| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ji Eun Kim, Min Jee Jo, So Yeon Bae, Shin Young Ahn, Gang Jee Ko, Young Joo Kwo. Mitochondrial SIRT3 as a protective factor against cyclosporine A-induced nephrotoxicity. Scientific reports. vol 14. issue 1. 2024-05-02. PMID:38698042. |
inhibition of sirt3 through sirna transfection exacerbated apoptosis, impaired the expression of the amp-activated protein kinase-peroxisome proliferator-activated receptor gamma coactivator 1 alpha (ampk-pgc1α) pathway, and worsened mitochondrial dysfunction induced by csa treatment. |
2024-05-02 |
2024-05-05 |
mouse |
| Shannon N Loftus, Mehrnaz Gharaee-Kermani, Bin Xu, Tyson M Moore, Andrew Hannoudi, Mischa J Mallbris, Benjamin Klein, Johann E Gudjonsson, J Michelle Kahlenber. Interferon alpha promotes caspase-8 dependent ultraviolet light-mediated keratinocyte apoptosis via interferon regulatory factor 1. Frontiers in immunology. vol 15. 2024-04-25. PMID:38660315. |
interferon alpha promotes caspase-8 dependent ultraviolet light-mediated keratinocyte apoptosis via interferon regulatory factor 1. |
2024-04-25 |
2024-04-28 |
Not clear |
| Liuyu Wang, Xiangkun Wu, Quanhui Wan, Yuqiang Yang, Chaojie Ga. Phloridzin reduces synovial hyperplasia and inflammation in rheumatoid arthritis rat by modulating mTOR pathway. International immunopharmacology. vol 133. 2024-04-18. PMID:38636369. |
moreover in-vitro study was performed on fibroblast-like synoviocytes (flss) and effect of phlorizin was estimated on proliferation, apoptosis and expression of mtor pathway protein after stimulating these cell lines with tumour necrosis factor alpha (tnf-α). |
2024-04-18 |
2024-04-21 |
rat |
| Xiao Xiao, Yanan Fu, Wanling You, Congcong Huang, Feng Zeng, Xinsheng Gu, Xiaoguang Sun, Jian Li, Qiwei Zhang, Weixing Du, Gong Cheng, Zhixin Liu, Long Li. Inhibition of the RLR signaling pathway by SARS-CoV-2 ORF7b is mediated by MAVS and abrogated by ORF7b-homologous interfering peptide. Journal of virology. 2024-04-04. PMID:38572974. |
studies have shown that the sars-cov-2 accessory protein orf7b induces host cell apoptosis through the tumor necrosis factor alpha (tnf-α) pathway and blocks the production of interferon beta (ifn-β). |
2024-04-04 |
2024-04-06 |
Not clear |
| Mustafa Oztatlici, Hulya Oztatlici, Suna Karadeniz Saygili, Ismail Kaya, Ilker Deniz Cingo. Cyclophosphamide stimulates endoplasmic reticulum stress and induces apoptotic cell death in human glioblastoma cell lines. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 65. issue 1. 2024-03-26. PMID:38527981. |
in this study, we aimed to investigate the effects of 4-hydroperoxy cyclophosphamide (4-hc), which is active form of cp, on glucose-regulated protein 78 (grp78), activating transcription factor 6 (atf6), phospho-protein kinase r (pkr)-like endoplasmic reticulum (er) kinase (p-perk), phospho-inositol-requiring enzyme 1 alpha (p-ire1α), eukaryotic translation initiation factor 2 alpha (eif2α), and caspase-3 messenger ribonucleic acids (mrnas) and proteins that play roles in the er stress pathway and apoptosis in u87 and t98 human glioblastoma cell lines. |
2024-03-26 |
2024-03-28 |
human |
| Yinghui Hao, Fangmei Xie, Jieyi He, Chenqiong Gu, Ying Zhao, Wenfeng Luo, Xiaoyu Song, Jian Shen, Li Yu, Zeping Han, Jinhua H. PLA inhibits TNF-α-induced PANoptosis of prostate cancer cells through metabolic reprogramming. The international journal of biochemistry & cell biology. 2024-02-26. PMID:38408537. |
further experiments showed that the addition of pla to prostate cancer cells could promote atp generation, enhance cysteine desulfurase (nfs1) expression, and reduce tumor necrosis factor alpha (tnf-α) levels, thereby inhibiting apoptosis in prostate cancer cells. |
2024-02-26 |
2024-03-02 |
Not clear |
| Monica Szmyd, Aisha Zanib, Victoria Behlow, Erin Hallman, Samantha Pfiffner, Raquel Yaldo, Nina Prudhomme, Katelyn Farrar, Sumi Dind. Modulation of Estrogen Receptor Alpha (ERα) and Tumor Suppressor Gene BRCA1 in Breast Cancer Cells by Bazedoxifene Acetate (BZA). Cancers. vol 16. issue 4. 2024-02-24. PMID:38398090. |
our study aimed to assess bza's effects on estrogen receptor alpha (erα) and tumor suppressor gene brca1 in t-47d and mcf-7 breast cancer cells, using western blots, cellular viability, apoptosis assays, and rt-qpcr. |
2024-02-24 |
2024-02-26 |
cattle |
| M-H Zhou, H Zhang, W-J Xu, X-B Zhen. Effect of PI3K/AKT/HIF-1α signaling pathway on oxidative stress and apoptosis in nucleus pulposus cells. European review for medical and pharmacological sciences. vol 28. issue 2. 2024-02-02. PMID:38305591. |
the aim of the study was to explore the expression of the phosphatidylinositol 3-kinase (pi3k)/protein kinase b (pkb/akt)/hypoxia-induced factor-1 alpha (hif-1α) signaling pathway and the apoptosis of nucleus pulposus cells (npcs) under different oxygen concentrations to clarify the biological characteristics of npcs and the molecular mechanism of intervertebral disc degeneration (ivdd). |
2024-02-02 |
2024-02-04 |
Not clear |
| Matilde Monti, Giorgia Ferrari, Valentina Grosso, Francesco Missale, Mattia Bugatti, Valeria Cancila, Stefania Zini, Agnese Segala, Luca La Via, Francesca Consoli, Matteo Orlandi, Alessandra Valerio, Claudio Tripodo, Marzia Rossato, William Verm. Impaired activation of plasmacytoid dendritic cells Frontiers in immunology. vol 14. 2024-01-19. PMID:38239354. |
interferon alpha (ifn-α) produced by pdcs induces growth arrest and apoptosis in tumor cells and modulates innate and adaptive immune cells involved in anti-cancer immunity. |
2024-01-19 |
2024-01-21 |
human |
| Siriwan Sakarin, Anudep Rungsipipat, Sittiruk Roytrakul, Janthima Jaresitthikunchai, Narumon Phaonakrop, Sawanya Charoenlappanit, Siriwan Thaisakun, Sirilak Disatian Surachetpon. Proteomic analysis of pulmonary arteries and lung tissues from dogs affected with pulmonary hypertension secondary to degenerative mitral valve disease. PloS one. vol 19. issue 1. 2024-01-05. PMID:38181036. |
differentially expressed proteins were identified, and top three upregulated and downregulated proteins in the pulmonary arteries of dmvd dogs with ph including sik family kinase 3 (sik3), collagen type i alpha 1 chain (col1a1), transforming growth factor alpha (tgf-α), apoptosis associated tyrosine kinase (aatyk), hepatocyte growth factor activator (hgfa) and tyrosine-protein phosphatase non-receptor type 13 (ptpn13) were chosen. |
2024-01-05 |
2024-01-08 |
Not clear |
| Shohei Miyata, Takashi Ishii, Susumu Kitanak. Reduction of HIF-1α/PD-L1 by Catalytic Topoisomerase Inhibitor Induces Cell Death Through Caspase Activation in Cancer Cells Under Hypoxia. Anticancer research. vol 44. issue 1. 2024-01-02. PMID:38159998. |
under severe hypoxia, cellular apoptosis is induced through hypoxia-inducible factor 1, alpha subunit (hif-1α)-dependent p53 accumulation and p53 phosphorylation via ataxia telangiectasia mutated and ataxia telangiectasia and rad3-related (atr) activation via replication stress-induced dna damage response (ddr) activation. |
2024-01-02 |
2024-01-05 |
Not clear |
| Boxin Zhao, Yunhui Zang, Lin Gui, Yingyu Xiang, Zhiyong Zhang, Xueyuan Sun, Jingyao Fan, Lijuan Huan. The effect of miR-223-3p on endothelial cells in coronary artery disease. In vitro cellular & developmental biology. Animal. 2023-12-28. PMID:38155264. |
in this study, we aimed to simulate the cad vascular microenvironment by treating endothelial cells with tumor necrosis factor alpha (tnf-α) to construct an endothelial cell apoptosis model. |
2023-12-28 |
2023-12-31 |
Not clear |
| Yu Xie, Lin Tan, Kun Wu, Deyun Li, Chengping L. MiR-455-3p mediates PPARα through UBN2 to promote apoptosis and autophagy in acute myeloid leukemia cells. Experimental hematology. vol 128. 2023-12-01. PMID:37805161. |
the interaction between ubn2 and peroxisome proliferator-activated receptor alpha (pparα) was confirmed by coimmunoprecipitation, and overexpression of pparα reversed the promoting effect of ubn2 knockdown on apoptosis and autophagy in aml cells. |
2023-12-01 |
2023-12-10 |
mouse |
| Meng Zhang, Yuanzhan Yang, Zhu Zhu, Zixuan Chen, Dongyang Huan. Implications of Activating the ANT2/mTOR/PGC-1α Feedback Loop: Insights into Mitochondria-Mediated Injury in Hypoxic Myocardial Cells. Current issues in molecular biology. vol 45. issue 11. 2023-11-25. PMID:37998720. |
additionally, we discovered that ant2 is involved in myocardial apoptosis by activating the mtor (mechanistic target of rapamycin kinase)-dependent pgc-1α (pparg coactivator 1 alpha) pathway, establishing a novel feedback loop during ami. |
2023-11-25 |
2023-11-28 |
mouse |
| Melayshia McFadden, Santosh Kumar Singh, Briana Kinnel, Sooryanarayana Varambally, Rajesh Sing. The effect of paclitaxel- and fisetin-loaded PBM nanoparticles on apoptosis and reversal of drug resistance gene ABCG2 in ovarian cancer. Journal of ovarian research. vol 16. issue 1. 2023-11-22. PMID:37990267. |
the present study shows that targeting folate receptor alpha (frα) through planetary ball milling (pbm) nanoparticles (nps) induces apoptosis in ovca cells. |
2023-11-22 |
2023-11-29 |
Not clear |
| Tong Chen, Lin Zhang, Liangyu Yao, Jiaochen Luan, Xiang Zhou, Rong Cong, Xuejiang Guo, Chao Qin, Ninghong Son. Zinc oxide nanoparticles-induced testis damage at single-cell resolution: Depletion of spermatogonia reservoir and disorder of Sertoli cell homeostasis. Environment international. vol 181. 2023-11-02. PMID:37918063. |
mechanically, zno nps triggered fatty acid accumulation in gc-1 cells through protein kinase b (akt)/mammalian target of rapamycin (mtor) signaling and peroxisome proliferator-activated receptor alpha (pparα)/acyl-coa oxidase 1 (acox1) axis, contributing to cell apoptosis. |
2023-11-02 |
2023-11-08 |
rat |
| Riccardo Leinardi, Jasmine Rita Petriglieri, Amandine Pochet, Yousof Yakoub, Marie Lelong, Alain Lescoat, Francesco Turci, Valérie Lecureur, François Huau. Distinct Pro-Inflammatory Mechanisms Elicited by Short and Long Amosite Asbestos Fibers in Macrophages. International journal of molecular sciences. vol 24. issue 20. 2023-10-30. PMID:37894824. |
in contrast, macrophage responses to non-internalizable lfa were associated with tumor necrosis factor alpha (tnf-α) release, caspase-3 and -7 activation, and apoptosis. |
2023-10-30 |
2023-11-08 |
Not clear |
| John C Woo. Cardiac complications in thalassemia throughout the lifespan: Victories and challenges. Annals of the New York Academy of Sciences. 2023-10-30. PMID:37902424. |
affected individuals have variable expression of alpha or beta chains that lead to their unbalanced utilization during hemoglobin formation, oxidative stress, and apoptosis of red cell precursors prior to maturation. |
2023-10-30 |
2023-11-08 |
Not clear |
| Qing-Ming Wang, Guang-Yu Lian, Su-Mei Sheng, Jing Xu, Long-Long Ye, Chao Min, Shu-Fang Gu. Exosomal lncRNA NEAT1 inhibits NK cell activity to promote multiple myeloma cell immune escape via an EZH2/PBX1 axis. Molecular cancer research : MCR. 2023-10-27. PMID:37889101. |
mm exosomes suppressed cell proliferation, promoted apoptosis, reduced natural killer group 2, member d (nkg2d)-positive cells, and the production of tumor necrosis factor alpha (tnf-α) and interferon-gamma (ifn-γ) in nk cells, whereas neat1-silenced exosomes had little effect. |
2023-10-27 |
2023-11-08 |
mouse |
| Vishal Devarkonda, Shravya Balmuri, Maria Antonia Costa Cruz Akabane, Hugo Akaban. Adalimumab-associated Philadelphia chromosome positive acute lymphoblastic leukaemia in a patient with Crohn's disease. BMJ case reports. vol 16. issue 10. 2023-10-25. PMID:37879713. |
however, these inhibitors can potentially increase the risk of secondary blood malignancies due to tnf alpha's role in various cellular processes such as angiogenesis, cell cycle proliferation, apoptosis and differentiation. |
2023-10-25 |
2023-11-08 |
human |