| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao-Ping Zhang, Stephen F Vatner, You-Tang Shen, Franco Rossi, Yimin Tian, Athanasios Peppas, Ranillo R G Resuello, Filipinas F Natividad, Dorothy E Vatne. Increased apoptosis and myocyte enlargement with decreased cardiac mass; distinctive features of the aging male, but not female, monkey heart. Journal of molecular and cellular cardiology. vol 43. issue 4. 2007-12-21. PMID:17720187. |
the old male hearts demonstrated increased apoptosis, which more than offset the myocyte hypertrophy. |
2007-12-21 |
2023-08-12 |
human |
| Peiyong Zhai, Shumin Gao, Eric Holle, Xianzhong Yu, Atsuko Yatani, Thomas Wagner, Junichi Sadoshim. Glycogen synthase kinase-3alpha reduces cardiac growth and pressure overload-induced cardiac hypertrophy by inhibition of extracellular signal-regulated kinases. The Journal of biological chemistry. vol 282. issue 45. 2007-12-12. PMID:17855351. |
in conclusion, up-regulation of gsk-3alpha inhibits cardiac growth and pressure overload-induced cardiac hypertrophy but increases fibrosis and apoptosis in the heart. |
2007-12-12 |
2023-08-12 |
mouse |
| Andrei S Chagin, Elham Karimian, Farasat Zaman, Masaharu Takigawa, Dionisios Chrysis, Lars Sävendah. Tamoxifen induces permanent growth arrest through selective induction of apoptosis in growth plate chondrocytes in cultured rat metatarsal bones. Bone. vol 40. issue 5. 2007-12-06. PMID:17293177. |
detailed analysis of sectioned growth plate cartilage revealed increased apoptosis of chondrocytes within the resting and hypertrophic zones. |
2007-12-06 |
2023-08-12 |
human |
| J Mialet-Perez, P Bianchi, O Kunduzova, A Parin. New insights on receptor-dependent and monoamine oxidase-dependent effects of serotonin in the heart. Journal of neural transmission (Vienna, Austria : 1996). vol 114. issue 6. 2007-11-28. PMID:17473906. |
this original mechanism of action of 5-ht is relevant in the heart since it is responsible for both cardiomyocyte hypertrophy and apoptosis. |
2007-11-28 |
2023-08-12 |
Not clear |
| Yao Su. Oxidative stress and cardiac repair/remodeling following infarction. The American journal of the medical sciences. vol 334. issue 3. 2007-11-13. PMID:17873534. |
accumulating evidence has demonstrated that oxidative stress participates in several aspects of cardiac repair/remodeling after infarction that include cardiomyocyte apoptosis, inflammatory/fibrogenic responses, and hypertrophy. |
2007-11-13 |
2023-08-12 |
Not clear |
| Nikiforos Ballian, Min Hu, Shi-He Liu, F Charles Brunicard. Proliferation, hyperplasia, neogenesis, and neoplasia in the islets of Langerhans. Pancreas. vol 35. issue 3. 2007-11-07. PMID:17895838. |
islet cell proliferation, hypertrophy, neogenesis, and apoptosis are the main determinants of endocrine cell mass in the pancreas, and their understanding has been improved by new clues of their genetic and molecular basis. |
2007-11-07 |
2023-08-12 |
Not clear |
| D Duguay, D deBloi. Differential regulation of Akt, caspases and MAP kinases underlies smooth muscle cell apoptosis during aortic remodelling in SHR treated with amlodipine. British journal of pharmacology. vol 151. issue 8. 2007-10-31. PMID:17592516. |
the regression of aortic hypertrophy is initiated by a transient wave of smooth muscle cell (smc) apoptosis in spontaneously hypertensive rats (shr) treated with antihypertensive drugs, although the molecular pathways remain unclear. |
2007-10-31 |
2023-08-12 |
rat |
| Ambrus Toth, Philip Nickson, Adel Mandl, Mark L Bannister, Kalman Toth, Peter Erhard. Endoplasmic reticulum stress as a novel therapeutic target in heart diseases. Cardiovascular & hematological disorders drug targets. vol 7. issue 3. 2007-10-29. PMID:17896961. |
initial events leading to upr and apoptosis in the heart include protein oxidation and disturbed calcium handling upon ischemia/reperfusion, and forced protein synthesis during cardiac hypertrophy. |
2007-10-29 |
2023-08-12 |
Not clear |
| Mario Gaudino, Amedeo Anselmi, Antonio Abbate, Leonarda Galiuto, Nicola Luciani, Franco Glieca, Gianfederico Possat. Myocardial apoptosis predicts postoperative course after aortic valve replacement in patients with severe left ventricular hypertrophy. The Journal of heart valve disease. vol 16. issue 4. 2007-10-25. PMID:17702357. |
myocardial apoptosis predicts postoperative course after aortic valve replacement in patients with severe left ventricular hypertrophy. |
2007-10-25 |
2023-08-12 |
Not clear |
| A K Sharma, S Dhingra, N Khaper, P K Singa. Activation of apoptotic processes during transition from hypertrophy to heart failure in guinea pigs. American journal of physiology. Heart and circulatory physiology. vol 293. issue 3. 2007-10-19. PMID:17616743. |
it is suggested that an increase in oxidative stress initiates mitochondrial death pathway during the hypertrophic stage, leading to apoptosis and heart failure at a later stage. |
2007-10-19 |
2023-08-12 |
Not clear |
| J J Li, S J Kwak, D S Jung, J-J Kim, T-H Yoo, D-R Ryu, S H Han, H Y Choi, J E Lee, S J Moon, D K Kim, D S Han, S-W Kan. Podocyte biology in diabetic nephropathy. Kidney international. Supplement. issue 106. 2007-10-18. PMID:17653209. |
as a result, many investigations have demonstrated that the diabetic milieu per se, hemodynamic changes, and local growth factors such as transforming growth factor-beta and angiotensin ii, which are considered mediators in the pathogenesis of diabetic nephropathy, induce directly and/or indirectly hypertrophy, apoptosis, and structural changes, and increase type iv collagen synthesis in podocytes. |
2007-10-18 |
2023-08-12 |
Not clear |
| Nicole H Purcell, Benjamin J Wilkins, Allen York, Marc K Saba-El-Leil, Sylvain Meloche, Jeffrey Robbins, Jeffery D Molkenti. Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 35. 2007-10-17. PMID:17709754. |
genetic inhibition of cardiac erk1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo. |
2007-10-17 |
2023-08-12 |
mouse |
| Francis J Miller, Mohammed Filali, Gina J Huss, Bojana Stanic, Ali Chamseddine, Thomas J Barna, Fred S Lam. Cytokine activation of nuclear factor kappa B in vascular smooth muscle cells requires signaling endosomes containing Nox1 and ClC-3. Circulation research. vol 101. issue 7. 2007-10-15. PMID:17673675. |
reactive oxygen species (ros) are mediators of intracellular signals for a myriad of normal and pathologic cellular events, including differentiation, hypertrophy, proliferation, and apoptosis. |
2007-10-15 |
2023-08-12 |
Not clear |
| Lan Kang, Chang-Jiang Ge, Shen-Jiang H. Beneficial effect of atorvastatin on left ventricular remodeling in spontaneously hypertensive rats. Pharmacology. vol 80. issue 2-3. 2007-10-04. PMID:17534121. |
by using these rats, we observed the effects of atorvastatin on lv hypertrophy and fibrosis, and investigated atorvastatin-induced cell apoptosis and p27 protein expression. |
2007-10-04 |
2023-08-12 |
rat |
| Laura Zelarayan, Christina Gehrke, Martin W Bergman. Role of beta-catenin in adult cardiac remodeling. Cell cycle (Georgetown, Tex.). vol 6. issue 17. 2007-10-04. PMID:17786052. |
the adult heart has a uniform cellular response to adapt to injury after infarct or increased wall stress in chronic hypertension: hypertrophy of adult cardiomyocytes increases muscle fiber mass while at the same time apoptosis of cardiomyocytes may lead to further loss of contractile mass. |
2007-10-04 |
2023-08-12 |
Not clear |
| Laura Zelarayan, Christina Gehrke, Martin W Bergman. Role of beta-catenin in adult cardiac remodeling. Cell cycle (Georgetown, Tex.). vol 6. issue 17. 2007-10-04. PMID:17786052. |
here we discuss these data in the context of beta-catenin's role in adult cardiomyocyte hypertrophy, apoptosis and possibly regeneration. |
2007-10-04 |
2023-08-12 |
Not clear |
| Y A Ahmed, L Tatarczuch, C N Pagel, H M S Davies, M Mirams, E J Macki. Physiological death of hypertrophic chondrocytes. Osteoarthritis and cartilage. vol 15. issue 5. 2007-09-27. PMID:17174118. |
these cells undergo hypertrophy and die by a mechanism that is morphologically distinct from apoptosis, but has not been characterized. |
2007-09-27 |
2023-08-12 |
Not clear |
| R Claus, D Günthner, H Letzgus. Effects of feeding fat-coated butyrate on mucosal morphology and function in the small intestine of the pig. Journal of animal physiology and animal nutrition. vol 91. issue 7-8. 2007-09-25. PMID:17615002. |
as shown earlier, pig rations with high starch and purine content initiate mucosal hypertrophy by stimulating mitotic activity and dna formation in the small intestine, whereas in the colon butyrate inhibits apoptosis and thus increases crypt depth. |
2007-09-25 |
2023-08-12 |
Not clear |
| Dinender K Singla, Gary E Lyons, Timothy J Kam. Transplanted embryonic stem cells following mouse myocardial infarction inhibit apoptosis and cardiac remodeling. American journal of physiology. Heart and circulatory physiology. vol 293. issue 2. 2007-09-18. PMID:17416601. |
in this study, we examined the effect of mouse es cells transplanted post-mi on cardiac apoptosis, fibrosis, and hypertrophy. |
2007-09-18 |
2023-08-12 |
mouse |
| Dinender K Singla, Gary E Lyons, Timothy J Kam. Transplanted embryonic stem cells following mouse myocardial infarction inhibit apoptosis and cardiac remodeling. American journal of physiology. Heart and circulatory physiology. vol 293. issue 2. 2007-09-18. PMID:17416601. |
terminal deoxynucleotidyl nick end labeling (tunel), immunofluorescence, and histology were used to examine the effect of transplanted es cells on apoptosis, fibrosis, and hypertrophy. |
2007-09-18 |
2023-08-12 |
mouse |