| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cihan Gur, Fatih Mehmet Kandemir, Ekrem Darendelioglu, Cuneyt Caglayan, Sefa Kucukler, Ozge Kandemir, Mustafa Ileritur. Morin protects against acrylamide-induced neurotoxicity in rats: an investigation into different signal pathways. Environmental science and pollution research international. vol 28. issue 36. 2021-09-20. PMID:33939091. |
biochemical and western blot analyses showed that acr increased malondialdehyde (mda), p38α mitogen-activated protein kinase (p38α mapk), nuclear factor kappa-b (nf-κb), tumor necrosis factor alpha (tnf-α), interleukin-1 beta (il-1β), interleukin-6 (il-6), cyclooxygenase-2 (cox-2), p53, caspase-3, bcl-2 associated x protein (bax), beclin-1, light chain 3a (lc3a), and light chain 3b (lc3b) levels and decreased those of superoxide dismutase (sod), catalase (cat), glutathione peroxidase (gpx), glutathione (gsh), b-cell lymphoma-2 (bcl-2), mammalian target of rapamycin (mtor), phosphoinositide 3-kinase (pi3k), and protein kinase b (akt) in brain tissue and therefore induced neurotoxicity by causing oxidative stress, inflammation, apoptosis, and autophagy. |
2021-09-20 |
2023-08-13 |
rat |
| Zahide Cavdar, Mehmet Asi Oktan, Cemre Ural, Ayse Kocak, Meryem Calisir, Cihan Heybeli, Serkan Yildiz, Seda Ozbal, Sevki Arslan, Bekir Ugur Ergur, Osman Yilmaz, Caner Cavda. Alpha lipoic acid attenuates iron induced oxidative acute kidney injury in rats. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 96. issue 6. 2021-09-17. PMID:32921159. |
we investigated the reno-protective effects of alpha lipoic acid (ala) by investigating its effects on the kidney isoform of nadph oxidase (nox4) and the specific signaling pathways, p38 mapk and pi3k/akt, which participate in apoptosis and survival, respectively. |
2021-09-17 |
2023-08-13 |
rat |
| Bhavisha A Patel, Valentina Giudice, Neal S Youn. Immunologic effects on the haematopoietic stem cell in marrow failure. Best practice & research. Clinical haematology. vol 34. issue 2. 2021-09-17. PMID:34404528. |
oligoclonal cytotoxic t cell expansion and an active role of proinflammatory cytokines, primarily interferon gamma (ifn-γ) and tumor necrosis factor alpha (tnf-α), are two main contributors to hspc growth inhibition and apoptosis in bmf. |
2021-09-17 |
2023-08-13 |
Not clear |
| Naoki Okada, Ko Sugiyama, Shunsuke Shichi, Yasuhito Shirai, Kaoru Goto, Fumio Sakane, Hidemitsu Kitamura, Akinobu Taketom. Combination therapy for hepatocellular carcinoma with diacylglycerol kinase alpha inhibition and anti-programmed cell death-1 ligand blockade. Cancer immunology, immunotherapy : CII. 2021-09-05. PMID:34482409. |
activation of diacylglycerol kinase alpha (dgkα) augments proliferation and suppresses apoptosis of cancer cells and induces t lymphocyte anergy. |
2021-09-05 |
2023-08-13 |
mouse |
| Zhonghao Su, Lanyue Sheng, Ping Yu, Na Ren, Yajuan Li, Zhenxia Qi. Regulation of microRNAs by IRE1α in apoptosis: implications for the pathomechanism of neurodegenerative diseases. The International journal of neuroscience. vol 130. issue 12. 2021-08-16. PMID:32070174. |
this review provides an overview of recent progress in unfolded protein response (upr) during apoptosis induced by abnormal protein aggregation and emphasizes on the potential role of inositol requiring enzyme 1 alpha (ire1α)-micrornas (mirnas) mediated apoptosis in nds, which will provide new insights in the pathogenesis of neurodegenerative diseases and novel therapeutic targets for the treatment of nds. |
2021-08-16 |
2023-08-13 |
Not clear |
| Yaxu Liang, Zhen Zhang, Jiayu Tu, Zhibo Wang, Xiaoxiao Gao, Kaiping Deng, M A El-Samahy, Peihua You, Yixuan Fan, Feng Wan. γ-Linolenic Acid Prevents Lipid Metabolism Disorder in Palmitic Acid-Treated Alpha Mouse Liver-12 Cells by Balancing Autophagy and Apoptosis via the LKB1-AMPK-mTOR Pathway. Journal of agricultural and food chemistry. vol 69. issue 29. 2021-07-29. PMID:34281337. |
γ-linolenic acid prevents lipid metabolism disorder in palmitic acid-treated alpha mouse liver-12 cells by balancing autophagy and apoptosis via the lkb1-ampk-mtor pathway. |
2021-07-29 |
2023-08-13 |
mouse |
| Sarah Hamed N Taha, Hala Saied Zaghloul, Abla Abd El Rahman Ali, Iman Fawzy Gaballah, Laila Ahmed Rashed, Basma Emad Aboulhod. The neurotoxic effect of long-term use of high-dose Pregabalin and the role of alpha tocopherol in amelioration: implication of MAPK signaling with oxidative stress and apoptosis. Naunyn-Schmiedeberg's archives of pharmacology. vol 393. issue 9. 2021-07-28. PMID:32377769. |
the neurotoxic effect of long-term use of high-dose pregabalin and the role of alpha tocopherol in amelioration: implication of mapk signaling with oxidative stress and apoptosis. |
2021-07-28 |
2023-08-13 |
Not clear |
| Sarah Hamed N Taha, Hala Saied Zaghloul, Abla Abd El Rahman Ali, Iman Fawzy Gaballah, Laila Ahmed Rashed, Basma Emad Aboulhod. The neurotoxic effect of long-term use of high-dose Pregabalin and the role of alpha tocopherol in amelioration: implication of MAPK signaling with oxidative stress and apoptosis. Naunyn-Schmiedeberg's archives of pharmacology. vol 393. issue 9. 2021-07-28. PMID:32377769. |
the role of alpha tocopherol in ameliorating the oxidative stress injury, and apoptosis induced by pregabalin, along with its role in normalizing neurotransmitters, modulating the erk/jnk/p38-mapk signaling pathways and improving the histopathological cortical changes, offers alpha tocopherol as a promising adjunctive therapy in patients undergoing prolonged pregabalin therapy as those suffering from prolonged seizures and neuropathies. |
2021-07-28 |
2023-08-13 |
Not clear |
| Redouane Rebai, Luc Jasmin, Abdennacer Bouda. Agomelatine effects on fat-enriched diet induced neuroinflammation and depression-like behavior in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 135. 2021-07-19. PMID:33453676. |
immediately after the second behavioral testing we measured the proinflammatory cytokines tumor necrosis factor alpha (tnf-α), interleukin 6 (il-6) and interleukin 1 beta (il-1β), markers of oxidative stress thiobarbituric acid reactive substances (tabrs), catalase (cat) and glutathione peroxidase (gpx), the growth factor bdnf, as well as the apoptosis marker caspase-3. |
2021-07-19 |
2023-08-13 |
rat |
| Xiang-Kun Zhao, Yi Tia. [Research Progress of Pharmacological Intervention of Sevoflurane-induced Nerve Injury in the Developing Brain]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 43. issue 3. 2021-07-12. PMID:34238424. |
sevoflurane is one of the most commonly used inhaled anesthetics in obstetric and pediatric general anesthesia.according to related literature,this article reviews major possible mechanisms including myelin formation damage,nerve inflammation,cell apoptosis,oxidative stress,inhibition of histone acetylation,synapsis and receptor changes of sevoflurane-induced neurotoxicity in animal experiments.furthermore,we summarize the neuroprotection effects and functioning mechanisms of anti-anemia medicine,plant-based drugs,alpha 2 adrenoceptor agonists and others,aiming to provide a basis for the brain protection of fetuses and infants during the perioperative period. |
2021-07-12 |
2023-08-13 |
Not clear |
| Omid Toupchian, Shima Abdollahi, Amin Salehi-Abargouei, Javad Heshmati, Cain C T Clark, Mohammad Hasan Sheikhha, Hossein Fallahzadeh, Hassan Mozaffari-Khosrav. The effects of resveratrol supplementation on PPARα, p16, p53, p21 gene expressions, and sCD163/sTWEAK ratio in patients with type 2 diabetes mellitus: A double-blind controlled randomized trial. Phytotherapy research : PTR. vol 35. issue 6. 2021-06-28. PMID:33580595. |
the present study sought to evaluate the effect of resveratrol supplementation on mrna expression levels of peroxisome proliferator-activated receptor alpha (pparα), p53, p21, p16, and serum levels of cluster of differentiation 163 (cd163) to tnf-like weak inducer of apoptosis (tweak) ratio in patients with type 2 diabetes. |
2021-06-28 |
2023-08-13 |
Not clear |
| Ian J Jackson, Muraly Puttabyatappa, Miranda Anderson, Meha Muralidharan, Almudena Veiga-Lopez, Brigid Gregg, Sean Limesand, Vasantha Padmanabha. Developmental programming: Prenatal testosterone excess disrupts pancreatic islet developmental trajectory in female sheep. Molecular and cellular endocrinology. vol 518. 2021-06-25. PMID:32726642. |
at gestational day 90, t-treatment led to maternal but not fetal hyperinsulinemia, decrease in pancreatic/fetal weight ratio and alpha cells, and a trend for increase in beta cell apoptosis in fetal pancreas. |
2021-06-25 |
2023-08-13 |
Not clear |
| Eman Taha Mohammed, Khalid S Hashem, Ahmed Z Abdelazem, Fatma A M A Fod. Prospective Protective Effect of Ellagic Acid as a SIRT1 Activator in Iron Oxide Nanoparticle-Induced Renal Damage in Rats. Biological trace element research. vol 198. issue 1. 2021-06-18. PMID:31933277. |
in the present study, the potent antioxidant and antiapoptotic effects of ea were indicated by the significant overexpression of sirt1 in renal tissues that leads to significant decreases in renal mda content, p53 protein level and forkhead-box transcription factor1 (foxo1) expression, and significant increases in renal gsh level, catalase activity, growth arrest and dna damage-inducible protein 45 alpha (gaddα45), and renal inhibition of apoptosis protein (kiap) gene expression levels in the ea + ionp-treated group. |
2021-06-18 |
2023-08-13 |
rat |
| Xiaobing Han, Liangfeng Chen, Zhongzhou Hu, Liangxin Chen, Peng Sun, Yujun Wang, Yangyang Li. Identification of proteins related with pemetrexed resistance by iTRAQ and PRM-based comparative proteomic analysis and exploration of IGF2BP2 and FOLR1 functions in non-small cell lung cancer cells. Journal of proteomics. vol 237. 2021-06-18. PMID:33561557. |
moreover, insulin-like growth factor (igf) 2 mrna-binding protein 2 (igf2bp2) or folate receptor alpha (folr1) knockdown weakened pem resistance, reduced cell viability and promoted cell apoptosis in a549/pem cells. |
2021-06-18 |
2023-08-13 |
Not clear |
| Dandan Chen, Yu Hou, Xingjun Ca. MiR-210-3p Enhances Cardiomyocyte Apoptosis and Mitochondrial Dysfunction by Targeting the NDUFA4 Gene in Sepsis-Induced Myocardial Dysfunction. International heart journal. vol 62. issue 3. 2021-06-10. PMID:33994501. |
the targeting regulatory relations between mir-210-3p and nadh dehydrogenase (ubiquinone) 1 alpha subcomplex 4 (ndufa4) were validated by dual luciferase reporter assay.the rat sepsis model showed increased serum tnf-α and il-6 levels, significant myocardial tissue injuries and apoptosis with decreased bcl-2 and increased caspase-1 protein levels. |
2021-06-10 |
2023-08-13 |
rat |
| Jian Wang, Xiean Ling, Min Zhou, Guanggui Ding, Bin Peng, Jun Wa. Thermal treatment decreases resistance to osimertinib in non-small cell lung cancer through the EGFR/PI3K/AKT pathway. Neoplasma. vol 68. issue 3. 2021-06-02. PMID:33724860. |
cell viability, apoptosis, sensitivity to osi, threonine-methionine amino acid substitution at position 790 (t790m) mutation levels, and protein expression of epidermal growth factor receptor (egfr), phosphatidylinositol 3-kinase (pi3k), protein kinase b (akt), hypoxia-inducible factor-1 alpha (hif-1a) were detected using different methods. |
2021-06-02 |
2023-08-13 |
mouse |
| Xin Tong, Mengyun Li, Na Liu, Wanjie Huang, Xindong Xue, Jianhua F. Hyperoxia induces endoplasmic reticulum stress‑associated apoptosis via the IRE1α pathway in rats with bronchopulmonary dysplasia. Molecular medicine reports. vol 23. issue 1. 2021-05-19. PMID:33179109. |
hyperoxia induces endoplasmic reticulum stress‑associated apoptosis via the ire1α pathway in rats with bronchopulmonary dysplasia. |
2021-05-19 |
2023-08-13 |
rat |
| Lucas Rafael Lopes, Vitor Almeida Ribeiro de Miranda, João Antonio Matheus Guimarães, Gabriel Garcez de Araujo Souza, Victor Soares Wainchtock, João Alves Grangeiro Neto, Rodrigo de Araújo Goes, Jamila Alessandra Perin. Association of TNF-α -308G > A polymorphism with susceptibility to tendinopathy in athletes: a case-control study. BMC sports science, medicine & rehabilitation. vol 13. issue 1. 2021-05-16. PMID:33985554. |
high levels of the tumor necrosis factor alpha (tnf-α) induce apoptosis and pro-inflammatory effects for primary degeneration of tendon and development of tendinopathy. |
2021-05-16 |
2023-08-13 |
Not clear |
| Qiaozhen Yang, Hongying Sun, Xiaxia Wang, Xuedi Yu, Jie Zhang, Bin Guo, Saiyin Hexig. Metabolic changes during malignant transformation in primary cells of oral lichen planus: Succinate accumulation and tumour suppression. Journal of cellular and molecular medicine. vol 24. issue 2. 2021-05-10. PMID:31793175. |
then, we found that succinate activated the hypoxia-inducible factor-1 alpha (hif-1α) pathway and induced apoptosis, which could also be up-regulated by the tumour suppressor lncrna meg3. |
2021-05-10 |
2023-08-13 |
Not clear |
| Hariharan Saminathan, Adhithiya Charli, Jie Luo, Nikhil Panicker, Richard Gordon, Jesse M Hostetter, Huajun Jin, Vellareddy Anantharam, Anumantha G Kanthasamy, Arthi Kanthasam. Fyn kinase mediates pro-inflammatory response in a mouse model of endotoxemia: Relevance to translational research. European journal of pharmacology. vol 881. 2021-05-10. PMID:32565338. |
importantly, endotoxemia-associated changes to levels of the serum pro-inflammatory cytokines tumor necrosis factor alpha (tnf-α) and interleukin-6 (il-6), splenocyte apoptosis and inducible nitric oxide synthase (inos) production in hepatocytes were also significantly attenuated in fyn ko mice. |
2021-05-10 |
2023-08-13 |
mouse |