| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lucas Rafael Lopes, Vitor Almeida Ribeiro de Miranda, João Antonio Matheus Guimarães, Gabriel Garcez de Araujo Souza, Victor Soares Wainchtock, João Alves Grangeiro Neto, Rodrigo de Araújo Goes, Jamila Alessandra Perin. Association of TNF-α -308G > A polymorphism with susceptibility to tendinopathy in athletes: a case-control study. BMC sports science, medicine & rehabilitation. vol 13. issue 1. 2021-05-16. PMID:33985554. |
high levels of the tumor necrosis factor alpha (tnf-α) induce apoptosis and pro-inflammatory effects for primary degeneration of tendon and development of tendinopathy. |
2021-05-16 |
2023-08-13 |
Not clear |
| Qiaozhen Yang, Hongying Sun, Xiaxia Wang, Xuedi Yu, Jie Zhang, Bin Guo, Saiyin Hexig. Metabolic changes during malignant transformation in primary cells of oral lichen planus: Succinate accumulation and tumour suppression. Journal of cellular and molecular medicine. vol 24. issue 2. 2021-05-10. PMID:31793175. |
then, we found that succinate activated the hypoxia-inducible factor-1 alpha (hif-1α) pathway and induced apoptosis, which could also be up-regulated by the tumour suppressor lncrna meg3. |
2021-05-10 |
2023-08-13 |
Not clear |
| Hariharan Saminathan, Adhithiya Charli, Jie Luo, Nikhil Panicker, Richard Gordon, Jesse M Hostetter, Huajun Jin, Vellareddy Anantharam, Anumantha G Kanthasamy, Arthi Kanthasam. Fyn kinase mediates pro-inflammatory response in a mouse model of endotoxemia: Relevance to translational research. European journal of pharmacology. vol 881. 2021-05-10. PMID:32565338. |
importantly, endotoxemia-associated changes to levels of the serum pro-inflammatory cytokines tumor necrosis factor alpha (tnf-α) and interleukin-6 (il-6), splenocyte apoptosis and inducible nitric oxide synthase (inos) production in hepatocytes were also significantly attenuated in fyn ko mice. |
2021-05-10 |
2023-08-13 |
mouse |
| P Zhang, B-G Chan. Inhibitory effect on the apoptosis of disc nucleus pulposus cells in rats by silencing COL9A3 gene to mediate MAPK signaling pathway: a study on the function and mechanism. European review for medical and pharmacological sciences. vol 24. issue 17. 2021-05-10. PMID:32964953. |
to explore the effect of collagen ix alpha 3 chain (col9a3) gene silencing on apoptosis of nucleus pulposus cells in rats with intervertebral disc degeneration (ivdd) and its regulatory mechanism, so as to provide potential reference for the treatment of ivdd. |
2021-05-10 |
2023-08-13 |
rat |
| Min Han, Xiao-Cui Chen, Ming-Hui Sun, Min-Tao Gai, Yi-Ning Yang, Xiao-Ming Gao, Xiang Ma, Bang-Dang Chen, Yi-Tong M. Overexpression of IκBα in cardiomyocytes alleviates hydrogen peroxide-induced apoptosis and autophagy by inhibiting NF-κB activation. Lipids in health and disease. vol 19. issue 1. 2021-05-03. PMID:32580730. |
overexpression of the inhibitor of κb alpha (iκbα) gene is hypothesized to have protective effects against apoptosis and autophagy in cardiomyocytes subjected to hydrogen peroxide (h |
2021-05-03 |
2023-08-13 |
Not clear |
| Kalpana Baghel, Rashmi Srivastav. Photoperiod dependent expression of estrogen receptor alpha in testes of Japanese quail: Involvement of Withania somnifera in apoptosis amelioration. Biochemical and biophysical research communications. vol 534. 2021-04-20. PMID:33129445. |
photoperiod dependent expression of estrogen receptor alpha in testes of japanese quail: involvement of withania somnifera in apoptosis amelioration. |
2021-04-20 |
2023-08-13 |
Not clear |
| Mariana Bezamat, Juliana F Souza, Fernanda M F Silva, Emilly G Corrêa, Aluhe L Fatturi, João A Brancher, Flávia M Carvalho, Tayla Cavallari, Laís Bertolazo, Cleber Machado-Souza, Mine Koruyucu, Merve Bayram, Andrea Racic, Benjamin M Harrison, Yan Y Sweat, Ariadne Letra, Deborah Studen-Pavlovich, Figen Seymen, Brad Amendt, Renata I Werneck, Marcelo C Costa, Adriana Modesto, Alexandre R Vieir. Gene-environment interaction in molar-incisor hypomineralization. PloS one. vol 16. issue 1. 2021-04-20. PMID:33406080. |
during head and neck development, the interferon regulatory factor 6 (irf6) gene is involved in the structure formation of the oral and maxillofacial regions, and the transforming growth factor alpha (tgfa) is an essential cell regulator, acting during proliferation, differentiation, migration and apoptosis. |
2021-04-20 |
2023-08-13 |
Not clear |
| Yan Li, Shouyan Yang, Honggang Yue, Dandi Yuan, Luxia Li, Jinghong Zhao, Lintao Zha. Unraveling LGALS1 as a Potential Immune Checkpoint and a Predictor of the Response to Anti-PD1 Therapy in Clear Cell Renal Carcinoma. Pathology oncology research : POR. vol 26. issue 3. 2021-04-01. PMID:31428993. |
at last, the genes which correlated with lgals1 expression in ccrcc patients were enriched in tnf alpha signaling pathway which is mainly correlated with t cell apoptosis and survival. |
2021-04-01 |
2023-08-13 |
Not clear |
| Monica M Olcina, Ryan K Kim, Nikolas G Balanis, Caiyun Grace Li, Rie von Eyben, Thomas G Graeber, Daniel Ricklin, Manuel Stucki, Amato J Giacci. Intracellular C4BPA Levels Regulate NF-κB-Dependent Apoptosis. iScience. vol 23. issue 10. 2021-03-17. PMID:33205012. |
here, we show that c4b-binding protein alpha chain (c4bpa), typically thought to reside in the extracellular space, is expressed intracellularly in cancer cells, where it interacts with the nf-κb family member rela and regulates apoptosis. |
2021-03-17 |
2023-08-13 |
Not clear |
| Qifeng Han, Todd Bradley, Wilton B Williams, Derek W Cain, David C Montefiori, Kevin O Saunders, Robert J Parks, Regina W Edwards, Guido Ferrari, Olaf Mueller, Xiaoying Shen, Kevin J Wiehe, Steven Reed, Christopher B Fox, Wes Rountree, Nathan A Vandergrift, Yunfei Wang, Laura L Sutherland, Sampa Santra, M Anthony Moody, Sallie R Permar, Georgia D Tomaras, Mark G Lewis, Koen K A Van Rompay, Barton F Hayne. Neonatal Rhesus Macaques Have Distinct Immune Cell Transcriptional Profiles following HIV Envelope Immunization. Cell reports. vol 30. issue 5. 2021-03-16. PMID:32023469. |
transcriptome analyses of neonatal versus adult immune cells after env vaccination reveal that neonatal macaques have higher levels of the apoptosis regulator bcl2 in t cells and lower levels of the immunosuppressive interleukin-10 (il-10) receptor alpha (il10ra) mrna transcripts in t cells, b cells, natural killer (nk) cells, and monocytes. |
2021-03-16 |
2023-08-13 |
Not clear |
| Guobin Xie, Yuqi Zhou, Xuhuang Tu, Xiaohong Ye, Lin Xu, Zhijian Xiao, Qiqiang Wang, Xin Wang, Mingxuan Du, Ziwen Chen, Xiaoqin Chi, Xiaoli Zhang, Ji Xia, Xiaowei Zhang, Yunxia Zhou, Zongxi Li, Chengrong Xie, Luoyan Sheng, Zhiping Zeng, Hu Zhou, Zhenyu Yin, Ying Su, Yang Xu, Xiao-Kun Zhan. Centrosomal Localization of RXRα Promotes PLK1 Activation and Mitotic Progression and Constitutes a Tumor Vulnerability. Developmental cell. vol 55. issue 6. 2021-03-15. PMID:33321102. |
retinoid x receptor alpha (rxrα), a nuclear receptor of transcription factor, controls various physiological and pathological pathways including cellular growth, proliferation, differentiation, and apoptosis. |
2021-03-15 |
2023-08-13 |
Not clear |
| Hongzhu Zhang, Tingting Fu, Cuiping Zhan. MicroRNA-1249 Targets G Protein Subunit Alpha 11 and Facilitates Gastric Cancer Cell Proliferation, Motility and Represses Cell Apoptosis. OncoTargets and therapy. vol 14. 2021-03-05. PMID:33658793. |
microrna-1249 targets g protein subunit alpha 11 and facilitates gastric cancer cell proliferation, motility and represses cell apoptosis. |
2021-03-05 |
2023-08-13 |
Not clear |
| Katarzyna Kaławaj, Adrianna Sławińska-Brych, Magdalena Mizerska-Kowalska, Aleksandra Żurek, Agnieszka Bojarska-Junak, Martyna Kandefer-Szerszeń, Barbara Zdzisińsk. Alpha Ketoglutarate Exerts In Vitro Anti-Osteosarcoma Effects through Inhibition of Cell Proliferation, Induction of Apoptosis via the JNK and Caspase 9-Dependent Mechanism, and Suppression of TGF-β and VEGF Production and Metastatic Potential of Cells. International journal of molecular sciences. vol 21. issue 24. 2021-03-04. PMID:33321940. |
alpha ketoglutarate exerts in vitro anti-osteosarcoma effects through inhibition of cell proliferation, induction of apoptosis via the jnk and caspase 9-dependent mechanism, and suppression of tgf-β and vegf production and metastatic potential of cells. |
2021-03-04 |
2023-08-13 |
Not clear |
| Jeremy J McGuire, Jeremy S Frieling, Chen Hao Lo, Tao Li, Ayaz Muhammad, Harshani R Lawrence, Nicholas J Lawrence, Leah M Cook, Conor C Lync. Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer. Nature communications. vol 12. issue 1. 2021-02-19. PMID:33526787. |
here, we report msc-derived interleukin-28 (il-28) triggers prostate cancer cell apoptosis via il-28 receptor alpha (il-28rα)-stat1 signaling. |
2021-02-19 |
2023-08-13 |
Not clear |
| Ritwik Patra, Nabarun Chandra Das, Suprabhat Mukherje. Exploring the Differential Expression and Prognostic Significance of the COL11A1 Gene in Human Colorectal Carcinoma: An Integrated Bioinformatics Approach. Frontiers in genetics. vol 12. 2021-02-19. PMID:33597969. |
collagen type xi alpha 1 (col11a1) is a minor fibrillary collagen that has an essential role in the regulation of cell division, differentiation, proliferation, migration, growth, and apoptosis of intestinal and colon cells. |
2021-02-19 |
2023-08-13 |
human |
| Ya-Ling Yang, Feng-Sheng Wang, Hung-Yu Lin, Ying-Hsien Huan. Exogenous Therapeutics of Microrna-29a Attenuates Development of Hepatic Fibrosis in Cholestatic Animal Model through Regulation of Phosphoinositide 3-Kinase p85 Alpha. International journal of molecular sciences. vol 21. issue 10. 2021-02-16. PMID:32455716. |
phosphoinositide 3-kinase p85 alpha (pi3kp85α) is implicated in the regulation of proteostasis mitochondrial integrity and unfolded protein response (upr) and apoptosis in hepatocytes. |
2021-02-16 |
2023-08-13 |
mouse |
| Yong Dong, Ju Bai, Yimeng Zhang, Ya Zhou, Xu Pan, Xiaohong Li, Qiongxiu Zhou, Yijin Chen, Mowen Lai, Bin Mao, Guohui Bian, Jia Feng, Fangxin Xie, Bo Chen, Tatsutoshi Nakahata, Yonggang Zhang, Feng M. Alpha lipoic acid promotes development of hematopoietic progenitors derived from human embryonic stem cells by antagonizing ROS signals. Journal of leukocyte biology. vol 108. issue 6. 2021-02-09. PMID:32640500. |
alpha lipoic acid (ala), a small antioxidant molecule, affects cell apoptosis by lowering the ros level. |
2021-02-09 |
2023-08-13 |
human |
| Jun-Chen Ge, Yu-Xi Wang, Zhi-Biao Chen, Dong-Feng Che. Integrin alpha 7 correlates with poor clinical outcomes, and it regulates cell proliferation, apoptosis and stemness via PTK2-PI3K-Akt signaling pathway in hepatocellular carcinoma. Cellular signalling. vol 66. 2021-02-03. PMID:31698037. |
integrin alpha 7 correlates with poor clinical outcomes, and it regulates cell proliferation, apoptosis and stemness via ptk2-pi3k-akt signaling pathway in hepatocellular carcinoma. |
2021-02-03 |
2023-08-13 |
human |
| Masumeh Sanaei, Fraidoon Kavoosi, Mehrnoosh Arablo. Effect of Curcumin in Comparison with Trichostatin A on the Reactivation of Estrogen Receptor Alpha gene Expression, Cell Growth Inhibition and Apoptosis Induction in Hepatocellular Carcinoma Hepa 1-6 Cell lLine. Asian Pacific journal of cancer prevention : APJCP. vol 21. issue 4. 2021-02-02. PMID:32334468. |
effect of curcumin in comparison with trichostatin a on the reactivation of estrogen receptor alpha gene expression, cell growth inhibition and apoptosis induction in hepatocellular carcinoma hepa 1-6 cell lline. |
2021-02-02 |
2023-08-13 |
Not clear |
| Yi Dong, Cheng Qian, Guangming Wan, Panshi Yan, Shenzhi Liang, Jiong Wan. Schizandrin A Protects Human Retinal Pigment Epithelial Cell Line ARPE-19 against HG-Induced Cell Injury by Regulation of miR-145. Molecular therapy. Nucleic acids. vol 19. 2021-01-10. PMID:31794890. |
we observed that scha accelerated cell proliferation, prohibited apoptosis, and restrained pro-inflammatory cytokines (monocyte chemoattractant protein-1 [mcp-1], interleukin-6 [il-6], and tumor necrosis factor alpha [tnf-α]) and reactive oxygen species (ros) level in hg-stimulated cells. |
2021-01-10 |
2023-08-13 |
human |