| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mingzheng Peng, Lei Qiang, Yan Xu, Cuidi Li, Tao Li, Jinwu Wan. IL-35 ameliorates collagen-induced arthritis by promoting TNF-α-induced apoptosis of synovial fibroblasts and stimulating M2 macrophages polarization. The FEBS journal. vol 286. issue 10. 2020-05-22. PMID:30834683. |
in this study, we investigated the effect of il-35 on the cia microenvironment and, specifically, the tumor necrosis factor alpha (tnf-α)-induced macrophage inflammatory response and apoptosis of fibroblast-like synoviocytes (flss). |
2020-05-22 |
2023-08-13 |
mouse |
| Neena Lala-Tabbert, Rim Lejmi-Mrad, Kristen Timusk, Marina Fukano, Janelle Holbrook, Martine St-Jean, Eric C LaCasse, Robert G Kornelu. Targeted ablation of the cellular inhibitor of apoptosis 1 (cIAP1) attenuates denervation-induced skeletal muscle atrophy. Skeletal muscle. vol 9. issue 1. 2020-05-04. PMID:31126323. |
the cellular inhibitor of apoptosis 1 (ciap1) protein is a positive regulator of tumor necrosis factor alpha (tnfα)-mediated classical nf-κb signaling, and ciap1 loss has been shown to enhance muscle regeneration during acute and chronic injury. |
2020-05-04 |
2023-08-13 |
Not clear |
| Tomonaga Ichikawa, Obeid Shanab, Shingo Nakahata, Shunsuke Shimosaki, Nawin Manachai, Masaya Ono, Hidekatsu Iha, Kazuya Shimoda, Kazuhiro Morishit. Novel PRMT5-mediated arginine methylations of HSP90A are essential for maintenance of HSP90A function in NDRG2 Biochimica et biophysica acta. Molecular cell research. vol 1867. issue 2. 2020-04-20. PMID:31765670. |
to investigate how the apoptosis is induced by the knockdown prmt5 expression, heat shock protein 90 alpha (hsp90a) was identified as a binding protein for ndrg2 or prmt5 by immunoprecipitation-mass analysis. |
2020-04-20 |
2023-08-13 |
human |
| Maria Liliana Piredda, Girish Gaur, Gianfranco Catalano, Mariadomenica Divona, Cristina Banella, Serena Travaglini, Maria Carmen Puzzangara, Maria Teresa Voso, Francesco Lo-Coco, Nelida Ines Noguer. PML/RARA inhibits expression of HSP90 and its target AKT. British journal of haematology. vol 184. issue 6. 2020-03-20. PMID:30536958. |
acute promyelocytic leukaemia (apl) is characterized by the presence of the promyelocytic leukaemia/retinoic acid receptor alpha (pml/rara) fusion protein, which deregulates expression of several genes involved in differentiation and apoptosis. |
2020-03-20 |
2023-08-13 |
Not clear |
| Dongping Xia, Beibei Chen, Xun Yan. Correlation of integrin alpha 7 with clinicopathological characteristics and survival profiles, as well as its regulatory role in cell proliferation, apoptosis, and stemness in non-small-cell lung cancer. Journal of clinical laboratory analysis. vol 33. issue 8. 2020-03-12. PMID:31418948. |
correlation of integrin alpha 7 with clinicopathological characteristics and survival profiles, as well as its regulatory role in cell proliferation, apoptosis, and stemness in non-small-cell lung cancer. |
2020-03-12 |
2023-08-13 |
Not clear |
| Dongping Xia, Beibei Chen, Xun Yan. Correlation of integrin alpha 7 with clinicopathological characteristics and survival profiles, as well as its regulatory role in cell proliferation, apoptosis, and stemness in non-small-cell lung cancer. Journal of clinical laboratory analysis. vol 33. issue 8. 2020-03-12. PMID:31418948. |
the present study aimed to evaluate the correlation of integrin alpha 7 (itga7) with patients' clinicopathological characteristics and survival profiles, as well as its influence on cell proliferation, apoptosis, and stemness in non-small-cell lung cancer (nsclc). |
2020-03-12 |
2023-08-13 |
Not clear |
| Ssu-Yu Chen, Shu-Ting Liu, Wun-Rong Lin, Chi-Kang Lin, Shih-Ming Huan. The Mechanisms Underlying the Cytotoxic Effects of Copper Via Differentiated Embryonic Chondrocyte Gene 1. International journal of molecular sciences. vol 20. issue 20. 2020-03-03. PMID:31652494. |
copper sulfate also increased the levels of apoptosis, senescence, mitochondrial dysfunction, autophagy, ros, and the expression of several stress proteins, including atf3, c-fos, dec1 (differentiated embryonic chondrocyte gene 1), p21, p53, and hif-1α (hypoxia-inducible factor 1 alpha). |
2020-03-03 |
2023-08-13 |
Not clear |
| Yueyue Wu, Fangyuan Chen, Xinmei Huang, Rui Zhang, Zhiyan Yu, Zaoping Chen, Jun Li. Berberine (BBR) Attenuated Palmitic Acid (PA)-Induced Lipotoxicity in Human HK-2 Cells by Promoting Peroxisome Proliferator-Activated Receptor α (PPAR-α). Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-02-20. PMID:31607744. |
evidence suggests that bbr ameliorates palmitate-induced lipid deposition and apoptosis in renal tubular epithelial cells (tecs), which tracks in tandem with the enhancement of peroxisome proliferator-activated receptor alpha (ppar-alpha). |
2020-02-20 |
2023-08-13 |
human |
| Rashmi Deshpande, Prerna Raina, Kavita Shinde, Prakash Mansara, Manjiri Karandikar, Ruchika Kaul-Ghaneka. Flax seed oil reduced tumor growth, modulated immune responses and decreased HPV E6 and E7 oncoprotein expression in a murine model of ectopic cervical cancer. Prostaglandins & other lipid mediators. vol 143. 2020-02-19. PMID:30959179. |
previously, we have reported that alpha linolenic acid (ala), induced apoptosis in cervical cancer cell lines and reduced expression of e6 and e7 oncoproteins with simultaneous decrease in cox2/vegf/map kinase proteins. |
2020-02-19 |
2023-08-13 |
mouse |
| Francesco Vieceli Dalla Sega, Raffaella Mastrocola, Giorgio Aquila, Francesca Fortini, Claudia Fornelli, Alessia Zotta, Alessia S Cento, Andrea Perrelli, Enrica Boda, Antonio Pannuti, Saverio Marchi, Paolo Pinton, Roberto Ferrari, Paola Rizzo, Saverio Francesco Rett. KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction. International journal of molecular sciences. vol 20. issue 19. 2020-02-10. PMID:31590384. |
silencing of krit1 in human aortic endothelial cells (haecs), coronary artery endothelial cells (hcaecs), and umbilical vein endothelial cells (huvecs) resulted in increased expression of endothelial proinflammatory adhesion molecules vascular cell adhesion molecule 1 (vcam-1) and intercellular adhesion molecule 1 (icam-1) and in enhanced susceptibility to tumor necrosis factor alpha (tnf-α)-induced apoptosis. |
2020-02-10 |
2023-08-13 |
human |
| Ke-Shi Zhang, Jun-Feng Wang, Shao-Long Zhang, Zhao Li, Zheng Pei, Zhen-Peng Gua. Effects of Tumor Necrosis Factor Alpha on the Expression of Programmed Cell Death Factor 5 in Arthritis. Orthopaedic surgery. vol 11. issue 4. 2020-02-06. PMID:31282065. |
to investigate the effect of tumor necrosis factor alpha (tnf-α) on the proliferation of fibroblast-like synoviocytes (fls) and the expression of programmed cell death factor 5 (pdcd5) in an inflammatory microenvironment, for the further understanding of the mechanism of action of tnf-α in promoting the proliferation of synovial cells and the apoptosis of the chondrocytes. |
2020-02-06 |
2023-08-13 |
Not clear |
| Hongyan Lu, Xiaoqing Chen, Yanmin Lu, Haitao Zhu, Wei Tang, Qiuxia Wan. Effects of C/EBPα overexpression on alveolar epithelial type II cell proliferation, apoptosis and surfactant protein-C expression after exposure to hyperoxia. BMC pulmonary medicine. vol 19. issue 1. 2020-01-30. PMID:31387550. |
this study aims to investigate the effects of ccaat/enhancer binding protein alpha (c/ebpα) overexpression on cell proliferation, apoptosis and surfactant protein-c(sp-c) in alveolar epithelial type ii (aec ii) cells after exposure to hyperoxia. |
2020-01-30 |
2023-08-13 |
Not clear |
| Amin Kawarizadeh, Mohammad Tabatabaei, Saeid Hosseinzadeh, Mina Farzaneh, Maryam Pourmontaser. The effects of probiotic Bacillus coagulans on the cytotoxicity and expression of alpha toxin gene of Clostridium perfringens type A. Anaerobe. vol 59. 2020-01-20. PMID:31125604. |
this study investigated, in vitro, the effects of bacillus coagulans and its culture extracts on alpha toxin gene expression, growth inhibition, cytotoxicity, and apoptosis induced by c. perfringens spore, germinated spore and its enterotoxin. |
2020-01-20 |
2023-08-13 |
Not clear |
| Amin Kawarizadeh, Mohammad Tabatabaei, Saeid Hosseinzadeh, Mina Farzaneh, Maryam Pourmontaser. The effects of probiotic Bacillus coagulans on the cytotoxicity and expression of alpha toxin gene of Clostridium perfringens type A. Anaerobe. vol 59. 2020-01-20. PMID:31125604. |
the findings of this study indicate that b. coagulans, with growth inhibition and reduced expression of alpha toxin in c. perfringens, can reduce the cytotoxicity and apoptosis rate induced on ht-29 cells. |
2020-01-20 |
2023-08-13 |
Not clear |
| Yonghua Shi, Shayahati Bieerkehazhi, Hong M. Next-generation proteasome inhibitor oprozomib enhances sensitivity to doxorubicin in triple-negative breast cancer cells. International journal of clinical and experimental pathology. vol 11. issue 5. 2020-01-19. PMID:31938346. |
oprozomib had cytotoxic effects on tnbc cells and increased dox-induced cytotoxic effects and apoptosis by enhancing dox-induced jnk/p38 mapk phosphorylation and inhibiting dox-induced inhibitory factor êb alpha degradation. |
2020-01-19 |
2023-08-13 |
Not clear |
| Yue Sun, Jing Yang, Weiwei Liu, Guodong Yao, Fanxing Xu, Toshihiko Hayashi, Satoshi Onodera, Takashi Ikejim. Attenuating effect of silibinin on palmitic acid-induced apoptosis and mitochondrial dysfunction in pancreatic β-cells is mediated by estrogen receptor alpha. Molecular and cellular biochemistry. vol 460. issue 1-2. 2020-01-13. PMID:31183735. |
attenuating effect of silibinin on palmitic acid-induced apoptosis and mitochondrial dysfunction in pancreatic β-cells is mediated by estrogen receptor alpha. |
2020-01-13 |
2023-08-13 |
rat |
| Surojeet Sengupta, Catherine M Sevigny, Poulomi Bhattacharya, V Craig Jordan, Robert Clark. Estrogen-Induced Apoptosis in Breast Cancers Is Phenocopied by Blocking Dephosphorylation of Eukaryotic Initiation Factor 2 Alpha (eIF2α) Protein. Molecular cancer research : MCR. vol 17. issue 4. 2020-01-09. PMID:30655322. |
estrogen-induced apoptosis in breast cancers is phenocopied by blocking dephosphorylation of eukaryotic initiation factor 2 alpha (eif2α) protein. |
2020-01-09 |
2023-08-13 |
Not clear |
| Olivia K Provance, Joan Lewis-Wamb. Deciphering the role of interferon alpha signaling and microenvironment crosstalk in inflammatory breast cancer. Breast cancer research : BCR. vol 21. issue 1. 2020-01-09. PMID:31060575. |
activation of the interferon alpha signaling pathway has been shown to contribute to apoptosis and cellular senescence but is also attributed to increased migration and drug resistance depending on the interferon-stimulated genes transcribed. |
2020-01-09 |
2023-08-13 |
Not clear |
| Wuhui Li, Hui Tan, Junmei Liu, Jie Hu, Jialin Cui, Shi Wang, Qingfeng Liu, Fangzhou Hu, Li Ren, Min Tao, Rurong Zhao, Conghui Yang, Qinbo Qin, Shaojun Li. Comparative analysis of testis transcriptomes associated with male infertility in triploid cyprinid fish. Reproduction, fertility, and development. vol 31. issue 2. 2019-12-06. PMID:30086823. |
in addition, the expression of a number of genes related to meiosis (inhibitor of dna binding 2 (id2), ovo like transcriptional repressor 1 (ovol1)), mitochondria (atp1b (atpase na+/k+ transporting subunit beta 1), atp2a (atpase, ca++ transporting, cardiac muscle, slow twitch 2), atp5a (atp synthase f1 subunit alpha), mitochondrially encoded cytochrome c oxidase i (cox1), nadh dehydrogenase subunit 4 (nd4)) and chromatin structure (histone 1 (h1), histone 2a (h2a), histone 2b (h2b), histone 3 (h3), histone 4 (h4)) was lower in the testes of 3nby, whereas the expression of genes encoding ubiquitin (ubiquitin conjugating enzymes (ubes), ring finger proteins (rnfs)) and apoptosis (casps (caspase 3, caspase 7,caspase 8), bcls (b-cell lymphoma 3, b-cell cll/lymphoma 2, b cell cll/lymphoma 10)) proteins involved in spermatid degeneration was higher. |
2019-12-06 |
2023-08-13 |
Not clear |
| Guilherme Lopes Gonçalves, Juliana Martins Costa-Pessoa, Karina Thieme, Bruna Bezerra Lins, Maria Oliveira-Souz. Intracellular albumin overload elicits endoplasmic reticulum stress and PKC-delta/p38 MAPK pathway activation to induce podocyte apoptosis. Scientific reports. vol 8. issue 1. 2019-12-02. PMID:30573754. |
using immunofluorescence images, flow cytometry and immunoblotting, we observed a time-dependent intracellular accumulation of fluorescent albumin-fitc-bsa, followed by concentration-and time-dependent effect of intracellular albumin overload on podocyte apoptosis, which was mediated by increased expression of the chaperone glucose-regulated-protein 78 (grp 78) and phosphorylated inositol-requiring enzyme 1 alpha (pire1-α), as well as protein kinase c delta (pkc-δ), p38mapk and cleaved caspase 12 expression. |
2019-12-02 |
2023-08-13 |
mouse |