| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xin Yang, Heling Zhang, Tong Qu, Yi Wang, Yongxian Zhong, Yuchen Yan, Xuefei Ji, Tiayan Chi, Peng Liu, Libo Zo. Tolfenamic acid inhibits ROS-generating oxidase Nox1-regulated p53 activity in intrastriatal injection of malonic acid rats. The journal of physiological sciences : JPS. vol 72. issue 1. 2022-07-19. PMID:35850611. |
tolfenamic acid reduced mouse double minute 2 (mdm2), phosphatase and tensin homologue (pten), p53-upregulated modulator of apoptosis (puma) and bcl2-associated x (bax) at the mrna level to inhibit apoptosis and downregulated sestrin 2 (sesn2) and hypoxia inducible factor 1, alpha subunit (hif-1α) mrna levels to exert antioxidative stress effects. |
2022-07-19 |
2023-08-14 |
mouse |
| De-Tian Jiang, Lei Tuo, Xiao Bai, Wei-Dong Bing, Qing-Xi Qu, Xin Zhao, Guang-Min Song, Yan-Wen Bi, Wen-Yu Su. Prostaglandin E1 reduces apoptosis and improves the homing of mesenchymal stem cells in pulmonary arterial hypertension by regulating hypoxia-inducible factor 1 alpha. Stem cell research & therapy. vol 13. issue 1. 2022-07-16. PMID:35842683. |
prostaglandin e1 reduces apoptosis and improves the homing of mesenchymal stem cells in pulmonary arterial hypertension by regulating hypoxia-inducible factor 1 alpha. |
2022-07-16 |
2023-08-14 |
rat |
| Yuxuan Zheng, Su Li, Shi-Hua Li, Shaoxiong Yu, Qihui Wang, Kehui Zhang, Liang Qu, Yuan Sun, Yuhai Bi, Fuchou Tang, Hua-Ji Qiu, George F Ga. Transcriptome profiling in swine macrophages infected with African swine fever virus at single-cell resolution. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 19. 2022-07-16. PMID:35507870. |
mechanistically, the production of tumor necrosis factor alpha (tnf-α) induced by asfv infection is necessary for cell apoptosis, highlighting the importance of tnf-α in asfv pathogenesis. |
2022-07-16 |
2023-08-16 |
Not clear |
| Guowu Hu, Pia J Hauk, Nannan Zhang, Waleed Elsegeiny, Carlos M Guardia, Amy Kullas, Kevin Crosby, Robin R Deterding, Michaela Schedel, Paul Reynolds, Jordan K Abbott, Vijaya Knight, Stefania Pittaluga, Mark Raffeld, Sergio D Rosenzweig, Juan S Bonifacino, Gulbu Uzel, Peter R Williamson, Erwin W Gelfan. Autophagy-associated immune dysregulation and hyperplasia in a patient with compound heterozygous mutations in Autophagy. 2022-07-15. PMID:35838483. |
autophagy-associated immune dysregulation and hyperplasia in a patient with compound heterozygous mutations in bcl2: bcl2 apoptosis regulator; bcl10: bcl10 immune signaling adaptor; card11: caspase recruitment domain family member 11; cbm: card11-bcl10-malt1; cr2: complement c3d receptor 2; ebna: epstein barr nuclear antigen; ebv: epstein-barr virus; fcgr3a; fc gamma receptor iiia; glild: granulomatous-lymphocytic interstitial lung disease; hv: healthy volunteer; ikbkb/ikb kinase: inhibitor of nuclear factor kappa b kinase subunit beta; il2ra: interleukin 2 receptor subunit alpha; malt1: malt1 paracaspase; ms4a1: membrane spanning 4-domain a1; mtor: mechanistic target of rapamycin kinase; myc: myc proto-oncogene, bhlh: transcription factor; ncam1: neural cell adhesion molecule 1; nfkb: nuclear factor kappa b; niaid: national institute of allergy and infectious diseases; nk: natural killer; ptprc: protein tyrosine phosphatase receptor type c; sell: selectin l; pbmcs: peripheral blood mononuclear cells; tr: t cell receptor; tregs: regulatory t cells; wt: wild-type. |
2022-07-15 |
2023-08-14 |
human |
| Soyeon Jeong, Ahmed K Farag, Hye Kyeong Yun, Yoon A Jeong, Dae Yeong Kim, Min Jee Jo, Seong Hye Park, Bo Ram Kim, Jung Lim Kim, Bu Gyeom Kim, Dae-Hee Lee, Eun Joo Roh, Sang Cheul O. AF8c, a Multi-Kinase Inhibitor Induces Apoptosis by Activating DR5/Nrf2 via ROS in Colorectal Cancer Cells. Cancers. vol 14. issue 13. 2022-07-09. PMID:35804815. |
af8c mediated p53-dependent apoptosis of crc cells via the generation of endoplasmic reticulum (er) stress and reactive oxygen species (ros), as well as activation of nuclear respiratory factor 2 alpha subunit (nrf2) and death receptor 5 (dr5), among others. |
2022-07-09 |
2023-08-14 |
mouse |
| Si-Ying Liu, Jian-Xu Rao, Jie Deng, Gui-Juan Zhang, Xiao-Ling Jiang, Jing Cheng, Huan Chen, Zhi-Gang Jiang, De-Lin Xu, Yi-Huai H. Feedback loop between hepatocyte nuclear factor 1α and endoplasmic reticulum stress mitigates liver injury by downregulating hepatocyte apoptosis. Scientific reports. vol 12. issue 1. 2022-07-08. PMID:35804081. |
hepatocyte nuclear factor alpha (hnf1α), endoplasmic reticulum (er) stress, and hepatocyte apoptosis contribute to severe acute exacerbation (sae) of liver injury. |
2022-07-08 |
2023-08-14 |
Not clear |
| Qing Li, Xianjie Zhang, Siyuan Li, Wen Li, Yunpeng Teng, Yukai Zhou, Hongfei Xion. Carnosol alleviates sevoflurane-induced cognitive dysfunction by mediating NF-κB pathway in aged rats. Drug development research. 2022-07-05. PMID:35781309. |
the results showed that carnosol can improve the cognitive dysfunction and reduce neuroinflammation in aged rats induced by sev; carnosol can reduce the activation of microglia and inhibit neuronal apoptosis in aged rats induced by sev; carnosol can phosphorylate p65 and nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha regulates the nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb) pathway. |
2022-07-05 |
2023-08-14 |
rat |
| Kaori Yoriki, Taisuke Mori, Kohei Aoyama, Yosuke Tarumi, Hisashi Kataoka, Tetsuya Kokabu, Jo Kitawak. Genistein induces long-term expression of progesterone receptor regardless of estrogen receptor status and improves the prognosis of endometrial cancer patients. Scientific reports. vol 12. issue 1. 2022-06-18. PMID:35717540. |
genistein inhibits cell growth by inducing cell cycle arrest in g2 and apoptosis; moreover, it upregulates prolonged expression of pr-b and forkhead box protein o1, regardless of estrogen receptor alpha expression in endometrial cancer cells. |
2022-06-18 |
2023-08-14 |
Not clear |
| Ruonan Liang, Shuaiyin Chen, Yuefei Jin, Ling Tao, Wangquan Ji, Peiyu Zhu, Dong Li, Yu Zhang, Weiguo Zhang, Guangcai Dua. The CXCL10/CXCR3 Axis Promotes Disease Pathogenesis in Mice upon CVA2 Infection. Microbiology spectrum. 2022-05-23. PMID:35604176. |
additionally, αcxcr3 treatment reduced viral loads and reversed the proinflammatory cytokine (interleukin 6 [il-6], tumor necrosis factor alpha [tnf-α], and il-1β) expression, apoptosis, and inflammatory cell infiltration induced by cva2. |
2022-05-23 |
2023-08-13 |
mouse |
| Yu-Ting Sun, Jun-Hong Cai, Shan Ba. Overexpression of lncRNA HCP5 in human umbilical cord mesenchymal stem cell-derived exosomes promoted the proliferation and inhibited the apoptosis of ovarian granulosa cells via the musashi RNA-binding protein 2/oestrogen receptor alpha 1 axis. Endocrine journal. 2022-05-11. PMID:35545536. |
overexpression of lncrna hcp5 in human umbilical cord mesenchymal stem cell-derived exosomes promoted the proliferation and inhibited the apoptosis of ovarian granulosa cells via the musashi rna-binding protein 2/oestrogen receptor alpha 1 axis. |
2022-05-11 |
2023-08-13 |
human |
| Ye Cao, Jiajia Zheng, Chentao L. Correction: miR-199a-3p knockdown inhibits dedifferentiated liposarcoma (DDLPS) cell viability and enhances apoptosis through targeting casein kinase-1 alpha (CK1α). RSC advances. vol 9. issue 56. 2022-05-09. PMID:35529749. |
correction: mir-199a-3p knockdown inhibits dedifferentiated liposarcoma (ddlps) cell viability and enhances apoptosis through targeting casein kinase-1 alpha (ck1α). |
2022-05-09 |
2023-08-13 |
Not clear |
| Ye Cao, Jiajia Zheng, Chentao L. Retracted Article: miR-199a-3p knockdown inhibits dedifferentiated liposarcoma (DDLPS) cell viability and enhances apoptosis through targeting casein kinase-1 alpha (CK1α). RSC advances. vol 9. issue 39. 2022-05-06. PMID:35519458. |
retracted article: mir-199a-3p knockdown inhibits dedifferentiated liposarcoma (ddlps) cell viability and enhances apoptosis through targeting casein kinase-1 alpha (ck1α). |
2022-05-06 |
2023-08-13 |
Not clear |
| Guo Wang, Xiaoyan Lin, Han Han, Hongxu Zhang, Xiaoli Li, Mei Feng, Chunming Jian. lncRNA H19 promotes glioblastoma multiforme development by activating autophagy by sponging miR-491-5p. Bioengineered. vol 13. issue 5. 2022-05-04. PMID:35506168. |
in addition, cell viability, proliferation, apoptosis and autophagy were respectively determined via cell counting kit-8 assay, clone formation assay, flow cytometry, western blotting and green fluorescent protein-microtubule-associated protein 1 light chain 3 alpha fluorescence analysis |
2022-05-04 |
2023-08-13 |
Not clear |
| Laura Fishe. Retraction: miR-199a-3p knockdown inhibits dedifferentiated liposarcoma (DDLPS) cell viability and enhances apoptosis through targeting casein kinase-1 alpha (CK1α). RSC advances. vol 11. issue 10. 2022-04-15. PMID:35427032. |
retraction: mir-199a-3p knockdown inhibits dedifferentiated liposarcoma (ddlps) cell viability and enhances apoptosis through targeting casein kinase-1 alpha (ck1α). |
2022-04-15 |
2023-08-13 |
Not clear |
| Meixia Yang, Jianhao Feng, Xianyong Lan, Yaru Tang, Yufang Zhang, Hongliang Zhang, Shuilian Wan. Cytosine-phosphate-guanine oligodeoxynucleotides regulate the cell cycle, apoptosis, and steroidogenesis of mouse ovarian granulosa cells by targeting inhibin alpha (1 ~ 32) fragments. In vitro cellular & developmental biology. Animal. 2022-04-05. PMID:35378691. |
cytosine-phosphate-guanine oligodeoxynucleotides regulate the cell cycle, apoptosis, and steroidogenesis of mouse ovarian granulosa cells by targeting inhibin alpha (1 ~ 32) fragments. |
2022-04-05 |
2023-08-13 |
mouse |
| Meixia Yang, Jianhao Feng, Xianyong Lan, Yaru Tang, Yufang Zhang, Hongliang Zhang, Shuilian Wan. Cytosine-phosphate-guanine oligodeoxynucleotides regulate the cell cycle, apoptosis, and steroidogenesis of mouse ovarian granulosa cells by targeting inhibin alpha (1 ~ 32) fragments. In vitro cellular & developmental biology. Animal. 2022-04-05. PMID:35378691. |
here, we investigated the effects of cpg-odns on the cell cycle, apoptosis, and steroidogenesis in mouse granulosa cells (mgcs), in combination with inhibin alpha (1 ~ 32) fragments. |
2022-04-05 |
2023-08-13 |
mouse |
| Meixia Yang, Jianhao Feng, Xianyong Lan, Yaru Tang, Yufang Zhang, Hongliang Zhang, Shuilian Wan. Cytosine-phosphate-guanine oligodeoxynucleotides regulate the cell cycle, apoptosis, and steroidogenesis of mouse ovarian granulosa cells by targeting inhibin alpha (1 ~ 32) fragments. In vitro cellular & developmental biology. Animal. 2022-04-05. PMID:35378691. |
in conclusion, this study demonstrated that cpg-odns may affect the cell cycle, apoptosis, and steroidogenesis by targeting the effects of inhibin alpha (1 ~ 32) fragments, supporting the potential role of cpg-odns in the development of granulosa cells. |
2022-04-05 |
2023-08-13 |
mouse |
| Piaopiao Xu, Xiangling Chen, Yongping Xu, Li Fu, Yun Li, Haoyu Fu, Qing Yao, Haitian Quan, Liguang Lo. Trastuzumab in combination with PEGylated interferon-α1b exerts synergistic antitumor activity through enhanced inhibition of HER2 downstream signaling and antibody-dependent cellular cytotoxicity. American journal of cancer research. vol 12. issue 2. 2022-03-09. PMID:35261786. |
in this study, we report that trastuzumab in combination with pegylated interferon-α1b (ifn-α1b), a polyethylene glycol (peg)-conjugated form of a subtype of interferon alpha (ifn-α), synergistically inhibited the proliferation of her2-positive cells, including bt-474 and sk-br-3 breast cancer cells and nci-n87 gastric cancer cells, and also induced their apoptosis, but had no effect on her2-negative mda-mb-231 breast cancer cells. |
2022-03-09 |
2023-08-13 |
Not clear |
| Rehab S Abdelrahman, Ramy A Abdelsalam, Marwa S Zaghlou. Beneficial effect of trimetazidine on folic acid-induced acute kidney injury in mice: Role of HIF-1α/HO-1. Journal of biochemical and molecular toxicology. 2022-02-22. PMID:35191561. |
finally, tmz amended fa-induced histopathological changes in kidneys. by mitigating functional alteration, oxidative stress, and preventing the development of inflammatory and apoptosis signals, tmz provides dose-dependent defense against fa-induced aki mainly via stimulation of hypoxia-inducible factor-1 alpha (hif-1α)/heme oxygenase-1 (ho-1) pathway. |
2022-02-22 |
2023-08-13 |
mouse |
| Xinghui Wang, Mengyao Zhu, Juan J Loor, Qianming Jiang, Yiwei Zhu, Wei Li, Xiliang Du, Yuxiang Song, Wenwen Gao, Lin Lei, Jianguo Wang, Guowen Liu, Xinwei L. Propionate alleviates fatty acid-induced mitochondrial dysfunction, oxidative stress, and apoptosis by upregulating PPARG coactivator 1 alpha in hepatocytes. Journal of dairy science. 2022-02-19. PMID:35181129. |
propionate alleviates fatty acid-induced mitochondrial dysfunction, oxidative stress, and apoptosis by upregulating pparg coactivator 1 alpha in hepatocytes. |
2022-02-19 |
2023-08-13 |
Not clear |