| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pegah Javadpour, Sahar Askari, Fatemeh Sadat Rashidi, Leila Dargahi, Abolhassan Ahmadiani, Rasoul Ghasem. Imipramine alleviates memory impairment and hippocampal apoptosis in STZ-induced sporadic Alzheimer's rat model: Possible contribution of MAPKs and insulin signaling. Behavioural brain research. vol 408. 2021-09-02. PMID:33775777. |
imipramine alleviates memory impairment and hippocampal apoptosis in stz-induced sporadic alzheimer's rat model: possible contribution of mapks and insulin signaling. |
2021-09-02 |
2023-08-13 |
rat |
| Chensheng Zhao, Fan Yang, Xiaona Wei, Jingwen Zhan. miR-139-5p upregulation alleviated spontaneous recurrent epileptiform discharge-induced oxidative stress and apoptosis in rat hippocampal neurons via regulating the Notch pathway. Cell biology international. vol 45. issue 2. 2021-08-31. PMID:33247610. |
mir-139-5p upregulation alleviated spontaneous recurrent epileptiform discharge-induced oxidative stress and apoptosis in rat hippocampal neurons via regulating the notch pathway. |
2021-08-31 |
2023-08-13 |
rat |
| Huifang Cao, Lichao Zhang, Zhenzhen Qu, Shuang Tian, Zhiyong Wang, Yuhang Jiang, Qian Hou, Lijing Jia, Weiping Wan. The protective effect of hydroxylated fullerene pretreatment on pilocarpine-induced status epilepticus. Brain research. vol 1764. 2021-08-25. PMID:33831409. |
the expressions of these proteins in hfs pretreatment groups increased more significantly than those in the epilepsy (ep) group, which effectively reduced lipid peroxidation and apoptosis in the hippocampus. |
2021-08-25 |
2023-08-13 |
rat |
| Jonathan Gagnon, Véronique Caron, Laurent Gyenizse, André Trembla. Atypic SUMOylation of Nor1/NR4A3 regulates neural cell viability and redox sensitivity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 9. 2021-08-23. PMID:34383980. |
nor1 responsive genes involved in cell proliferation and metabolism, such as activating transcription factor 3, cyclin d1, casp8 and fadd-like apoptosis regulator, and enolase 3 were upregulated in response to psum disruption in mouse ht-22 hippocampal neuronal cells and human neuroblastoma sh-sy5y cells. |
2021-08-23 |
2023-08-13 |
mouse |
| Cong Hu, Yuanyuan Huang, Lingzhi Wu, Hailin Zhao, Chen Pac Soo, Qingquan Lian, Daqing M. Apoptosis and necroptosis occur in the different brain regions of hippocampus in a rat model of hypoxia asphyxia. The International journal of neuroscience. vol 131. issue 9. 2021-08-20. PMID:32345086. |
apoptosis and necroptosis occur in the different brain regions of hippocampus in a rat model of hypoxia asphyxia. |
2021-08-20 |
2023-08-13 |
rat |
| Xiao-Yu Yang, Qiu-Jun Li, Wen-Chao Zhang, Shao-Qiang Zheng, Zhi-Jun Qu, Yang Xi, Geng Wan. AMPK-SIRT1-PGC1α Signal Pathway Influences the Cognitive Function of Aged Rats in Sevoflurane-Induced Anesthesia. Journal of molecular neuroscience : MN. vol 70. issue 12. 2021-08-19. PMID:32514740. |
hippocampal neuronal apoptosis was evaluated by tunel and fluoro-jade c (fjc) staining, and the expression of cleaved caspase-3 was detected by immunohistochemistry. |
2021-08-19 |
2023-08-13 |
rat |
| He Yu, Zhong-Mei He, Kun Shi, Yan Zhao, Ying Zong, Jian-Ming Li, Wei-Jia Chen, Rui D. [Study on antidepressant effect of total alkaloids of Fibraurea recisa]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 14. 2021-08-18. PMID:34402292. |
this study aimed to investigate the antidepressant effects of total alkaloids of fibraurea recisa in ht22 cells damaged by corticosterone (cort) in vitro and in a mouse model of chronic unpredictable mild stress (cums) as well as the underlying mechanisms.in cellular experiments,the viability of cort-damaged ht22 cells was detected using cell counting kit-8 (cck-8),and the cell apoptosis was detected by hoechst 33258 staining.in animal experiments,c57bl/6n mice were randomly divided into the control group,model group,low (100 mg·kg~(-1)),medium (200 mg·kg~(-1)) and high (400 mg·kg~(-1))-dose of total alkaloids of f.recisa groups,and positive control group.after 21 days of cums exposure,their depressive behaviors were observed in behavioral and morris water maze tests.the serum levels of 5-hydroxytryptamine (5-ht),dopamine (da),and norepinephrine (ne) were assessed by elisa.the expression levels of apoptosis-related proteins bcl-2,bax and cleaved caspase-3 in ht22 cells and mouse hippocampus were detected by western blot.the results suggested that total alkaloids of f.recisa alleviated the damage of ht22 cells induced by cort in a dose-dependent manner.the hoechst 33258 staining uncovered that total alkaloids of f.recisa better reduced the blue spots and inhibited cell apoptosis.the results of animal experiments showed that total alkaloids of f.recisa significantly improved the depression-like behaviors of mice and increased the serum levels of 5-ht,da and ne as compared with those in the model group.the western blot assays revealed a significant up-regulation of bcl-2 protein expression,but an obvious reduction in bax and cleaved caspase-3protein expression in the total alkaloids of f.recisa group.in conclusion,total alkaloids of f.recisa inhibited depression possibly by regulating the apoptosis-related protein expression or elevating the monoamine neurotransmitter levels in the brain. |
2021-08-18 |
2023-08-13 |
mouse |
| I V Kastyro, I V Reshetov, G V Khamidulin, S S Shilin, V I Torshin, M G Kostyaeva, V I Popadyuk, T Y Yunusov, P E Shmaevsky, K P Shalamov, A D Kupryakova, E S Doroginskaya, A D Sedelnikov. Influence of Surgical Trauma in the Nasal Cavity on the Expression of p53 Protein in the Hippocampus of Rats. Doklady. Biochemistry and biophysics. vol 497. issue 1. 2021-08-13. PMID:33895923. |
a quantitative assessment of the apoptosis of neurons in the pyramidal layer of the hippocampus in the subfields ca1, ca2, ca3, and dentate gyrus (dg) on days 2, 4, and 6 after surgery was carried out. |
2021-08-13 |
2023-08-13 |
rat |
| I V Kastyro, I V Reshetov, G V Khamidulin, S S Shilin, V I Torshin, M G Kostyaeva, V I Popadyuk, T Y Yunusov, P E Shmaevsky, K P Shalamov, A D Kupryakova, E S Doroginskaya, A D Sedelnikov. Influence of Surgical Trauma in the Nasal Cavity on the Expression of p53 Protein in the Hippocampus of Rats. Doklady. Biochemistry and biophysics. vol 497. issue 1. 2021-08-13. PMID:33895923. |
the stress effect of modeling septoplasty in rats, accompanied by sensory deprivation of the peripheral part of the olfactory analyzer, provoked the expression of p53 and the initiation of apoptosis mechanisms in various subfields of the hippocampus. |
2021-08-13 |
2023-08-13 |
rat |
| Bin Zhang, Mengshi Yang, Qiongyu Yan, Xiaojian Xu, Fei Niu, Jinqian Dong, Yuan Zhuang, Shenghua Lu, Qianqian Ge, Baiyun Li. The Dual Dose-Dependent Effects of Corticosterone on Hippocampal Cell Apoptosis After Traumatic Brain Injury Depend on the Activation Ratio of Mineralocorticoid Receptors to Glucocorticoid Receptors. Frontiers in pharmacology. vol 12. 2021-08-13. PMID:34381366. |
the dual dose-dependent effects of corticosterone on hippocampal cell apoptosis after traumatic brain injury depend on the activation ratio of mineralocorticoid receptors to glucocorticoid receptors. |
2021-08-13 |
2023-08-13 |
rat |
| Liangyuan Suo, Mingyu Wan. Dexmedetomidine facilitates the expression of nNOS in the hippocampus to alleviate surgery-induced neuroinflammation and cognitive dysfunction in aged rats. Experimental and therapeutic medicine. vol 22. issue 3. 2021-08-11. PMID:34373724. |
following animal sacrifice, the hippocampus was collected and cell apoptosis was determined by terminal dexynucleotidyl transferase (tdt)-mediated dutp nick end labeling staining. |
2021-08-11 |
2023-08-13 |
rat |
| Jian Xu, Mingqiang Sun, Xiaodong Li, Lei Huang, Zhenzhong Gao, Jian Gao, Anmu Xi. MicroRNA expression profiling after recurrent febrile seizures in rat and emerging role of miR-148a-3p/SYNJ1 axis. Scientific reports. vol 11. issue 1. 2021-08-10. PMID:33441699. |
moreover, overexpression of mir-148a-3p resulted in activation of pi3k/akt signaling pathway and the apoptosis of hippocampal neurons. |
2021-08-10 |
2023-08-13 |
rat |
| Ekaterina A Rudnitskaya, Tatiana A Kozlova, Alena O Burnyasheva, Natalia A Stefanova, Nataliya G Kolosov. Glia Not Neurons: Uncovering Brain Dysmaturation in a Rat Model of Alzheimer's Disease. Biomedicines. vol 9. issue 7. 2021-08-09. PMID:34356887. |
we noticed an additional peak of neurogenesis, which coincides in time with the peak of apoptosis in the hippocampus of oxys rats on postnatal day three. |
2021-08-09 |
2023-08-13 |
rat |
| Saima Khatoon, Nidhi Bharal Agarwal, Mohammed Samim, Ozair Ala. Neuroprotective Effect of Fisetin Through Suppression of IL-1R/TLR Axis and Apoptosis in Pentylenetetrazole-Induced Kindling in Mice. Frontiers in neurology. vol 12. 2021-08-07. PMID:34354662. |
their hippocampus and cortex were assessed for neuronal damage, inflammation, and apoptosis. |
2021-08-07 |
2023-08-13 |
mouse |
| Jiaoying Jia, Ming Wang, Min Liu, Zhigang Tan, Yan Cui, Mengqiang Y. MiR-421 Binds to PINK1 and Enhances Neural Stem Cell Self-Renewal Frontiers in cell and developmental biology. vol 9. 2021-08-07. PMID:34354990. |
it has been documented that microrna (mir)-421 represses the autophagy and apoptosis of mouse hippocampal neurons and confers a role in the repair of ischemic brain injury (ibi). |
2021-08-07 |
2023-08-13 |
mouse |
| Zhiheng Wang, Lijun Han, Huizi ShangTing, Ping Che. Effect of hesperidin on CORT-induced apoptosis and oxidative stress of mouse hippocampal nerve cells by up-regulating miR-146a-5p. Pakistan journal of pharmaceutical sciences. vol 33. issue 3(Special). 2021-08-06. PMID:33361027. |
effect of hesperidin on cort-induced apoptosis and oxidative stress of mouse hippocampal nerve cells by up-regulating mir-146a-5p. |
2021-08-06 |
2023-08-13 |
mouse |
| Zhiheng Wang, Lijun Han, Huizi ShangTing, Ping Che. Effect of hesperidin on CORT-induced apoptosis and oxidative stress of mouse hippocampal nerve cells by up-regulating miR-146a-5p. Pakistan journal of pharmaceutical sciences. vol 33. issue 3(Special). 2021-08-06. PMID:33361027. |
this study aims to investigate the effect of hesperidin on cort-induced apoptosis and oxidative stress of mouse hippocampal nerve cells by up-regulating mir-146a-5p and related mechanism. |
2021-08-06 |
2023-08-13 |
mouse |
| Xiyu Gao, Dewei He, Dianfeng Liu, Guiqiu Hu, Yufei Zhang, Tianyu Meng, Yingchun Su, Ang Zhou, Bingxu Huang, Jian Du, Shoupeng F. Beta-naphthoflavone inhibits LPS-induced inflammation in BV-2 cells via AKT/Nrf-2/HO-1-NF-κB signaling axis. Immunobiology. vol 225. issue 4. 2021-08-05. PMID:32747020. |
we also found that bnf reduced the apoptosis rate of human neuroblastoma cells (shsy5y) and mouse hippocampal neuron cell line (ht22) by inhibiting release of inflammatory mediators in lps-exposed bv2 cells. |
2021-08-05 |
2023-08-13 |
mouse |
| Ying Yang, Wei Chen, Xiaoming Wang, Wei G. Impact of mitochondrial aldehyde dehydrogenase 2 on cognitive impairment in the AD model mouse. Acta biochimica et biophysica Sinica. vol 53. issue 7. 2021-08-05. PMID:33954430. |
furthermore, our results suggested that aldh2 protects against aβ hippocampal neuronal toxicity possibly through alleviating toxic aldehydes and ros, as well as increasing atp production to preserve mitochondrial integrity and reduce neuronal apoptosis. |
2021-08-05 |
2023-08-13 |
mouse |
| Vladimir F Lazarev, Magda Tsolaki, Elena R Mikhaylova, Konstantin A Benken, Maxim A Shevtsov, Alina D Nikotina, Mirna Lechpammer, Vladimir A Mitkevich, Alexander A Makarov, Alexey A Moskalev, Sergey A Kozin, Boris A Margulis, Irina V Guzhova, Evgeny Nudle. Extracellular GAPDH Promotes Alzheimer Disease Progression by Enhancing Amyloid-β Aggregation and Cytotoxicity. Aging and disease. vol 12. issue 5. 2021-08-04. PMID:34341704. |
lentivirus-driven gapdh overexpression in two ad animal models increased the level of apoptosis of hippocampal cells, neural degeneration, and cognitive dysfunction. |
2021-08-04 |
2023-08-13 |
Not clear |