| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yahong Cheng, Chengcheng Gai, Yijing Zhao, Tingting Li, Yan Song, Qian Luo, Danqing Xin, Zige Jiang, Wenqiang Chen, Dexiang Liu, Zhen Wan. Engineered Extracellular Vesicles Loaded with MiR-100-5p Antagonist Selectively Target the Lesioned Region to Promote Recovery from Brain Damage. Neuroscience bulletin. 2025-04-01. PMID:40167866. |
mechanistically, we identified protein phosphatase 3 catalytic subunit alpha (ppp3ca) as a novel candidate target gene of mir-100-5p, inhibiting c-fos expression and neuronal apoptosis following hi insult. |
2025-04-01 |
2025-04-03 |
mouse |
| Yanmeng Li, Qin Ouyang, Zhibin Chen, Donghu Zhou, Zhenkun Li, Xiaoxi Yang, Jiang Long, Guangyong Chen, Xiaojin Li, Siyu Jia, Huaduan Zi, Saiping Qi, Hengcheng Tang, Bei Zhang, Yamei Niu, Anjian Xu, Weimin Tong, Jidong Jia, Jian Huan. Novel role of general transcript factor IIH subunit 2 (GTF2H2) in the development and sex disparity of hepatocellular carcinoma. Oncogene. 2025-02-19. PMID:39972070. |
here, it was identified that gtf2h2 inhibited growth and invasive mobility and induced apoptosis of hcc cells, which was up-regulated by estrogen-dependent estrogen receptor alpha (erα) signaling. |
2025-02-19 |
2025-02-23 |
mouse |
| S Lu, T T Chen, J K Zhan. Nimodipine ameliorates cognitive dysfunction and neurological injury after subarachnoid hemorrhage in rats by upregulating microRNA-31-5p targeting hypoxia-inducible factor 1 subunit alpha inhibitor. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 75. issue 6. 2025-02-09. PMID:39923226. |
the sah rat model was established, mir-31-5p and hypoxia-inducible factor 1 subunit alpha inhibitor (hif1an) expressions were detected 48 h after modeling, and neurobehavioral function, neuronal apoptosis, activation of microglia, and inflammation were evaluated. |
2025-02-09 |
2025-02-11 |
rat |
| Tobias Wikerholmen, Erlend Moen Taule, Emma Rigg, Birgitte Feginn Berle, Magnus Sættem, Katharina Sarnow, Halala Sdik Saed, Terje Sundstrøm, Frits Thorse. Repurposing neuroleptics: clozapine as a novel, adjuvant therapy for melanoma brain metastases. Clinical & experimental metastasis. vol 42. issue 2. 2025-01-24. PMID:39856383. |
through flow cytometry and proteome screening, we found that clozapine induced apoptosis in mbm cells and potentially altered the tumor immunological environment by upregulating proteins such as macrophage inflammatory protein-1 alpha (mip-1α) and interleukin-8 (il-8). |
2025-01-24 |
2025-01-28 |
human |
| Langhnoja Jaldeep, Buch Lipi, Pillai Prakas. Neurotrophomodulatory effect of TNF-α through NF-κB in rat cortical astrocytes. Cytotechnology. vol 77. issue 1. 2025-01-08. PMID:39776978. |
tumor necrosis factor alpha (tnf-α) is a well-known pro-inflammatory cytokine originally recognized for its ability to induce apoptosis and cell death. |
2025-01-08 |
2025-01-13 |
rat |
| Xiaofeng Zhang, Lugen Zuo, Xue Song, Wenjing Zhang, Zi Yang, Zhiyuan Wang, Yibing Guo, Sitang Ge, Lian Wang, Yueyue Wang, Zhijun Geng, Jing Li, Jianguo H. The mesenteric adipokine SFRP5 alleviated intestinal epithelial apoptosis improving barrier dysfunction in Crohn's disease. iScience. vol 27. issue 12. 2025-01-06. PMID:39759008. |
the results of this study revealed that the level of sfpr5 increased in the diseased mat (htmat) of cd patients and aggregated among intestinal epithelial cells in the diseased intestine and that it could ameliorate intestinal barrier dysfunction in tumor necrosis factor alpha (tnf-α)-stimulated colonic organoids and 2,4,6-trinitrobenzenesulfonic acid (tnbs)-induced mice at least in part through the inhibition of wnt5a-mediated apoptosis in epithelial cells. |
2025-01-06 |
2025-01-08 |
mouse |
| M Kilic, H Kasperczyk, S Fulda, K-M Debati. Editorial Expression of Concern: Role of hypoxia inducible factor-1 alpha in modulation of apoptosis resistance. Oncogene. 2024-12-12. PMID:39668244. |
editorial expression of concern: role of hypoxia inducible factor-1 alpha in modulation of apoptosis resistance. |
2024-12-12 |
2024-12-22 |
Not clear |
| Binru Zheng, Jia Shang, Yuanqing Wei, Qianqian Tao, Jizhou Yin, An Kang, Rui Liu, Hongzhen Lian, Shuying Ha. Chemoproteomic profiling by bioorthogonal probes to reveal the novel targets of acrylamide in microglia. Journal of hazardous materials. vol 484. 2024-12-05. PMID:39637805. |
aa was found to induce neurotoxicity by binding to newly identified targets, proteasome 26s subunit, non atpase 9 (psmd9) and nadh dehydrogenase (ubiquinone) 1 alpha subcomplex 5 (ndufa5), interfering with the ubiquitin-proteasome system, and inducing mitochondria-dependent apoptosis. |
2024-12-05 |
2024-12-08 |
Not clear |
| Haibo Xie, Yuansheng Duan, Pengcheng Zhou, Yu Li, Jihong Gao, Ruixuan Cheng, Zhibing Liu, Jiaxiang Zhang, Qixing Zh. TNF-α-downregulated SIRT1 regulates mitochondrial-autophagy and apoptosis in renal vascular endothelial cells involved in trichloroethylene-induced immune kidney injury. International immunopharmacology. vol 143. issue Pt 2. 2024-10-30. PMID:39476564. |
this study investigated how trichloroethylene (tce) sensitization-induced tumor necrosis factor alpha (tnf-α) deposition in renal vascular endothelial cells affects apoptosis and its underlying mechanisms. |
2024-10-30 |
2024-11-02 |
mouse |
| L Li, Y Liao, Z Y Li. [Mechanism of protective effect of metformin against septic cardiomyopathy based on the P38 MAPK/JNK signaling pathway]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. vol 58. issue 10. 2024-10-20. PMID:39428241. |
ultrasound imaging system was used to detect cardiac function, and tunel method was used to detect apoptosis rate of myocardial tissues; real-time fluorescence quantitative polymerase chain reaction (rt-qpcr) was used to detect the levels of mrna of jnk, p38 mapk of p38 mapk signaling pathway in the myocardial tissues of mice; plasma creatine kinase isoenzyme (ck-mb), brain natriuretic peptide (bnp), tumor necrosis factor alpha (tnf-α), and interleukin 6 (il-6) levels were measured by enzyme-linked immunosorbent assay (elisa) in all groups of mice; and protein kinase c, and protein kinase c levels were measured by protein blotting in cardiac muscle tissue. |
2024-10-20 |
2024-10-23 |
mouse |
| Fengqin Luo, Juan Zhang, Yunfei Miao, Danhong Wu, Hongxia Shen, Man L. Paeoniflorin regulates microglia-astrocyte crosstalk, inhibits inflammatory response, and alleviates neuropathic pain through HSP90AA1/HMGB1 signaling pathway. The international journal of biochemistry & cell biology. 2024-10-12. PMID:39395636. |
paeoniflorin alleviated mechanical abnormal pain, decreased levels of ionized calcium binding adapter molecule-1 (iba-1), glial fibrillary acidic protein, heat shock protein 90 alpha family class a member 1 (hsp90aa1, inflammatory factor) and high mobility group box 1 (hmgb1, inflammation-related protein), and inhibited neuronal apoptosis in chronic constrictive injury rats or lipopolysaccharide-induced bv-2 cells. |
2024-10-12 |
2024-10-15 |
mouse |
| Bojie Ma, Chaode Gu, Renwei Lu, Panpan Lian, Wentong Wang, Zhiqiang Huang, Zhonglan Su, Hongwei Wan. Inhibition of KPNA2 by ivermectin reduces E2F1 nuclear translocation to attenuate keratinocyte proliferation and ameliorate psoriasis-like lesions. International immunopharmacology. vol 143. issue Pt 1. 2024-10-10. PMID:39388894. |
karyopherin subunit alpha 2 (kpna2), a nuclear transport protein involved in cellular activities such as differentiation, proliferation, apoptosis, and immune response, has emerged as a potential biomarker in several diseases. |
2024-10-10 |
2024-10-13 |
mouse |
| Mohammad Yousefi Zardak, Fatemeh Keshavarz, Ali Mahyaei, Morteza Gholami, Fatemeh Sadat Moosavi, Elham Abbasloo, Farzaneh Abdollahi, Maryam Hossein Rezaei, Elham Madadizadeh, Nasrin Soltani, Fatemeh Bejeshk, Niyan Salehi, Fahimeh Rostamabadi, Fatemeh Bagheri, Mahla Jafaraghae, Mahdiyeh Ranjbar Zeydabadi, Meraj Baghgoli, Gholamreza Sepehri, Mohammad Abbas Bejesh. Quercetin as a therapeutic agent activate the Nrf2/Keap1 pathway to alleviate lung ischemia-reperfusion injury. Scientific reports. vol 14. issue 1. 2024-10-04. PMID:39367100. |
furthermore, we examined markers related to inflammation (interleukin-1β and tumor necrosis factor alpha), oxidative stress (malondialdehyde, total oxidant status, superoxide dismutase, glutathione peroxidase, total antioxidant capacity), lung edema (wet/dry lung weight ratio and total protein concentration), apoptosis (bax and bcl2 protein), and histopathological alterations (intra-alveolar edema, alveolar hemorrhage, and neutrophil infiltration). |
2024-10-04 |
2024-10-07 |
rat |
| Rilong Jin, Chen Li, Yute Yang, Jie Xi. AEBP1 restores osteoblastic differentiation under dexamethasone treatment by activating PI3K/AKT signalling. Clinical and experimental pharmacology & physiology. vol 51. issue 11. 2024-10-03. PMID:39358837. |
aebp1-overexpressed lentiviral vectors increased relative cell viability, alkaline phosphatase (alp) staining, alizarin red staining and osteoblastic differentiation markers including osteocalcin (ocn), osteopontin (opn), collagen type i alpha 1 (col1a1), runt-related transcription factor 2 (runx2) and bone morphogenetic protein 2 (bmp2), but decreased cell apoptosis rate in mc3t3-e1 cells under dex treatment; besides, aebp1-overexpressed lentiviral vectors positively regulated p-pi3k and p-akt expressions. |
2024-10-03 |
2024-10-05 |
Not clear |
| Seda Kocak, Ibrahim Guner, Muhittin Onur Yaman, Tugba Ekiz Yilmaz, Emine Elif Guzel Meydanli, Nermin Yelmen, Gulderen Sahi. Alpha B-crystallin Ameliorates Imbalance of Redox Homeostasis, Inflammation and Apoptosis in an Acute Lung Injury Model with Rats. Medeniyet medical journal. vol 39. issue 3. 2024-10-01. PMID:39350576. |
alpha b-crystallin ameliorates imbalance of redox homeostasis, inflammation and apoptosis in an acute lung injury model with rats. |
2024-10-01 |
2024-10-03 |
rat |
| Fan Chen, Zian Zhang, Wenzhe Wang, Chang Liu, Zhenchao Huang, Chaoqun Yu, Zhen Jia, Haining Zhan. Omega-3 fatty acids protect cartilage from acute injurie by reducing the mechanical sensitivity of chondrocytes. Journal of orthopaedic surgery and research. vol 19. issue 1. 2024-09-29. PMID:39342268. |
epa was incorporated into the culture medium, followed by assays to evaluate cell viability, calcium (ca²⁺) influx, apoptosis, reactive oxygen species (ros) levels, and collagen type ii alpha (col-2a) expression. |
2024-09-29 |
2024-10-01 |
human |
| Zhaowenbin Zhang, Chen Fan, Qing Xu, Feng Guo, Wenbo Li, Zhen Zeng, Yuze Xu, Jing Yu, Hongping Ge, Chen Yang, Jiang Chan. A New Strategy to Inhibit Scar Formation by Accelerating Normal Healing Using Silicate Bioactive Materials. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-09-28. PMID:39340818. |
the underlining mechanisms include stimulation of integrin subunit alpha 2 expression in dermal fibroblasts to accelerate wound healing, and induction of apoptosis of hypertrophic scar fibroblasts by directly stimulating the n-acylsphingosine amidohydrolase 2 expression in hypertrophic scar fibroblasts, and indirectly upregulating the secretion of cathepsin k in dermal fibroblasts. |
2024-09-28 |
2024-10-01 |
rabbit |
| Nataly de Dios, Rodrigo Riedel, Malena Schanton, Paula Balestrini, Luciano Pérez, Antonio Pérez-Pérez, Tomás Etcheverry, Roberto Casale, Mariana Farina, Víctor Sánchez-Margalet, Julieta Maymó, Cecilia Varon. Placental apoptosis increased by hypoxia inducible factor-1 stabilization is counteracted by leptin†. Biology of reproduction. vol 111. issue 3. 2024-09-15. PMID:38924703. |
obtained data demonstrate that hypoxia-inducible factor-1 alpha stabilization induces apoptosis in human placenta and leptin counteracts this effect, reinforcing its role as a survival cytokine. |
2024-09-15 |
2024-09-18 |
human |
| Liangping Li, Zetian Huang, Yuying Huang, Yongkun Li, Xuesong Ma, Pingping Li, Wenqing Du, Hui Wang, Yufei Zhao, Shulan Zeng, Yan Peng, Guohai Zhan. Pomalidomide sensitizes lung cancer cells to TRAIL/CDDP-induced apoptosis via directly targeting electron transfer flavoprotein alpha subunit. Bioorganic chemistry. vol 153. 2024-09-12. PMID:39265523. |
pomalidomide sensitizes lung cancer cells to trail/cddp-induced apoptosis via directly targeting electron transfer flavoprotein alpha subunit. |
2024-09-12 |
2024-09-15 |
Not clear |
| Lorena Palacios-Navarro, Leodan A Crispin, Juan P Muñoz, Gloria M Cala. Effects of Curcumin and Estrogen Receptor Alpha in Luminal Breast Cancer Cells. Diagnostics (Basel, Switzerland). vol 14. issue 16. 2024-09-01. PMID:39202273. |
the results indicated that in the mcf-7 human breast cancer cell line, e2 and curcumin decreased cell proliferation and the colony-forming capacity and down-regulated protein expression as well as important molecules associated with cell proliferation, such as pcna and estrogen receptor alpha; genes associated with the epithelial-mesenchymal transition, such as β-catenin, vimentin, and e-cadherin; and molecules associated with apoptosis. |
2024-09-01 |
2024-09-04 |
human |