Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Tao Yan, Fan Weng, Changfa Gu. miR-124-3p may exert its effects in hypertrophic cardiomyopathy by inhibiting cardiomyocyte apoptosis. International journal of cardiology. 2024-08-20. PMID:39163926. |
mir-124-3p may exert its effects in hypertrophic cardiomyopathy by inhibiting cardiomyocyte apoptosis. |
2024-08-20 |
2024-08-23 |
Not clear |
Neha E H Dinesh, Nissan Baratang, Justine Rosseau, Ronit Mohapatra, Ling Li, Ramshaa Mahalingam, Kerstin Tiedemann, Philippe M Campeau, Dieter P Reinhard. Fibronectin Isoforms Promote Postnatal Skeletal Development. Matrix biology : journal of the International Society for Matrix Biology. 2024-08-19. PMID:39159790. |
analysis of chondrogenesis in fndko mice demonstrated changes in the resting, proliferating and hypertrophic growth plate zones, consistent alterations in chondrogenic markers such as collagen type ii and x, decreased apoptosis of hypertrophic chondrocytes, and downregulation of bone formation markers. |
2024-08-19 |
2024-08-22 |
mouse |
Betul Rabia Erdogan, Ebru Arioglu-Ina. SGLT2 inhibitors: how do they affect the cardiac cells. Molecular and cellular biochemistry. 2024-08-19. PMID:39160356. |
among these, sglt2is inhibit fibrosis, hypertrophy, apoptosis, inflammation, and oxidative stress. |
2024-08-19 |
2024-08-22 |
Not clear |
Xin Liu, Lin-Ting Cheng, Qian-Ru Ye, Hao-Cheng Gao, Jin-Wei Zhu, Kai Zhao, Hua-Min Liu, Yun-Jie Wang, Tahereh Alinejad, Xiu-Hua Zhang, Gao-Zhi Che. Cyy-272, an indazole derivative, effectively mitigates obese cardiomyopathy as a JNK inhibitor. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 178. 2024-08-11. PMID:39128188. |
the high-lipid state caused by obesity can maintain the heart in a prolonged low-grade inflammatory state and cause ventricular remodeling, leading to a series of pathologies, such as hypertrophy, fibrosis, and apoptosis, which eventually develop into obese cardiomyopathy. |
2024-08-11 |
2024-08-14 |
Not clear |
Xin Liu, Lin-Ting Cheng, Qian-Ru Ye, Hao-Cheng Gao, Jin-Wei Zhu, Kai Zhao, Hua-Min Liu, Yun-Jie Wang, Tahereh Alinejad, Xiu-Hua Zhang, Gao-Zhi Che. Cyy-272, an indazole derivative, effectively mitigates obese cardiomyopathy as a JNK inhibitor. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 178. 2024-08-11. PMID:39128188. |
it significantly inhibits inflammation in cardiomyocytes and heart tissues induced by high lipid concentrations, further alleviating the resulting hypertrophy, fibrosis, and apoptosis. |
2024-08-11 |
2024-08-14 |
Not clear |
Silvia Giardinelli, Giovanni Meliota, Donatella Mentino, Gabriele D'Amato, Maria Felicia Faienz. Molecular Basis of Cardiomyopathies in Type 2 Diabetes. International journal of molecular sciences. vol 25. issue 15. 2024-08-10. PMID:39125850. |
interstitial inflammation, oxidative stress, myocardial apoptosis, mitochondria dysfunction, defective cardiac metabolism, cardiac remodeling, hypertrophy and fibrosis with consequent impaired contractility are the most common mechanisms implicated. |
2024-08-10 |
2024-08-13 |
Not clear |
Khwanchit Boonha, Wei-Wen Kuo, Bruce Chi-Kang Tsai, Dennis Jine-Yuan Hsieh, Kuan-Ho Lin, Shang-Yeh Lu, Chia-Hua Kuo, Liang-Yo Yang, Chih-Yang Huan. Enhanced IGF-IIRα Expression Exacerbates Lipopolysaccharide-Induced Cardiac Inflammation, Hypertrophy, and Apoptosis Through Calcineurin Activation. Environmental toxicology. 2024-08-07. PMID:39109785. |
enhanced igf-iirα expression exacerbates lipopolysaccharide-induced cardiac inflammation, hypertrophy, and apoptosis through calcineurin activation. |
2024-08-07 |
2024-08-09 |
Not clear |
Jie Ding, Aminah I Fayyaz, Yuchuan Ding, Dandan Liang, Ming Lu. Role of Specificity Protein 1 (SP1) in Cardiovascular Diseases: Pathological Mechanisms and Therapeutic Potentials. Biomolecules. vol 14. issue 7. 2024-07-27. PMID:39062521. |
sp1 is implicated in the regulation of apoptosis, cell hypertrophy, inflammation, oxidative stress, lipid metabolism, plaque stabilization, endothelial dysfunction, fibrosis, calcification, and other pathological processes. |
2024-07-27 |
2024-07-29 |
Not clear |
Wencan Li, Xiang Liu, Zheng Liu, Qichang Xing, Renzhu Liu, Qinxuan Wu, Yixiang Hu, Jiani Zhan. The signaling pathways of selected traditional Chinese medicine prescriptions and their metabolites in the treatment of diabetic cardiomyopathy: a review. Frontiers in pharmacology. vol 15. 2024-07-18. PMID:39021834. |
growing evidence suggests that myocardial fibrosis, inflammation, oxidative stress, apoptosis, cardiac hypertrophy, and advanced glycation end product deposition were the main pathologic mechanisms of dcm. |
2024-07-18 |
2024-07-20 |
Not clear |
Song Zhang, Mitchell C Lock, Michelle Tie, I Caroline McMillen, Kimberley J Botting, Janna L Morriso. Cardiac programming in the placentally restricted sheep fetus in early gestation. The Journal of physiology. 2024-07-08. PMID:38975864. |
while there was no change in the proportion of cardiomyocytes that were proliferating in the early gestation pr heart, there was an increase in measures of apoptosis, and markers of autophagy and pathological hypertrophy in the pr fetal heart. |
2024-07-08 |
2024-07-11 |
human |
Weixuan Chen, Daniel Rams, Maciej Zając, Raghad Albalawi, Andrew J Atkinson, Abimbola J Aminu, Malgorzata Mazur, Mateusz K Hołda, Jerzy Walocha, Krzysztof Gil, Marcin Kuniewicz, Halina Dobrzynsk. Morphology of human sinoatrial node and its surrounding right atrial muscle in the global obesity pandemic-does fat matter? Frontiers in medicine. vol 11. 2024-07-06. PMID:38966523. |
the impacts of aging and obesity on fibrosis, apoptosis and cellular hypertrophy were investigated in the sn and ra. |
2024-07-06 |
2024-07-08 |
human |
Xi Yao, Xinyue Huang, Jianghua Chen, Weiqiang Lin, Jingyan Tia. Roles of non-coding RNA in diabetic cardiomyopathy. Cardiovascular diabetology. vol 23. issue 1. 2024-07-02. PMID:38951895. |
diabetic cardiomyopathy (dcm) is characterized by cardiomyocyte hypertrophy, myocardial fibrosis, apoptosis, ventricular remodeling, and cardiac dysfunction in individuals with diabetes, ultimately leading to heart failure and mortality. |
2024-07-02 |
2024-07-04 |
human |
Bingyan Hou, Dan Yu, Haotian Bai, Xiaowei D. Research progress of miRNA in heart failure: prediction and treatment. Journal of cardiovascular pharmacology. 2024-06-26. PMID:38922572. |
this review summarizes the multiple roles of mirnas in the prediction and treatment of heart failure (hf), including the molecular mechanisms regulating cell apoptosis, myocardial fibrosis, cardiac hypertrophy and ventricular remodelling, and highlights the importance of mirnas in the prognosis of hf. |
2024-06-26 |
2024-06-29 |
Not clear |
Zhi-Hua Deng, Yao-Xin Chen, Xue-Gao, Jing-Yu Yang, Xia-Ying Wei, Guo-Xing Zhang, Jin-Xian Qia. Mesenchymal stem cell-derived exosomes ameliorate hypoxic pulmonary hypertension by inhibiting the Hsp90aa1/ERK/pERK pathway. Biochemical pharmacology. 2024-06-23. PMID:38909785. |
the results showed that msc-exos could not only reduce the elevation of rvsp, right ventricular hypertrophy and the degree of pulmonary vascular remodeling in hph rats, but also reduce the proliferation, migration and apoptosis resistance of pasmcs. |
2024-06-23 |
2024-06-26 |
rat |
Waruna Thotamune, Sithurandi Ubeysinghe, Kendra K Shrestha, Mahmoud Elhusseiny Mostafa, Michael C Young, Ajith Karunarathn. Optical Control of Cell-Surface and Endomembrane-Exclusive β-Adrenergic Receptor Signaling. The Journal of biological chemistry. 2024-06-20. PMID:38901558. |
emerging evidence indicates pathological molecular signatures in deeper endomembrane βars signaling, likely contributing to conditions such as cardiomyocyte hypertrophy and apoptosis. |
2024-06-20 |
2024-06-23 |
Not clear |
Lingji Li, Ranran Xi, Bing Gao, Yonglei Zeng, Qiang Ma, Tiantian Gong, Jing Wan. Research progress of autophagy in heart failure. American journal of translational research. vol 16. issue 5. 2024-06-17. PMID:38883358. |
in the context of heart failure, autophagy coexists with apoptosis and necrosis, influencing myocardial hypertrophy and ventricular remodeling. |
2024-06-17 |
2024-06-19 |
Not clear |
Han Xu, Ouyang Li, Dayoung Kim, Mengjuan Xue, Zhijun Bao, Fan Yan. Aged microbiota exacerbates cardiac failure by PPARα/PGC1α pathway. Biochimica et biophysica acta. Molecular basis of disease. vol 1870. issue 7. 2024-06-11. PMID:38823462. |
the epicardium of aged fmt recipients shows fat accumulation, accompanied by cardiomyocyte hypertrophy, cardiac fibrosis and increased cellular apoptosis. |
2024-06-11 |
2024-06-14 |
mouse |
Linna Zhao, Yiping Qin, Yangong Liu, Liping An, Weizhe Liu, Chuang Zhang, Qiuhang Song, Cheng Dai, Juanjuan Zhang, Aiying L. The total xanthones extracted from Gentianella acuta alleviates HFpEF by activating the IRE1α/Xbp1s pathway. Journal of cellular and molecular medicine. vol 28. issue 11. 2024-06-07. PMID:38847482. |
the results demonstrated that txg alleviated hfpef by reducing the expressions of genes associated with myocardial hypertrophy, fibrosis and apoptosis. |
2024-06-07 |
2024-06-10 |
mouse |
Linna Zhao, Yiping Qin, Yangong Liu, Liping An, Weizhe Liu, Chuang Zhang, Qiuhang Song, Cheng Dai, Juanjuan Zhang, Aiying L. The total xanthones extracted from Gentianella acuta alleviates HFpEF by activating the IRE1α/Xbp1s pathway. Journal of cellular and molecular medicine. vol 28. issue 11. 2024-06-07. PMID:38847482. |
in conclusion, txg alleviates myocardial hypertrophy, fibrosis and apoptosis through the activation of the ire1α/xbp1s signalling pathway, suggesting its potential beneficial effects on hfpef patients. |
2024-06-07 |
2024-06-10 |
mouse |
Jiang Lai, Chunxiao L. Review on the pharmacological effects and pharmacokinetics of scutellarein. Archiv der Pharmazie. 2024-06-07. PMID:38849327. |
these mechanisms encompass the scavenging of free radicals, inhibition of the activation of inflammatory signaling pathways and expression of inflammatory mediators, inhibition of the activity of crucial viral proteins, suppression of gluconeogenesis, amelioration of insulin resistance, improvement of cerebral ischemia-reperfusion injury, induction of apoptosis in cancer cells, and prevention of myocardial hypertrophy, among others. |
2024-06-07 |
2024-06-10 |
Not clear |