| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenqian Zhang, Jun Hong, Wencheng Zheng, Aijun Liu, Ying Yan. High glucose exacerbates neuroinflammation and apoptosis at the intermediate stage after post-traumatic brain injury. Aging. vol 13. issue 12. 2021-07-21. PMID:34176788. |
histopathological staining and analyses of serum and hippocampal mrna and protein levels indicated that neuroinflammation and apoptosis were induced in tbi rats and exacerbated by hyperglycemia. |
2021-07-21 |
2023-08-13 |
rat |
| Wei Chen, Jianwu Zhang, Jing Wang, Yunxiang Li, Wenhu Liu, Jun Xi. Lycopene supplementation protects vascular dementia gerbils against the impairment of learning and memory. Folia neuropathologica. vol 59. issue 2. 2021-07-21. PMID:34284544. |
lyc also reduced pathological changes in the hippocampus caused by vad, reduced apoptosis, and decreased vad mediated bcl-2/bax expression. |
2021-07-21 |
2023-08-13 |
Not clear |
| Wei Chen, Jianwu Zhang, Jing Wang, Yunxiang Li, Wenhu Liu, Jun Xi. Lycopene supplementation protects vascular dementia gerbils against the impairment of learning and memory. Folia neuropathologica. vol 59. issue 2. 2021-07-21. PMID:34284544. |
we therefore conclude that lyc can improve the learning and memory ability of vad gerbils, the mechanism of which may be related to reduced oxidative stress and apoptosis in vad hippocampus neurons. |
2021-07-21 |
2023-08-13 |
Not clear |
| Wei Pan, Xingyu Song, Qibo Hu, Yunfeng Zhan. miR-485 inhibits histone deacetylase HDAC5, HIF1α and PFKFB3 expression to alleviate epilepsy in cellular and rodent models. Aging. vol 13. issue 10. 2021-07-20. PMID:34021541. |
cells were transfected with overexpression or knockdown of mir-485, hdac5, hypoxia-inducible factor-1alpha (hif1α), or 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 enzyme (pfkfb3) to verify their roles in apoptosis, oxidative stress, and inflammation in epileptic hippocampal neurons. |
2021-07-20 |
2023-08-13 |
mouse |
| Wenjie Su, Min Xie, Yao Li, Xinran Gong, Jiacen L. Topiramate Reverses Physiological and Behavioral Alterations by Postoperative Cognitive Dysfunction in Rat Model Through Inhibiting TNF Signaling Pathway. Neuromolecular medicine. vol 22. issue 2. 2021-07-19. PMID:31758388. |
besides, inhibition of fas enhanced tpm-induced down-regulation of apoptosis of neuronal cell in hippocampus tissues of pocd rats. |
2021-07-19 |
2023-08-13 |
rat |
| Wenjie Su, Min Xie, Yao Li, Xinran Gong, Jiacen L. Topiramate Reverses Physiological and Behavioral Alterations by Postoperative Cognitive Dysfunction in Rat Model Through Inhibiting TNF Signaling Pathway. Neuromolecular medicine. vol 22. issue 2. 2021-07-19. PMID:31758388. |
our results revealed that treatment of pocd rats with tpm could suppress neuronal apoptosis in the hippocampus tissues, and the neuroprotective effects of tpm may relate with the regulation of tumor necrosis factor (tnf) signaling pathway. |
2021-07-19 |
2023-08-13 |
rat |
| Pengfei Liu, Quansheng Gao, Lei Guan, Yanting Hu, Jingwen Jiang, Teng Gao, Weixuan Sheng, Xinying Xue, Hui Qiao, Tianzuo L. Atorvastatin attenuates surgery-induced BBB disruption and cognitive impairment partly by suppressing NF-κB pathway and NLRP3 inflammasome activation in aged mice. Acta biochimica et biophysica Sinica. vol 53. issue 5. 2021-07-16. PMID:33674828. |
atorvastatin could also reverse the surgery-induced increase of systemic and hippocampal cytokines, including il-1β, tnf-α, and il-6, accompanied by inhibiting the nuclear factor kappa-b (nf-κb) pathway and nucleotide-binding oligomerization domain, or leucine rich repeat and pyrin domain containing 3 (nlrp3) inflammasome activation, as well as hippocampal neuronal apoptosis. |
2021-07-16 |
2023-08-13 |
mouse |
| Yun-Sheng Zhu, Zhen Liu, Jia Min, Ying-Fen Xion. Dexmedetomidine reduces the apoptosis of rat hippocampal neurons via mediating ERK1/2 signal pathway by targeting miR-155. Acta histochemica. vol 123. issue 5. 2021-07-16. PMID:34048989. |
dexmedetomidine reduces the apoptosis of rat hippocampal neurons via mediating erk1/2 signal pathway by targeting mir-155. |
2021-07-16 |
2023-08-13 |
rat |
| Yun-Sheng Zhu, Zhen Liu, Jia Min, Ying-Fen Xion. Dexmedetomidine reduces the apoptosis of rat hippocampal neurons via mediating ERK1/2 signal pathway by targeting miR-155. Acta histochemica. vol 123. issue 5. 2021-07-16. PMID:34048989. |
dex, via down-regulating the expression of mir-155, could activate the erk1/2 pathway, thereby mitigating the apoptosis and oxidative stress injury and increasing the mmp, thereby protecting hippocampal cells from ogd/r injury. |
2021-07-16 |
2023-08-13 |
rat |
| Niels Haan, Laura J Westacott, Jenny Carter, Michael J Owen, William P Gray, Jeremy Hall, Lawrence S Wilkinso. Haploinsufficiency of the schizophrenia and autism risk gene Cyfip1 causes abnormal postnatal hippocampal neurogenesis through microglial and Arp2/3 mediated actin dependent mechanisms. Translational psychiatry. vol 11. issue 1. 2021-07-14. PMID:34031371. |
we demonstrate that haploinsufficiency of cyfip1 leads to increased numbers of adult-born hippocampal neurons due to reduced apoptosis, without altering proliferation. |
2021-07-14 |
2023-08-13 |
Not clear |
| Congfeng Tang, Xuejiao Liu, Hailing Zhu, Quan L. Antagonizing effect of icaritin on apoptosis and injury of hippocampal neurocytes induced by amyloid beta Journal of receptor and signal transduction research. vol 40. issue 6. 2021-07-13. PMID:32476534. |
antagonizing effect of icaritin on apoptosis and injury of hippocampal neurocytes induced by amyloid beta |
2021-07-13 |
2023-08-13 |
Not clear |
| Zhiguo Chen, Jiangang Liu, Qingmei Chen, Min Su, Haifeng Lu, Yi Yang, Guoqing Zhou, Xianxian Zhang, Yuan Liu, Wanli Dong, Qi Fan. Down-regulation of UBA6 exacerbates brain injury by inhibiting the activation of Notch signaling pathway to promote cerebral cell apoptosis in rat acute cerebral infarction model. Molecular and cellular probes. vol 53. 2021-07-13. PMID:32497710. |
the results of flow cytometry and western blot assays further demonstrated that uba6 inhibition induced the apoptosis of hippocampal neurons and increased cleaved-caspase-3/9 protein levels. |
2021-07-13 |
2023-08-13 |
rat |
| Zhiguo Chen, Jiangang Liu, Qingmei Chen, Min Su, Haifeng Lu, Yi Yang, Guoqing Zhou, Xianxian Zhang, Yuan Liu, Wanli Dong, Qi Fan. Down-regulation of UBA6 exacerbates brain injury by inhibiting the activation of Notch signaling pathway to promote cerebral cell apoptosis in rat acute cerebral infarction model. Molecular and cellular probes. vol 53. 2021-07-13. PMID:32497710. |
in conclusion, down-regulated uba6 intensified mcao-induced brain injury by inhibiting the activation of notch signaling pathway to promote the apoptosis of hippocampal neurons and was used to predict the poor prognosis of aci. |
2021-07-13 |
2023-08-13 |
rat |
| Yin Du, Xiaozhen Ma, Lei Ma, Siyuan Li, Juan Zheng, Junlin Lv, Long Cui, Jianrui L. Inhibition of microRNA-148b-3p alleviates oxygen-glucose deprivation/reoxygenation-induced apoptosis and oxidative stress in HT22 hippocampal neuron via reinforcing Sestrin2/Nrf2 signalling. Clinical and experimental pharmacology & physiology. vol 47. issue 4. 2021-07-12. PMID:31868937. |
inhibition of microrna-148b-3p alleviates oxygen-glucose deprivation/reoxygenation-induced apoptosis and oxidative stress in ht22 hippocampal neuron via reinforcing sestrin2/nrf2 signalling. |
2021-07-12 |
2023-08-13 |
Not clear |
| Xia Li, Sheng-Wu Wang, Xi-Ling Li, Feng-Yuan Yu, Hai-Ming Con. Knockdown of long non-coding RNA TUG1 depresses apoptosis of hippocampal neurons in Alzheimer's disease by elevating microRNA-15a and repressing ROCK1 expression. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. vol 69. issue 9. 2021-07-08. PMID:32577774. |
knockdown of long non-coding rna tug1 depresses apoptosis of hippocampal neurons in alzheimer's disease by elevating microrna-15a and repressing rock1 expression. |
2021-07-08 |
2023-08-13 |
Not clear |
| Qing Zeng, Qi Xiong, Mei Zhou, Xiang Tian, Kai Yue, Yi Li, Xiji Shu, Qin R. Resveratrol attenuates methamphetamine-induced memory impairment via inhibition of oxidative stress and apoptosis in mice. Journal of food biochemistry. vol 45. issue 2. 2021-07-08. PMID:33502009. |
further results validated oxidative stress parameters, apoptosis, and expression of keap1 were significantly increased, while the translocation and activation of nuclear factor erythroid 2-related factor 2 (nrf2) into the nucleus and expression of its downstream proteins were greatly decreased in the hippocampus after meth exposure (p < .05). |
2021-07-08 |
2023-08-13 |
mouse |
| Zhiheng Zhang, Wenhan Liu, Meilun Shen, Xiangying Ma, Rouqian Li, Xiaodi Jin, Hui Bai, Li Ga. Protective Effect of GM1 Attenuates Hippocampus and Cortex Apoptosis After Ketamine Exposure in Neonatal Rat via PI3K/AKT/GSK3β Pathway. Molecular neurobiology. vol 58. issue 7. 2021-07-06. PMID:33733293. |
protective effect of gm1 attenuates hippocampus and cortex apoptosis after ketamine exposure in neonatal rat via pi3k/akt/gsk3β pathway. |
2021-07-06 |
2023-08-13 |
rat |
| Zhiheng Zhang, Wenhan Liu, Meilun Shen, Xiangying Ma, Rouqian Li, Xiaodi Jin, Hui Bai, Li Ga. Protective Effect of GM1 Attenuates Hippocampus and Cortex Apoptosis After Ketamine Exposure in Neonatal Rat via PI3K/AKT/GSK3β Pathway. Molecular neurobiology. vol 58. issue 7. 2021-07-06. PMID:33733293. |
the morris water maze (mwm) test, the number of cortical and hippocampal cells, apoptosis, and akt/gsk3β pathway were analyzed. |
2021-07-06 |
2023-08-13 |
rat |
| Zhiheng Zhang, Wenhan Liu, Meilun Shen, Xiangying Ma, Rouqian Li, Xiaodi Jin, Hui Bai, Li Ga. Protective Effect of GM1 Attenuates Hippocampus and Cortex Apoptosis After Ketamine Exposure in Neonatal Rat via PI3K/AKT/GSK3β Pathway. Molecular neurobiology. vol 58. issue 7. 2021-07-06. PMID:33733293. |
we found that gm1 protected against ketamine-induced apoptosis in the hippocampus and cortex by reducing the expression of bcl-2 and caspase-3, and by increasing the expression of bax. |
2021-07-06 |
2023-08-13 |
rat |
| Zhiheng Zhang, Wenhan Liu, Meilun Shen, Xiangying Ma, Rouqian Li, Xiaodi Jin, Hui Bai, Li Ga. Protective Effect of GM1 Attenuates Hippocampus and Cortex Apoptosis After Ketamine Exposure in Neonatal Rat via PI3K/AKT/GSK3β Pathway. Molecular neurobiology. vol 58. issue 7. 2021-07-06. PMID:33733293. |
we showed that gm1 lessens ketamine-induced apoptosis in the hippocampus and cortex of young rats by regulating the pi3k/akt/gsk3β pathway. |
2021-07-06 |
2023-08-13 |
rat |