| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rumeng Tan, Hongzhe Tian, Bo Yang, Bo Zhang, Chen Dai, Zhenyi Han, Meixi Wang, Yakun Li, Lai Wei, Dong Chen, Guangyao Wang, Huifang Yang, Fan He, Zhishui Che. Autophagy and Akt in the protective effect of erythropoietin helix B surface peptide against hepatic ischaemia/reperfusion injury in mice. Scientific reports. vol 8. issue 1. 2019-11-13. PMID:30279567. |
we assessed alanine aminotransferase (alt), aspartate aminotransferase (ast) and lactate dehydrogenase (ldh) levels in mouse sera, and performed haematoxylin/eosin (he) staining, immunohistochemistry, electron microscopy, immunofluorescence microscopy, and western blotting on liver tissue to detect the degree of liver injury, liver apoptosis, autophagy, and the expression of microtubule associated protein 1 light chain 3 alpha (map1lc3, or lc3), beclin 1, phospho-mtor, mtor, phospho-akt (p-akt), and akt. |
2019-11-13 |
2023-08-13 |
mouse |
| Cristiana Barbati, Marta Vomero, Tania Colasanti, Marco Diociaiuti, Fulvia Ceccarelli, Sara Ferrigno, Annacarla Finucci, Francesca Miranda, Lucia Novelli, Carlo Perricone, Francesca Romana Spinelli, Simona Truglia, Fabrizio Conti, Guido Valesini, Cristiano Alessandr. TNFα expressed on the surface of microparticles modulates endothelial cell fate in rheumatoid arthritis. Arthritis research & therapy. vol 20. issue 1. 2019-10-09. PMID:30526655. |
mps could represent a link between autoimmunity and endothelial dysfunction by expressing tumor necrosis factor alpha (tnfα), a key cytokine involved in the pathogenesis of ra, altering endothelial apoptosis and autophagy. |
2019-10-09 |
2023-08-13 |
Not clear |
| M Arias-Álvarez, R M García-García, J López-Tello, P G Rebollar, A Gutiérrez-Adán, P L Lorenz. α-Tocopherol modifies the expression of genes related to oxidative stress and apoptosis during in vitro maturation and enhances the developmental competence of rabbit oocytes. Reproduction, fertility, and development. vol 30. issue 12. 2019-09-30. PMID:29966585. |
the present study investigated, for the first time in the rabbit model, the effect of adding α-tocopherol (0, 100, 200 and 400µm) during ivm on putative transcripts involved in antioxidant defence (superoxide dismutase 2, mitochondrial (sod2), glutathione peroxidase 1 (gpx1), catalase (cat)), cell cycle regulation and apoptosis cascade (apoptosis tumour protein 53 (tp53), caspase 3, apoptosis-related cysteine protease (casp3)), cell cycle progression (cellular cycle v-akt murine thymoma viral oncogene homologue 1 (akt1)), cumulus expansion (gap junction protein, alpha 1, 43 kda (gja1) and prostaglandin-endoperoxide synthase 2 (prostaglandin g/h synthase and cyclo-oxygenase) (ptgs2)) and metabolism (glucose-6-phosphate dehydrogenase (g6pd)). |
2019-09-30 |
2023-08-13 |
rabbit |
| Jorge Andrés Castillo, Silvio Urcuqui-Inchim. Mechanisms of monocyte cell death triggered by dengue virus infection. Apoptosis : an international journal on programmed cell death. vol 23. issue 11-12. 2019-09-30. PMID:30267240. |
for example, denv can induce apoptosis in monocytes related with the production of tumor necrosis factor alpha (tnf-α). |
2019-09-30 |
2023-08-13 |
Not clear |
| Ali Khames, Marwa M Khalaf, Amany M Gad, Ola M Abd El-Raouf, Mohamed Ahmed Kandei. Nicorandil combats doxorubicin-induced nephrotoxicity via amendment of TLR4/P38 MAPK/NFκ-B signaling pathway. Chemico-biological interactions. vol 311. 2019-09-16. PMID:31376360. |
nephrotoxicity was assessed by biochemical tests through measuring kidney function biomarkers such as [serum levels of urea, creatinine, albumin and total protein] besides renal kidney injury molecule-1 (kim-1) and cystatin c], oxidative stress parameters such as [renal tissue malondialdehyde (mda), reduced glutathione (gsh), sod, catalase and nrf-2], mediators of inflammation such as [toll like receptor 4 (tlr-4), nuclear factor kappa-light-chain-enhancer of activated b cells (nf-kb), p38 mapk, interleukin 1 beta (il-1 β), and tumor necrosis factor alpha (tnf-α)] and markers of apoptosis [bax and bcl-2 in renal tissue]. |
2019-09-16 |
2023-08-13 |
rat |
| Mohammed A El-Magd, Yasser Mohamed, Eman S El-Shetry, Shafika A Elsayed, Maha Abo Gazia, Ghada A Abdel-Aleem, Noha M Shafik, Walied S Abdo, Nabila I El-Desouki, Mohamed A Basyon. Melatonin maximizes the therapeutic potential of non-preconditioned MSCs in a DEN-induced rat model of HCC. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 114. 2019-08-29. PMID:30925457. |
the obtained data revealed that administration of mel before mscs treatment without preconditioning yielded a better ameliorative effect against den-induced hepatocellular carcinoma (hcc) as evidenced by: 1) reduced serum levels of alpha fetoprotein and gamma-glutamyl transferase; 2) decreased number and area of glutathione s-transferase placental positive foci; 3) induced apoptosis (as indicated by increased cleaved caspase-3 activity, upregulated expression of proapoptotic genes bax and caspase 3 and downregulated expression of anti-apoptotic genes bcl2, survivin); 4) decreased malondialdehyde level and increased activities of superoxide dismutase, catalase, and glutathione peroxidase enzymes; and 5) reduced inflammation, angiogenesis and metastasis as indicated by downregulated expression of interleukin 1 beta, nuclear factor kappa b, vascular endothelial growth factor, and matrix metallopeptidase 9 genes and upregulated expression of metalloproteinase inhibitor 1 gene. |
2019-08-29 |
2023-08-13 |
rat |
| Chang-Youh Tsai, Ko-Jen Li, Song-Chou Hsieh, Hsien-Tzung Liao, Chia-Li Y. What's wrong with neutrophils in lupus? Clinical and experimental rheumatology. vol 37. issue 4. 2019-07-29. PMID:30557133. |
these include excessive interferon alpha (ifn-α) expression, aberrant cytokine/chemokine/growth factor production, skewing of t cell immune responses toward th2 and th17 pathways, polyclonal b cell activation, increased apoptosis and net formation, defective clearance of cell debris and net-related molecules, and abnormal ectosome/exosome release in the plasma. |
2019-07-29 |
2023-08-13 |
Not clear |
| Carlos F de la Cruz-Herrera, Maite Baz-Martínez, Ahmed El Motiam, Santiago Vidal, Manuel Collado, Anxo Vidal, Manuel S Rodríguez, Mariano Esteban, Carmen Riva. Phosphorylable tyrosine residue 162 in the double-stranded RNA-dependent kinase PKR modulates its interaction with SUMO. Scientific reports. vol 7. issue 1. 2019-07-24. PMID:29070839. |
activated dsrna-dependent serine/threonine kinase pkr phosphorylates the alpha subunit of eukaryotic initiation factor 2 (eif2α), resulting in a shut-off of general translation, induction of apoptosis, and inhibition of virus replication. |
2019-07-24 |
2023-08-13 |
Not clear |
| Alexander V Sirotkin, Andrej Benčo, Milos Mlynček, Abdel H Harrath, Saleh Alwasel, Jan Kotwic. The involvement of the phosphorylatable and nonphosphorylatable transcription factor CREB-1 in the control of human ovarian cell functions. Comptes rendus biologies. vol 342. issue 3-4. 2019-07-22. PMID:31028003. |
the expression of total and phosphorylated creb-1, markers of proliferation (pcna) and apoptosis (bax), as well as the release of progesterone, oxytocin, prostaglandin f2 alpha (pgf2), prostaglandin e2 (pge2), and insulin-like growth factor i (igf-i) were compared by immunocytochemistry, enzyme immunoassay (eia), and immunoradiometric assay (irma). |
2019-07-22 |
2023-08-13 |
human |
| Zhongzhi Jia, Weishuai Lian, Haifeng Shi, Chuanwu Cao, Shilong Han, Kai Wang, Maoquan Li, Xiaoping Zhan. Ischemic Postconditioning Protects Against Intestinal Ischemia/Reperfusion Injury via the HIF-1α/miR-21 Axis. Scientific reports. vol 7. issue 1. 2019-07-08. PMID:29170412. |
ipostc decreased i/r injury and suppressed apoptosis in the intestinal tissues concomitant with the induction of hypoxia inducible factor 1 alpha (hif-1α) and the upregulation of mir-21. |
2019-07-08 |
2023-08-13 |
rat |
| Na Zhao, Lan Mi, Xunjun Zhang, Minyao Xu, Haiyi Yu, Zhongwei Liu, Xiaojun Liu, Gongchang Guan, Wei Gao, Junkui Wan. Enhanced MiR-711 transcription by PPARγ induces endoplasmic reticulum stress-mediated apoptosis targeting calnexin in rat cardiomyocytes after myocardial infarction. Journal of molecular and cellular cardiology. vol 118. 2019-06-25. PMID:29522763. |
additionally, the transfection of a mir-711 mimic into cardiomyocytes induced the endoplasmic reticulum (er) stress-induced apoptosis response by upregulating glucose-regulated protein 78 (grp78), activating transcription factor (atf6), spliced x-box binding protein 1 (xbp1), apoptotic signal-regulating kinase 1 (ask1), ccaat-enhancer binding protein homologous protein (chop), caspase-12, and endoplasmic reticulum oxidoreductase 1 alpha (ero1a). |
2019-06-25 |
2023-08-13 |
rat |
| Paolo Armando Gagliardi, Luca Prim. Irreversible Activation of Rho-activated Kinases Resulted from Evolution of Proteolytic Sites within Disordered Regions in Coiled-coil Domain. Molecular biology and evolution. vol 36. issue 2. 2019-06-20. PMID:30517755. |
activation of rho-associated protein kinase 1 (rock1) and myotonic dystrophy kinase-related cdc42-binding kinase alpha (mrckα) by caspases during apoptosis in vertebrates represents a prototypical example of co-option of kinases by proteases. |
2019-06-20 |
2023-08-13 |
Not clear |
| Haci Ahmet Deveci, Yener Akyuva, Gökhan Nur, Mustafa Nazıroğl. Alpha lipoic acid attenuates hypoxia-induced apoptosis, inflammation and mitochondrial oxidative stress via inhibition of TRPA1 channel in human glioblastoma cell line. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 111. 2019-06-13. PMID:30590317. |
alpha lipoic acid attenuates hypoxia-induced apoptosis, inflammation and mitochondrial oxidative stress via inhibition of trpa1 channel in human glioblastoma cell line. |
2019-06-13 |
2023-08-13 |
human |
| Shu-Ting Liu, Shu-Min Zhong, Xue-Yan Li, Feng Gao, Fang Li, Meng-Lu Zhang, Ke Zhu, Xing-Huai Sun, Xin Wang, Yanying Miao, Xiong-Li Yang, Zhongfeng Wan. EphrinB/EphB forward signaling in Müller cells causes apoptosis of retinal ganglion cells by increasing tumor necrosis factor alpha production in rat experimental glaucomatous model. Acta neuropathologica communications. vol 6. issue 1. 2019-06-12. PMID:30355282. |
ephrinb/ephb forward signaling in müller cells causes apoptosis of retinal ganglion cells by increasing tumor necrosis factor alpha production in rat experimental glaucomatous model. |
2019-06-12 |
2023-08-13 |
rat |
| Hong Li, Xia Zhang, Long Gao, Jie Min, Yali Zhang, Ren Zhang, Yucheng Yan. TNF-alpha is upregulated in subacute thyroiditis and stimulates expression of miR-155-5p in thyroid follicle cells. Discovery medicine. vol 26. issue 142. 2019-06-04. PMID:30399324. |
tumor necrosis factor alpha (tnf-α) regulates the expression of proinflammatory cytokines and apoptosis in thyroids. |
2019-06-04 |
2023-08-13 |
rat |
| Sahika Cingir Koker, Ermira Jahja, Huma Shehwana, Ayse Gokce Keskus, Ozlen Kon. Cholinergic Receptor Nicotinic Alpha 5 (CHRNA5) RNAi is associated with cell cycle inhibition, apoptosis, DNA damage response and drug sensitivity in breast cancer. PloS one. vol 13. issue 12. 2019-05-10. PMID:30543688. |
cholinergic receptor nicotinic alpha 5 (chrna5) rnai is associated with cell cycle inhibition, apoptosis, dna damage response and drug sensitivity in breast cancer. |
2019-05-10 |
2023-08-13 |
Not clear |
| Xiuge Gao, Lin Peng, Xiangchun Ruan, Xin Chen, Hui Ji, Junxiao Ma, Han Ni, Shanxiang Jiang, Dawei Gu. Transcriptome profile analysis reveals cardiotoxicity of maduramicin in primary chicken myocardial cells. Archives of toxicology. vol 92. issue 3. 2019-05-10. PMID:29128925. |
pro-inflammatory cytokines including tumor necrosis factor alpha (tnf-α) and interleukin-8 (il-8), apoptosis ratios, cleaved caspase-3, intracellular calcium level and ca |
2019-05-10 |
2023-08-13 |
human |
| Marie Ménard, Clélia Costechareyre, Gabriel Ichim, Jonathan Blachier, David Neves, Loraine Jarrosson-Wuilleme, Reinhard Depping, Jan Koster, Pierre Saintigny, Patrick Mehlen, Servane Tauszig-Delamasur. Hey1- and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth. PLoS biology. vol 16. issue 5. 2019-04-18. PMID:29750782. |
by investigating interacting partners that might facilitate trkc-induced cell death, we have identified the basic helix-loop-helix (bhlh) transcription factor hey1 and importin-α3 (karyopherin alpha 4 [kpna4]) as direct interactors of trkc intracellular domain, and we show that hey1 is required for trkc-induced apoptosis. |
2019-04-18 |
2023-08-13 |
mouse |
| Neslihan Çoban, Çağrı Güleç, Bilge Özsait Selçuk, Nihan Erginel-Ünaltun. Role of simvastatin and RORα activity in the macrophage apoptotic pathway. Anatolian journal of cardiology. vol 17. issue 5. 2019-04-18. PMID:28613211. |
this study was conducted to explore the effects of simvastatin and retinoic acid receptor-related orphan receptor alpha (rorα) ligands on apoptosis in human acute monocytic leukemia (thp-1) macrophage cells. |
2019-04-18 |
2023-08-13 |
human |
| Gabriel H Campolina-Silva, Rex A Hess, Cleida A Oliveir. Seasonal variation of cell proliferation and apoptosis in the efferent ductules and epididymis of the Neotropical bat Artibeus lituratus (Chiroptera, Phyllostomidae). General and comparative endocrinology. vol 273. 2019-04-08. PMID:29427632. |
the increased proliferative activity at this phase was positively correlated with the expression of estrogen receptor alpha (erα), whereas the variation in apoptosis appears to be unrelated to the local expression of androgen and estrogen receptors. |
2019-04-08 |
2023-08-13 |
Not clear |