| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Berra, J Milanini, D E Richard, M Le Gall, F Viñals, E Gothié, D Roux, G Pagès, J Pouysségu. Signaling angiogenesis via p42/p44 MAP kinase and hypoxia. Biochemical pharmacology. vol 60. issue 8. 2000-10-31. PMID:11007955. |
we demonstrate that p42/p44 map kinases play a pivotal role in angiogenesis by exerting a determinant action at three levels: i) persistent activation of p42/p44 map kinases abrogates apoptosis; ii) p42/p44 map kinase activity is critical for controlling proliferation and growth arrest of confluent endothelial cells; and iii) p42/p44 map kinases promote vegf (vascular endothelial growth factor) expression by activating its transcription via recruitment of the ap-2/sp1 (activator protein-2) complex on the proximal region (-88/-66) of the vegf promoter and by direct phosphorylation of hypoxia-inducible factor 1 alpha (hif-1 alpha). |
2000-10-31 |
2023-08-12 |
Not clear |
| B P Neve, J C Fruchart, B Stael. Role of the peroxisome proliferator-activated receptors (PPAR) in atherosclerosis. Biochemical pharmacology. vol 60. issue 8. 2000-10-31. PMID:11007963. |
furthermore, ppar alpha inhibits expression of monocyte-recruiting proteins such as vascular cell adhesion molecule (vcam)-1 and induces apoptosis in monocyte-derived macrophages. |
2000-10-31 |
2023-08-12 |
Not clear |
| P Pootrakul, P Sirankapracha, S Hemsorach, W Moungsub, R Kumbunlue, A Piangitjagum, P Wasi, L Ma, S L Schrie. A correlation of erythrokinetics, ineffective erythropoiesis, and erythroid precursor apoptosis in thai patients with thalassemia. Blood. vol 96. issue 7. 2000-10-25. PMID:11001918. |
thus, it appears that alpha-chain deposition in erythroid precursors, either alpha(a) or alpha(cs), leads to accelerated apoptosis and ineffective erythropoiesis. |
2000-10-25 |
2023-08-12 |
Not clear |
| M A Daemen, V H Heemskerk, C van't Veer, G Denecker, T G Wolfs, P Vandenabeele, W A Buurma. Functional protection by acute phase proteins alpha(1)-acid glycoprotein and alpha(1)-antitrypsin against ischemia/reperfusion injury by preventing apoptosis and inflammation. Circulation. vol 102. issue 12. 2000-10-19. PMID:10993862. |
functional protection by acute phase proteins alpha(1)-acid glycoprotein and alpha(1)-antitrypsin against ischemia/reperfusion injury by preventing apoptosis and inflammation. |
2000-10-19 |
2023-08-12 |
Not clear |
| Y M Kim, T H Kim, H T Chung, R V Talanian, X M Yin, T R Billia. Nitric oxide prevents tumor necrosis factor alpha-induced rat hepatocyte apoptosis by the interruption of mitochondrial apoptotic signaling through S-nitrosylation of caspase-8. Hepatology (Baltimore, Md.). vol 32. issue 4 Pt 1. 2000-10-19. PMID:11003621. |
we investigated the role played by nitric oxide (no) in mitochondrial apoptotic signaling in tumor necrosis factor alpha (tnf-alpha) plus actinomycin d (tnf-alpha/actd)-induced apoptosis. |
2000-10-19 |
2023-08-12 |
human |
| R J Rodenburg, A Ganga, P L van Lent, L B van de Putte, W J van Venrooi. The antiinflammatory drug sulfasalazine inhibits tumor necrosis factor alpha expression in macrophages by inducing apoptosis. Arthritis and rheumatism. vol 43. issue 9. 2000-10-19. PMID:11014343. |
the antiinflammatory drug sulfasalazine inhibits tumor necrosis factor alpha expression in macrophages by inducing apoptosis. |
2000-10-19 |
2023-08-12 |
Not clear |
| G Bitan, L Scheibler, D F Mierke, M Rosenblatt, M Chore. Ligand-integrin alpha v beta 3 interaction determined by photoaffinity cross-linking: a challenge to the prevailing model. Biochemistry. vol 39. issue 36. 2000-10-13. PMID:10998238. |
integrin alpha(v)beta(3) plays a crucial role in angiogenesis, apoptosis, and bone remodeling, mainly by interacting with matrix proteins through recognition of an arg-gly-asp (rgd) motif. |
2000-10-13 |
2023-08-12 |
Not clear |
| Y Zermati, S Fichelson, F Valensi, J M Freyssinier, P Rouyer-Fessard, E Cramer, J Guichard, B Varet, O Hermin. Transforming growth factor inhibits erythropoiesis by blocking proliferation and accelerating differentiation of erythroid progenitors. Experimental hematology. vol 28. issue 8. 2000-10-10. PMID:10989189. |
interferon gamma and alpha act principally by inducing apoptosis. |
2000-10-10 |
2023-08-12 |
human |
| R Nath, M Huggins, S B Glantz, J S Morrow, K McGinnis, R Nadimpalli, K K Wang. Development and characterization of antibodies specific to caspase-3-produced alpha II-spectrin 120 kDa breakdown product: marker for neuronal apoptosis. Neurochemistry international. vol 37. issue 4. 2000-10-02. PMID:10825575. |
development and characterization of antibodies specific to caspase-3-produced alpha ii-spectrin 120 kda breakdown product: marker for neuronal apoptosis. |
2000-10-02 |
2023-08-12 |
human |
| S Smida Rezgui, S Honore, J B Rognoni, P M Martin, C Pene. Up-regulation of alpha 2 beta 1 integrin cell-surface expression protects A431 cells from epidermal growth factor-induced apoptosis. International journal of cancer. vol 87. issue 3. 2000-09-28. PMID:10897040. |
up-regulation of alpha 2 beta 1 integrin cell-surface expression protects a431 cells from epidermal growth factor-induced apoptosis. |
2000-09-28 |
2023-08-12 |
Not clear |
| S Smida Rezgui, S Honore, J B Rognoni, P M Martin, C Pene. Up-regulation of alpha 2 beta 1 integrin cell-surface expression protects A431 cells from epidermal growth factor-induced apoptosis. International journal of cancer. vol 87. issue 3. 2000-09-28. PMID:10897040. |
moreover, the involvement of alpha 2 beta 1 integrin up-regulation in the survival of a431 cells that escape egf-induced apoptosis was verified using the blocking anti-alpha 2 beta 1 integrin antibody, which was shown to decrease the survival of egf-stimulated cells. |
2000-09-28 |
2023-08-12 |
Not clear |
| I Gout, G Middleton, J Adu, N N Ninkina, L B Drobot, V Filonenko, G Matsuka, A M Davies, M Waterfield, V L Buchma. Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein. The EMBO journal. vol 19. issue 15. 2000-09-28. PMID:10921882. |
overexpression of ruk(l) in cultured primary neurons induces apoptosis, an effect that could be reversed by co-expression of constitutively activated forms of the p110 alpha catalytic subunit of pi 3-kinase or its downstream effector pkb/akt. |
2000-09-28 |
2023-08-12 |
Not clear |
| J Yuan, L Zhou, X Qi. [The relationship between LPS-induced apoptosis in hepatocyte, Kupffer cell and hepatocytic damage]. Zhonghua yi xue za zhi. vol 78. issue 6. 2000-09-26. PMID:10923503. |
to study the role of tumor necrosis factor (tnf alpha) in the mechanisms of liver injury and the relationship between lps-induced apoptosis in hepatocyte (hc), kupffer cell (kc), and hepatic damage. |
2000-09-26 |
2023-08-12 |
Not clear |
| T Bellido, M Huening, M Raval-Pandya, S C Manolagas, S Christako. Calbindin-D28k is expressed in osteoblastic cells and suppresses their apoptosis by inhibiting caspase-3 activity. The Journal of biological chemistry. vol 275. issue 34. 2000-09-25. PMID:10835428. |
transient transfection of rat calbindin-d(28k) cdna blocked tumor necrosis factor alpha (tnfalpha)-induced apoptosis in osteoblastic mc3t3-e1 cells, as determined by cell viability and nuclear morphology of cells cotransfected with the green fluorescent protein targeted to the nucleus, whereas transfection of the empty vector had no effect. |
2000-09-25 |
2023-08-12 |
rat |
| B van de Water, I B Tijdens, A Verbrugge, M Huigsloot, A A Dihal, J L Stevens, S Jaken, G J Mulde. Cleavage of the actin-capping protein alpha -adducin at Asp-Asp-Ser-Asp633-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells. The Journal of biological chemistry. vol 275. issue 33. 2000-09-21. PMID:10823823. |
cleavage of the actin-capping protein alpha -adducin at asp-asp-ser-asp633-ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells. |
2000-09-21 |
2023-08-12 |
human |
| L Rössig, J Haendeler, C Hermann, P Malchow, C Urbich, A M Zeiher, S Dimmele. Nitric oxide down-regulates MKP-3 mRNA levels: involvement in endothelial cell protection from apoptosis. The Journal of biological chemistry. vol 275. issue 33. 2000-09-21. PMID:10846176. |
the cytosolic map kinase phosphatase map kinase phosphatase-3 (mkp-3) induces apoptosis of endothelial cells in response to tumor necrosis factor alpha (tnfalpha) via dephosphorylation of the map kinase erk1/2, leading to bcl-2 proteolysis. |
2000-09-21 |
2023-08-12 |
Not clear |
| A Khoshnan, C Tindell, I Laux, D Bae, B Bennett, A E Ne. The NF-kappa B cascade is important in Bcl-xL expression and for the anti-apoptotic effects of the CD28 receptor in primary human CD4+ lymphocytes. Journal of immunology (Baltimore, Md. : 1950). vol 165. issue 4. 2000-09-14. PMID:10925251. |
transduction of proliferating cd4+ t cells with a tetracycline-regulated retrovirus encoding for a dominant-interfering, degradation-resistant i-kappabalpha (inhibitor of kappa b alpha factor) mutant induced apoptosis. |
2000-09-14 |
2023-08-12 |
human |
| Y Osman, T Kawamura, T Naito, K Takeda, L Van Kaer, K Okumura, T Ab. Activation of hepatic NKT cells and subsequent liver injury following administration of alpha-galactosylceramide. European journal of immunology. vol 30. issue 7. 2000-09-13. PMID:10940881. |
when 2 microg (or more)/mouse of alpha(-galcer was injected i.p., the majority of nkt cells disappeared in the liver and spleen, possibly undergoing apoptosis, on day 1. |
2000-09-13 |
2023-08-12 |
mouse |
| F Grignani, M Valtieri, M Gabbianelli, V Gelmetti, R Botta, L Luchetti, B Masella, O Morsilli, E Pelosi, P Samoggia, P G Pelicci, C Peschl. PML/RAR alpha fusion protein expression in normal human hematopoietic progenitors dictates myeloid commitment and the promyelocytic phenotype. Blood. vol 96. issue 4. 2000-09-07. PMID:10942402. |
expression of pml/rar alpha fusion protein in human hpc/hsc dictates the acute promyelocytic leukemia (apl) phenotype, largely through these previously unreported effects: rapid induction of hpc/hsc differentiation to the promyelocytic stage, followed by maturation arrest, which is abolished by retinoic acid; reprogramming of hpc commitment to preferential granulopoietic differentiation, irrespective of the hgf stimulus (transduction of single sibling hpc formally demonstrated this effect); hpc protection from apoptosis induced by hgf deprivation. |
2000-09-07 |
2023-08-12 |
human |
| H T Idriss, J H Naismit. TNF alpha and the TNF receptor superfamily: structure-function relationship(s). Microscopy research and technique. vol 50. issue 3. 2000-08-31. PMID:10891884. |
tumour necrosis factor alpha (tnf alpha), is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and is responsible for a diverse range of signalling events within cells, leading to necrosis or apoptosis. |
2000-08-31 |
2023-08-12 |
Not clear |