| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Farid Shokri, Mohammad Zarei, Alireza Komaki, Safoura Raoufi, Fatemeh Ramezani-Aliakbar. Effect of diminazene on cardiac hypertrophy through mitophagy in rat models with hyperthyroidism induced by levothyroxine. Naunyn-Schmiedeberg's archives of pharmacology. 2023-08-26. PMID:37632551. |
hyperthyroidism is associated with the alteration in molecular pathways involved in the regulation of mitochondrial mass and apoptosis, which contribute to the development of cardiac hypertrophy. |
2023-08-26 |
2023-09-07 |
rat |
| Farid Shokri, Mohammad Zarei, Alireza Komaki, Safoura Raoufi, Fatemeh Ramezani-Aliakbar. Effect of diminazene on cardiac hypertrophy through mitophagy in rat models with hyperthyroidism induced by levothyroxine. Naunyn-Schmiedeberg's archives of pharmacology. 2023-08-26. PMID:37632551. |
dize is effective in attenuating hyperthyroidism-induced cardiac hypertrophy by modulating the mitophagy-related pathway, suppressing apoptosis and oxidative stress. |
2023-08-26 |
2023-09-07 |
rat |
| Chih-Chia Chang, Kun-Ling Tsai, Hui-Ching Cheng, Wan-Ching Chou, Yu-Ting Huang, Pei-Ling Hsieh, Shin-Da Le. Mangiferin Protects Against Angiotensin-II-Enhanced Hypertrophic Markers and Apoptosis in H9c2 Cardiomyocytes. The American journal of Chinese medicine. 2023-08-24. PMID:37615589. |
mangiferin protects against angiotensin-ii-enhanced hypertrophic markers and apoptosis in h9c2 cardiomyocytes. |
2023-08-24 |
2023-09-07 |
Not clear |
| Chan Yang, Hanyu Liu, Ziyan Xie, Qiangfei Yang, Lian Du, Chunguang Xi. The protective role of shenqi compound in type 2 diabetes: A comprehensive investigation of pancreatic β-cell function and mass. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 166. 2023-08-12. PMID:37572639. |
the results demonstrate multiple beneficial effects of sqc, including significant control of blood glucose levels (p < 0.05), inhibition of insulin resistance (measured by western blot), reduction of hyperinsulinemia (p < 0.05), attenuation of oxidative stress (p < 0.05), suppression of inflammation (p < 0.05), protection against islet hypertrophy and beta cell proliferation (evaluated through pathological staining), and inhibition of β-cell apoptosis and senescence (also assessed through pathological staining). |
2023-08-12 |
2023-08-16 |
rat |
| Shan Ren, Yuge Wang, Yanyan Zhang, Peimei Yan, Dan Xiao, Yu Zhao, Weiwei Jia, Lin Ding, Haiying Dong, Can Wei, Song Lin, Yan Li. Paeoniflorin alleviates AngII-induced cardiac hypertrophy in H9c2 cells by regulating oxidative stress and Nrf2 signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-08-05. PMID:37542855. |
furthermore, in angii-induced cardiomyocyte hypertrophy, paeoniflorin restores h9c2 apoptosis by restoring bax, bcl-2 cyt-c, caspase 3, and caspase 9 levels. |
2023-08-05 |
2023-08-14 |
cat |
| Chunkun Yang, Jiawen Cheng, Qinwei Zhu, Qingquan Pan, Kui Ji, Jun L. Review of the Protective Mechanism of Paeonol on Cardiovascular Disease. Drug design, development and therapy. vol 17. 2023-08-01. PMID:37525853. |
in addition, pae improves ventricular remodeling by inhibiting myocardial apoptosis, hypertrophy and fibrosis. |
2023-08-01 |
2023-08-14 |
Not clear |
| Francesca Veronesi, Viviana Costa, Daniele Bellavia, Valentina Basoli, Gianluca Giavares. Epigenetic Modifications of MiRNAs in Osteoarthritis: A Systematic Review on Their Methylation Levels and Effects on Chondrocytes, Extracellular Matrix and Joint Inflammation. Cells. vol 12. issue 14. 2023-07-29. PMID:37508486. |
osteoarthritis (oa) is a joint disorder characterized by progressive degeneration of cartilage extracellular matrix (ecm), chondrocyte hypertrophy and apoptosis and inflammation. |
2023-07-29 |
2023-08-14 |
Not clear |
| Chantelle Thimm, Lars Erichsen, Wasco Wruck, James Adjay. Unveiling Angiotensin II and Losartan-Induced Gene Regulatory Networks Using Human Urine-Derived Podocytes. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37445727. |
elevated ang ii levels lead to a pro-fibrotic, inflammatory, and hypertrophic milieu that induces apoptosis in podocytes. |
2023-07-14 |
2023-08-14 |
human |
| YiFu Tian, CaiXia Zhou, XiaoYang Bu, Qian Lv, Qin Huan. Puerarin Attenuates High-Glucose and High-Lipid-Induced Inflammatory Injury in H9c2 Cardiomyocytes via CAV3 Protein Upregulation. Journal of inflammation research. vol 16. 2023-07-05. PMID:37404717. |
puerarin has been shown to reduce the inflammation, apoptosis and hypertrophy of cardiomyocytes induced by hghl, in which this study aims to investigate the underlying mechanisms. |
2023-07-05 |
2023-08-14 |
Not clear |
| . Erratum to miR-211-5p inhibits the proliferation, migration, invasion, and induces apoptosis of human hypertrophic scar fibroblasts by regulating TGFβR2 expression. Annals of translational medicine. vol 11. issue 9. 2023-07-05. PMID:37405004. |
erratum to mir-211-5p inhibits the proliferation, migration, invasion, and induces apoptosis of human hypertrophic scar fibroblasts by regulating tgfβr2 expression. |
2023-07-05 |
2023-08-14 |
human |
| Kaiyu Zhang, Yafei Li, Ying Huang, Kangyun Su. PiRNA in Cardiovascular Disease: Focus on Cardiac Remodeling and Cardiac Protection. Journal of cardiovascular translational research. 2023-07-05. PMID:37407865. |
over expression of pirna could promote cardiac apoptosis and cardiac hypertrophy, thus targeted therapy which inhibits expression of associated pirna may reduce cardiac remodeling and reduce inflammation caused by necrotic cardiomyocytes. |
2023-07-05 |
2023-08-14 |
Not clear |
| Y Wang, Z Liu, G Ma, Y Xu, Y L. Mouth breathing induces condylar remodelling and chondrocyte apoptosis via both the extrinsic and mitochondrial pathways in male adolescent rats. Tissue & cell. vol 83. 2023-07-03. PMID:37399641. |
tdt-mediated dutp nick end labelling staining and immunohistochemistry analyses showed that apoptosis occurred in the proliferative and hypertrophic layers of cartilage in the mouth breathing group. |
2023-07-03 |
2023-08-14 |
rat |
| Chih-Chia Chang, Hui-Ching Cheng, Wan-Ching Chou, Yu-Ting Huang, Pei-Ling Hsieh, Pei-Ming Chu, Shin-Da Le. Sesamin suppresses angiotensin-II-enhanced oxidative stress and hypertrophic markers in H9c2 cells. Environmental toxicology. 2023-06-26. PMID:37357850. |
in conclusion, sa could attenuate ang-ii-induced cardiac hypertrophic injuries by inhibiting oxidative stress, apoptosis, and inflammation in h9c2 cells. |
2023-06-26 |
2023-08-14 |
Not clear |
| Shan Mi, Feng Huang, Mingli Jiao, Zhuang Qian, Mingming Han, Zheng Miao, Heqin Zha. Inhibition of MEG3 ameliorates cardiomyocyte apoptosis and autophagy by regulating the expression of miRNA-129-5p in a mouse model of heart failure. Redox report : communications in free radical research. vol 28. issue 1. 2023-06-20. PMID:37338021. |
the long non-coding rna, maternally expressed gene 3 (meg3), are involved in myocardial fibrosis and compensatory hypertrophy, but its role on cardiomyocyte apoptosis and autophagy in heart failure (hf) remains unclear. |
2023-06-20 |
2023-08-14 |
mouse |
| Shanshan Wei, Wanjun Ma, Yuanying Yang, Taoli Sun, Chuanhao Jiang, Jian Liu, Bikui Zhang, Wenqun L. Trastuzumab potentiates doxorubicin-induced cardiotoxicity via activating the NLRP3 inflammasome in vivo and in vitro. Biochemical pharmacology. 2023-06-18. PMID:37331637. |
compared with the wild type mice, the systolic dysfunction, myocardial hypertrophy, cardiomyocyte apoptosis and oxidative stress induced by dox combined tra were alleviated in nlrp3 gene knockout mice. |
2023-06-18 |
2023-08-14 |
mouse |
| Andrea Ruiz-Velasco, Rida Raja, Xinyi Chen, Haresh Ganenthiran, Namrita Kaur, Nasser Hawimel O Alatawi, Jessica M Miller, Riham R E Abouleisa, Qinghui Ou, Xiangjun Zhao, Oveena Fonseka, Xin Wang, Susanne S Hille, Norbert Frey, Tao Wang, Tamer M A Mohamed, Oliver J Müller, Elizabeth J Cartwright, Wei Li. Restored autophagy is protective against PAK3-induced cardiac dysfunction. iScience. vol 26. issue 6. 2023-06-16. PMID:37324527. |
myocardium with pak3 overexpression displayed hypertrophic growth, excessive fibrosis, and aggravated apoptosis following isoprenaline stimulation as early as two days. |
2023-06-16 |
2023-08-14 |
mouse |
| Zhi Lin, Xi Cheng, Hui Zhen. Umbelliferon: a review of its pharmacology, toxicity and pharmacokinetics. Inflammopharmacology. 2023-06-12. PMID:37308634. |
the action mechanisms of umbelliferone include inhibition of oxidative stress, inflammation, and apoptosis, improvement of insulin resistance, myocardial hypertrophy, and tissue fibrosis, in addition to regulation of blood glucose and lipid metabolism. |
2023-06-12 |
2023-08-14 |
Not clear |
| Neda Hedayati, Alireza Yaghoobi, Marziyeh Salami, Yasaman Gholinezhad, Farnaz Aghadavood, Reza Eshraghi, Mohammad-Hossein Aarabi, Mina Homayoonfal, Zatollah Asemi, Hamed Mirzaei, Mohammad Hajijafari, Alireza Mafi, Malihe Rezae. Impact of polyphenols on heart failure and cardiac hypertrophy: clinical effects and molecular mechanisms. Frontiers in cardiovascular medicine. vol 10. 2023-06-09. PMID:37293283. |
our results indicated polyphenols are repeatedly indicated to regulate various heart failure-related vital molecules and signaling pathways, such as inactivating fibrotic and hypertrophic factors, preventing mitochondrial dysfunction and free radical production, the underlying causes of apoptosis, and also improving lipid profile and cellular metabolism. |
2023-06-09 |
2023-08-14 |
Not clear |
| Nikolaos Spilias, Trejeeve Martyn, Kara J Denby, Serge C Harb, Zoran B Popovic, Samir R Kapadi. Left Ventricular Systolic Dysfunction in Aortic Stenosis: Pathophysiology, Diagnosis, Management, and Future Directions. Structural heart : the journal of the Heart Team. vol 6. issue 5. 2023-06-08. PMID:37288060. |
myocyte apoptosis and myocardial fibrosis are the 2 key mechanisms responsible for the transition from the initial adaptation phase of lv hypertrophy to the phase of heart failure with reduced ejection fraction. |
2023-06-08 |
2023-08-14 |
Not clear |
| Rebai Ben Ammar, Sarah Abdulaziz Alamer, Maged Elsayed Mohamed, Duaa Althumairy, Saeed Y Al-Ramadan, Manal Alfwuaires, Nancy S Younis, Thnaian A Althnaian, Ibrahim R I H, Peramaiyan Rajendra. Potential inhibitory effect of geraniol isolated from lemongrass ( Natural product research. 2023-05-25. PMID:37226502. |
according to these results, gnl may protect the heart by reducing hypertrophy in mice and modulating biomarkers of fibrosis and apoptosis. |
2023-05-25 |
2023-08-14 |
mouse |