| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liang Han, Yanhao Xu, Yuxiu Sh. Molecular Mechanism of the ATF6α/S1P/S2P Signaling Pathway in Hippocampal Neuronal Apoptosis in SPS Rats. Journal of molecular neuroscience : MN. vol 71. issue 12. 2021-11-19. PMID:33738762. |
apoptosis of hippocampal neurons is one of the mechanisms of hippocampal atrophy in posttraumatic stress disorder (ptsd), and it is also an important cause of memory impairment in ptsd patients. |
2021-11-19 |
2023-08-13 |
rat |
| Liang Han, Yanhao Xu, Yuxiu Sh. Molecular Mechanism of the ATF6α/S1P/S2P Signaling Pathway in Hippocampal Neuronal Apoptosis in SPS Rats. Journal of molecular neuroscience : MN. vol 71. issue 12. 2021-11-19. PMID:33738762. |
endoplasmic reticulum stress (ers) mediated by activated transcription factor 6α (atf6α)/site 1 protease (s1p)/s2p is involved in cell apoptosis, but it is not clear whether it is involved in hippocampal neuron apoptosis caused by ptsd. |
2021-11-19 |
2023-08-13 |
rat |
| Liang Han, Yanhao Xu, Yuxiu Sh. Molecular Mechanism of the ATF6α/S1P/S2P Signaling Pathway in Hippocampal Neuronal Apoptosis in SPS Rats. Journal of molecular neuroscience : MN. vol 71. issue 12. 2021-11-19. PMID:33738762. |
apoptosis of hippocampal neurons was detected by tunel staining. |
2021-11-19 |
2023-08-13 |
rat |
| Liang Han, Yanhao Xu, Yuxiu Sh. Molecular Mechanism of the ATF6α/S1P/S2P Signaling Pathway in Hippocampal Neuronal Apoptosis in SPS Rats. Journal of molecular neuroscience : MN. vol 71. issue 12. 2021-11-19. PMID:33738762. |
sps induced apoptosis of hippocampal neurons by activating ers mediated by atf6α, suggesting that ers-induced apoptosis is involved in the occurrence of ptsd. |
2021-11-19 |
2023-08-13 |
rat |
| Oğuz Kose, Ahmet Altin, Sevda Kurt Bayrakdar, Semih Alperen Bostan, Tolga Mercantepe, Kerimali Akyildiz, Levent Tumkaya, Adnan Yilmaz, Sefanur Kose, Hatice Yemenoglu, Leyla Turker Sener, Göker Kulusl. Influences of periodontitis on hippocampal inflammation, oxidative stress, and apoptosis in rats. Journal of periodontal research. vol 56. issue 6. 2021-11-19. PMID:34486732. |
influences of periodontitis on hippocampal inflammation, oxidative stress, and apoptosis in rats. |
2021-11-19 |
2023-08-13 |
rat |
| Juan Wan, Tao Xia. MiR-1224 downregulation inhibits OGD/R-induced hippocampal neuron apoptosis through targeting Ku protein. Metabolic brain disease. 2021-11-19. PMID:34797485. |
mir-1224 downregulation inhibits ogd/r-induced hippocampal neuron apoptosis through targeting ku protein. |
2021-11-19 |
2023-08-13 |
mouse |
| Juan Wan, Tao Xia. MiR-1224 downregulation inhibits OGD/R-induced hippocampal neuron apoptosis through targeting Ku protein. Metabolic brain disease. 2021-11-19. PMID:34797485. |
this study aimed to investigate the function of mir-1224 in ogd/r-induced hippocampal neuron apoptosis, as well as the regulatory mechanism of mir-1224 in ischemic cerebrovascular disease. |
2021-11-19 |
2023-08-13 |
mouse |
| Juan Wan, Tao Xia. MiR-1224 downregulation inhibits OGD/R-induced hippocampal neuron apoptosis through targeting Ku protein. Metabolic brain disease. 2021-11-19. PMID:34797485. |
our findings indicated that mir-1224 downregulation suppressed ogd/r-induced hippocampal neuron apoptosis by targeting ku protein, suggesting that mir-1224 could serve as a new target for ischemic cerebrovascular disease treatment. |
2021-11-19 |
2023-08-13 |
mouse |
| Qingsong Li, Xi Zhan. Genistein attenuates cognitive deficits and neuroapoptosis in hippocampus induced by ketamine exposure in neonatal rats. Synapse (New York, N.Y.). vol 75. issue 1. 2021-11-18. PMID:32639628. |
hippocampal tissue was harvested for histological and biochemical analysis to determine neuronal apoptosis and proteins involved in the apoptotic pathways. |
2021-11-18 |
2023-08-13 |
rat |
| Qingsong Li, Xi Zhan. Genistein attenuates cognitive deficits and neuroapoptosis in hippocampus induced by ketamine exposure in neonatal rats. Synapse (New York, N.Y.). vol 75. issue 1. 2021-11-18. PMID:32639628. |
additionally, ketamine-induced neuronal apoptosis in rat hippocampus was attenuated by genistein treatment. |
2021-11-18 |
2023-08-13 |
rat |
| Felipe Kawa Odorcyk, R T Ribeiro, A C Roginski, L E Duran-Carabali, N S Couto-Pereira, C Dalmaz, M Wajner, C A Nett. Differential Age-Dependent Mitochondrial Dysfunction, Oxidative Stress, and Apoptosis Induced by Neonatal Hypoxia-Ischemia in the Immature Rat Brain. Molecular neurobiology. vol 58. issue 5. 2021-11-18. PMID:33417220. |
considering that hip3 and the sham animals showed no alteration of mitochondrial functions, redox homeostasis, and showed no apoptosis, our data suggest an age-dependent vulnerability of the hippocampus to hypoxia-ischemia. |
2021-11-18 |
2023-08-13 |
rat |
| Du Xiao, Jingdan Lv, Zhigang Zheng, Yi Liu, Yonggen Zhang, Cuizhu Luo, Liu Qi, Bing Qin, Chao Li. Mechanisms of microRNA‑142 in mitochondrial autophagy and hippocampal damage in a rat model of epilepsy. International journal of molecular medicine. vol 47. issue 6. 2021-11-18. PMID:33846769. |
additionally, the pathological changes in the hippocampus, the ultrastructure of the mitochondria, and degeneration and the apoptosis of neurons were observed using different staining methods. |
2021-11-18 |
2023-08-13 |
human |
| Du Xiao, Jingdan Lv, Zhigang Zheng, Yi Liu, Yonggen Zhang, Cuizhu Luo, Liu Qi, Bing Qin, Chao Li. Mechanisms of microRNA‑142 in mitochondrial autophagy and hippocampal damage in a rat model of epilepsy. International journal of molecular medicine. vol 47. issue 6. 2021-11-18. PMID:33846769. |
consequently, apoptosis increased, and mitochondrial autophagy decreased, in the hippocampus of epileptic rats. |
2021-11-18 |
2023-08-13 |
human |
| Yongping Chen, Lin Li, Jiuyan Zhang, Hailin Cui, Jiucheng Wang, Chuqiao Wang, Mingxian Shi, Honggang Fa. Dexmedetomidine Alleviates Lipopolysaccharide-Induced Hippocampal Neuronal Apoptosis via Inhibiting the p38 MAPK/c-Myc/CLIC4 Signaling Pathway in Rats. Molecular neurobiology. vol 58. issue 11. 2021-11-18. PMID:34363182. |
dexmedetomidine alleviates lipopolysaccharide-induced hippocampal neuronal apoptosis via inhibiting the p38 mapk/c-myc/clic4 signaling pathway in rats. |
2021-11-18 |
2023-08-13 |
rat |
| Yongping Chen, Lin Li, Jiuyan Zhang, Hailin Cui, Jiucheng Wang, Chuqiao Wang, Mingxian Shi, Honggang Fa. Dexmedetomidine Alleviates Lipopolysaccharide-Induced Hippocampal Neuronal Apoptosis via Inhibiting the p38 MAPK/c-Myc/CLIC4 Signaling Pathway in Rats. Molecular neurobiology. vol 58. issue 11. 2021-11-18. PMID:34363182. |
here, we investigated the neuroprotective role and molecular mechanism of dex against lipopolysaccharide (lps)-induced hippocampal neuronal apoptosis. |
2021-11-18 |
2023-08-13 |
rat |
| Yongping Chen, Lin Li, Jiuyan Zhang, Hailin Cui, Jiucheng Wang, Chuqiao Wang, Mingxian Shi, Honggang Fa. Dexmedetomidine Alleviates Lipopolysaccharide-Induced Hippocampal Neuronal Apoptosis via Inhibiting the p38 MAPK/c-Myc/CLIC4 Signaling Pathway in Rats. Molecular neurobiology. vol 58. issue 11. 2021-11-18. PMID:34363182. |
dex also attenuated lps-induced inflammation and hippocampal apoptosis by inhibiting the increase of interleukin-1β, interleukin-6, interleukin-18, and tumor necrosis factor-α levels and downregulating the expression of mitochondrial apoptosis pathway-related proteins. |
2021-11-18 |
2023-08-13 |
rat |
| Yongping Chen, Lin Li, Jiuyan Zhang, Hailin Cui, Jiucheng Wang, Chuqiao Wang, Mingxian Shi, Honggang Fa. Dexmedetomidine Alleviates Lipopolysaccharide-Induced Hippocampal Neuronal Apoptosis via Inhibiting the p38 MAPK/c-Myc/CLIC4 Signaling Pathway in Rats. Molecular neurobiology. vol 58. issue 11. 2021-11-18. PMID:34363182. |
taken together, the findings indicate that dex attenuates lps-induced hippocampal neuronal apoptosis by regulating the p38 mapk/c-myc/clic4 signaling pathway. |
2021-11-18 |
2023-08-13 |
rat |
| Zhi-Meng Wang, Cong Liu, Ying-Ying Wang, Yu-Sen Deng, Xuan-Cheng He, Hong-Zhen Du, Chang-Mei Liu, Zhao-Qian Ten. SerpinA3N deficiency deteriorates impairments of learning and memory in mice following hippocampal stab injury. Cell death discovery. vol 6. 2021-11-17. PMID:33014432. |
here, we report that the serine protease inhibitor serpina3n is upregulated in hippocampal neurons in the early stage of hippocampal stab injury (hsi), while its deficiency causes a greater degree of neuronal apoptosis and severer impairments of spatial learning and memory in mice after hsi. |
2021-11-17 |
2023-08-13 |
mouse |
| Mi Tian, Wei Wang, Kai Wang, Peng Jin, Cameron Lenahan, Yao Wang, Jiaying Tan, Huimei Wen, Shuixiang Deng, Feng Zhao, Ye Gon. Dexmedetomidine alleviates cognitive impairment by reducing blood-brain barrier interruption and neuroinflammation via regulating Th1/Th2/Th17 polarization in an experimental sepsis model of mice. International immunopharmacology. 2021-11-17. PMID:34785141. |
blood brain barrier (bbb) permeability, hippocampal inflammation, hippocampal neural apoptosis, and t helper (th) cell subgroups were assessed. |
2021-11-17 |
2023-08-13 |
mouse |
| Ruixiang Li, Jiahua Hu, Sue Ca. The Clinical Significance of miR-135b-5p and Its Role in the Proliferation and Apoptosis of Hippocampus Neurons in Children with Temporal Lobe Epilepsy. Developmental neuroscience. vol 42. issue 5-6. 2021-11-16. PMID:33596573. |
the clinical significance of mir-135b-5p and its role in the proliferation and apoptosis of hippocampus neurons in children with temporal lobe epilepsy. |
2021-11-16 |
2023-08-13 |
rat |