| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shu Kasama, Mayumi Furuya, Takuji Toyama, Shuichi Ichikawa, Masahiko Kurabayash. Effect of atrial natriuretic peptide on left ventricular remodelling in patients with acute myocardial infarction. European heart journal. vol 29. issue 12. 2008-11-12. PMID:18490430. |
anp inhibits apoptosis and hypertrophy of cardiac myocytes, and inhibits proliferation and fibrosis of cardiac fibroblasts. |
2008-11-12 |
2023-08-12 |
Not clear |
| Yasushi Oshima, Toru Akiyama, Atsuhiko Hikita, Mitsuyasu Iwasawa, Yuichi Nagase, Masaki Nakamura, Hidetoshi Wakeyama, Naohiro Kawamura, Toshiyuki Ikeda, Ung-il Chung, Lothar Hennighausen, Hiroshi Kawaguchi, Kozo Nakamura, Sakae Tanak. Pivotal role of Bcl-2 family proteins in the regulation of chondrocyte apoptosis. The Journal of biological chemistry. vol 283. issue 39. 2008-11-10. PMID:18632667. |
during endochondral ossification, chondrocytes undergo hypertrophic differentiation and die by apoptosis. |
2008-11-10 |
2023-08-12 |
mouse |
| Yasushi Oshima, Toru Akiyama, Atsuhiko Hikita, Mitsuyasu Iwasawa, Yuichi Nagase, Masaki Nakamura, Hidetoshi Wakeyama, Naohiro Kawamura, Toshiyuki Ikeda, Ung-il Chung, Lothar Hennighausen, Hiroshi Kawaguchi, Kozo Nakamura, Sakae Tanak. Pivotal role of Bcl-2 family proteins in the regulation of chondrocyte apoptosis. The Journal of biological chemistry. vol 283. issue 39. 2008-11-10. PMID:18632667. |
finally, we generated chondrocyte-specific bcl-x knock-out mice using the cre-loxp recombination system, and we provided evidence that the hypertrophic chondrocyte layer was shortened in those mice because of an increased apoptosis of prehypertrophic and hypertrophic chondrocytes, with the mice afflicted with dwarfism as a result. |
2008-11-10 |
2023-08-12 |
mouse |
| Takashi Doi, Tsuyoshi Sakoda, Takafumi Akagami, Toshio Naka, Yoshitomo Mori, Takeshi Tsujino, Tohru Masuyama, Mitsumasa Ohyanag. Aldosterone induces interleukin-18 through endothelin-1, angiotensin II, Rho/Rho-kinase, and PPARs in cardiomyocytes. American journal of physiology. Heart and circulatory physiology. vol 295. issue 3. 2008-10-16. PMID:18660453. |
il-18 induces myocardial hypertrophy, loss of contractility of cardiomyocytes, and apoptosis leading myocardial dysfunction. |
2008-10-16 |
2023-08-12 |
rat |
| Hsi-Chin Wu, Yu-Lan Yeh, Wei-Wen Kuo, Shu-Kuei Huang, Wu-Hsien Kuo, Dennis Jine-Yuan Hsieh, Ching-Lin Wu, Chang-Hai Tsai, Shin-Da Lee, Chih-Yang Huan. P38 mitogen-activated protein kinase pathways are involved in the hypertrophy and apoptosis of cardiomyocytes induced by Porphyromonas gingivalis conditioned medium. Cell biochemistry and function. vol 26. issue 2. 2008-10-10. PMID:17894423. |
p38 mitogen-activated protein kinase pathways are involved in the hypertrophy and apoptosis of cardiomyocytes induced by porphyromonas gingivalis conditioned medium. |
2008-10-10 |
2023-08-12 |
Not clear |
| Hsi-Chin Wu, Yu-Lan Yeh, Wei-Wen Kuo, Shu-Kuei Huang, Wu-Hsien Kuo, Dennis Jine-Yuan Hsieh, Ching-Lin Wu, Chang-Hai Tsai, Shin-Da Lee, Chih-Yang Huan. P38 mitogen-activated protein kinase pathways are involved in the hypertrophy and apoptosis of cardiomyocytes induced by Porphyromonas gingivalis conditioned medium. Cell biochemistry and function. vol 26. issue 2. 2008-10-10. PMID:17894423. |
the surrounding medium of periodontal pathogen porphyromonas gingivalis (p. gingivalis) increased cardiomyocyte hypertrophy and apoptosis whereas actinobaeillus actinomycetemcomitans and prevotella intermedia had no effects. |
2008-10-10 |
2023-08-12 |
Not clear |
| Hsi-Chin Wu, Yu-Lan Yeh, Wei-Wen Kuo, Shu-Kuei Huang, Wu-Hsien Kuo, Dennis Jine-Yuan Hsieh, Ching-Lin Wu, Chang-Hai Tsai, Shin-Da Lee, Chih-Yang Huan. P38 mitogen-activated protein kinase pathways are involved in the hypertrophy and apoptosis of cardiomyocytes induced by Porphyromonas gingivalis conditioned medium. Cell biochemistry and function. vol 26. issue 2. 2008-10-10. PMID:17894423. |
the purpose of this study is to clarify the role of p38 pathway in p. gingivalis conditioned medium-induced h9c2 myocardial cell hypertrophy and apoptosis. |
2008-10-10 |
2023-08-12 |
Not clear |
| John A Muraski, Kimberlee M Fischer, Weitao Wu, Christopher T Cottage, Pearl Quijada, Matt Mason, Shabana Din, Natalie Gude, Roberto Alvarez, Marcello Rota, Jan Kajstura, Zeping Wang, Erik Schaefer, Xiongen Chen, Scott MacDonnel, Nancy Magnuson, Stephen R Houser, Piero Anversa, Mark A Sussma. Pim-1 kinase antagonizes aspects of myocardial hypertrophy and compensation to pathological pressure overload. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 37. 2008-10-09. PMID:18784362. |
transgenic overexpression of pim-1 protects mice from pressure-overload-induced hypertrophy relative to wild-type controls as evidenced by improved hemodynamic function, decreased apoptosis, increases in antihypertrophic proteins, smaller myocyte size, and inhibition of hypertrophic signaling after challenge. |
2008-10-09 |
2023-08-12 |
mouse |
| Elham Karimian, Andrei S Chagin, Jennifer Gjerde, Terhi Heino, Ernst A Lien, Claes Ohlsson, Lars Sävendah. Tamoxifen impairs both longitudinal and cortical bone growth in young male rats. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 23. issue 8. 2008-10-06. PMID:18348701. |
analysis of the tibial growth plate of treated rats showed elevated chondrocyte proliferation (brdu) and apoptosis (tunel), as well as decreases in the number of hypertrophic chondrocytes and in the size of terminal hypertrophic chondrocytes. |
2008-10-06 |
2023-08-12 |
rat |
| Meijing Wang, Troy A Markel, Daniel R Meldru. Interleukin 18 in the heart. Shock (Augusta, Ga.). vol 30. issue 1. 2008-09-15. PMID:18562922. |
the possible cellular and molecular mechanisms concerning il-18-induced myocardial injury include induction of inflammation, increased apoptosis, a cardiac hypertrophy effect, modulation of mitogen activated protein kinase activation, and changes in intracellular calcium. |
2008-09-15 |
2023-08-12 |
Not clear |
| Bo Cao, Meng-Chen Jiang, Zhi-Yong Lei, Shu-Fang Bai, Hong Che. Effects of PLAB on apoptosis and Smad signal pathway of hypertrophic scar fibroblasts. Journal of Asian natural products research. vol 10. issue 1-2. 2008-09-09. PMID:18253883. |
effects of plab on apoptosis and smad signal pathway of hypertrophic scar fibroblasts. |
2008-09-09 |
2023-08-12 |
Not clear |
| Bo Cao, Meng-Chen Jiang, Zhi-Yong Lei, Shu-Fang Bai, Hong Che. Effects of PLAB on apoptosis and Smad signal pathway of hypertrophic scar fibroblasts. Journal of Asian natural products research. vol 10. issue 1-2. 2008-09-09. PMID:18253883. |
our results showed that plab induced apoptosis in hypertrophic scar fibroblasts and inhibited cell proliferation of hypertrophic scar fibroblast. |
2008-09-09 |
2023-08-12 |
Not clear |
| Bo Cao, Meng-Chen Jiang, Zhi-Yong Lei, Shu-Fang Bai, Hong Che. Effects of PLAB on apoptosis and Smad signal pathway of hypertrophic scar fibroblasts. Journal of Asian natural products research. vol 10. issue 1-2. 2008-09-09. PMID:18253883. |
inducing apoptosis by plab in hypertrophic scar fibroblast was assessed by various morphological and biochemical characteristics, including cell shrinkage, chromatin condensation, membrane blebbing, formation of apoptotic bodies, and dna ladder formation. |
2008-09-09 |
2023-08-12 |
Not clear |
| Bo Cao, Meng-Chen Jiang, Zhi-Yong Lei, Shu-Fang Bai, Hong Che. Effects of PLAB on apoptosis and Smad signal pathway of hypertrophic scar fibroblasts. Journal of Asian natural products research. vol 10. issue 1-2. 2008-09-09. PMID:18253883. |
these results suggest that plab inhibits hypertrophic scar fibroblast growth through apoptosis and smad signal pathway. |
2008-09-09 |
2023-08-12 |
Not clear |
| Xuehui Yang, Lauren K Harkins, Olga Zubanova, Anne Harrington, Dmitry Kovalenko, Robert J Nadeau, Pei-Yu Chen, Jessica L Toher, Volkhard Lindner, Lucy Liaw, Robert Friese. Overexpression of Spry1 in chondrocytes causes attenuated FGFR ubiquitination and sustained ERK activation resulting in chondrodysplasia. Developmental biology. vol 321. issue 1. 2008-09-08. PMID:18582454. |
the fgf signaling pathway plays essential roles in endochondral ossification by regulating osteoblast proliferation and differentiation, chondrocyte proliferation, hypertrophy, and apoptosis. |
2008-09-08 |
2023-08-12 |
Not clear |
| David R Grubb, Oliver Vasilevski, Huy Huynh, Elizabeth A Woodcoc. The extreme C-terminal region of phospholipase Cbeta1 determines subcellular localization and function; the "b" splice variant mediates alpha1-adrenergic receptor responses in cardiomyocytes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 22. issue 8. 2008-09-03. PMID:18390926. |
in cardiomyocytes, responses initiated by alpha(1)-adrenergic receptor activation involve only plcbeta1b, and the selective targeting of this splice variant to the sarcolemma provides a potential therapeutic target to reduce hypertrophy, apoptosis, and arrhythmias. |
2008-09-03 |
2023-08-12 |
Not clear |
| Mo Chen, Mei Zhu, Hani Awad, Tian-Fang Li, Tzong-Jen Sheu, Brendan F Boyce, Di Chen, Regis J O'Keef. Inhibition of beta-catenin signaling causes defects in postnatal cartilage development. Journal of cell science. vol 121. issue Pt 9. 2008-08-22. PMID:18397998. |
col2a1-icat transgenic mice showed reduced chondrocyte proliferation and differentiation, and an increase in chondrocyte apoptosis, leading to decreased widths of the proliferating and hypertrophic zones, delayed formation of the secondary ossification center, and reduced skeletal growth. |
2008-08-22 |
2023-08-12 |
mouse |
| Brent E Bobick, William M Kuly. Regulation of cartilage formation and maturation by mitogen-activated protein kinase signaling. Birth defects research. Part C, Embryo today : reviews. vol 84. issue 2. 2008-08-06. PMID:18546337. |
endochondral ossification is a highly regulated, multistep cell specification program involving the initial differentiation of prechondrogenic mesenchymal cells into hyaline chondrocytes, terminal differentiation of hyaline chondrocytes into hypertrophic chondrocytes, and finally, apoptosis of hypertrophic chondrocytes followed by bone matrix deposition. |
2008-08-06 |
2023-08-12 |
Not clear |
| Jianjian Shi, Yi-Wei Zhang, Lelia J Summers, Gerald W Dorn, Lei We. Disruption of ROCK1 gene attenuates cardiac dilation and improves contractile function in pathological cardiac hypertrophy. Journal of molecular and cellular cardiology. vol 44. issue 3. 2008-08-04. PMID:18178218. |
we have recently reported that rho-associated coiled-coil containing protein kinase 1 (rock1) homozygous knockout mice exhibited reduced cardiac fibrosis and cardiomyocyte apoptosis, while displaying a preserved compensatory hypertrophic response to pressure overload. |
2008-08-04 |
2023-08-12 |
mouse |
| Timothy E Cullingford, Matthew J Butler, Andrew K Marshall, El Li Tham, Peter H Sugden, Angela Cler. Differential regulation of Krüppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines. Biochimica et biophysica acta. vol 1783. issue 6. 2008-07-31. PMID:18406357. |
the dynamic regulation of expression of multiple klf family members in cardiac myocytes suggests that, as a family, they are actively involved in regulating phenotypic responses (hypertrophy and apoptosis) to extracellular stimuli. |
2008-07-31 |
2023-08-12 |
rat |