| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chenxi Zhu, Wenzong Zhou, Mingming Han, Ying Yang, Yiming Li, Qichen Jiang, Weiwei L. Dietary polystyrene nanoplastics exposure alters hepatic glycolipid metabolism, triggering inflammatory responses and apoptosis in Monopterus albus. The Science of the total environment. 2023-05-29. PMID:37247739. |
overexpression of the cytokines genes interleukin 1 (il1b) and interleukin-8 (il8), tumor necrosis factor alpha (tnf-α), activation of mapk signaling pathway, and increased gene expression of c-jun amino-terminal kinases (jnk) and p38 indicate that exposure to nps may lead to hepatopancreas apoptosis through oxidative stress and inflammation. |
2023-05-29 |
2023-08-14 |
cat |
| Y-X Li, X-X Ma, C-L Zhao, S Chang, S-W Meng, Y Li. The effect of microRNA-663b in the inhibition of interleukin-1-induced nucleus pulposus cell apoptosis and inflammatory response. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 74. issue 1. 2023-05-28. PMID:37245236. |
compared with the mimic negative control (nc) group, the expression of inflammatory factors in the microrna-663b overexpression group was inhibited (p<0.05), and the expression of type 2 collagen and polysaccharide protein increased (p<0.05), and the apoptosis of nucleus pulposus cells was inhibited (p<0.01), and the number of tunel-positive cells decreased significantly (p<0.01), and the microrna and protein expression of il1r1, the ratio of p-p65/p65 and phospho-nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha (p-iκbα)/nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha (iκbα) protein expression were significantly decreased (p<0.05). |
2023-05-28 |
2023-08-14 |
Not clear |
| Lin Zhu, Xi Yao, Ying Mo, Ming-Wei Chen, Si-Chen Li, Jian-Qiao Liu, Hai-Ying Li. miR-4433a-3p promotes granulosa cell apoptosis by targeting peroxisome proliferator-activated receptor alpha and inducing immune cell infiltration in polycystic ovarian syndrome. Journal of assisted reproduction and genetics. 2023-05-19. PMID:37204637. |
mir-4433a-3p promotes granulosa cell apoptosis by targeting peroxisome proliferator-activated receptor alpha and inducing immune cell infiltration in polycystic ovarian syndrome. |
2023-05-19 |
2023-08-14 |
Not clear |
| Xianfeng Wang, Wenkai Mao, Xiaofeng M. TLN1 synergizes with ITGA5 to ameliorate cardiac microvascular endothelial cell dysfunction. Folia morphologica. 2023-05-05. PMID:37144848. |
the involvement of talin-1 (tln1) and integrin alpha 5 (itga5) in the proliferation, apoptosis, angiogenesis, inflammatory response, and oxidative stress in cmvecs were assessed. |
2023-05-05 |
2023-08-14 |
Not clear |
| Carmen Amititeloaie, Liliana Chelaru, Gabriela Luminiţa Geleţu, Anca Sava, Alexandra Jităreanu, Andreea Mihaela Tibeică, Marcel Costulean. Apoptosis of pro-B lymphocytes induced by NR4A1 activation in the presence of gingival fibroblast exosomes and TNFα, caspase 8, STAT3, and Akt pathways modulators. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 64. issue 1. 2023-05-02. PMID:37128789. |
in order to experimentally evaluate the apoptosis of pro-b type lymphocytes, induced as a result of the known activation of orphan nuclear receptor 4a1 (nr4a1), through cytosporone b (csn-b, 10 μm), in the presence or absence of exosomes derived from gingival fibroblasts, we administered as a treatment: 1 μm r-7050 [functional inhibitor of tumor necrosis factor alpha (tnfα)], 1 μm z-ietd-fmk (functional inhibitor of caspase 8), 1 μm gsk690693 (functional inhibitor of akt 1∕2∕3 pathways) and, last but not least, 1 μm scutellarin [functional inhibitor of receptor activator of nuclear factor-kappa b ligand (rankl)] and therefore of the signal transducer and activator of transcription 3 (stat3) pathway. |
2023-05-02 |
2023-08-14 |
Not clear |
| Zhen Zhao, Jin-Fa Du, Qiao-Lei Wang, Fang-Ning Qiu, Xu-Yan Chen, Feng-Jie Liu, Ping Li, Yan Jiang, Hui-Jun L. An integrated strategy combining network toxicology and feature-based molecular networking for exploring hepatotoxic constituents and mechanism of Epimedii Folium-induced hepatotoxicity in vitro. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-04-20. PMID:37080529. |
ef-treated alpha mouse liver 12 (aml12) cells showed increased reactive oxygen species (ros), reduced glutathione (gsh) and mitochondrial membrane potential (mmp), and apoptosis and cholestasis were further observed. |
2023-04-20 |
2023-08-14 |
mouse |
| Yiming Li, Xinglin Du, Wen Li, Qichen Jiang, Yucong Ye, Ying Yang, Xingguo Liu, Yunlong Zhao, Xuan Ch. Two genes related to apoptosis in the hepatopancreas of juvenile prawn, Macrobrachium nipponense: Molecular characterization and transcriptional response to nanoplastic exposure. The Science of the total environment. 2023-03-17. PMID:36931509. |
to study the effects of exposure to nanoplastics on hepatopancreas cell apoptosis, c-jun n-terminal kinase (jnk) and phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (pik3ca) genes were selected, and hepatotoxic enzyme activities and toll pathway- and apoptosis-related gene expression were determined. |
2023-03-17 |
2023-08-14 |
human |
| Hitha Gopalan Nair, Aneta Jurkiewicz, Damian Graczy. Inhibition of RNA Polymerase III Augments the Anti-Cancer Properties of TNFα. Cancers. vol 15. issue 5. 2023-03-11. PMID:36900285. |
tumour necrosis factor alpha (tnfα) is a multifunctional cytokine that plays a pivotal role in apoptosis, cell survival, as well as in inflammation and immunity. |
2023-03-11 |
2023-08-14 |
Not clear |
| Osama Y Althunibat, Mohammad H Abukhalil, Muthana M Jghef, Manal A Alfwuaires, Abdulmohsen I Algefare, Bader Alsuwayt, Reem Alazragi, Mohammed A S Abourehab, Afaf F Almuqati, Shaik Karimulla, Saleem H Aladaile. Hepatoprotective effect of taxifolin on cyclophosphamide-induced oxidative stress, inflammation, and apoptosis in mice: Involvement of Nrf2/HO-1 signaling. Biomolecules and biomedicine. 2023-02-10. PMID:36762432. |
livers of cp-injected mice also showed increased inflammatory response (nf-κb p65 activation, increased levels of proinflammatory cytokines tumor necrosis factor alpha [tnf-α], interleukin 1 beta [il-1β] and il-6) and apoptosis (decreased bcl-2 and increased bax and caspase-3 expression levels). |
2023-02-10 |
2023-08-14 |
mouse |
| Fang Fu, Chen Chen, Kun Du, Lu-Shan Li, Ru Li, Ting-Ying Lei, Qiong Deng, Dan Wang, Qiu-Xia Yu, Xin Yang, Jin Han, Min Pan, Li Zhen, Li-Na Zhang, Jian Li, Fa-Tao Li, Yong-Ling Zhang, Xiang-Yi Jing, Fu-Cheng Li, Dong-Zhi Li, Can Lia. Ndufa4 Regulates the Proliferation and Apoptosis of Neurons via miR-145a-5p/Homer1/Ccnd2. Molecular neurobiology. 2023-02-10. PMID:36763283. |
this study aimed to investigate the role of nadh dehydrogenase 1 alpha subcomplex 4 (ndufa4) in regulating downstream signaling cascades and neuronal proliferation and apoptosis. |
2023-02-10 |
2023-08-14 |
mouse |
| Lewei Zheng, Qian Yang, Chengxin Li, Gaoran Xu, Qianqian Yuan, Jinxuan Hou, Gaosong W. Ubiquitin-Specific Peptidase 8 Modulates Cell Proliferation and Induces Cell Cycle Arrest and Apoptosis in Breast Cancer by Stabilizing Estrogen Receptor Alpha. Journal of oncology. vol 2023. 2023-01-16. PMID:36644233. |
ubiquitin-specific peptidase 8 modulates cell proliferation and induces cell cycle arrest and apoptosis in breast cancer by stabilizing estrogen receptor alpha. |
2023-01-16 |
2023-08-14 |
Not clear |
| Maria Eugenia Ferreiro, Cinthia Soledad Méndez, Leilane Glienke, Cristian Marcelo Sobarzo, María Jimena Ferraris, Daniel Alberto Pisera, Livia Lustig, Patricia Verónica Jacobo, María Susana Thea. Unraveling the effect of the inflammatory microenvironment in spermatogenesis progression. Cell and tissue research. 2023-01-10. PMID:36627392. |
eao is characterized by high intratesticular levels of nitric oxide (no) and tumor necrosis factor alpha (tnfα) causing germ cell apoptosis and sertoli cell dysfunction. |
2023-01-10 |
2023-08-14 |
rat |
| Madhuri Jayathirtha, Danielle Whitham, Shelby Alwine, Mary Donnelly, Anca-Narcisa Neagu, Costel C Dari. Investigating the Function of Human Jumping Translocation Breakpoint Protein (hJTB) and Its Interacting Partners through In-Solution Proteomics of MCF7 Cells. Molecules (Basel, Switzerland). vol 27. issue 23. 2022-12-11. PMID:36500393. |
deregulated jtb expression was found to be associated with several proteins involved in mitochondrial organization and function, oxidative stress (os), apoptosis, and interferon alpha and gamma signaling. |
2022-12-11 |
2023-08-14 |
human |
| Sharmila Biswas, Baishakhi Tikader, Sandip Kar, Ganesh A Viswanatha. Modulation of signaling cross-talk between pJNK and pAKT generates optimal apoptotic response. PLoS computational biology. vol 18. issue 10. 2022-10-14. PMID:36240239. |
tumor necrosis factor alpha (tnfα) is a well-known modulator of apoptosis by maintaining a balance between proliferation and cell-death in normal cells. |
2022-10-14 |
2023-08-14 |
Not clear |
| Chang Liu, Sijie Li, Xiaoxiao Zhang, Chunxiang Jin, Baofeng Zhao, Liying Li, Qing Robert Miao, Ying Jin, Zhimin Fa. Nogo-B receptor increases glycolysis and the paclitaxel resistance of estrogen receptor-positive breast cancer via the HIF-1α-dependent pathway. Cancer gene therapy. 2022-10-14. PMID:36241702. |
ngbr knockdown inhibited glycolysis and promoted paclitaxel-induced apoptosis by attenuating hif-1α expression in er-positive breast cancer cells via ngbr-mediated estrogen receptor alpha (erα)/hypoxia-inducible factor-1 alpha (hif-1α) and nuclear factor-kappa b subunit (nf-κb)/hif-1α signaling pathways. |
2022-10-14 |
2023-08-14 |
Not clear |
| Mathilde Lamarque, Emilie-Fleur Gautier, François Rodrigues, Flavia Guillem, Elisa Bayard, Cédric Broussard, Thiago Maciel Trovati, Jean-Benoît Arlet, Patrick Mayeux, Olivier Hermine, Geneviève Courtoi. Role of Caspase-10-P13tBID axis in erythropoiesis regulation. Cell death and differentiation. 2022-10-06. PMID:36202990. |
erythropoietin (epo) by inducing casein kinase i alpha (ckiα) expression, which in turn phosphorylates p18-tbid, prevents the generation of myr-p15-tbid (leading to apoptosis) and allows the generation of p13-tbid by caspase-10. |
2022-10-06 |
2023-08-14 |
Not clear |
| Kejian Shi, Di Meng, Ying Wang, Wenjia Tian, Yi Zhang, Jiajia A. ATM/IKK alpha axis regulates the crosstalk between autophagy and apoptosis in selenite-treated Jurkat cells. Chemico-biological interactions. 2022-09-16. PMID:36113632. |
atm/ikk alpha axis regulates the crosstalk between autophagy and apoptosis in selenite-treated jurkat cells. |
2022-09-16 |
2023-08-14 |
mouse |
| Kejian Shi, Di Meng, Ying Wang, Wenjia Tian, Yi Zhang, Jiajia A. ATM/IKK alpha axis regulates the crosstalk between autophagy and apoptosis in selenite-treated Jurkat cells. Chemico-biological interactions. 2022-09-16. PMID:36113632. |
therefore, our findings had fully confirmed survivin-2b dependent activation of atm/ikk alpha axis might be another crosstalk between autophagy and apoptosis of selenite-treated leukemia cells. |
2022-09-16 |
2023-08-14 |
mouse |
| Radoslava Vlčková, Drahomíra Sopková, Zuzana Andrejčáková, Martina Lecová, Dušan Fabian, Zuzana Šefčíková, Alireza Seidavi, Alexander V Sirotki. Dietary Supplementation of Flaxseed ( Life (Basel, Switzerland). vol 12. issue 8. 2022-08-26. PMID:36013331. |
the 72 indexes of secondary and tertiary follicular cells, oocytes, corpora lutea, and ovarian stroma have been quantified: diameter, markers of proliferation pcna and apoptosis caspase 3, receptors to fsh, oxytocin, estrogen (alpha and beta), and progesterone. |
2022-08-26 |
2023-08-14 |
mouse |
| Carlos Alfredo Silva-Islas, Ricardo Alberto Santana-Martínez, Juan Carlos León-Contreras, Diana Barrera-Oviedo, Jose Pedraza-Chaverri, Rogelio Hernández-Pando, Perla D Maldonad. Quinolinic Acid Induces Alterations in Neuronal Subcellular Compartments, Blocks Autophagy Flux and Activates Necroptosis and Apoptosis in Rat Striatum. Molecular neurobiology. 2022-08-18. PMID:35980566. |
additionally, quin administration increased tumor necrosis factor alpha (tnfα) and receptor-interacting protein kinase 3 (ripk3) levels and its phosphorylation (p-ripk3), as well as decreased b-cell lymphoma 2 (bcl-2) and increased bcl-2-associated x protein (bax) levels and c-jun n-terminal kinase (jnk) phosphorylation, suggesting an activation of necroptosis and apoptosis, respectively. |
2022-08-18 |
2023-08-14 |
rat |