| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B A Fischer, S Mundle, A A Col. Tumor necrosis factor-alpha induced DNA cleavage in human articular chondrocytes may involve multiple endonucleolytic activities during apoptosis. Microscopy research and technique. vol 50. issue 3. 2000-08-31. PMID:10891889. |
apoptosis was induced in the chondrocytes by either tumor necrosis factor alpha (tnf alpha), interleukin 1-beta (il-1 beta), or anti-fas antibody but only after 48 hours in culture. |
2000-08-31 |
2023-08-12 |
human |
| I S Kim, D H Kim, S M Han, M U Chin, H J Nam, H P Cho, S Y Choi, B J Song, E R Kim, Y S Bae, Y H Moo. Truncated form of importin alpha identified in breast cancer cell inhibits nuclear import of p53. The Journal of biological chemistry. vol 275. issue 30. 2000-08-31. PMID:10930427. |
a significant increase in the p21(waf1/cip1) mrna level and induction of apoptosis were also observed in importin alpha overexpressing cells. |
2000-08-31 |
2023-08-12 |
Not clear |
| A Mathur, M L Vallan. 2,2',3,3',4,4'-Hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether (HBDDE)-induced neuronal apoptosis independent of classical protein kinase C alpha or gamma inhibition. Biochemical pharmacology. vol 60. issue 6. 2000-08-29. PMID:10930535. |
2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether (hbdde)-induced neuronal apoptosis independent of classical protein kinase c alpha or gamma inhibition. |
2000-08-29 |
2023-08-12 |
Not clear |
| A Mathur, M L Vallan. 2,2',3,3',4,4'-Hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether (HBDDE)-induced neuronal apoptosis independent of classical protein kinase C alpha or gamma inhibition. Biochemical pharmacology. vol 60. issue 6. 2000-08-29. PMID:10930535. |
furthermore, hbdde induced apoptosis even after phorbol-ester-mediated down-regulation of pkc alpha and gamma, indicating that this effect is independent of these isoforms. |
2000-08-29 |
2023-08-12 |
Not clear |
| C Weber, W Er. Modulation of vascular cell activation, function, and apoptosis: role of antioxidants and nuclear factor-kappa B. Current topics in cellular regulation. vol 36. 2000-08-25. PMID:10842754. |
hence, the inhibition of nf-kappa b mobilization by antioxidative or anti-inflammatory agents or by adenoviral i kappa b alpha overexpression, as reviewed herein, may act in concert to suppress endothelial activation and to induce smc apoptosis. |
2000-08-25 |
2023-08-12 |
human |
| S M Quirk, R M Harman, S C Huber, R G Cowa. Responsiveness of mouse corpora luteal cells to Fas antigen (CD95)-mediated apoptosis. Biology of reproduction. vol 63. issue 1. 2000-08-24. PMID:10859241. |
the effect of pretreatment of cultures with cytokines interferon gamma (ifn) and tumor necrosis factor alpha (tnf) was examined because these cytokines demonstrated effects on fas-mediated apoptosis in other cell types. |
2000-08-24 |
2023-08-12 |
mouse |
| M Li, A A Be. Induction of necrotic-like cell death by tumor necrosis factor alpha and caspase inhibitors: novel mechanism for killing virus-infected cells. Journal of virology. vol 74. issue 16. 2000-08-18. PMID:10906200. |
however, and similar to most cell types, mouse fibroblasts are normally resistant to tumor necrosis factor alpha (tnf-alpha)-induced apoptosis. |
2000-08-18 |
2023-08-12 |
mouse |
| E M Grossman, W E Longo, N Panesar, J E Mazuski, D L Kaminsk. The role of cyclooxygenase enzymes in the growth of human gall bladder cancer cells. Carcinogenesis. vol 21. issue 7. 2000-08-17. PMID:10874020. |
employing a human gall bladder cancer cell line, mitogenesis, apoptosis and prostaglandin e(2) (pge(2)) formation were evaluated in response to serum and hepatocyte growth factor and transforming growth factor alpha stimulation in the presence and absence of specific cox-1 and -2 inhibitors. |
2000-08-17 |
2023-08-12 |
human |
| S Jeay, G E Sonenshein, M C Postel-Vinay, E Baixera. Growth hormone prevents apoptosis through activation of nuclear factor-kappaB in interleukin-3-dependent Ba/F3 cell line. Molecular endocrinology (Baltimore, Md.). vol 14. issue 5. 2000-08-10. PMID:10809229. |
overexpression of the mutated ikappab alpha (a32/36) protein, known to inhibit nf-kappab activity, resulted in death of growth factor-deprived ba/f3 ghr cells, and addition of gh was no longer able to rescue these cells from apoptosis. |
2000-08-10 |
2023-08-12 |
rat |
| E Nisoli, L Briscini, A Giordano, C Tonello, S M Wiesbrock, K T Uysal, S Cinti, M O Carruba, G S Hotamisligi. Tumor necrosis factor alpha mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 14. 2000-08-10. PMID:10884431. |
tumor necrosis factor alpha mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity. |
2000-08-10 |
2023-08-12 |
mouse |
| J Margreiter, A Schlager, A Balogh, H Maier, D Balogh, K H Lindner, D Fuchs, W Schobersberge. Exogenous neopterin causes cardiac contractile dysfunction in the isolated perfused rat heart. Journal of molecular and cellular cardiology. vol 32. issue 7. 2000-08-09. PMID:10860768. |
recent studies report neopterin also to exhibit distinct effects: neopterin induces inducible nitric oxide synthase expression in rat vascular smooth muscle cells and activates translocation of nuclear factor- kappa b. neopterin may also induce oxidative stress causing apoptotic cell death, or superinduce tumor necrosis factor- alpha -mediated apoptosis. |
2000-08-09 |
2023-08-12 |
rat |
| W K Hofmann, U Kalina, S Koschmieder, G Seipelt, D Hoelzer, O G Ottman. Defective megakaryocytic development in myelodysplastic syndromes. Leukemia & lymphoma. vol 38. issue 1-2. 2000-07-24. PMID:10811444. |
premature apoptosis of the bone marrow cells and inhibitory effects of cytokines such as tumor necrosis factor alpha have been implicated as contributing to altered megakaryopoiesis in mds, but their significance remains unclear. |
2000-07-24 |
2023-08-12 |
human |
| G Atsumi, M Murakami, K Kojima, A Hadano, M Tajima, I Kud. Distinct roles of two intracellular phospholipase A2s in fatty acid release in the cell death pathway. Proteolytic fragment of type IVA cytosolic phospholipase A2alpha inhibits stimulus-induced arachidonate release, whereas that of type VI Ca2+-independent phospholipase A2 augments spontaneous fatty acid release. The Journal of biological chemistry. vol 275. issue 24. 2000-07-20. PMID:10747887. |
cytosolic phospholipase a(2)alpha (cpla(2)alpha; type iva), an essential initiator of stimulus-dependent arachidonic acid (aa) metabolism, underwent caspase-mediated cleavage at asp(522) during apoptosis. |
2000-07-20 |
2023-08-12 |
Not clear |
| S Y Hong, W H Yoon, J H Park, S G Kang, J H Ahn, T H Le. Involvement of two NF-kappa B binding elements in tumor necrosis factor alpha -, CD40-, and epstein-barr virus latent membrane protein 1-mediated induction of the cellular inhibitor of apoptosis protein 2 gene. The Journal of biological chemistry. vol 275. issue 24. 2000-07-20. PMID:10751398. |
involvement of two nf-kappa b binding elements in tumor necrosis factor alpha -, cd40-, and epstein-barr virus latent membrane protein 1-mediated induction of the cellular inhibitor of apoptosis protein 2 gene. |
2000-07-20 |
2023-08-12 |
Not clear |
| Y Wang, T R Wu, S Cai, T Welte, Y E Chi. Stat1 as a component of tumor necrosis factor alpha receptor 1-TRADD signaling complex to inhibit NF-kappaB activation. Molecular and cellular biology. vol 20. issue 13. 2000-07-20. PMID:10848577. |
activated tumor necrosis factor alpha (tnf-alpha) receptor 1 (tnfr1) recruits tnfr1-associated death domain protein (tradd), which in turn triggers two opposite signaling pathways leading to caspase activation for apoptosis induction and nf-kappab activation for antiapoptosis gene upregulation. |
2000-07-20 |
2023-08-12 |
Not clear |
| M E Wagener, B T Konieczny, Z Dai, G H Ring, F G Lakki. Alloantigen-driven T cell death mediated by Fas ligand and tumor necrosis factor-alpha is not essential for the induction of allograft acceptance. Transplantation. vol 69. issue 11. 2000-07-13. PMID:10868653. |
fas ligand (fasl)-fas and tumor necrosis factor alpha (tnfalpha)-tumor necrosis factor receptor (tnfr) interactions regulate immune responses and contribute to self-tolerance by mediating antigen-driven t cell apoptosis. |
2000-07-13 |
2023-08-12 |
Not clear |
| S C Beck, T F Meye. IgA1 protease from Neisseria gonorrhoeae inhibits TNFalpha-mediated apoptosis of human monocytic cells. FEBS letters. vol 472. issue 2-3. 2000-06-30. PMID:10788628. |
here, we report on the inhibition of tumor necrosis factor alpha (tnfalpha)-mediated apoptosis of the human myelo-monocytic cell line u937 by highly purified iga1 protease. |
2000-06-30 |
2023-08-12 |
human |
| A P Sampso. The role of eosinophils and neutrophils in inflammation. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. vol 30 Suppl 1. 2000-06-27. PMID:10849470. |
leukotriene b4 and cytokines such as il-8, granulocyte-macrophage colony stimulating factor (gm-csf), and tumour necrosis factor (tnf)alpha chemoattract neutrophils and reduce neutrophil apoptosis, and selective agents directed against these may prevent neutrophil influx and accumulation. |
2000-06-27 |
2023-08-12 |
Not clear |
| S Tuttle, T Stamato, M L Perez, J Biaglo. Glucose-6-phosphate dehydrogenase and the oxidative pentose phosphate cycle protect cells against apoptosis induced by low doses of ionizing radiation. Radiation research. vol 153. issue 6. 2000-06-23. PMID:10825753. |
here we report that the enhanced alpha component of radiation-induced cell killing is associated with a significant increase in the incidence of ionizing radiation-induced apoptosis in the g6pd(-) cells. |
2000-06-23 |
2023-08-12 |
Not clear |
| J E Gschwend, W R Fair, C T Powel. Bryostatin 1 induces prolonged activation of extracellular regulated protein kinases in and apoptosis of LNCaP human prostate cancer cells overexpressing protein kinase calpha. Molecular pharmacology. vol 57. issue 6. 2000-06-22. PMID:10825394. |
previously, we reported that 12-o-tetradecanoylphorbol-13-acetate (tpa)-induced apoptosis of lncap human prostate cancer cells was accompanied by prolonged translocation of protein kinase c (pkc)alpha to non-nuclear membranes and that tpa-resistant lncap cells had down-regulated pkcalpha. |
2000-06-22 |
2023-08-12 |
human |