| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Piaopiao Xu, Xiangling Chen, Yongping Xu, Li Fu, Yun Li, Haoyu Fu, Qing Yao, Haitian Quan, Liguang Lo. Trastuzumab in combination with PEGylated interferon-α1b exerts synergistic antitumor activity through enhanced inhibition of HER2 downstream signaling and antibody-dependent cellular cytotoxicity. American journal of cancer research. vol 12. issue 2. 2022-03-09. PMID:35261786. |
in this study, we report that trastuzumab in combination with pegylated interferon-α1b (ifn-α1b), a polyethylene glycol (peg)-conjugated form of a subtype of interferon alpha (ifn-α), synergistically inhibited the proliferation of her2-positive cells, including bt-474 and sk-br-3 breast cancer cells and nci-n87 gastric cancer cells, and also induced their apoptosis, but had no effect on her2-negative mda-mb-231 breast cancer cells. |
2022-03-09 |
2023-08-13 |
Not clear |
| Rehab S Abdelrahman, Ramy A Abdelsalam, Marwa S Zaghlou. Beneficial effect of trimetazidine on folic acid-induced acute kidney injury in mice: Role of HIF-1α/HO-1. Journal of biochemical and molecular toxicology. 2022-02-22. PMID:35191561. |
finally, tmz amended fa-induced histopathological changes in kidneys. by mitigating functional alteration, oxidative stress, and preventing the development of inflammatory and apoptosis signals, tmz provides dose-dependent defense against fa-induced aki mainly via stimulation of hypoxia-inducible factor-1 alpha (hif-1α)/heme oxygenase-1 (ho-1) pathway. |
2022-02-22 |
2023-08-13 |
mouse |
| Xinghui Wang, Mengyao Zhu, Juan J Loor, Qianming Jiang, Yiwei Zhu, Wei Li, Xiliang Du, Yuxiang Song, Wenwen Gao, Lin Lei, Jianguo Wang, Guowen Liu, Xinwei L. Propionate alleviates fatty acid-induced mitochondrial dysfunction, oxidative stress, and apoptosis by upregulating PPARG coactivator 1 alpha in hepatocytes. Journal of dairy science. 2022-02-19. PMID:35181129. |
propionate alleviates fatty acid-induced mitochondrial dysfunction, oxidative stress, and apoptosis by upregulating pparg coactivator 1 alpha in hepatocytes. |
2022-02-19 |
2023-08-13 |
Not clear |
| Ya-Li Wu, Xiao-Yan Wang, Hui Zhang, Yu-Long Chen, Ming-Liang Zhang, Xiao-Fei Chen, Lu Niu, Wei-Xia Li, Jin-Fa Tan. [Study on alleviating effect of Glycyrrhizae Radix et Rhizoma on Psoraleae Fructus-induced liver injury based on network pharmacology and cell experiments]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 1. 2022-02-18. PMID:35178925. |
the predicted core targets were proto-oncogene tyrosine-protein kinase(src), phosphatidylinositol 4,5-bisphosphate 3-kinase subunit alpha(pik3 ca), rac-alpha serine/threonine-protein kinase(akt1), etc, with pi3 k-akt signaling pathway, mapk signaling pathway, apoptosis, toll-like receptor signaling pathway, and nf-κb signaling pathway mainly involved. |
2022-02-18 |
2023-08-13 |
Not clear |
| Runnan Wang, Lanmei Lin, Xiaonian Lu, Juan Du, Jinhua X. LncRNA AGXT2L1-2:2 facilitates keratinocytes proliferation and inhibits apoptosis by interacting with estrogen-related receptor alpha in psoriasis. Molecular and cellular probes. 2022-02-17. PMID:35176472. |
lncrna agxt2l1-2:2 facilitates keratinocytes proliferation and inhibits apoptosis by interacting with estrogen-related receptor alpha in psoriasis. |
2022-02-17 |
2023-08-13 |
Not clear |
| Jiantao Zhang, Qi Li, Ruth S Cruz Cosme, Volodymyr Gerzanich, Qiyi Tang, J Marc Simard, Richard Y Zha. Genome-Wide Characterization of SARS-CoV-2 Cytopathogenic Proteins in the Search of Antiviral Targets. mBio. 2022-02-15. PMID:35164548. |
in human pulmonary and kidney epithelial cells, orf3a induced cellular oxidative stress associated with apoptosis and necrosis and caused activation of proinflammatory response with production of the cytokines tumor necrosis factor alpha (tnf-α), interleukin-6 (il-6), and ifn-β1, possibly through the activation of nuclear factor kappa b (nf-κb). |
2022-02-15 |
2023-08-13 |
human |
| Boguslawa Korona, Dagmara Korona, Wanfeng Zhao, Andrew C Wotherspoon, Ming-Qing D. CCR6 activation links innate immune responses to MALT lymphoma development. Haematologica. 2022-02-10. PMID:35142152. |
in the present study, we demonstrated that these mutations impaired ccr6 receptor internalization and were activating changes, being more potent in apoptosis resistance, malignant transformation, migration and intracellular signaling, particularly in the presence of ligands ccl20, hbd2 (human beta defensin 2) and hd5 (human alpha defensin 5). |
2022-02-10 |
2023-08-13 |
human |
| Qiu-Yuan Gong, Lin Cai, Yao Jing, Wei Wang, Dian-Xu Yang, Shi-Wen Chen, Heng-Li Tia. Urolithin A alleviates blood-brain barrier disruption and attenuates neuronal apoptosis following traumatic brain injury in mice. Neural regeneration research. vol 17. issue 9. 2022-02-10. PMID:35142690. |
we found that ua greatly reduced brain edema; increased the expression of tight junction proteins in injured cortex; increased the immunopositivity of two neuronal autophagy markers, microtubule-associated protein 1a/b light chain 3a/b (lc3) and p62; downregulated protein kinase b (akt) and mammalian target of rapamycin (mtor), two regulators of the phosphatidylinositol 3-kinase (pi3k)/akt/mtor signaling pathway; decreased the phosphorylation levels of inhibitor of nfκb (iκb) kinase alpha (ikkα) and nuclear factor kappa b (nfκb), two regulators of the neuroinflammation-related akt/ikk/nfκb signaling pathway; reduced blood-brain barrier permeability and neuronal apoptosis in injured cortex; and improved mouse neurological function. |
2022-02-10 |
2023-08-13 |
mouse |
| Anna Markowska, Joanna Stanislawiak-Rudowicz, Tomasz Kasprzak, Janina Markowska, Monika Szarszewsk. Metformin in selected malignancies in women. Ginekologia polska. 2022-01-24. PMID:35072253. |
the mechanism of the antitumor action of metformin is pleiotropic and involves several signalling pathways, including ampk/mtor (mitogen activated protein kinase/mammalian target rapamycin), stat3 (signal transducer and activator of transcription) and numerous factors: nf-kb (nuclear factor kappa), hif-1 alpha (hypoxia inducible factor 1), igf-1 (insulin-like growth factor-1), which affect cell proliferation and apoptosis. |
2022-01-24 |
2023-08-13 |
Not clear |
| Akshamal M Gamage, Kai Sen Tan, Wharton O Y Chan, Zhe Zhang Ryan Lew, Jing Liu, Chee Wah Tan, Deepa Rajagopalan, Quy Xiao Xuan Lin, Le Min Tan, Prasanna Nori Venkatesh, Yew Kwang Ong, Mark Thong, Raymond Tzer Pin Lin, Shyam Prabhakar, De Yun Wang, Lin-Fa Wan. Human Nasal Epithelial Cells Sustain Persistent SARS-CoV-2 Infection mBio. 2022-01-18. PMID:35038898. |
we identified a unique population of cells harboring high viral loads present at both 3 and 28 dpi, characterized by expression of cell stress-related genes ddit3 and atf3 and enriched for genes involved in tumor necrosis factor alpha (tnf-α) signaling and apoptosis. |
2022-01-18 |
2023-08-13 |
human |
| Yingjie Wang, Deng Tong, Yingfei Sun, Huanling Sun, Fule Liu, Mengyun Zou, Ronglong Luo, Xiuli Pen. DF-1 cells prevent MG-HS infection through gga-miR-24-3p/RAP1B mediated decreased proliferation and increased apoptosis. Research in veterinary science. vol 141. 2021-12-06. PMID:34749101. |
meanwhile, overexpressed gga-mir-24-3p increased the levels of tumor necrosis factor alpha (tnf-α) and interleukin-1β (il-1β), and significantly inhibited cell proliferation as well as promoted mg-infected df-1 cell apoptosis, whereas inhibition of gga-mir-24-3p had the opposite effect. |
2021-12-06 |
2023-08-13 |
chicken |
| Zhifu Cui, Xiaoxu Shen, Xianxian Zhang, Fugui Li, Felix Kwame Amevor, Qing Zhu, Yan Wang, Diyan Li, Gang Shu, Yaofu Tian, Xiaoling Zha. A functional polymorphism of inhibin alpha subunit at miR-181b-1-3p-binding site regulates proliferation and apoptosis of chicken ovarian granular cells. Cell and tissue research. vol 384. issue 2. 2021-11-24. PMID:33439349. |
a functional polymorphism of inhibin alpha subunit at mir-181b-1-3p-binding site regulates proliferation and apoptosis of chicken ovarian granular cells. |
2021-11-24 |
2023-08-13 |
chicken |
| Rong Feng, Liang Chen, Keping Che. Cytotoxicity and changes in gene expression under aluminium potassium sulfate on Spodoptera frugiperda 9 cells. Ecotoxicology (London, England). vol 30. issue 10. 2021-11-23. PMID:34546441. |
through rna-seq transcriptomics, we found that aluminium ions may inhibit the expression of regulatory-associated protein of mtor, tdins-dependent protein kinase-1, and small heat shock proteins (heat shock 70 kda protein and crystallin alpha b), leading to changes in mtor-related pathways (such as the longevity regulation pathway and pi3k-akt signalling pathway), and promoting cell apoptosis. |
2021-11-23 |
2023-08-13 |
human |
| Chuan Zhang, Huiping Zhu, Hui Jie, Hengyue Ding, Hongwen Su. Arbutin ameliorated ulcerative colitis of mice induced by dextran sodium sulfate (DSS). Bioengineered. 2021-11-16. PMID:34783296. |
dss promotes pathological injury, the levels of pro-inflammatory factors containing tumor necrosis factor alpha (tnf-α), interleukin- 6 (il-6) and myeloperoxidase (mpo), and cell apoptosis in the mouse colon. |
2021-11-16 |
2023-08-13 |
mouse |
| Georgios Kokolakis, Robert Sabat, Sabine Krüger-Krasagakis, Jürgen Eberl. Ambivalent Effects of Tumor Necrosis Factor Alpha on Apoptosis of Malignant and Normal Human Keratinocytes. Skin pharmacology and physiology. vol 34. issue 2. 2021-11-15. PMID:33730739. |
ambivalent effects of tumor necrosis factor alpha on apoptosis of malignant and normal human keratinocytes. |
2021-11-15 |
2023-08-13 |
human |
| Georgios Kokolakis, Robert Sabat, Sabine Krüger-Krasagakis, Jürgen Eberl. Ambivalent Effects of Tumor Necrosis Factor Alpha on Apoptosis of Malignant and Normal Human Keratinocytes. Skin pharmacology and physiology. vol 34. issue 2. 2021-11-15. PMID:33730739. |
tumor necrosis factor alpha (tnfα) is a pro-inflammatory cytokine that may paradoxically induce either apoptosis or cell survival. |
2021-11-15 |
2023-08-13 |
human |
| Guoqi Su, Yuheng Luo, Daiwen Chen, Bing Yu, Jun H. NF-κB-dependent induction of porcine β-defensin 114 regulates intestinal epithelium homeostasis. International journal of biological macromolecules. vol 192. 2021-11-09. PMID:34619281. |
importantly, pbd114 suppresses endotoxin-induced inflammation and apoptosis in iecs through downregulation of two critical inflammation-associated signaling proteins, nf-kappa-b inhibitor alpha (ikb-α) and extracellular signal-regulated kinase1/2 (erk1/2). |
2021-11-09 |
2023-08-13 |
mouse |
| Jae Seok Yoon, Hyo-Jung Lee, Deok Yong Sim, Eunji Im, Ji Eon Park, Woon Yi Park, Ja Il Koo, Bum Sang Shim, Sung-Hoon Ki. Moracin D induces apoptosis in prostate cancer cells via activation of PPAR gamma/PKC delta and inhibition of PKC alpha. Phytotherapy research : PTR. 2021-10-28. PMID:34709688. |
moracin d induces apoptosis in prostate cancer cells via activation of ppar gamma/pkc delta and inhibition of pkc alpha. |
2021-10-28 |
2023-08-13 |
Not clear |
| Y J Park, S Lee, T J Kieffer, G L Warnock, N Safikhan, M Speck, Z Hao, M Woo, L Marzba. Deletion of Fas protects islet beta cells from cytotoxic effects of human islet amyloid polypeptide. Diabetologia. 2021-10-21. PMID:22301943. |
cultured hiapp-expressing mouse islets with fas deletion had similar amyloid levels, but lower caspase-3 activation and beta cell apoptosis, and a higher islet beta:alpha cell ratio and insulin response to glucose, compared with islets expressing fas and hiapp. |
2021-10-21 |
2023-08-12 |
mouse |
| Mahnoush Kolahdouz, Faranak Jafari, Farahnaz Falanji, Samad Nazemi, Mohammad Mohammadzadeh, Mehdi Molavi, Bahareh Ami. Clavulanic Acid Attenuating Effect on the Diabetic Neuropathic Pain in Rats. Neurochemical research. vol 46. issue 7. 2021-10-18. PMID:33846883. |
the expression of the glutamate transport 1 (glt1), genes of oxidative stress including inducible nitric oxide synthase (inos), proinflammatory cytokine, tumor necrosis factor alpha (tnf-α), as well as genes involved in the apoptosis including bcl2, bcl2-associated x (bax) were measured in the spinal cord tissue by real time pcr, on day 42. |
2021-10-18 |
2023-08-13 |
rat |