| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yongping Chen, Lin Li, Jiuyan Zhang, Hailin Cui, Jiucheng Wang, Chuqiao Wang, Mingxian Shi, Honggang Fa. Dexmedetomidine Alleviates Lipopolysaccharide-Induced Hippocampal Neuronal Apoptosis via Inhibiting the p38 MAPK/c-Myc/CLIC4 Signaling Pathway in Rats. Molecular neurobiology. vol 58. issue 11. 2021-11-18. PMID:34363182. |
dex also attenuated lps-induced inflammation and hippocampal apoptosis by inhibiting the increase of interleukin-1β, interleukin-6, interleukin-18, and tumor necrosis factor-α levels and downregulating the expression of mitochondrial apoptosis pathway-related proteins. |
2021-11-18 |
2023-08-13 |
rat |
| Yongping Chen, Lin Li, Jiuyan Zhang, Hailin Cui, Jiucheng Wang, Chuqiao Wang, Mingxian Shi, Honggang Fa. Dexmedetomidine Alleviates Lipopolysaccharide-Induced Hippocampal Neuronal Apoptosis via Inhibiting the p38 MAPK/c-Myc/CLIC4 Signaling Pathway in Rats. Molecular neurobiology. vol 58. issue 11. 2021-11-18. PMID:34363182. |
taken together, the findings indicate that dex attenuates lps-induced hippocampal neuronal apoptosis by regulating the p38 mapk/c-myc/clic4 signaling pathway. |
2021-11-18 |
2023-08-13 |
rat |
| Zhi-Meng Wang, Cong Liu, Ying-Ying Wang, Yu-Sen Deng, Xuan-Cheng He, Hong-Zhen Du, Chang-Mei Liu, Zhao-Qian Ten. SerpinA3N deficiency deteriorates impairments of learning and memory in mice following hippocampal stab injury. Cell death discovery. vol 6. 2021-11-17. PMID:33014432. |
here, we report that the serine protease inhibitor serpina3n is upregulated in hippocampal neurons in the early stage of hippocampal stab injury (hsi), while its deficiency causes a greater degree of neuronal apoptosis and severer impairments of spatial learning and memory in mice after hsi. |
2021-11-17 |
2023-08-13 |
mouse |
| Mi Tian, Wei Wang, Kai Wang, Peng Jin, Cameron Lenahan, Yao Wang, Jiaying Tan, Huimei Wen, Shuixiang Deng, Feng Zhao, Ye Gon. Dexmedetomidine alleviates cognitive impairment by reducing blood-brain barrier interruption and neuroinflammation via regulating Th1/Th2/Th17 polarization in an experimental sepsis model of mice. International immunopharmacology. 2021-11-17. PMID:34785141. |
blood brain barrier (bbb) permeability, hippocampal inflammation, hippocampal neural apoptosis, and t helper (th) cell subgroups were assessed. |
2021-11-17 |
2023-08-13 |
mouse |
| Ruixiang Li, Jiahua Hu, Sue Ca. The Clinical Significance of miR-135b-5p and Its Role in the Proliferation and Apoptosis of Hippocampus Neurons in Children with Temporal Lobe Epilepsy. Developmental neuroscience. vol 42. issue 5-6. 2021-11-16. PMID:33596573. |
the clinical significance of mir-135b-5p and its role in the proliferation and apoptosis of hippocampus neurons in children with temporal lobe epilepsy. |
2021-11-16 |
2023-08-13 |
rat |
| Caitlin A Finney, Margaret J Morris, R Frederick Westbrook, Nicole M Jone. Hippocampal silent infarct leads to subtle cognitive decline that is associated with inflammation and gliosis at twenty-four hours after injury in a rat model. Behavioural brain research. vol 401. 2021-11-15. PMID:33358919. |
principal component analysis indicated the main variables associated with hippocampal si included increased time spent with the unmoved object, gliosis, apoptosis and inflammation as well as decreased exploration proportion and ca1 cells. |
2021-11-15 |
2023-08-13 |
rat |
| Caitlin A Finney, Margaret J Morris, R Frederick Westbrook, Nicole M Jone. Hippocampal silent infarct leads to subtle cognitive decline that is associated with inflammation and gliosis at twenty-four hours after injury in a rat model. Behavioural brain research. vol 401. 2021-11-15. PMID:33358919. |
further, this appears to be driven by early degenerative processes including apoptosis, gliosis and inflammation, suggesting that these may be targets for early interventions treating hippocampal si and its cognitive consequences. |
2021-11-15 |
2023-08-13 |
rat |
| Gino P Asuni, Andrew Speidell, Italo Mocchett. Neuronal apoptosis induced by morphine withdrawal is mediated by the p75 neurotrophin receptor. Journal of neurochemistry. vol 158. issue 2. 2021-11-12. PMID:33742683. |
at the same time, trkb, the receptor that is crucial for bdnf-mediated synaptic plasticity in the hippocampus, was decreased, suggesting that withdrawal alters the neurotrophin receptor environment to favor synaptic remodeling and apoptosis. |
2021-11-12 |
2023-08-13 |
mouse |
| Gino P Asuni, Andrew Speidell, Italo Mocchett. Neuronal apoptosis induced by morphine withdrawal is mediated by the p75 neurotrophin receptor. Journal of neurochemistry. vol 158. issue 2. 2021-11-12. PMID:33742683. |
indeed, we observed evidence of neuronal apoptosis in the hippocampus, including activation of c-jun n-terminal kinase (jnk) and increased active caspase-3. |
2021-11-12 |
2023-08-13 |
mouse |
| Ying Huang, Xiangping Liao, Huaiwei Wang, Jianghong Luo, Shanquan Zhong, Ziliang Zhang, Fang Zhang, Jianping Chen, Fuhua Xi. Effects of imperatorin on apoptosis and synaptic plasticity in vascular dementia rats. Scientific reports. vol 11. issue 1. 2021-11-12. PMID:33883654. |
collectively, our findings demonstrated that imp was effective in the treatment of 2vo-induced vd via inhibiting apoptosis of hippocampus neurons and reducing the synaptic plasticity destroy. |
2021-11-12 |
2023-08-13 |
rat |
| Yongjie Xu, Shengju Liu, Liying Zhu, Longguang Dai, Wen Qian, Jingzhi Zhang, Xing Li, Wei Pa. Green tea protects against hippocampal neuronal apoptosis in diabetic encephalopathy by inhibiting JNK/MLCK signaling. Molecular medicine reports. vol 24. issue 2. 2021-11-12. PMID:34132368. |
green tea protects against hippocampal neuronal apoptosis in diabetic encephalopathy by inhibiting jnk/mlck signaling. |
2021-11-12 |
2023-08-13 |
rat |
| Yongjie Xu, Shengju Liu, Liying Zhu, Longguang Dai, Wen Qian, Jingzhi Zhang, Xing Li, Wei Pa. Green tea protects against hippocampal neuronal apoptosis in diabetic encephalopathy by inhibiting JNK/MLCK signaling. Molecular medicine reports. vol 24. issue 2. 2021-11-12. PMID:34132368. |
we previously found that myosin light chain kinase (mlck) regulates apoptosis in high glucose‑induced hippocampal neurons. |
2021-11-12 |
2023-08-13 |
rat |
| Yongjie Xu, Shengju Liu, Liying Zhu, Longguang Dai, Wen Qian, Jingzhi Zhang, Xing Li, Wei Pa. Green tea protects against hippocampal neuronal apoptosis in diabetic encephalopathy by inhibiting JNK/MLCK signaling. Molecular medicine reports. vol 24. issue 2. 2021-11-12. PMID:34132368. |
in addition, a type 1 diabetes rat model was established and green tea extract was administered, and the morris water maze test, cell counting kit‑8 assays, flow cytometry, western blotting and terminal deoxynucleotidyl transferase‑mediated dutp nick end‑labelling assays were used to examine the effects of green tea on hippocampal neuronal apoptosis in diabetic rats. |
2021-11-12 |
2023-08-13 |
rat |
| Yongjie Xu, Shengju Liu, Liying Zhu, Longguang Dai, Wen Qian, Jingzhi Zhang, Xing Li, Wei Pa. Green tea protects against hippocampal neuronal apoptosis in diabetic encephalopathy by inhibiting JNK/MLCK signaling. Molecular medicine reports. vol 24. issue 2. 2021-11-12. PMID:34132368. |
the results demonstrated that green tea can protect against hippocampal neuronal apoptosis by inhibiting the jnk/mlck pathway and ultimately improves cognitive function in diabetic rats. |
2021-11-12 |
2023-08-13 |
rat |
| Nasrin Hashemi-Firouzi, Siamak Shahidi, Sara Soleimani As. Chronic stimulation of the serotonergic 5-HT4 receptor modulates amyloid-beta-related impairments in synaptic plasticity and memory deficits in male rats. Brain research. vol 1773. 2021-11-12. PMID:34695393. |
furthermore, neuronal apoptosis was measured in the hippocampus. |
2021-11-12 |
2023-08-13 |
rat |
| Oluwaseun Samuel Faborode, Ernest Dalle, Musa Vuyisile Mabandl. Exposure to footshock stress downregulates antioxidant genes and increases neuronal apoptosis in an Aβ(1-42) rat model of Alzheimer's disease. Neurochemistry international. vol 150. 2021-11-11. PMID:34419526. |
furthermore, oxidative stress level was sustained, which was associated with increased apoptosis in the amygdala and hippocampus. |
2021-11-11 |
2023-08-13 |
rat |
| Irfannuddin Irfannuddin, Siti Fazzaura Putri Sarahdeaz, Krisna Murti, Budi Santoso, Noriyuki Koibuch. The effect of ketogenic diets on neurogenesis and apoptosis in the dentate gyrus of the male rat hippocampus. The journal of physiological sciences : JPS. vol 71. issue 1. 2021-11-10. PMID:33461486. |
the effect of ketogenic diets on neurogenesis and apoptosis in the dentate gyrus of the male rat hippocampus. |
2021-11-10 |
2023-08-13 |
rat |
| Nishant Ranjan Chauhan, Rahul Kumar, Avinash Gupta, Ramesh Chand Meena, Sarita Nanda, Kamla Prasad Mishra, Shashi Bala Sing. Heat stress induced oxidative damage and perturbation in BDNF/ERK1/2/CREB axis in hippocampus impairs spatial memory. Behavioural brain research. vol 396. 2021-11-09. PMID:32890597. |
pronounced increase of caspase3 expression and fluoro jade-c (fj-c) positive cells were observed in shs resulting in neuronal injury and apoptosis in ca3 region of hippocampus culminating in spatial memory deficit. |
2021-11-09 |
2023-08-13 |
rat |
| Nishant Ranjan Chauhan, Rahul Kumar, Avinash Gupta, Ramesh Chand Meena, Sarita Nanda, Kamla Prasad Mishra, Shashi Bala Sing. Heat stress induced oxidative damage and perturbation in BDNF/ERK1/2/CREB axis in hippocampus impairs spatial memory. Behavioural brain research. vol 396. 2021-11-09. PMID:32890597. |
in conclusion, shs induces pathological alterations that include oxidative damage and apoptosis of hippocampal neurons, disturbing bdnf/erk1/2/creb axis that may affect spatial memory. |
2021-11-09 |
2023-08-13 |
rat |
| Wei Fen. Tectorigenin attenuates cognitive impairments in mice with chronic cerebral ischemia by inhibiting the TLR4/NF-κB signaling pathway. Bioscience, biotechnology, and biochemistry. vol 85. issue 7. 2021-11-09. PMID:34014269. |
cell viability and apoptosis of transfected ht22 cells and toll-like receptor-4 (tlr4)/nuclear factor-kappab (nf-κb) pathway-related factor levels in hippocampal tissue and ogd/r models were detected. |
2021-11-09 |
2023-08-13 |
mouse |