| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Wang, Linxiang Cai, Hui Li, Hnahua Chen, Tao Yang, Yehong Tan, Zijian Guo, Xiaoyong Wan. Overcoming Cancer Resistance to Platinum Drugs by Inhibiting Cholesterol Metabolism. Angewandte Chemie (International ed. in English). 2023-08-24. PMID:37612842. |
in addition to producing reactive oxygen species and active platinum(ii) species to damage dna, fp and dfp inhibited cellular cholesterol accumulation, promoted cholesterol efflux, upregulated peroxisome proliferator-activated receptor alpha (pparα), induced caspase-1 activation and gasdermin d (gsdmd) cleavage, thus leading to both apoptosis and pyroptosis in cancer cells. |
2023-08-24 |
2023-09-07 |
Not clear |
| Yujian Li, Xuan Ka. Cuproptosis-Related Genes MTF1 and LIPT1 as Novel Prognostic Biomarker in Acute Myeloid Leukemia. Biochemical genetics. 2023-08-10. PMID:37561332. |
gene ontology (go), kyoto encyclopedia of genes and genomes (kegg) and gene set enrichment analysis (gsea) revealed that biological functions such as metal ion transmembrane transporter activity, haptoglobin binding and oxygen carrier activity, pathways such as interferon alpha response, coagulation, uv response dn, apoptosis, hypoxia and heme metabolism all play a role in the development of aml. |
2023-08-10 |
2023-08-16 |
Not clear |
| Zeyu Yin, Shilong You, Shu Zhang, Linlin Zhang, Boquan Wu, Xinyue Huang, Saien Lu, Liu Cao, Ying Zhang, Da Li, Xingang Zhang, Jingwei Liu, Yingxian Sun, Naijin Zhan. Atorvastatin rescues vascular endothelial injury in hypertension by WWP2-mediated ubiquitination and degradation of ATP5A. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 166. 2023-08-09. PMID:37557013. |
by ubiquitinating atp5a (atp synthase mitochondrial f1 complex subunit alpha), wwp2 degraded atp5a via the proteasome pathway, stabilizing bcl-2/bax in the mitochondrial pathway of apoptosis. |
2023-08-09 |
2023-08-16 |
mouse |
| Ze-Hua Xu, Hang Zhang, Chang-Jun Zhang, Si-Jian Yu, Jing Yuan, Kangxin Jin, Zi-Bing Ji. REG1A protects retinal photoreceptors from blue light damage. Annals of the New York Academy of Sciences. 2023-08-02. PMID:37531162. |
we demonstrate that regenerating islet-derived 1 alpha (reg1a) prevents photoreceptors from undergoing this ld-induced apoptosis by increasing expression of the anti-apoptotic gene bcl2 and downregulating expression of the pro-apoptotic gene bax, resulting in reduced mitochondrial damage and improved aerobic capacity in photoreceptor cells. |
2023-08-02 |
2023-08-14 |
human |
| Ruizhou Liu, Zhendong Liu, Hui Chen, Shiping He, Shihan Wang, Jihang Dai, Xiaolei L. Ginkgolide K delays the progression of osteoarthritis by regulating YAP to promote the formation of cartilage extracellular matrix. Phytotherapy research : PTR. 2023-08-01. PMID:37527970. |
transcriptome sequencing revealed that gk may activate hypoxia-inducible factor 1 alpha via the hypoxia signaling pathway, which, in turn, activates yes-associated protein and inhibits apoptosis of oa chondrocytes. |
2023-08-01 |
2023-08-14 |
rat |
| Su Been Park, Gun Hee Cho, Young Eun Park, Hyang Sook Chu. Emodin, an Emerging Mycotoxin, Induces Endoplasmic Reticulum Stress-Related Hepatotoxicity through IRE1α-XBP1 Axis in HepG2 Cells. Toxins. vol 15. issue 7. 2023-07-28. PMID:37505724. |
we hypothesized that emodin could induce endoplasmic reticulum (er) stress through the inositol-requiring enzyme 1 alpha (ire1α)-x-box-binding protein 1 (xbp1) pathway and apoptosis, which are closely correlated and contribute to hepatotoxicity. |
2023-07-28 |
2023-08-14 |
Not clear |
| Kirill E Medvedev, R Dustin Schaeffer, Kenneth S Chen, Nick V Grishi. Pan-cancer structurome reveals overrepresentation of beta sandwiches and underrepresentation of alpha helical domains. Scientific reports. vol 13. issue 1. 2023-07-25. PMID:37491511. |
on the other hand, proteins with exclusively alpha domains are important elements of homeostasis, apoptosis and transmembrane transport. |
2023-07-25 |
2023-08-14 |
human |
| Zeynep Bengisu Kaya, Elif Karakoc, Pamela J McLean, Esen Saka, Pergin Atill. Post-inflammatory administration of FASEB bioAdvances. vol 5. issue 7. 2023-07-07. PMID:37415931. |
internalized α-syn can trigger expression and secretion of inflammatory cytokines such as tumor necrosis factor alpha (tnf-α), interleukin (il)-1β, il-2, and il-6 and induce neuroinflammation, apoptosis, and mitophagy that results in cellular death. |
2023-07-07 |
2023-08-14 |
Not clear |
| Heba M Mahmoud, Deiaa E Elsayed Abouzed, Amira M Abo-Youssef, Ramadan A M Hemeid. Zafirlukast protects against hepatic ischemia-reperfusion injury in rats via modulating Bcl-2/Bax and NF-κB/SMAD-4 pathways. International immunopharmacology. vol 122. 2023-07-07. PMID:37418987. |
inflammatory cytokines, tumor necrosis factor alpha (tnf-α) and interleukin-33 (il-33), in addition to apoptosis biomarkers, bcl2 associated x protein (bax), b-cell lymphoma 2 (bcl2) and galactine-9 (gal9) proteins were also assessed. |
2023-07-07 |
2023-08-14 |
rat |
| Yongting Zhang, Liang Hong, Xuehui Li, Yuyu Li, Xujun Zhang, Jingjing Jiang, Fan Shi, Hongyan Dia. M1 macrophage-derived exosomes promote autoimmune liver injury by transferring long noncoding RNA H19 to hepatocytes. MedComm. vol 4. issue 4. 2023-07-03. PMID:37398637. |
mechanistically, h19 upregulated the transcription of hypoxia-inducible factor-1 alpha (hif-1α), which accumulated in the cytoplasm and mediated hepatocyte apoptosis by upregulating p53. |
2023-07-03 |
2023-08-14 |
Not clear |
| Yusheng Li, Hengzhen Li, Lijie Wang, Wenqing Xie, Dongliang Yuan, Zeqin Wen, Tiancheng Zhang, Jieyu Lai, Zixuan Xiong, Yunhan Shan, Wei Jian. The p65-LOC727924-miR-26a/KPNA3-p65 regulatory loop mediates vasoactive intestinal peptide effects on osteoarthritis chondrocytes. International immunopharmacology. vol 122. 2023-07-01. PMID:37392568. |
in oa chondrocytes, loc727924 knockdown boosted cell viability, suppressed cell apoptosis, reactive oxygen species (ros) accumulation, increased aggrecan and collagen ii, decreased matrix metallopeptidase (mmp)-3/13 and adam metallopeptidase with thrombospondin type 1 motif (adamts)-4/5 levels, and reduced the levels of tumor necrosis factor alpha (tnf-α), interleukin 1 beta (il-1β), and interleukin 6 (il-6). |
2023-07-01 |
2023-08-14 |
mouse |
| David Szaraz, Zdenek Danek, Bretislav Lipovy, Jan Krivanek, Marcela Buchtova, Barbora Moldovan Putnova, Iveta Putnova, Jan Stembirek, Tomas Andrasina, Petra Divacka, Lydie Izakovicova Holla, Petra Borilova Linhartov. Primary cilia and hypoxia-associated signaling in developmental odontogenic cysts in relation to autosomal dominant polycystic kidney disease - A novel insight. Heliyon. vol 9. issue 6. 2023-06-30. PMID:37389068. |
these can lead to excessive proliferation and formation of cell agglomerates, which is followed by hypoxia-driven apoptosis in the centers of such agglomerates (controlled by molecules such as hypoxia-inducible factor-1 alpha), leading to cavity formation and, finally, the ocs development. |
2023-06-30 |
2023-08-14 |
Not clear |
| Yangyang Zhang, Rui Kong, Wenbo Yang, Keyi Hu, Zhongjie Zhao, Le Li, Xinglong Geng, Liwei Liu, Hongze Chen, Peng Xiao, Danxi Liu, Yan Luo, Hua Chen, Jisheng Hu, Bei Su. DUSP2 recruits CSNK2A1 to suppress AKT1-mediated apoptosis resistance under hypoxic microenvironment in pancreatic cancer. Cancer letters. 2023-06-30. PMID:37390887. |
mechanistically, dusp2 competed with akt1 to bind to casein kinase 2 alpha 1 (csnk2a1) and inhibited the phosphorylation of akt1, which plays a crucial role in apoptosis resistance. |
2023-06-30 |
2023-08-14 |
Not clear |
| Alexander V Sirotkin, Adam Tarko, Zuzana Fabova, Igor Valocky, Saleh Alwasel, Jan Kotwica, Abdel Halim Harrat. Can flaxseed, chia or puncture vine affect mare ovarian cell functions and prevent the toxic effect of the environmental contaminant toluene? Theriogenology. vol 208. 2023-06-24. PMID:37354861. |
markers of cell proliferation (accumulation of proliferating cell nuclear antigen, pcna) and apoptosis (accumulation of bax), viability (trypan blue extrusion) and the release of progesterone (p), oxytocin (ot) and prostaglandin f 2 alpha (pgf) were measured. |
2023-06-24 |
2023-08-14 |
Not clear |
| Zhaoqing Gong, Xinlei Shi, Weizhen Xu, Yuan Fang, Meijia Fang, Minhua Yao, Yu Jiang, Hongshu Sui, Mingjiu Lu. LncRNA PWRN2 promotes polycystic ovary syndrome progression via epigenetically reducing ATRX by recruiting LSD1. Reproductive biology. vol 23. issue 3. 2023-06-15. PMID:37320994. |
the protein levels of apoptosis markers and alpha thalassemia retardation syndrome x-linked (atrx) were determined by western blot. |
2023-06-15 |
2023-08-14 |
rat |
| Bailey L Arruda, Rachel A Kanefsky, Samantha Hau, Garrett M Janzen, Tavis K Anderson, Amy L Vincent Bake. Mucin 4 is a cellular biomarker of necrotizing bronchiolitis in influenza A virus infection. Microbes and infection. 2023-06-09. PMID:37295769. |
mucin 4 (muc4) is a transmembrane mucin that consists of an alpha subunit responsible for surface protection and intracellular beta subunit involved in signal transduction which repress apoptosis and stimulate epithelial proliferation. |
2023-06-09 |
2023-08-14 |
human |
| Kalpana Baghel, Mukesh Kumar Niranjan, Rashmi Srivastav. Withania somnifera inhibits photorefractoriness which triggers neuronal apoptosis in both pre-optic and paraventricular hypothalamic area of Coturnix coturnix japonica: involvement of oxidative stress induced p53 dependent Caspase-3 mediated low immunoreactivity of estrogen receptor alpha. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2023-06-02. PMID:37266906. |
withania somnifera inhibits photorefractoriness which triggers neuronal apoptosis in both pre-optic and paraventricular hypothalamic area of coturnix coturnix japonica: involvement of oxidative stress induced p53 dependent caspase-3 mediated low immunoreactivity of estrogen receptor alpha. |
2023-06-02 |
2023-08-14 |
Not clear |
| Chenxi Zhu, Wenzong Zhou, Mingming Han, Ying Yang, Yiming Li, Qichen Jiang, Weiwei L. Dietary polystyrene nanoplastics exposure alters hepatic glycolipid metabolism, triggering inflammatory responses and apoptosis in Monopterus albus. The Science of the total environment. 2023-05-29. PMID:37247739. |
overexpression of the cytokines genes interleukin 1 (il1b) and interleukin-8 (il8), tumor necrosis factor alpha (tnf-α), activation of mapk signaling pathway, and increased gene expression of c-jun amino-terminal kinases (jnk) and p38 indicate that exposure to nps may lead to hepatopancreas apoptosis through oxidative stress and inflammation. |
2023-05-29 |
2023-08-14 |
cat |
| Y-X Li, X-X Ma, C-L Zhao, S Chang, S-W Meng, Y Li. The effect of microRNA-663b in the inhibition of interleukin-1-induced nucleus pulposus cell apoptosis and inflammatory response. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 74. issue 1. 2023-05-28. PMID:37245236. |
compared with the mimic negative control (nc) group, the expression of inflammatory factors in the microrna-663b overexpression group was inhibited (p<0.05), and the expression of type 2 collagen and polysaccharide protein increased (p<0.05), and the apoptosis of nucleus pulposus cells was inhibited (p<0.01), and the number of tunel-positive cells decreased significantly (p<0.01), and the microrna and protein expression of il1r1, the ratio of p-p65/p65 and phospho-nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha (p-iκbα)/nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha (iκbα) protein expression were significantly decreased (p<0.05). |
2023-05-28 |
2023-08-14 |
Not clear |
| Lin Zhu, Xi Yao, Ying Mo, Ming-Wei Chen, Si-Chen Li, Jian-Qiao Liu, Hai-Ying Li. miR-4433a-3p promotes granulosa cell apoptosis by targeting peroxisome proliferator-activated receptor alpha and inducing immune cell infiltration in polycystic ovarian syndrome. Journal of assisted reproduction and genetics. 2023-05-19. PMID:37204637. |
mir-4433a-3p promotes granulosa cell apoptosis by targeting peroxisome proliferator-activated receptor alpha and inducing immune cell infiltration in polycystic ovarian syndrome. |
2023-05-19 |
2023-08-14 |
Not clear |