21383882. |
however, apoptotic cells are rarely detected in such patient material and there is evidence of anti-apoptotic signaling changes in the same tissue, including upregulation of bcl-2 and bcl-w. from animal studies there is evidence that both brief and prolonged seizures can cause neuronal apoptosis within the hippocampus. |
2021-10-20 |
2023-08-12 |
Not clear |
| Shaowei Yin, Yilin Meng, Caixia Liu, Yuan Wan. MIUH Inhibits the Hippocampal Neuron Growth in Fetal Rat by Affecting the PTEN Pathway. Neurochemical research. vol 46. issue 8. 2021-10-18. PMID:34003417. |
the proliferation, apoptosis, and autophagy of hippocampal neurons in fetal rats were studied via flow cytometry, immunofluorescence staining, jc-1 staining, western blotting, and real-time polymerase chain reaction at different time points (6, 24, 48, and 72 h). |
2021-10-18 |
2023-08-13 |
rat |
| Shaowei Yin, Yilin Meng, Caixia Liu, Yuan Wan. MIUH Inhibits the Hippocampal Neuron Growth in Fetal Rat by Affecting the PTEN Pathway. Neurochemical research. vol 46. issue 8. 2021-10-18. PMID:34003417. |
the results showed that miuh significantly inhibited the proliferation of hippocampal neurons and promoted their apoptosis and autophagy. |
2021-10-18 |
2023-08-13 |
rat |
| Jian Liu, Lin Liu, Yuan-Shan Han, Jian Yi, Chun Guo, Hong-Qing Zhao, Jia Ling, Yu-Hong Wan. The molecular mechanism underlying mitophagy-mediated hippocampal neuron apoptosis in diabetes-related depression. Journal of cellular and molecular medicine. vol 25. issue 15. 2021-10-15. PMID:34213839. |
the molecular mechanism underlying mitophagy-mediated hippocampal neuron apoptosis in diabetes-related depression. |
2021-10-15 |
2023-08-13 |
rat |