| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fang Ma, Honglin Liu, Tongtong Xia, Zhenghao Zhang, Shengchao Ma, Yinju Hao, Jiangyong Shen, Yideng Jiang, Nan L. HSFAS mediates fibroblast proliferation, migration, trans-differentiation and apoptosis in hypertrophic scars via interacting with ADAMTS8. Acta biochimica et biophysica Sinica. 2023-11-25. PMID:38006215. |
hsfas mediates fibroblast proliferation, migration, trans-differentiation and apoptosis in hypertrophic scars via interacting with adamts8. |
2023-11-25 |
2023-11-28 |
human |
| Maria Ryaboshapkina, Regina Ye, Yumei Ye, Yochai Birnbau. Effects of Dapagliflozin on Myocardial Gene Expression in BTBR Mice with Type 2 Diabetes. Cardiovascular drugs and therapy. 2023-11-02. PMID:37914900. |
we have previously shown that dapagliflozin reduces cardiac hypertrophy, inflammation, fibrosis, and apoptosis and increases ejection fraction in btbr mice with type 2 diabetes. |
2023-11-02 |
2023-11-08 |
mouse |
| Cheng Zeng, Jing Liu, Xialei Zheng, Xinqun Hu, Yuhu H. Prostaglandin and prostaglandin receptors: present and future promising therapeutic targets for pulmonary arterial hypertension. Respiratory research. vol 24. issue 1. 2023-11-02. PMID:37915044. |
the mechanisms involved in this process include inflammation, vascular matrix remodeling, endothelial cell apoptosis and proliferation, vasoconstriction, vascular smooth muscle cell proliferation and hypertrophy. |
2023-11-02 |
2023-11-08 |
Not clear |
| Wei Jiao, Jie Hao, Jin-Ming Liu, Wei-Nian Gao, Jia-Jia Zhao, Yong-Jun L. Mesenchymal stem cells-derived extracellular vesicle-incorporated H19 attenuates cardiac remodeling in rats with heart failure. The Kaohsiung journal of medical sciences. 2023-10-27. PMID:37885317. |
cardiac remodeling is manifested by hypertrophy and apoptosis of cardiomyocytes, resulting in the progression of cardiovascular diseases. |
2023-10-27 |
2023-11-08 |
rat |
| Milton Packe. Qiliqiangxin: a Multifaceted Holistic Treatment for Heart Failure or a Pharmacological Probe for the Identification of Cardioprotective Mechanisms? European journal of heart failure. 2023-10-25. PMID:37877337. |
in contrast, in prolonged measured cardiac stress (as in chronic heart failure), qlqx ameliorated oxidative stress, maladaptive hypertrophy, cardiomyocyte apoptosis, and proinflammatory and profibrotic pathways, while enhancing mitochondrial health and promoting glucose and fatty acid oxidation and atp production. |
2023-10-25 |
2023-11-08 |
Not clear |
| Sheng-Ping Chao, Wen-Lin Cheng, Wenjuan Yi, Huan-Huan Cai, Keqiong Deng, Jian-Lei Cao, Ziyue Zeng, Hairong Wang, Xiaoyan W. N-acetylcysteine alleviates phenylephrine-induced cardiomyocyte dysfunction via engaging PI3K/AKT signaling pathway. American journal of hypertension. 2023-10-21. PMID:37864839. |
increased ros and oxidative stress response lead to cardiomyocyte hypertrophy and apoptosis, which play crucial roles in the pathogenesis of heart failure. |
2023-10-21 |
2023-11-08 |
Not clear |
| Xiandeng Li, Ying Zhang, Xiaodong Xing, Mi Li, Yan Liu, Ajing Xu, Jian Zhan. Podocyte injury of diabetic nephropathy: Novel mechanism discovery and therapeutic prospects. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 168. 2023-10-14. PMID:37837883. |
disruptions in podocyte function, including hypertrophy, shedding, reduced density, and apoptosis, can impair the integrity of the glomerular filtration barrier, resulting in elevated proteinuria, abnormal glomerular filtration rate, and increased creatinine levels. |
2023-10-14 |
2023-11-08 |
Not clear |
| Yang Liu, Xing Lyu, Shengyu Tan, Xiangyu Zhan. Research Progress of Exosomal Non-Coding RNAs in Cardiac Remodeling. International journal of medical sciences. vol 20. issue 11. 2023-10-04. PMID:37790853. |
exosomal non-coding rnas play an important part in pathological cardiac remodelings, such as cardiomyocyte hypertrophy, cardiomyocyte apoptosis, and cardiac fibrosis. |
2023-10-04 |
2023-10-07 |
Not clear |
| Yan Zhang, Yu Huang, Quan-Xin Ma, Song-Tao Xu, Liye Shen, Yan-Yun Xu, Tu Hai-Ye, Min-Li Chen, Yi-Li Ron. Guanxinning tablets improve myocardial hypertrophy by inhibiting the activation of MEK-ERK1/2 signaling pathway. Journal of applied biomedicine. vol 21. issue 3. 2023-09-25. PMID:37747313. |
the results of in vitro experiments showed that gxn was safe for primary cardiomyocytes and could improve cardiomyocyte hypertrophy and reduce the apoptosis of cardiomyocytes in pathological state, which may be related to the inhibition of the over-activation of mek-erk1/2 signaling pathway. |
2023-09-25 |
2023-10-07 |
rat |
| Cory R Elowe, Courtney Babbitt, Alexander R Gerso. White-throated Sparrow ( Physiological genomics. 2023-09-11. PMID:37694280. |
furthermore, based on transcriptional changes, we hypothesize that seasonal hypertrophy balances satellite cell recruitment and apoptosis, while little evidence appeared in the transcriptome to support mstn, igf1, and mtor-mediated pathways for muscle growth. |
2023-09-11 |
2023-10-07 |
Not clear |
| Lingling Yuan, Jinsheng Duan, Hong Zho. Perspectives of circular RNAs in diabetic complications from biological markers to potential therapeutic targets (Review). Molecular medicine reports. vol 28. issue 4. 2023-09-08. PMID:37681455. |
circrna ldl receptor related protein 6, circrna actin related protein 2, circ_0000064, circ‑0101383, circ_0123996, hsa_circ_0003928 and circ_0000285 mediate inflammation, apoptosis and autophagy of podocytes, mesangial cell hypertrophy and proliferation, as well as tubulointerstitial fibrosis, in diabetic nephropathy by regulating the expression of micrornas and proteins. |
2023-09-08 |
2023-10-07 |
human |
| Dennis Jine Yuan Hsieh, Md Nazmul Islam, Wei-Wen Kuo, Marthandam Asokan Shibu, Chin-Hu Lai, Pi-Yu Lin, Shinn-Zong Lin, Michael Yu-Chih Chen, Chih-Yang Huan. A combination of isoliquiritigenin with Artemisia argyi and Ohwia caudata water extracts attenuates oxidative stress, inflammation, and apoptosis by modulating Nrf2/Ho-1 signaling pathways in SD rats with doxorubicin-induced acute cardiotoxicity. Environmental toxicology. 2023-09-04. PMID:37661764. |
the water extract of aa and oc with isl could be a potential herbal drug treatment for cardiac hypertrophy, inflammatory disease, and apoptosis, which can lead to sudden heart failure. |
2023-09-04 |
2023-09-07 |
rat |
| Archana Molangiri, Saikanth Varma, Kota Sri Naga Hridayanka, Myadara Srinivas, Suryam Reddy Kona, Ahamed Ibrahim, Asim K Duttaroy, Sanjay Basa. Gestational exposure to bisphenol S induces microvesicular steatosis in male rat offspring by modulating metaflammation. The Science of the total environment. 2023-09-03. PMID:37660821. |
the adipose hypertrophy was augmented by tissue inflammation, endoplasmic reticulum (er) stress, and apoptosis due to increased expression of pro-inflammatory (il6, il1β, crp, cox2) cytokines, er stress modulator (chop), and apoptotic effector (caspase 3). |
2023-09-03 |
2023-09-07 |
rat |
| Qian Liu, Cheng Xu, Jing Jin, Wenxiang Li, Jingjia Liang, Shijie Zhou, Zhenkun Weng, Yong Zhou, Xudong Liao, Aihua G. Early-life exposure to lead changes cardiac development and compromises long-term cardiac function. The Science of the total environment. 2023-08-31. PMID:37652374. |
the results showed early-life lead exposure predisposed offspring mice to decreased ejection fraction, increased left ventricular volume, accompanied by hypertrophy and dilation, cardiomyocyte sarcomere dysplasia, abnormal mitochondrial structure, mitochondrial dysfunction, and decreased expression of key sarcomeric and mitochondrial genes, rendering them more susceptible to cardiac hypertrophy, vascular wall thickening, cardiac fibrosis, apoptosis, and heart failure induced by ang ii infusion. |
2023-08-31 |
2023-09-07 |
mouse |
| Xinxin Zhang, Ning Wang, Peng Fu, Yanliang An, Fangfang Sun, Chengdong Wang, Xiao Han, Yunlong Zhang, Xiaohong Yu, Ying Li. Dapagliflozin Attenuates HFpEF Remodeling and Dysfunction by Elevating β-Hydroxybutyrate-activated Citrate Synthase. Journal of cardiovascular pharmacology. 2023-08-29. PMID:37643027. |
this study's results showed that administration of dapagliflozin (dapa, sglt2 inhibitor) significantly limited the 2-hit-induced cardiomyocyte hypertrophy, apoptosis, inflammation, oxidative stress, and fibrosis. |
2023-08-29 |
2023-09-07 |
rat |
| Prem Swaroop Yadav, Garyfallia Papaioannou, Margaret M Kobelski, Marie B Dema. Phosphate-induced activation of VEGFR2 leads to caspase-9-mediated apoptosis of hypertrophic chondrocytes. iScience. vol 26. issue 9. 2023-08-28. PMID:37636062. |
phosphate-induced activation of vegfr2 leads to caspase-9-mediated apoptosis of hypertrophic chondrocytes. |
2023-08-28 |
2023-09-07 |
Not clear |
| Prem Swaroop Yadav, Garyfallia Papaioannou, Margaret M Kobelski, Marie B Dema. Phosphate-induced activation of VEGFR2 leads to caspase-9-mediated apoptosis of hypertrophic chondrocytes. iScience. vol 26. issue 9. 2023-08-28. PMID:37636062. |
low circulating phosphate (pi) leads to rickets, characterized by expansion of the hypertrophic chondrocytes (hcs) in the growth plate due to impaired hc apoptosis. |
2023-08-28 |
2023-09-07 |
Not clear |
| Farid Shokri, Mohammad Zarei, Alireza Komaki, Safoura Raoufi, Fatemeh Ramezani-Aliakbar. Effect of diminazene on cardiac hypertrophy through mitophagy in rat models with hyperthyroidism induced by levothyroxine. Naunyn-Schmiedeberg's archives of pharmacology. 2023-08-26. PMID:37632551. |
hyperthyroidism is associated with the alteration in molecular pathways involved in the regulation of mitochondrial mass and apoptosis, which contribute to the development of cardiac hypertrophy. |
2023-08-26 |
2023-09-07 |
rat |
| Farid Shokri, Mohammad Zarei, Alireza Komaki, Safoura Raoufi, Fatemeh Ramezani-Aliakbar. Effect of diminazene on cardiac hypertrophy through mitophagy in rat models with hyperthyroidism induced by levothyroxine. Naunyn-Schmiedeberg's archives of pharmacology. 2023-08-26. PMID:37632551. |
dize is effective in attenuating hyperthyroidism-induced cardiac hypertrophy by modulating the mitophagy-related pathway, suppressing apoptosis and oxidative stress. |
2023-08-26 |
2023-09-07 |
rat |
| Chih-Chia Chang, Kun-Ling Tsai, Hui-Ching Cheng, Wan-Ching Chou, Yu-Ting Huang, Pei-Ling Hsieh, Shin-Da Le. Mangiferin Protects Against Angiotensin-II-Enhanced Hypertrophic Markers and Apoptosis in H9c2 Cardiomyocytes. The American journal of Chinese medicine. 2023-08-24. PMID:37615589. |
mangiferin protects against angiotensin-ii-enhanced hypertrophic markers and apoptosis in h9c2 cardiomyocytes. |
2023-08-24 |
2023-09-07 |
Not clear |