| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dan Yang, Di Fan, Zhen Guo, Fang-Yuan Liu, Ming-Yu Wang, Peng An, Zheng Yang, Qi-Zhu Tan. SENP1 Protects Against Pressure Overload-Induced Cardiac Remodeling and Dysfunction Via Inhibiting STAT3 Signaling. Journal of the American Heart Association. 2022-11-12. PMID:36370010. |
cardiac-specific senp1 knockdown markedly exacerbated transverse aortic constriction-induced cardiac hypertrophy, systolic dysfunction, fibrotic response, and cellular apoptosis. |
2022-11-12 |
2023-08-14 |
mouse |
| Alaa El-Din H Sayed, Mervat N Hana, Mohamed Hamed, Hany M R Abdel-Latif, Jae-Seong Lee, Hamdy A M Solima. Protective efficacy of dietary natural antioxidants on microplastic particles-induced histopathological lesions in African catfish (Clarias gariepinus). Environmental science and pollution research international. 2022-11-07. PMID:36342605. |
histological analysis of the kidney for group 2 (fed 500 mg/kg mps alone) revealed distributed tissue dissociation, regional glomerular hypertrophy or shrinkage, melanomacrophage accumulation, and expansion of bowman's space, while liver tissue exhibited dilation and rupture of the central vein wall, hemorrhage, cytoplasmic vacuolation, and cellular necrosis or apoptosis. |
2022-11-07 |
2023-08-14 |
Not clear |
| Yunhan Zhao, Bettina Celvin, Maria C Denis, Niki Karagianni, Cecilia Aulin, Farasat Zaman, Lars Sävendah. TNF overexpression and dexamethasone treatment impair chondrogenesis and bone growth in an additive manner. Scientific reports. vol 12. issue 1. 2022-10-28. PMID:36307458. |
in the growth plates of hutnftg mice, increased apoptosis, suppressed indian hedgehog, decreased hypertrophy, and disorganized chondrocyte columns were observed. |
2022-10-28 |
2023-08-14 |
mouse |
| Olga Kachanova, Arseniy Lobov, Anna Malashichev. The Role of the Notch Signaling Pathway in Recovery of Cardiac Function after Myocardial Infarction. International journal of molecular sciences. vol 23. issue 20. 2022-10-27. PMID:36293363. |
it is involved in the formation of the heart in embryogenesis and in the restoration of cardiac function after mi due to: (1) reducing oxidative stress; (2) prevention of apoptosis; (3) regulation of inflammation; (4) containment of fibrosis and hypertrophy of cardiomyocytes; (5) tissue revascularization; and (6) regulation of proliferation and differentiation of cardiomyocytes. |
2022-10-27 |
2023-08-14 |
Not clear |
| Hongyi Zhao, Xi Wang, Yanhong Tang, Qingyan Zhao, Congxin Huan. Inhibition of intermittent calcium-activated potassium channel (SK4) attenuates Ang II-induced hypertrophy of human-induced stem cell-derived cardiomyocytes via targeting Ras-Raf-MEK1/2-ERK1/2 and CN-NFAT signaling pathways. Cell biology international. 2022-10-23. PMID:36273427. |
the downregulation of sk4 by a specific inhibitor tram-34 markedly ameliorated cardiac hypertrophy (reflected by the mrna levels of atrial natriuretic peptide, brain natriuretic peptide, and β-myosin heavy chain) and apoptosis (reflected by the level of caspase 3, bax, and bcl-2) induced by ang ii treatment. |
2022-10-23 |
2023-08-14 |
Not clear |
| Shiji Wang, Guang Wang, Lihua Dong, Xingang Liu, Weiyun Pan, Jinfeng Han, Ying L. The Overexpression of miR-377 Aggravates Sepsis-Induced Myocardial Hypertrophy by Binding to Rcan2 and Mediating CaN Activity. Oxidative medicine and cellular longevity. vol 2022. 2022-10-21. PMID:36267816. |
intriguingly, mir-377 has been correlated with cardiomyocyte apoptosis, whereas its effect on myocardial hypertrophy remains to be illustrated. |
2022-10-21 |
2023-08-14 |
mouse |
| Lishan Lin, Yaling Yu, Kangping Liu, Yixin Jiang, Zhenlei Zho. Downregulation of miR-30b-5p Facilitates Chondrocyte Hypertrophy and Apoptosis via Targeting Runx2 in Steroid-Induced Osteonecrosis of the Femoral Head. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232582. |
downregulation of mir-30b-5p facilitates chondrocyte hypertrophy and apoptosis via targeting runx2 in steroid-induced osteonecrosis of the femoral head. |
2022-10-14 |
2023-08-14 |
Not clear |
| Lishan Lin, Yaling Yu, Kangping Liu, Yixin Jiang, Zhenlei Zho. Downregulation of miR-30b-5p Facilitates Chondrocyte Hypertrophy and Apoptosis via Targeting Runx2 in Steroid-Induced Osteonecrosis of the Femoral Head. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232582. |
the nobly increased expression of matrix metallopeptidase 13 (mmp13) and type x collagen (col10a1) as runx2 downstream genes contributed to the hypertrophic differentiation of chondrocytes, and the efficiently upregulated level of matrix metallopeptidase 9 (mmp9) may trigger chondrocyte apoptosis with mps treatments. |
2022-10-14 |
2023-08-14 |
Not clear |
| Lishan Lin, Yaling Yu, Kangping Liu, Yixin Jiang, Zhenlei Zho. Downregulation of miR-30b-5p Facilitates Chondrocyte Hypertrophy and Apoptosis via Targeting Runx2 in Steroid-Induced Osteonecrosis of the Femoral Head. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232582. |
the cell transfection experiment revealed that mir-30b-5p inhibited chondrocyte hypertrophy and suppressed mps-induced apoptosis. |
2022-10-14 |
2023-08-14 |
Not clear |
| Lishan Lin, Yaling Yu, Kangping Liu, Yixin Jiang, Zhenlei Zho. Downregulation of miR-30b-5p Facilitates Chondrocyte Hypertrophy and Apoptosis via Targeting Runx2 in Steroid-Induced Osteonecrosis of the Femoral Head. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232582. |
as a result, our findings showed that mir-30b-5p modulated runx2, mmp9, mmp13, and col10a1 expression, thereby mediating chondrocyte hypertrophic differentiation and apoptosis during the sonfh process. |
2022-10-14 |
2023-08-14 |
Not clear |
| Xiangning Cui, Yan Wang, Han Liu, Mengjun Shi, Jingwu Wang, Yifei Wan. The Molecular Mechanisms of Defective Copper Metabolism in Diabetic Cardiomyopathy. Oxidative medicine and cellular longevity. vol 2022. 2022-10-14. PMID:36238639. |
copper deficiency can induce cardiac hypertrophy and aggravate cardiomyopathy, while copper excess can mediate various types of cell death, such as autophagy, apoptosis, cuproptosis, pyroptosis, and cardiac hypertrophy and fibrosis. |
2022-10-14 |
2023-08-14 |
human |
| Jooho Park, Dong Wook Shi. Senotherapeutics and Their Molecular Mechanism for Improving Aging. Biomolecules & therapeutics. 2022-10-13. PMID:36226551. |
these senescent cells accumulate in many tissues and exhibit diverse phenotypes, such as resistance to apoptosis, production of senescence-associated secretory phenotype, cellular flattening, and cellular hypertrophy. |
2022-10-13 |
2023-08-14 |
human |
| Haixia Sun, Junling Liu, Yuxin Su, Fang Li, Mingyue Zhang, Jia Li, Meiling Son. The role and mechanism of NDST1/NULP1 regulating right ventricular hypertrophy in hypoxic pulmonary hypertension. General physiology and biophysics. vol 41. issue 5. 2022-10-12. PMID:36222339. |
an in vitro cell experiment showed that inhibition of ndst1 expression enhanced cell viability, reduced cell apoptosis, alleviated cardiomyocyte hypertrophy, decreased inflammation and increased phosphorylated akt level, however, over-expression of ndst1 had opposite effects on these aspects. |
2022-10-12 |
2023-08-14 |
rat |
| Jiacheng Fang, Yuxuan Zhang, Delong Chen, Yiyue Zheng, Jun Jian. Exosomes and Exosomal Cargos: A Promising World for Ventricular Remodeling Following Myocardial Infarction. International journal of nanomedicine. vol 17. 2022-10-11. PMID:36217495. |
here, we summarize the pathological mechanisms of vr following mi, including cardiac myocyte hypertrophy, cardiac fibrosis, inflammation, pyroptosis, apoptosis, autophagy, angiogenesis, and metabolic disorders, and the roles of exosomal cargos in these processes, with a focus on proteins and ncrnas. |
2022-10-11 |
2023-08-14 |
Not clear |
| Shuang Chen, You Li, Shuai Fu, Yang Li, Chao Wang, Ping Sun, Hairu Li, Jiawei Tian, Guo-Qing D. Melatonin alleviates arginine vasopressin-induced cardiomyocyte apoptosis via increasing Mst1-Nrf2 pathway activity to reduce oxidative stress. Biochemical pharmacology. 2022-10-02. PMID:36183803. |
this hypertrophy, along with cardiomyocyte apoptosis, results from oxidative stress. |
2022-10-02 |
2023-08-14 |
Not clear |
| Shuang Chen, You Li, Shuai Fu, Yang Li, Chao Wang, Ping Sun, Hairu Li, Jiawei Tian, Guo-Qing D. Melatonin alleviates arginine vasopressin-induced cardiomyocyte apoptosis via increasing Mst1-Nrf2 pathway activity to reduce oxidative stress. Biochemical pharmacology. 2022-10-02. PMID:36183803. |
therefore, the antioxidant drug, melatonin (mel), is commonly used to treat cardiac hypertrophy and apoptosis; however, whether it could alleviate avp-induced myocardialinjury remains to be addressed. |
2022-10-02 |
2023-08-14 |
Not clear |
| Mary C Wingard, Suman Dalal, Paige L Shook, Paulina Ramirez, Muhammad U Raza, Patrick Johnson, Barbara A Connelly, Douglas P Thewke, Mahipal Singh, Krishna Sing. Deficiency of ataxia-telangiectasia mutated kinase attenuates Western-type diet-induced cardiac dysfunction in female mice. Physiological reports. vol 10. issue 18. 2022-09-19. PMID:36117462. |
previously, we have shown that wd consumption in male atm (ataxia-telangiectasia mutated kinase) deficient mice associates with accelerated body weight (bw) gain, cardiac systolic dysfunction with increased preload, and exacerbation of hypertrophy, apoptosis, and inflammation. |
2022-09-19 |
2023-08-14 |
mouse |
| Mary C Wingard, Suman Dalal, Paige L Shook, Paulina Ramirez, Muhammad U Raza, Patrick Johnson, Barbara A Connelly, Douglas P Thewke, Mahipal Singh, Krishna Sing. Deficiency of ataxia-telangiectasia mutated kinase attenuates Western-type diet-induced cardiac dysfunction in female mice. Physiological reports. vol 10. issue 18. 2022-09-19. PMID:36117462. |
myocardial fibrosis, myocyte hypertrophy, and apoptosis were higher in wt-wd versus wt-nc. |
2022-09-19 |
2023-08-14 |
mouse |
| Mary C Wingard, Suman Dalal, Paige L Shook, Paulina Ramirez, Muhammad U Raza, Patrick Johnson, Barbara A Connelly, Douglas P Thewke, Mahipal Singh, Krishna Sing. Deficiency of ataxia-telangiectasia mutated kinase attenuates Western-type diet-induced cardiac dysfunction in female mice. Physiological reports. vol 10. issue 18. 2022-09-19. PMID:36117462. |
however, apoptosis was significantly lower and hypertrophy was significantly higher in hko-wd versus wt-wd. |
2022-09-19 |
2023-08-14 |
mouse |
| Hongxiang Hong, Jianbin Su, Chao Huang, Xu Lu, Zhiming Cu. Comprehensive insights into the function and molecular and pharmacological regulation of neuron-derived orphan receptor 1, an orphan receptor. Frontiers in pharmacology. vol 13. 2022-09-16. PMID:36110555. |
these include regulation of cellular apoptosis and regeneration, neuron formation, contextual fearing memory, inflammation, vascular smooth muscle proliferation, insulin secretion, and tumor development, whereby nor1 mediates the pathogenesis of numerous diseases such as cerebral ischemia, depression, post-traumatic stress disorder, atherosclerosis, abdominal aortic aneurysm, cardiac hypertrophy, diabetes, osteoarthritis, rheumatoid arthritis, and cancer. |
2022-09-16 |
2023-08-14 |
Not clear |