| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J D Noti, A K Johnso. Integrin alpha 5 beta 1 suppresses apoptosis triggered by serum starvation but not phorbol ester in MCF-7 breast cancer cells that overexpress protein kinase C-alpha. International journal of oncology. vol 18. issue 1. 2001-02-15. PMID:11115559. |
integrin alpha 5 beta 1 suppresses apoptosis triggered by serum starvation but not phorbol ester in mcf-7 breast cancer cells that overexpress protein kinase c-alpha. |
2001-02-15 |
2023-08-12 |
mouse |
| b' V Cupi\\xc4\\x87, M Coli\\xc4\\x87, L Pavici\\xc4\\x87, D Vucevi\\xc4\\x87, V M Varagi\\xc4\\x8. Immunomodulatory effect of xylazine, an alpha(2) adrenergic agonist, on rat spleen cells in culture. Journal of neuroimmunology. vol 113. issue 1. 2001-02-08. PMID:11137573.' |
cumulatively, these results suggest that the immunosuppressive properties of xylazine on splenocytes in vitro are due to increased apoptosis of lymphocytes, predominantly involve no-independent pathways, and are probably independent of its action through alpha(2) adrenoreceptors. |
2001-02-08 |
2023-08-12 |
rat |
| M T Esser, J W Bess, K Suryanarayana, E Chertova, D Marti, M Carrington, L O Arthur, J D Lifso. Partial activation and induction of apoptosis in CD4(+) and CD8(+) T lymphocytes by conformationally authentic noninfectious human immunodeficiency virus type 1. Journal of virology. vol 75. issue 3. 2001-02-02. PMID:11152488. |
noninfectious cxcr4-tropic hiv-1 virions, but not microvesicles, partially activated freshly isolated cd4(+) and cd8(+) peripheral blood mononuclear cell t lymphocytes to express fasl and fas, but not cd69 or cd25 (interleukin-2 receptor alpha) and eventually die via apoptosis starting 4 to 6 days postexposure. |
2001-02-02 |
2023-08-12 |
human |
| L Smith, L Chen, M E Reyland, T A DeVries, R V Talanian, S Omura, J B Smit. Activation of atypical protein kinase C zeta by caspase processing and degradation by the ubiquitin-proteasome system. The Journal of biological chemistry. vol 275. issue 51. 2001-02-01. PMID:11016947. |
induction of apoptosis in hela cells by tumor necrosis factor alpha plus cycloheximide evoked the conversion of full-length epitope-tagged pkczeta to two catalytic domain polypeptides and increased pkczeta activity. |
2001-02-01 |
2023-08-12 |
human |
| J Petrik, M Srinivasan, R Aalinkeel, S Coukell, E Arany, M S Patel, D J Hil. A long-term high-carbohydrate diet causes an altered ontogeny of pancreatic islets of Langerhans in the neonatal rat. Pediatric research. vol 49. issue 1. 2001-02-01. PMID:11134497. |
islets from hc animals were relatively deficient in alpha cells and had a greater incidence of islet cells with fragmented dna, indicative of apoptosis. |
2001-02-01 |
2023-08-12 |
rat |
| b' K A Candido, K Shimizu, J C McLaughlin, R Kunkel, J A Fuller, B G Redman, E K Thomas, B J Nickoloff, J J Mul\\xc3\\xa. Local administration of dendritic cells inhibits established breast tumor growth: implications for apoptosis-inducing agents. Cancer research. vol 61. issue 1. 2001-02-01. PMID:11196166.' |
the baseline level of tumor apoptosis could be increased substantially by tumor necrosis factor alpha administration, leading to a greater dc-mediated antitumor effect. |
2001-02-01 |
2023-08-12 |
Not clear |
| J Gotzmann, S Vlcek, R Foisne. Caspase-mediated cleavage of the chromosome-binding domain of lamina-associated polypeptide 2 alpha. Journal of cell science. vol 113 Pt 21. 2001-01-25. PMID:11034905. |
using various cell systems, including jurkat, hl-60, and hela cells, and different death-inducing agents, such as anti-fas antibody, topoisomerase inhibitors, and staurosporine, we found that lap2 alpha was cleaved during apoptosis as rapidly as lamin b in a caspase-dependent manner yielding stable n- and c-terminal fragments of approximately 50 and 28 kda, respectively. |
2001-01-25 |
2023-08-12 |
Not clear |
| J Gotzmann, S Vlcek, R Foisne. Caspase-mediated cleavage of the chromosome-binding domain of lamina-associated polypeptide 2 alpha. Journal of cell science. vol 113 Pt 21. 2001-01-25. PMID:11034905. |
our data suggest that early cleavage of lap2 alpha) is important for chromatin reorganization during apoptosis. |
2001-01-25 |
2023-08-12 |
Not clear |
| F Diaz, L Y Bourguigno. Selective down-regulation of IP(3)receptor subtypes by caspases and calpain during TNF alpha -induced apoptosis of human T-lymphoma cells. Cell calcium. vol 27. issue 6. 2001-01-18. PMID:11013462. |
selective down-regulation of ip(3)receptor subtypes by caspases and calpain during tnf alpha -induced apoptosis of human t-lymphoma cells. |
2001-01-18 |
2023-08-12 |
human |
| M Majka, A Janowska-Wieczorek, J Ratajczak, M A Kowalska, G Vilaire, Z K Pan, M Honczarenko, L A Marquez, M Poncz, M Z Ratajcza. Stromal-derived factor 1 and thrombopoietin regulate distinct aspects of human megakaryopoiesis. Blood. vol 96. issue 13. 2001-01-18. PMID:11110685. |
it was also found that though inhibition of phosphatidyl-inositol 3-kinase (pi-3k) by ly294002 in alpha(iib)beta(3)(+) cells induced apoptosis and inhibited chemotaxis adhesion and the secretion of mmp-9 and vegf, the inhibition of mapk p42/44 (by the mek inhibitor u0126) had no effect on the survival, proliferation, and migration of these cells. |
2001-01-18 |
2023-08-12 |
human |
| L Schandené, F Roufosse, A de Lavareille, P Stordeur, A Efira, B Kennès, E Cogan, M Goldma. Interferon alpha prevents spontaneous apoptosis of clonal Th2 cells associated with chronic hypereosinophilia. Blood. vol 96. issue 13. 2001-01-18. PMID:11110703. |
interferon alpha prevents spontaneous apoptosis of clonal th2 cells associated with chronic hypereosinophilia. |
2001-01-18 |
2023-08-12 |
Not clear |
| M Aoyama, D R Grabowski, K A Holmes, L A Rybicki, R M Bukowski, M K Ganapathi, R Ganapath. Cell cycle phase specificity in the potentiation of etoposide-induced DNA damage and apoptosis by KN-62, an inhibitor of calcium-calmodulin-dependent enzymes. Biochemical pharmacology. vol 61. issue 1. 2001-01-18. PMID:11137708. |
in agreement with the results on apoptosis in the resistant hl-60/dox0.05 cells, the enhanced depletion of the alpha and beta isoforms of topoisomerase ii by vp-16 + kn-62 was observed in g(1), s, and g(2)+m cells. |
2001-01-18 |
2023-08-12 |
Not clear |
| B B Whitlock, S Gardai, V Fadok, D Bratton, P M Henso. Differential roles for alpha(M)beta(2) integrin clustering or activation in the control of apoptosis via regulation of akt and ERK survival mechanisms. The Journal of cell biology. vol 151. issue 6. 2001-01-17. PMID:11121444. |
differential roles for alpha(m)beta(2) integrin clustering or activation in the control of apoptosis via regulation of akt and erk survival mechanisms. |
2001-01-17 |
2023-08-12 |
Not clear |
| B B Whitlock, S Gardai, V Fadok, D Bratton, P M Henso. Differential roles for alpha(M)beta(2) integrin clustering or activation in the control of apoptosis via regulation of akt and ERK survival mechanisms. The Journal of cell biology. vol 151. issue 6. 2001-01-17. PMID:11121444. |
both clustering and activation of alpha(m)beta(2) delays spontaneous, or unstimulated, apoptosis, maintains mitochondrial membrane potential, and prevents cytochrome c release. |
2001-01-17 |
2023-08-12 |
Not clear |
| B B Whitlock, S Gardai, V Fadok, D Bratton, P M Henso. Differential roles for alpha(M)beta(2) integrin clustering or activation in the control of apoptosis via regulation of akt and ERK survival mechanisms. The Journal of cell biology. vol 151. issue 6. 2001-01-17. PMID:11121444. |
in contrast, in the presence of proapoptotic stimuli, such as fas ligation, tnfalpha, or uv irradiation, ligation of active alpha(m)beta(2) resulted in enhanced mitochondrial changes and apoptosis. |
2001-01-17 |
2023-08-12 |
Not clear |
| B B Whitlock, S Gardai, V Fadok, D Bratton, P M Henso. Differential roles for alpha(M)beta(2) integrin clustering or activation in the control of apoptosis via regulation of akt and ERK survival mechanisms. The Journal of cell biology. vol 151. issue 6. 2001-01-17. PMID:11121444. |
when proapoptotic stimuli were combined with either alpha(m)beta(2) clustering or activation, akt activity was blocked, allowing integrin activation to enhance apoptosis. |
2001-01-17 |
2023-08-12 |
Not clear |
| B B Whitlock, S Gardai, V Fadok, D Bratton, P M Henso. Differential roles for alpha(M)beta(2) integrin clustering or activation in the control of apoptosis via regulation of akt and ERK survival mechanisms. The Journal of cell biology. vol 151. issue 6. 2001-01-17. PMID:11121444. |
clustered, inactive alpha(m)beta(2) continued to inhibit stimulated apoptosis due to maintained erk activity. |
2001-01-17 |
2023-08-12 |
Not clear |
| R E Voll, E Jimi, R J Phillips, D F Barber, M Rincon, A C Hayday, R A Flavell, S Ghos. NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development. Immunity. vol 13. issue 5. 2001-01-11. PMID:11114380. |
inhibition of nf-kappa b in isolated thymocytes in vitro results in spontaneous apoptosis of cells expressing the pre-tcr, whereas inhibition of nf-kappa b in transgenic mice through expression of a mutated, superrepressor form of i kappa b alpha leads to a loss of beta-selected thymocytes. |
2001-01-11 |
2023-08-12 |
mouse |
| M Suzuki, R J Youle, N Tjandr. Structure of Bax: coregulation of dimer formation and intracellular localization. Cell. vol 103. issue 4. 2001-01-08. PMID:11106734. |
bax consists of 9 alpha helices where the assembly of helices alpha1 through alpha 8 resembles that of the apoptosis inhibitor, bcl-x(l). |
2001-01-08 |
2023-08-12 |
Not clear |
| M Nagaki, T Naiki, D A Brenner, Y Osawa, M Imose, H Hayashi, Y Banno, S Nakashima, H Moriwak. Tumor necrosis factor alpha prevents tumor necrosis factor receptor-mediated mouse hepatocyte apoptosis, but not fas-mediated apoptosis: role of nuclear factor-kappaB. Hepatology (Baltimore, Md.). vol 32. issue 6. 2001-01-04. PMID:11093734. |
tumor necrosis factor alpha prevents tumor necrosis factor receptor-mediated mouse hepatocyte apoptosis, but not fas-mediated apoptosis: role of nuclear factor-kappab. |
2001-01-04 |
2023-08-12 |
mouse |